Adaptive network nanomedicine: An integrated model for homeopathic medicine

Frontiers in Bioscience - Scholar

Volumn 5 S, Issue 2, 2013, Pages 685-708

  Bell, Iris R ^a,b,c   Schwartz, Gary E ^a,c  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF NURSING   (United States)

^c University of Arizona   (United States)

Author keywords

Adaptation; Complex adaptive systems; Cross adaptation; Homeopathy; Hormesis; Nanomedicine; Nanoparticles; Network medicine; Review; Stress response network; Time dependent sensitization

Indexed keywords

BELLADONNA ALKALOID; COPPER; HEAT SHOCK PROTEIN; INFLAMMASOME; INTERLEUKIN 1BETA; NANOBUBBLE; NANOCRYSTAL; NANOMATERIAL; NANOPARTICLE; POLYETHYLENE; POLYGLACTIN; POLYPROPYLENE; QUANTUM DOT; SILICON DIOXIDE; SILVER NANOPARTICLE; SILVER NITRATE; TIN; ZINC;

ADAPTATION; ARTICLE; BIOAVAILABILITY; BIOLOGICAL ACTIVITY; BIOSYNTHESIS; BRAIN FUNCTION; CELLULAR STRESS RESPONSE; CHEMICAL STRESS; CHRONIC STRESS; COLLOID; COST CONTROL; CYTOKINE RELEASE; DRUG DELIVERY SYSTEM; ELECTROMAGNETIC FIELD; ENVIRONMENTAL CHANGE; EVIDENCE BASED PRACTICE; FLUORESCENCE SPECTROSCOPY; GELSEMIUM; GENE TARGETING; HEART ARRHYTHMIA; HOMEOPATHY; HORMESIS; HUMAN; HYDRASTIS; HYPERICUM; IMMUNE RESPONSE; IN VITRO STUDY; INTEGRATIVE MEDICINE; NANOMEDICINE; NANOTECHNOLOGY; NERVE CELL PLASTICITY; NONHUMAN; OXIDATIVE STRESS; PARTICLE SIZE; PHASE TRANSITION; PHYSIOLOGICAL STRESS; PLACEBO EFFECT; POKEWEED; QUANTUM CHEMISTRY; STEADY STATE; THUJA; TRANSMISSION ELECTRON MICROSCOPY; ULTRASOUND; METHODOLOGY; REVIEW;

HOMEOPATHY; HUMANS; NANOMEDICINE;

EID: 84883214650     PISSN: 19450516     EISSN: 19450524     Source Type: Journal    
DOI: 10.2741/s400     Document Type: Article

References (280)

1. P. Fisher: What is homeopathy? An introduction. Front Biosci (Elite Ed) 4, 1669-82 (2012)
2. P. N. Kaul: Alternative therapeutic modalities. Alternative medicine. Progress in Drug Research 47, 251-277 (1996)
3. M. Frass, R. P.Strassl, H. Friehs, M. Mullner, M. Kundi and A.D. Kaye: Use and acceptance of complementary and alternative medicine among the general population and medical personnel: a systematic review. Ochsner J 12(1), 45-56 (2012)
4. R. L. Nahin, P. M. Barnes, B. J. Stussman and B. Bloom: Costs of Complementary and Alternative Medicine (CAM) and Frequency of Visits to CAM Practitioners: United States, 2007. In: National Health Statistics Reports. National Center for Health Statistics, Hyattsville, MD (2009)
5. C. Witt and H. Albrecht: New Directions in Homeopathy Research. KVC Verlag, Essen, Germany (2009)
6. G. Bornhoft and P. F. Matthiessen: Homeopathy in Healthcare- Effectiveness, Appropriateness, Safety, Costs. Springer (2011)
7. M. Rossignol, B. Begaud, P. Engel, B. Avouac, F. Lert, F. Rouillon, J. Benichou, J. Massol, G. Duru, A. M. Magnier, D. Guillemot, L. Grimaldi-Bensouda, L. Abenhaim and for the EPI3-LA-SER group: Impact of physician preferences for homeopathic or conventional medicines on patients with musculoskeletal disorders: results from the EPI3-MSD cohort. Pharmacoepidemiol Drug Saf (2012)
8. P. Bellavite, M. Marzotto, S. Chirumbolo and A. Conforti: Advances in homeopathy and immunology: a review of clinical research. Front Biosci (Schol Ed) 3, 1363-89 (2011)
9. E. Malarczyk, M. Pazdzioch-Czochra, M. Graz, J. Kochmanska-Rdest and A. Jarosz-Wilkolazka: Nonlinear changes in the activity of the oxygen-dependent demethylase system in Rhodococcus erythropolis cells in the presence of low and very low doses of formaldehyde. Nonlinear Biomed Phys 5(1), 9 (2011)
10. P. Bellavite, Signorini, A.: The Emerging Science of Homeopathy. Complexity, Biodynamics, and Nanopharmacology. North Atlantic Books, Berkeley (2002)
11. Lancet: The end of homeopathy. Lancet 366, 690 (2005)
12. R. Ludtke and A. L. Rutten: The conclusions on the effectiveness of homeopathy highly depend on the set of analyzed trials. J Clin Epidemiol 61(12), 1197-204 (2008)
13. A. Shang, K. Huwiler-Muntener, L. Nartey, P. Juni, S. Dorig, J. A. Sterne, D. Pewsner and M. Egger: Are the clinical effects of homoeopathy placebo effects? Comparative study of placebo-controlled trials of homoeopathy and allopathyLancet 366(9487), 726-32 (2005)
14. M. Aickin: The end of biomedical journals: There is madness in their methods. Journal of Alternative & Complementary Medicine 11(5), 755-757 (2005)
15. J. Jacobs, A. L. Williams, C. Girard, N. V.Y. and D. Katz: Homeopathy for attention-deficit/hyperactivity disorder: a pilot randomized controlled trial. Journal of Alternative & Complementary Medicine 11(5), 799-806 (2005)
16. S. Brien, L. Lachance, P. Prescott, C. McDermott and G. Lewith: Homeopathy has clinical benefits in rheumatoid arthritis patients that are attributable to the consultation process but not the homeopathic remedy: a randomized controlled clinical trial. Rheumatology (Oxford) 50(6), 1070-82 (2011)
17. A. P. Bikker, S. W. Mercer and D. Reilly: A pilot prospective study on the consultation and relational empathy, patient enablement, and health changes over 12 months in patients going to the Glasgow Homoeopathic Hospital. J Altern Complement Med 11(4), 591-600 (2005)
18. I. R. Bell, M. Koithan and D. Pincus: Research methodological implications of nonlinear dynamical systems models for whole systems of complementary and alternative medicine. Forschende Komplementarmedizin und Klassische Naturheilkunde 19(Supplement 1), 15-21 (2012)
