Immunoglobulin heavy chain variable region gene replacement as a mechanism for receptor revision in rheumatoid arthritis synovial tissue B lymphocytes

Journal of Experimental Medicine

Volumn 192, Issue 8, 2000, Pages 1151-1164

  Itoh, Kenji ^a   Meffre, Eric ^d   Albesiano, Emilia ^a   Farber, Andrew ^a   Dines, David ^b,c   Stein, Peter ^b,c   Asnis, Stanley E ^a   Furie, Richard A ^a   Jain, Rita I ^a   Chiorazzi, Nicholas ^a  

^a NORTH SHORE UNIVERSITY HOSPITAL   (United States)

^b LONG ISLAND JEWISH MEDICAL CENTER   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Antibody diversity; Autoimmunity; Immune tolerance; Recombinase activating genes; Rheumatoid factor

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN RECEPTOR; RECOMBINASE; RHEUMATOID FACTOR; SIGNAL PEPTIDE;

ADULT; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; BINDING SITE; CASE REPORT; FEMALE; GENE EXPRESSION; GENE REARRANGEMENT; GENE SEQUENCE; GERMINAL CENTER; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCOMPETENCE; IMMUNOLOGICAL TOLERANCE; MALE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SEQUENCE ANALYSIS; SYNOVIUM;

ADULT; ARTHRITIS, RHEUMATOID; B-LYMPHOCYTES; BASE SEQUENCE; FEMALE; GENE LIBRARY; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; GENES, IMMUNOGLOBULIN; HIP JOINT; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN ISOTYPES; IMMUNOGLOBULIN M; IMMUNOGLOBULIN VARIABLE REGION; KNEE JOINT; MALE; MOLECULAR SEQUENCE DATA; MUTATION; POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; SYNOVIAL MEMBRANE; VARIATION (GENETICS);

EID: 0034675956     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.8.1151     Document Type: Article

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