The 12/23 rule is enforced at the cleavage step of V(D)J recombination in vivo

Genes to Cells

Volumn 1, Issue 6, 1996, Pages 543-553

  Steen, Sharri Bockheim ^a   Gomelsky, Larissa ^a   Roth, David B ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; HOMEODOMAIN PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR; PRIMER DNA; PROTEIN; RAG 1 PROTEIN; RAG-1 PROTEIN; RAG2 PROTEIN, MOUSE; V(D)J RECOMBINATION ACTIVATING PROTEIN 2;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; CELL LINE; CHO CELL; GENETIC RECOMBINATION; GENETICS; HAMSTER; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VARIABLE REGION; MOUSE; NUCLEOTIDE SEQUENCE;

ANIMALS; BASE SEQUENCE; CELL LINE; CHO CELLS; CONSERVED SEQUENCE; CRICETINAE; DNA PRIMERS; DNA-BINDING PROTEINS; GENES, IMMUNOGLOBULIN; HOMEODOMAIN PROTEINS; IMMUNOGLOBULIN VARIABLE REGION; MICE; MODELS, GENETIC; PROTEINS; RECEPTORS, ANTIGEN, T-CELL; RECOMBINATION, GENETIC;

EID: 0030155949     PISSN: 13569597     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2443.1996.d01-259.x     Document Type: Article

References (5)

1. Akamatsu, Y., Tsurushita, N., Nagawa, F., et al. (1994) Essential residues in V(D)J recombination signals. J. Immunol. 153, 4520-4529.
2. Bushman, F.D. S: Craigie, R. (1991) Activities of human immunodeficiency virus (HIV) integration protein in vitro: specific cleavage and integration of HIV DNA. Proc. Natl. Acad. Sci. USA 88, 1339-1343.
3. Chen, J.-W., Lee, J. & Jayaram, M. (1992) DNA cleavage in trans by the active site tyrosine during Flp recombination: switching protein partners before exchanging strands. Cell 69, 647-658.
4. Grindley, N.D.F. (1993) Analysis of a nucleoprotein complex: the synaptosome of γδ resolvase. Science 262, 738-740.
5. Zhu, C. & Roth, D.D. (1995) Characterization of coding ends in thymocytes of scid mice: Implications for the mechanism of V(D)J recombination. Immunity 2, 101-112.