19. R. T. Mathie, H. Roniger, M. Van Wassenhoven, J. Frye, J. Jacobs, M. Oberbaum, M. F. Bordet, C. Nayak, G. Chaufferin, J. A. Ives, F. Dantas and P. Fisher: Method for appraising model validity of randomised controlled trials of homeopathic treatment: Multi-rater concordance study. BMC Med Res Methodol 12(1), 49 (2012)
20. H. Frei, R. Everts, K. von Ammon, F. Kaufmann, D. Walther, S. F. Schmitz, M. Collenberg, M. Steinlin, C. Lim and A. Thurneysen: Randomised controlled trials of homeopathy in hyperactive children: Treatment procedure leads to an unconventional study design Experience with open-label homeopathic treatment preceding the Swiss ADHD placebo controlled, randomised, double-blind, cross-over trial. Homeopathy 96(1), 35-41 (2007)
21. G. T. Lewith, A. D. Watkins, M. E. Hyland, S. Shaw, J. A. Broomfield, G. Dolan and S. T. Holgate: Use of ultramolecular potencies of allergen to treat asthmatic people allergic to house dust mite: double blind randomised controlled clinical trial. BMJ 324(7336), 520-523 (2002)
22. M. E. Hyland and G. T. Lewith: Oscillatory effects in a homeopathic clinical trial: an explanation using complexity theory, and implications for clinical practice. Homeopathy 91(3), 145-149 (2002)
23. M. van Wassenhoven and G. Ives: An observational study of patients receiving homeopathic treatment. Homeopathy 93(1), 3-11 (2004)
24. R. Pomposelli, V. Piasere, C. Andreoni, G. Costini, E. Tonini, A. Spalluzzi, D. Rossi, C. Quarenghi, M. E. Zanolin and P. Bellavite: Observational study of homeopathic and conventional therapies in patients with diabetic polyneuropathy. Homeopathy 98(1), 17-25 (2009)
25. E. Rossi, C. Endrizzi, M. A. Panozzo, A. Bianchi and M. Da Fre: Homeopathy in the public health system: a seven-year observational study at Lucca Hospital (Italy). Homeopathy 98(3), 142-8 (2009)
26. M. Trichard, Chaufferin, G., Nicoloyannis, N.: Pharmacoeconomic comparison between homeopathic and antibiotic treatment strategies in recurrent acute rhinopharyngitis in children. Homeopathy. Journal of the Faculty of Homeopathy 94(1), 3-9 (2005)
27. I. R. Bell, Howerter, A., Jackson, N., Brooks, A.J., Schwartz, G.E.: Multi-week resting EEG cordance change patterns from repeated olfactory activation with two constitutionally-salient homeopathic remedies in healthy young adults. J Alternative and Complementary Medicine 18(5), 445-53 (2012)
28. I. R. Bell, D. A. Lewis, 2nd, G. E. Schwartz, S. E. Lewis, O. Caspi, A. Scott, A. J. Brooks and C. M. Baldwin: Electroencephalographic cordance patterns distinguish exceptional clinical responders with fibromyalgia to individualized homeopathic medicines. Journal of Alternative & Complementary Medicine 10(2), 285-99 (2004)
29. I. R. Bell, A. Howerter, N. Jackson, M. Aickin, C. M. Baldwin and R. R. Bootzin: Effects of homeopathic medicines on polysomnographic sleep of young adults with histories of coffee-related insomnia. Sleep Med 12(5), 505-11 (2011)
30. I. R. Bell, D. A. Lewis, 2nd, S. E. Lewis, G. E. Schwartz, A. J. Brooks, A. Scott and C. M. Baldwin: EEG alpha sensitization in individualized homeopathic treatment of fibromyalgia. International Journal of Neuroscience 114(9), 1195-220 (2004)
31. I. R. Bell, Brooks, A.J., Howerter, A., Jackson, N., Schwartz, G.E.: Short term effects of repeated olfactory administration of homeopathic Sulphur or Pulsatilla on electroencephalographic alpha power in healthy young adults. Homeopathy 100(4), 203-11 (2011)
32. I. R. Bell, A. J. Brooks, A. Howerter, N. Jackson and G. E. Schwartz: Acute electroencephalographic effects from repeated olfactory administration of homeopathic remedies in individuals with self-reported chemical sensitivity. Alternative Therapies in Health and Medicine in press (2012)
33. G. Ruiz-Vega, Perez-Ordaz, L., Cortes-Galvan L., Juarez-G, F.M.: A kinetic approach to caffeine-Coffea cruda interaction. Homeopathy: The Journal of the Faculty of Homeopathy., 92(1), 19-29 (2003)
34. G. Ruiz-Vega, Poitevin, B., Pérez-Ordaz, L.: Histamine at high dilution reduces spectral density in delta band in sleeping rats. Homeopathy94(2), 86-91 (2005)
35. I. R. Bell, A. Howerter, N. Jackson, M. Aickin and R. R. Bootzin: Nonlinear dynamical systems effects of homeopathic remedies on multiscale entropy and correlation dimension of slow wave sleep EEG in young adults with histories of coffee-induced insomnia. Homeopathy 101(3), 182-92 (2012)
36. G. Ruiz, Torres, J.L.: Homeopathic effect on the sleep pattern of rats. British Homoeopathic Journal 86, 201-206 (1997)
37. M. A. Myagkova, T. V. Abramenko, O. N. Panchenko and O. I. Epstein: Antibodies to delta sleepinducing peptide in ultralow doses: study of the effect by enzyme immunoassay. Bull Exp Biol Med 135 Suppl 7, 102-4 (2003)
38. D. Das, A. De, S. Dutta, R. Biswas, N. Boujedaini and A. R. Khuda-Bukhsh: Potentized homeopathic drug Arsenicum Album 30C positively modulates protein biomarkers and gene expressions in Saccharomyces cerevisae exposed to arsenate. Zhong Xi Yi Jie He Xue Bao 9(7), 752-60 (2011)
39. A. R. Khuda-Bukhsh: Towards understanding molecular mechanisms of action of homeopathic drugs: an overview. Mol Cell Biochem 253(1-2), 339-45 (2003)
40. A. R. Khuda-Bukhsh, S. S. Bhattacharyya, S. Paul, S. Dutta, N. Boujedaini and P. Belon: Modulation of Signal Proteins: A Plausible Mechanism to Explain How a Potentized Drug Secale Cor 30C Diluted beyond Avogadro's Limit Combats Skin Papilloma in Mice. Evid Based Complement Alternat Med 2011, 286320 (2011)
41. A. R. Khuda-Bukhsh, A. De, D. Das, S. Dutta and N. Boujedaini: Analysis of the capability of ultra-highly diluted glucose to increase glucose uptake in arsenite-stressed bacteria Escherichia coli. Zhong Xi Yi Jie He Xue Bao 9(8), 901-12 (2011)
