Expressed antibody repertoires in human cord blood cells: 454 sequencing and IMGT/HighV-QUEST analysis of germline gene usage, junctional diversity, and somatic mutations

Immunogenetics

Volumn 64, Issue 5, 2012, Pages 337-350

  Prabakaran, Ponraj ^a,b   Chen, Weizao ^a   Singarayan, Maria G ^c   Stewart, Claudia C ^b   Streaker, Emily ^a   Feng, Yang ^a   Dimitrov, Dimiter S ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

^c NONE   (United States)

Author keywords

454 Sequencing; Antibody library; Antibody repertoire; Antibodyome; Human cord blood; IgM; IMGT HighV QUEST; Immunoglobulin

Indexed keywords

EXONUCLEASE; IMMUNOGLOBULIN M ANTIBODY; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN M; PRIMER DNA;

ARTICLE; FEMALE; GENE EXPRESSION; GENE REARRANGEMENT; GENETIC VARIABILITY; GERM LINE; HUMAN; HUMAN CELL; MALE; NEWBORN; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SOMATIC MUTATION; UMBILICAL CORD BLOOD; ADULT; ANTIBODY SPECIFICITY; B LYMPHOCYTE; BLOOD; COMPARATIVE STUDY; COMPLEMENTARITY DETERMINING REGION; CYTOLOGY; FETUS BLOOD; GENETICS; IMMUNOGENETICS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; MUTATION; NUCLEOTIDE SEQUENCE; VDJ RECOMBINATION;

ADULT; ANTIBODY DIVERSITY; B-LYMPHOCYTES; BASE SEQUENCE; COMPLEMENTARITY DETERMINING REGIONS; DNA PRIMERS; FEMALE; FETAL BLOOD; GENE REARRANGEMENT, B-LYMPHOCYTE; GERM-LINE MUTATION; HUMANS; IMMUNOGENETIC PHENOMENA; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN M; IMMUNOGLOBULIN VARIABLE REGION; INFANT, NEWBORN; MALE; V(D)J RECOMBINATION;

EID: 84862269218     PISSN: 00937711     EISSN: 14321211     Source Type: Journal    
DOI: 10.1007/s00251-011-0595-8     Document Type: Article

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