42. P. Mallick, J. C. Mallick, B. Guha and A. R. Khuda-Bukhsh: Ameliorating effect of microdoses of a potentized homeopathic drug, Arsenicum Album, on arsenic-induced toxicity in mice. BMC Complement Altern Med 3, 7 (2003)
43. P. Gal, T. Vasilenko, I. Kovac, M. Kostelnikova, J. Jakubco, P. Szabo, B. Dvorankova, F. Sabol, H. J. Gabius and K. Smetana, Jr.: Atropa belladonna L. water extract: Modulator of extracellular matrix formation in vitro and in vivo. Physiol Res (2012)
44. E. C. Ive, I. M. Couchman and L. Reddy: Therapeutic effect of Arsenicum album on leukocytes. Int J Mol Sci 13(3), 3979-87 (2012)
45. S. Pathak, A. S. Multani, P. Banerji and P. Banerji: Ruta 6 selectively induces cell death in brain cancer cells but proliferation in normal peripheral blood lymphocytes: A novel treatment for human brain cancer. Int J Oncol23(4), 975-82 (2003)
46. S. Porozov, L. Cahalon, M. Weiser, D. Branski, O. Lider and M. Oberbaum: Inhibition of IL-1beta and TNFalpha secretion from resting and activated human immunocytes by the homeopathic medication Traumeel S. Clinical & Developmental Immunology 11(2), 143-9 (2004)
47. C. Ramachandran, P. K. Nair, R. T. Clement and S. J. Melnick: Investigation of cytokine expression in human leukocyte cultures with two immune-modulatory homeopathic preparations. J Altern Complement Med 13(4), 403-7 (2007)
48. S. Bertani, S. Lussignoli, G. Andrioli, P. Bellavite and A. Conforti: Dual effects of a homeopathic mineral complex on carrageenan-induced oedema in rats. British Homoeopathic Journal, 88(3), 101-5 (1999)
49. S. Das, S. K. Saha, A. De, D. Das and A. R. Khuda-Bukhsh: Potential of the homeopathic remedy, Arnica Montana 30C, to reduce DNA damage in Escherichia coli exposed to ultraviolet irradiation through up-regulation of nucleotide excision repair genes. Zhong Xi Yi Jie He Xue Bao 10(3), 337-46 (2012)
50. A. De, D. Das, S. Dutta, D. Chakraborty, N. Boujedaini and A. R. Khuda-Bukhsh: Potentized homeopathic drug Arsenicum Album 30C inhibits intracellular reactive oxygen species generation and up-regulates expression of arsenic resistance gene in arsenine-exposed bacteria Escherichia coli. J Chinese Integrative Med 10(2), 210-27 (2012)
51. S. Lussignoli, S. Bertani, H. Metelmann, P. Bellavite and A. Conforti: Effect of Traumeel S, a homeopathic formulation, on blood-induced inflammation in rats. Complementary Therapies in Medicine 7(4), 225-30 (1999)
52. R. Van Wijk and F. A. Wiegant: Postconditioning hormesis and the homeopathic Similia principle: Molecular aspects. Hum Exp Toxicol 29(7), 561-5 (2010)
53. R. Van Wijk and F. A. Wiegant: Postconditioning hormesis and the similia principle. Front Biosci (Elite Ed, 3, 1128-38 (2011)
54. F. A. Wiegant, H. A. Prins and R. Van Wijk: Postconditioning hormesis put in perspective: an overview of experimental and clinical studies. Dose Response 9(2), 209-24 (2011)
55. C. C. de Oliveira, S. M. de Oliveira, V. M. Goes, C. M. Probst, M. A. Krieger and F. Buchi Dde: Gene expression profiling of macrophages following mice treatment with an immunomodulator medication. J Cell Biochem 104(4), 1364-77 (2008)
56. P. Belon, Cumps J, Ennis M, Mannaioni PF, Roberfroid M, Sainte-Laudy J, Wiegant FA.: Histamine dilutions modulate basophil activation. Inflamm Res 53(5), 181-8 (2004)
57. C. O. Coelho Moreira, J. de Fatima Ferreira Borges da Costa, M. F. Leal, E. Ferreira de Andrade, A. P. Rezende, A. A. Imbeloni, J. A. Pereira Carneiro Muniz, M. de Arruda Cardoso Smith, R. R. Burbano and P. P. de Assumpcao: Lymphocyte proliferation stimulated by activated Cebus apella macrophages treated with a complex homeopathic immune response modifiers. Homeopathy 101(1), 74-9 (2012
58. W. K. Pereira, M. V. Lonardoni, R. Grespan, S. M. Caparroz-Assef, R. K. Cuman and C. A. Bersani-Amado: Immunomodulatory effect of Canova medication on experimental Leishmania amazonensis infection. J Infect 51(2), 157-64 (2005)
59. I. R. Bell: Homeopathy as systemic adaptational nanomedicine: The nanoparticle-cross-adaptationsensitization model. American Journal of Homeopathic Medicine in press (2012)
60. R. P. Upadhyay, C. Nayak: Homeopathy emerging as nanomedicine. Int J High Dilution Res 10(37), 299-310 (2011)
61. P. S. Chikramane, A. K. Suresh, J. R. Bellare and S. G. Kane: Extreme homeopathic dilutions retain starting materials: A nanoparticulate perspective. Homeopathy 99(4), 231-42 (2010)
62. S. S. Bhattacharyya, J. Das, S. Das, A. Samadder, D. Das, A. De, S. Paul and A. R. Khuda-Bukhsh: Rapid green synthesis of silver nanoparticles from silver nitrate by a homeopathic mother tincture Phytolacca Decandra. Zhong Xi Yi Jie He Xue Bao 10(5), 546-54 (2012)
63. S. S. Bhattacharyya, S. K. Mandal, R. Biswas, S. Paul, S. Pathak, N. Boujedaini, P. Belon and A. R. Khuda-Bukhsh: In vitro studies demonstrate anticancer activity of an alkaloid of the plant Gelsemium sempervirens. Exp Biol Med (Maywood) 233(12), 1591-601 (2008)
64. J. A. Ives, J. R. Moffett, P. Arun, D. Lam, T. I. Todorov, A. B. Brothers, D. J. Anick, J. Centeno, M. A. Namboodiri and W. B. Jonas: Enzyme stabilization by glass-derived silicates in glass-exposed aqueous solutions. Homeopathy 99(1), 15-24 (2010)
65. B. M. Mohamed, N. K. Verma, A. Prina-Mello, Y. Williams, A. M. Davies, G. Bakos, L. Tormey, C. Edwards, J. Hanrahan, A. Salvati, I. Lynch, K. Dawson, D. Kelleher and Y. Volkov: Activation of stress-related signalling pathway in human cells upon SiO2 nanoparticles exposure as an early indicator of cytotoxicity. J Nanobiotechnology 9, 29 (2011)
66. X. Yang, J. Liu, H. He, L. Zhou, C. Gong, X. Wang, L. Yang, J. Yuan, H. Huang, L. He, B. Zhang and Z. Zhuang: SiO2 nanoparticles induce cytotoxicity and protein expression alteration in HaCaT cells. Part Fibre Toxicol 7, 1 (2010)
67. M. Zhu, Y. Li, J. Shi, W. Feng, G. Nie and Y. Zhao: Exosomes as extrapulmonary signaling conveyors for nanoparticle-induced systemic immune activation. Small 8(3), 404-12 (2012)
68. M. Zhu, X. Tian, X. Song, Y. Li, Y. Tian, Y. Zhao and G. Nie: Nanoparticle-Induced Exosomes Target Antigen-Presenting Cells to Initiate Th1-Type Immune Activation. Small (2012)
69. I. Iavicoli, E. J. Calabrese and M. A. Nascarella: Exposure to nanoparticles and hormesis. Dose Response 8(4), 501-17 (2010)
70. F. M. Winnik and D. Maysinger: Quantum Dot Cytotoxicity and Ways To Reduce It. Acc Chem Res (2012)
71. S. Hahnemann: Organon of the Medical Art. 6th ed. Birdcage Books, Redmond, WA (1843)
72. C. L. DeCastro and B. S. Mitchell: Nanoparticles from mechanical attrition. In: Synthesis, Functionalization, and Surface Treatment of Nanoparticles. Ed M. I. Baraton. American Scientific Publisher, Valencia, CA (2002)
73. C. Tang, T. Zhou, J. Yang, Q. Zhang, F. Chen, Q. Fu and L. Yang: Wet-grinding assisted ultrasonic dispersion of pristine multi-walled carbon nanotubes (MWCNTs) in chitosan solution. Colloids Surf B Biointerfaces 86(1), 189-97 (2011)
74. Z. Zhu, K. Margulis-Goshen, S. Magdassi, Y. Talmon and C. W. Macosko: Polyelectrolyte stabilized drug nanoparticles via flash nanoprecipitation: a model study with beta-carotene. J Pharm Sci 99(10), 4295-306 (2010)
75. D. Philip: Green synthesis of gold and silver nanoparticles using Hibiscus rosa sinensis. Physica E: Low Dimens Sys Nanostruct 42, 1417-24 (2010)
76. S. S. Bhattacharyya, S. Paul and A. R. Khuda-Bukhsh: Encapsulated plant extract (Gelsemium sempervirens) poly (lactide-co-glycolide) nanoparticles enhance cellular uptake and increase bioactivity in vitro. Exp Biol Med (Maywood) 235(6), 678-88 (2010)
77. D. J. Prakash, S. Arulkumar and M. Sabesan: Effect of nanohypericum (Hypericum perforatum gold nanoparticles) treatment on restraint stress induced behavioral and biochemical alteration in male albino mice. Pharmacognosy Res 2(6), 330-4 (2010)
78. M. L. Rao, R. Roy, I. R. Bell and R. Hoover: The defining role of structure (including epitaxy) in the plausibility of homeopathy. Homeopathy 96(3), 175-82 (2007)
79. M. A. Hampton and A. V. Nguyen: Nanobubbles and the nanobubble bridging capillary force. Adv Colloid Interface Sci 154(1-2), 30-55 (2010)
80. E. Y. Lukianova-Hleb, X. Ren, P. E. Constantinou, B. P. Danysh, D. L. Shenefelt, D. D. Carson, M. C. Farach-Carson, V. A. Kulchitsky, X. Wu, D. S. Wagner and D. O. Lapotko: Improved Cellular Specificity of Plasmonic Nanobubbles versus Nanoparticles in Heterogeneous Cell Systems. PLoS ONE 7(4), e34537 (2012)
81. D. Wen: Intracellular hyperthermia: Nanobubbles and their biomedical applications. Int J Hyperthermia 25(7), 533-41 (2009)
82. A. R. Abbasi and A. Morsali: Influence of solvents on the morphological properties of AgBr nano-structures prepared using ultrasound irradiation. Ultrason Sonochem 19(3), 540-5 (2012)
83. C. Buzea, I. I. Pacheco and K. Robbie: Nanomaterials and nanoparticles: sources and toxicity. Biointerphases 2(4), MR17-71 (2007)
84. E. Roduner: Size matters: why nanomaterials are different. Chemical Society Reviews 35(7), 583-92 (2006)
85. M. Song, S. Yuan, J. Yin, X. Wang, Z. Meng, H. Wang and G. Jiang: Size-dependent toxicity of nano-C60 aggregates: More sensitive indication by apoptosis-related Bax translocation in cultured human cells. Environ Sci Technol 46(6), 3457-64 (2012)
86. D. Napierska, L. C. Thomassen, V. Rabolli, D. Lison, L. Gonzalez, M. Kirsch-Volders, J. A. Martens and P. H. Hoet: Size-dependent cytotoxicity of monodisperse silica nanoparticles in human endothelial cells. Small 5(7) 846-53 (2009)
87. R. Yanagisawa, H. Takano, K. I. Inoue, E. Koike, K. Sadakane and T. Ichinose: Size effects of polystyrene nanoparticles on atopic dermatitislike skin lesions in NC/NGA mice. Int J Immunopathol Pharmacol 23(1), 131-41 (2010)
88. H. B. Nair, B. Sung, V. R. Yadav, R. Kannappan, M. M. Chaturvedi and B. B. Aggarwal: Delivery of antiinflammatory nutraceuticals by nanoparticles for the prevention and treatment of cancer. Biochem Pharmacol 80(12), 1833-43 (2010)
89. A. Bershteyn, M. C. Hanson, M. P. Crespo, J. J. Moon, A. V. Li, H. Suh and D. J. Irvine: Robust IgG responses to nanograms of antigen using a biomimetic lipid-coated particle vaccine. J Control Release 157(3), 354-65 (2012)
90. M. Diwan, P. Elamanchili, M. Cao and J. Samuel: Dose sparing of CpG oligodeoxynucleotide vaccine adjuvants by nanoparticle delivery. Curr Drug Deliv 1(4), 405-12 (2004)
91. A. L. Armstead and B. Li: Nanomedicine as an emerging approach against intracellular pathogens. Int J Nanomedicine 6, 3281-93 (2011)
92. L. Zhongfa, M. Chiu, J. Wang, W. Chen, W. Yen, P. Fan-Havard, L. D. Yee and K. K. Chan: Enhancement of curcumin oral absorption and pharmacokinetics of curcuminoids and curcumin metabolites in mice. Cancer Chemother Pharmacol 69(3), 679-89 (2012)
93. M. O. Oyewumi, A. Kumar and Z. Cui: Nanomicroparticles as immune adjuvants: correlating particle sizes and the resultant immune responses. Expert Rev Vaccines 9(9), 1095-107 (2010)
94. H. Zhang, X. He, Z. Zhang, P. Zhang, Y. Li, Y. Ma, Y. Kuang, Y. Zhao and Z. Chai: Nano-CeO2 exhibits adverse effects at environmental relevant concentrations. Environ Sci Technol 45(8), 3725-30 (2011)
95. I. Iavicoli, V. Leso, L. Fontana and A. Bergamaschi: Toxicological effects of titanium dioxide nanoparticles: a review of in vitro mammalian studies. Eur Rev Med Pharmacol Sci 15(5), 481-508 (2011)
96. P. Kovacic and R. Somanathan: Biomechanisms of nanoparticles (toxicants, antioxidants and therapeutics): electron transfer and reactive oxygen species. J Nanosci Nanotechnol 10(12), 7919-30 (2010)
97. K. Wittmaack: Novel dose metric for apparent cytotoxicity effects generated by in vitro cell exposure to silica nanoparticles. Chem Res Toxicol 24(2), 150-8 (2011)
98. L. Harhaji, A. Isakovic, N. Raicevic, Z. Markovic, B. Todorovic-Markovic, N. Nikolic, S. Vranjes-Djuric, I. Markovic and V. Trajkovic: Multiple mechanisms underlying the anticancer action of nanocrystalline fullerene. Eur J Pharmacol 568(1-3), 89-98 (2007)
99. A. R. Khuda-Bukhsh, S. S. Bhattacharyya, S. Paul and N. Boujedaini: Polymeric nanoparticle encapsulation of a naturally occurring plant scopoletin and its effects on human melanoma cell A375. Zhong Xi Yi Jie He Xue Bao 8(9), 853-62 (2010)
100. B. Yang, Q. Wang, R. Lei, C. Wu, C. Shi, Y. Yuan, Y. Wang, Y. Luo, Z. Hu, H. Ma and M. Liao: Systems toxicology used in nanotoxicology: Mechanistic insights into the hepatotoxicity of nano-copper particles from toxicogenomics. J Nanosci Nanotechnol 10(12), 8527-37 (2010)
101. E. Merisko-Liversidge and G. G. Liversidge: Nanosizing for oral and parenteral drug delivery: a perspective on formulating poorly-water soluble compounds using wet media milling technology. Adv Drug Deliv Rev 63(6), 427-40 (2011)
102. E. Merisko-Liversidge, G. G. Liversidge and E. R. Cooper: Nanosizing: a formulation approach for poorly water-soluble compounds. Eur J Pharm Sci 18(2), 113-20 (2003)
103. M. Elsabahy and K. L. Wooley: Design of polymeric nanoparticles for biomedical delivery applications. Chem Soc Rev 41(7), 2545-61 (2012)
104. S. K. Singh, K. K. Srinivasan, K. Gowthamarajan, D. S. Singare, D. Prakash and N. B. Gaikwad: Investigation of preparation parameters of nanosuspension by top-down media milling to improve the dissolution of poorly watersoluble glyburide. Eur J Pharm Biopharm 78(3), 441-6 (2011)
105. M. Wang, G. C. Rutledge, A. S. Myerson and B. L. Trout: Production and characterization of carbamazepine nanocrystals by electrospraying for continuous pharmaceutical manufacturing. J Pharm Sci 101(3), 1178-88 (2012)
106. V. Caron, J. F. Willart, R. Lefort, P. Derollez, F. Danede and M. Descamps: Solid state amorphization kinetic of alpha lactose upon mechanical milling. Carbohydr Res 346(16), 2622-8 (2011)
107. M. A. Tavares Cardoso, M. Talebi, P. A. Soares, C. U. Yurteri and J. R. van Ommen: Functionalization of lactose as a biological carrier for bovine serum albumin by electrospraying. Int J Pharmaceutics 414(1-2), 1-5 (2011)
108. L. Song, K. Yang, W. Jiang, P. Du and B. Xing: Adsorption of bovine serum albumin on nano and bulk oxide particles in deionized water. Colloids Surf B Biointerfaces 94, 341-6 (2012)
109. D. J. Anick and J. A. Ives: The silica hypothesis for homeopathy: physical chemistry. Homeopathy., 96(3), 189-95 (2007)
110. Y. Liu, C. Lou, H. Yang, M. Shi and H. Miyoshi: Silica nanoparticles as promising drug/gene delivery carriers and fluorescent nano-probes: recent advances. Curr Cancer Drug Targets, 11(2), 156-63 (2011)
111. G. Bhakta, A. Shrivastava and A. Maitra: Magnesium phosphate nanoparticles can be efficiently used in vitro and in vivo as non-viral vectors for targeted gene delivery. J Biomed Nanotechnol, 5(1), 106-14 (2009)
112. S. Baumgartner: The State of Basic Research on Homeopathy. In: New Directions in Homeopathy Research. Ed C. Witt&H. Albrecht. KVC Verlag, Essen, Germany (2009)
113. S. Das, J. Das, A. Samadder, S. Bhattacharyya, D. Das, A. R. Khuda-Bukhsh: Biosynthesized silver nanoparticles by ethanolic extracts of Phytolacca decandra, Gelsemium sempervirens, Hydastis canadensis and Thuja occidentalis induce differential cytotoxicity through G2/M arrest in A375 cells. Colloids Surf B: Biointerfaces 101, 325-336 (2013)
114. H. K. Baca, E. C. Carnes, C. E. Ashley, D. M. Lopez, C. Douthit, S. Karlin, C. J. Brinker: Cell-directedassembly: directing the formation of nano/bio interfaces and architectures with living cells. Biochim Biophys Acta 1810(3), 259-67 (2011)
115. C. C. Perry and T. Keeling-Tucker: Model studies of colloidal silica precipitation using biosilica extracts from Equisetum telmateia. Colloid Polym Sci 281, 652-664 (2003)
116. B. Ruan and M. Jacobi: Ultrasonication effects on thermal and rheological properties of carbon nanotube suspensions. Nanoscale Research Letters 7(1), 127 (2012)
117. H. Konakanchi, R. Vajjha, D. Misra and D. Das: Electrical conductivity measurements of nanofluids and development of new correlations. J Nanosci Nanotechnol 11(8), 6788-95 (2011)
118. P. Yao and S. Hughes: Macroscopic entanglement and violation of Bell's inequalities between two spatially separated quantum dots in a planar photonic crystal system. Opt Express 17(14), 11505-14 (2009)
119. V. Elia and M. Niccoli: New physico-chemical properties of extremely diluted aqueous solutions. Journal of Thermal Analysis and Calorimetry 75, 815-836 (2004)
120. V. Elia and M. Niccoli: Thermodynamics of extremely diluted aqueous solutions. Annals of the New York Academy of Sciences 879, 241-248 (1999)
121. V. Elia, E. Napoli and R. Germano: The 'Memory of Water': an almost deciphered enigma. Dissipative structures in extremely dilute aqueous solutions. Homeopathy 96(3), 163-9 (2007)
122. L. Rey: Thermoluminescence of ultra-high dilutions of lithium chloride and sodium chloride. Physica A: Statistical mechanics and its applications 323, 67-74 (2003)
123. V. N. Pustovit and T. V. Shahbazyan: Fluorescence quenching near small metal nanoparticles. J Chem Phys 136(20), 204701 (2012)
124. H. Walach: Entanglement model of homeopathy as an example of generalised entanglement predicted by weak quantum theory. Forschende Komplementarmedizin/ Research in Complementary Medicine 10(4), 192-200 (2003)
125. O. A. Williams, J. Hees, C. Dieker, W. Jager, L. Kirste and C. E. Nebel: Size-dependent reactivity of diamond nanoparticles. ACS Nano 4(8), 4824-30 (2010)
126. S. S. Mano, K. Kanehira, S. Sonezaki and A. Taniguchi: Effect of Polyethylene Glycol Modification of TiO2 Nanoparticles on Cytotoxicity and Gene Expressions in Human Cell Lines. Int J Mol Sci 13(3), 3703-17 (2012)
127. J. Zilinskas, J. Zekonis, G. Zekonis, R. Sadzeviciene, M. Sapragoniene, J. Navickaite and I. Barzdziukaite: Inhibition of peripheral blood neutrophil oxidative burst in periodontitis patients with a homeopathic medication Traumeel S. Med Sci Monit 17(5), CR284-91 (2011)
128. C. R. Patil, A. D. Rambhade, R. B. Jadhav, K. R. Patil, V. K. Dubey, B. M. Sonara and S. S. Toshniwal: Modulation of arthritis in rats by Toxicodendron pubescens and its homeopathic dilutions. Homeopathy 100(3), 131-7 (2011)
129. D. R. Patel, I. A. Ansari, Y. N. Kachchhi, R. B. Patel, K. R. Patil, R. B. Jadhav and C. R. Patil: Toxicodendron pubescens retains its anti-arthritic efficacy at 1M, 10M and CM homeopathic dilutions. Homeopathy 101(3), 165-70 (2012)
130. G. E. Batley, J. K. Kirby and M. J. McLaughlin: Fate and Risks of Nanomaterials in Aquatic and Terrestrial Environments. Acc Chem Res (2012)
131. J. Feng, J. M. Slocik, M. Sarikaya, R. R. Naik, B. L. Farmer and H. Heinz: Influence of the Shape of Nanostructured Metal Surfaces on Adsorption of Single Peptide Molecules in Aqueous Solution. Small (2012)
132. S. Guha, X. Ma, M. J. Tarlov and M. R. Zachariah: Quantifying Ligand Adsorption to Nanoparticles Using Tandem Differential Mobility Mass Analysis. Anal Chem (2012)
133. Y. Liu, K. Kathan, W. Saad and R. K. Prudhomme: Ostwald ripening of B-carotene nanoparticles. Physical Review Letters98(035102), 1-4 (2007)
134. C. Sengel, C. Hascicek and N. Gonul: Design of vitamin E d-alpha-Tocopheryl Polyethylene Glycol 1000 Succinate-Emulsified Poly (D,L-Lactide-co-Glycolide) Nanoparticles: Influence of Duration of Ultrasonication Energy. J Young Pharm 3(3), 171-5 (2011)
135. N. C. Sukul, Bala, S.K., Bhattacharyya, B.: Prolonged cataleptogenic effects of potentized homoeopathic drugs. Psychopharmacology 89, 338-339 (1986)
136. W. Pongratz, Nograsek, A., Endler, C.: Highly diluted agitated silver nitrate and wheat seedling development. Effect kinetics of a process of successive agitation phases. In: Fundamental Research in Ultra High Dilution and Homeopathy. Ed J. Schulte, Endler, P.C. Kluwer Academic Publishers, Dordrecht, The Netherlands (1998)
137. W. Pongratz and P. C. Endler: Reappraisal of a classical botanical experiment in ultra high dilution research. Energetic coupling in a wheat model. In: Ultra High Dilution. Ed P. C. Endler and J. Schulte. Kluwer Academic Publishers, Dordrecht, Netherlands (1994)
138. P. Magnani, A. Conforti, E. Zanolin, M. Marzotto and P. Bellavite: Dose-effect study of Gelsemium sempervirens in high dilutions on anxiety-related responses in mice. Psychopharmacology (Berl) 210(4), 533-45 (2010)
139. H. L. Xin and H. Zheng: In situ Observation of Oscillatory Growth of Bismuth Nanoparticles. Nano Lett (2012)
140. X. Zhang, M. R. Servos and J. Liu: Ultrahigh Nanoparticle Stability against Salt, pH, and Solvent with Retained Surface Accessibility via Depletion Stabilization. J Am Chem Soc 134(24), 9910-3 (2012)
141. T. R. Downs, M. E. Crosby, T. Hu, S. Kumar, A. Sullivan, K. Sarlo, B. Reeder, M. Lynch, M. Wagner, T. Mills and S. Pfuhler: Silica nanoparticles administered at the maximum tolerated dose induce genotoxic effects through an inflammatory reaction while gold nanoparticles do not. Mutat Res 745(1-2), 38-50 (2012)
142. S. L. Demento, S. C. Eisenbarth, H. G. Foellmer, C. Platt, M. J. Caplan, W. Mark Saltzman, I. Mellman, M. Ledizet, E. Fikrig, R. A. Flavell and T. M. Fahmy: Inflammasomeactivating nanoparticles as modular systems for optimizing vaccine efficacy. Vaccine 27(23), 3013-21 (2009)
143. WJ Sandberg, M Lag, JA Holme, B Friede, M Gualtieri, M Kruszewski, PE Schwarze, T Skuland, M Refsnes: Comparison of non-crystalline silica nanoparticles in IL-1beta release from macrophages. Part Fibre Toxicol 9(1), 32 (2012)
144. T. Wang, H. Jiang, Q. Zhao, S. Wang, M. Zou and G. Cheng: Enhanced mucosal and systemic immune responses obtained by porous silica nanoparticles used as an oral vaccine adjuvant: Effect of silica architecture on immunological properties. Int J Pharm (2012)
145. I. Blute, R. J. Pugh, J. van de Pas and I. Callaghan: Silica nanoparticle sols. Part 3: Monitoring the state of agglomeration at the air/water interface using the Langmuir-Blodgett technique. J Colloid Interface Sci 336(2), 584-91 (2009)
146. L. Y. Chang, E. Osawa and A. S. Barnard: Confirmation of the electrostatic self-assembly of nanodiamonds. Nanoscale 3(3), 958-62 (2011)
147. V. K. Sharma: Aggregation and toxicity of titanium dioxide nanoparticles in aquatic environment-A review. J Environ Sci Health A Tox Hazard Subst Environ Eng 44(14), 1485-95 (2009)
148. S. Mahesh, A. Gopal, R. Thirumalai and A. Ajayaghosh: Light-induced Ostwald ripening of organic nanodots to rods. J Am Chem Soc 134(17), 7227-30 (2012)
149. S. Verma, R. Gokhale and D. J. Burgess: A comparative study of top-down and bottom-up approaches for the preparation of micro/nanosuspensions. Int J Pharm 380(1-2), 216-22 (2009)
150. K. Khosravi-Darani, M. R. Mozafari, L. Rashidi and M. Mohammadi: Calcium based non-viral gene delivery: an overview of methodology and applications. Acta Med Iran 48(3), 133-41 (2010)
151. A. Kovtun, R. Heumann and M. Epple: Calcium phosphate nanoparticles for the transfection of cells. Biomed Mater Eng 19(2-3), 241-7 (2009)
152. L. Sun, L. C. Chow, S. A. Frukhtbeyn and J. E. Bonevich: Preparation and Properties of Nanoparticles of Calcium Phosphates With Various Ca/P Ratios. J Res Natl Inst Stand Technol 115(4), 243-255 (2010)
153. C. Ruggiero, L. Pastorino and O. L. Herrera: Nanotechnology based targeted drug delivery. Conf Proc IEEE Eng Med Biol Soc 2010, 3731-2 (2010)
154. B. D. Ulery, D. Kumar, A. E. Ramer-Tait, D. W. Metzger, M. J. Wannemuehler and B. Narasimhan: Design of a protective single-dose intranasal nanoparticle-based vaccine platform for respiratory infectious diseases. PLoS ONE 6(3), e17642 (2011)
155. S. D. Xiang, C. Selomulya, J. Ho, V. Apostolopoulos and M. Plebanski:
156. S Gariboldi, M Palazzo, L Zanobbio, GF Dusio, V Mauro, U Solimene, D Cardani, M Mantovani, C Rumio: Low dose oral administration of cytokines for treatment of allergic asthma. Pulm Pharmacol Ther 22(6), 497-510 (2009)
157. J. Ali, M. Ali, S. Baboota, J. K. Sahani, C. Ramassamy, L. Dao and Bhavna: Potential of nanoparticulate drug delivery systems by intranasal administration. Curr Pharm Des 16(14), 1644-53 (2010)
158. G. A. Silva: Nanotechnology approaches to crossing the blood-brain barrier and drug delivery to the CNS. BMC Neurosci 9 Suppl 3, S4 (2008)
159. S. S. Bansal, M. Goel, F. Aqil, M. V. Vadhanam and R. C. Gupta: Advanced drug delivery systems of curcumin for cancer chemoprevention. Cancer Prev Res (Phila) 4(8), 1158-71 (2011)
160. D. Ghosh, S. T. Choudhury, S. Ghosh, A. K. Mandal, S. Sarkar, A. Ghosh, K. D. Saha and N. Das: Nanocapsulated curcumin: oral chemopreventive formulation against diethylnitrosamine induced hepatocellular carcinoma in rat. Chem Biol Interact 195(3), 206-14 (2012)
161. S. Chakraborty, S. Stalin, N. Das, S. T. Choudhury, S. Ghosh and S. Swarnakar: The use of nano-quercetin to arrest mitochondrial damage and MMP-9 upregulation during prevention of gastric inflammation induced by ethanol in rat. Biomaterials 33(10), 2991-3001 (2012)
162. M. C. Daniel and D. Astruc: Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. Chem Rev 104(1), 293-346 (2004)
163. L. Montagnier, J. Aissa, S. Ferris, J.-L. Montagnier and C. Lavallee: Electromagnetic signals are produced by aqueous nanostructures derived from bacterial DNA sequences. Interdisciplinary Sci Comput Life Sci 1, 81-90 (2009)
164. M. Tang, T. Zhang, Y. Xue, S. Wang, M. Huang, Y. Yang, M. Lu, H. Lei, L. Kong and P. Yuepu: Dose dependent in vivo metabolic characteristics of titanium dioxide nanoparticles. J Nanosci Nanotechnol 10(12), 8575-83 (2010)
165. A. Maitra: Calcium phosphate nanoparticles: secondgeneration nonviral vectors in gene therapy. Expert Rev Mol Diagn 5(6), 893-905 (2005)
166. S. L. Fink, T. Bergsbaken and B. T. Cookson: Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms. Proc Natl Acad Sci U S A 105(11), 4312-7 (2008)
167. T. Ichinohe, I. K. Pang and A. Iwasaki: Influenza virus activates inflammasomes via its intracellular M2 ion channel. Nat Immunol 11(5), 404-10 (2010)
168. H. M. Lee, J. M. Yuk, K. H. Kim, J. Jang, G. Kang, J. B. Park, J. W. Son and E. K. Jo: Mycobacterium abscessus activates the NLRP3 inflammasome via Dectin-1-Syk and p62/SQSTM1. Immunol Cell Biol (2011)
169. T. Strowig, J. Henao-Mejia, E. Elinav and R. Flavell: Inflammasomes in health and disease. Nature 481(7381), 278-86 (2012)
170. M. Winter, H. D. Beer, V. Hornung, U. Kramer, R. P. Schins and I. Forster: Activation of the inflammasome by amorphous silica and TiO2 nanoparticles in murine dendritic cells. Nanotoxicology 5(3), 326-40 (2011)
171. V. Petrilli, C. Dostert, D. A. Muruve and J. Tschopp: The inflammasome: a danger sensing complex triggering innate immunity. Curr Opin Immunol 19(6), 615-22 (2007)
172. V. Petrilli and F. Martinon: The inflammasome, autoinflammatory diseases, and gout. Joint Bone Spine 74(6), 571-6 (2007)
173. V. Petrilli, S. Papin, C. Dostert, A. Mayor, F. Martinon and J. Tschopp: Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death Differ 14(9), 1583-9 (2007)
174. V. Hornung, F. Bauernfeind, A. Halle, E. O. Samstad, H. Kono, K. L. Rock, K. A. Fitzgerald and E. Latz: Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol 9(8), 847-56 (2008)
175. I. J. Elenkov, D. G. Iezzoni, A. Daly, A. G. Harris and G. P. Chrousos: Cytokine dysregulation, inflammation and well-being. Neuroimmunomodulation 12(5), 255-69 (2005)
176. H. Wei, K. K. Chadman, D. P. McCloskey, A. M. Sheikh, M. Malik, W. T. Brown and X. Li: Brain IL-6 elevation causes neuronal circuitry imbalances and mediates autism-like behaviors. Biochim Biophys Acta (2012)
177. D. Demirovic and S. I. Rattan: Establishing cellular stress response profiles as biomarkers of homeodynamics, health and hormesis. Exp Gerontol (2012
178. B. Dancso, Z. Spiro, M. A. Arslan, M. T. Nguyen, D. Papp, P. Csermely and C. Soti: The heat shock connection of metabolic stress and dietary restriction. Curr Pharm Biotechnol 11(2), 139-45 (2010)
179. A. Mihalik and P. Csermely: Heat shock partially dissociates the overlapping modules of the yeast proteinprotein interaction network: a systems level model of adaptation. PLoS Comput Biol 7(10), e1002187 (2011)
180. M. S. Szalay, I. A. Kovacs, T. Korcsmaros, C. Bode and P. Csermely: Stress-induced rearrangements of cellular networks: Consequences for protection and drug design. FEBS Lett 581(19), 3675-80 (2007)
181. P. Csermely: Chaperone overload is a possible contributor to 'civilization diseases'. Trends Genet 17(12), 701-4 (2001)
182. I. A. Kovacs, M. S. Szalay and P. Csermely: Water and molecular chaperones act as weak links of protein folding networks: energy landscape and punctuated equilibrium changes point towards a game theory of proteins. FEBS Lett 579(11), 2254-60 (2005)
183. G. Nardai, E. M. Vegh, Z. Prohaszka and P. Csermely: Chaperone-related immune dysfunction: an emergent property of distorted chaperone networks. Trends Immunol 27(2), 74-9 (2006)
184. I. N. Karatsoreos and B. S. McEwen: Psychobiological allostasis: resistance, resilience and vulnerability. Trends Cogn Sci 15(12), 576-84 (2011)
185. S. I. Rattan and T. Deva: Testing the hormetic nature of homeopathic interventions through stress response pathways. Hum Exp Toxicol 29(7), 551-4 (2010)
186. E. J. Calabrese, K. A. Bachmann, A. J. Bailer, P. M. Bolger, J. Borak, L. Cai, N. Cedergreen, M. G. Cherian, C. C. Chiueh, T. W. Clarkson, R. R. Cook, D. M. Diamond, D. J. Doolittle, M. A. Dorato, S. O. Duke, L. Feinendegen, D. E. Gardner, R. W. Hart, K. L. Hastings, A. W. Hayes, G. R. Hoffmann, J. A. Ives, Z. Jaworowski, T. E. Johnson, W. B. Jonas, N. E. Kaminski, J. G. Keller, J. E. Klaunig, T. B. Knudsen, W. J. Kozumbo, T. Lettieri, S. Z. Liu, A. Maisseu, K. I. Maynard, E. J. Masoro, R. O. McClellan, H. M. Mehendale, C. Mothersill, D. B. Newlin, H. N. Nigg, F. W. Oehme, R. F. Phalen, M. A. Philbert, S. I. Rattan, J. E. Riviere, J. Rodricks, R. M. Sapolsky, B. R. Scott, C. Seymour, D. A. Sinclair, J. Smith-Sonneborn, E. T. Snow, L. Spear, D. E. Stevenson, Y. Thomas, M. Tubiana, G. M. Williams and M. P. Mattson: Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework. Toxicol Appl Pharmacol 222(1), 122-8 (2007)
187. V. Calabrese, C. Cornelius, S. Cuzzocrea, I. Iavicoli, E. Rizzarelli and E. J. Calabrese: Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity. Mol Aspects Med 32(4-6), 279-304 (2011)
188. V. Calabrese, C. Cornelius, A. T. Dinkova-Kostova, I. Iavicoli, R. Di Paola, A. Koverech, S. Cuzzocrea, E. Rizzarelli and E. J. Calabrese: Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity. Biochim Biophys Acta 1822(5), 753-83 (2012)
189. A. R. Stebbing: A mechanism for hormesis-A problem in the wrong discipline. Crit Rev Toxicol 33(3-4), 463-7 (2003)
190. A. M. Vaiserman: Hormesis, adaptive epigenetic reorganization, and implications for human health and longevity. Dose Response 8(1), 16-21 (2010)
191. A. M. Vaiserman: Hormesis and epigenetics: is there a link? Ageing Res Rev 10(4), 413-21 (2011)
192. E. J. Calabrese: Converging concepts: adaptive response, preconditioning, and the Yerkes-Dodson Law are manifestations of hormesis. Ageing Res Rev 7(1), 8-20 (2008)
193. E. J. Calabrese and M. P. Mattson: Hormesis provides a generalized quantitative estimate of biological plasticity. J Cell Commun Signal 5(1), 25-38 (2011)
194. H. B. Hale: Cross-adaptation. Environmental Research 2, 423-34 (1969)
195. J. C. Launay, Y. Besnard, A. Guinet-Lebreton and G. Savourey: Acclimation to intermittent hypobaric hypoxia modifies responses to cold at sea level. Aviat Space Environ Med 77(12), 1230-5 (2006)
196. S. M. Antelman, A. J. Eichler, C. A. Black and D. Kocan: Interchangeability of stress and amphetamine in sensitization. Science 207(4428), 329-31 (1980)
197. S. M. Antelman, J. Levine and S. Gershon: Timedependent sensitization: The odyssey of a scientific heresy from the laboratory to the door of the clinic. Molecular Psychiatry 5(4), 350-6 (2000)
198. F. A. Wiegant, N. Spieker and R. van Wijk: Stressorspecific enhancement of hsp induction by low doses of stressors in conditions of self-and cross-sensitization. Toxicology 127(1-3), 107-19 (1998)
199. B. A. Sorg, M. L. Tschirgi, S. Swindell, L. Chen and J. Fang: Repeated formaldehyde effects in an animal model for multiple chemical sensitivity. Annals of the New York Academy of Sciences 933, 57-67 (2001)
200. B. A. Gosnell: Sucrose intake enhances behavioral sensitization produced by cocaine. Brain Res 1031(2), 194-201 (2005)
201. B. A. Sorg, J. R. Willis, R. E. See, B. Hopkins and H. H. Westberg: Repeated low-level formaldehyde exposure produces cross-sensitization to cocaine: possible relevance to chemical sensitivity in humans. Neuropsychopharmacology 18(5), 385-94 (1998)
202. D. Pincus and A. Metten: Nonlinear dynamics in biopsychosocial resilience. Nonlinear Dynamics Psychol Life Sci 14(4), 353-80 (2010)
203. M. Koithan, I. R. Bell, K. Niemeyer and D. Pincus: A complex systems science perspective for whole systems of CAM research. Forschende Komplementarmedizin und Klassische Naturheilkunde 19(Supplement 1), 7-14 (2012)
204. E. J. Calabrese: Hormesis and medicine. Br J Clin Pharmacol 66(5), 594-617 (2008
205. M. P. Mattson: Hormesis defined. Aging Research Rev7(1), 1-7 (2008)
206. E. J. Calabrese: Stress biology and hormesis: The Yerkes-Dodson law in psychology-A special case of the hormesis dose response. Crit Rev Toxicol 38(5), 453-62 (2008)
207. G. Li and H. He: Hormesis, allostatic buffering capacity and physiological mechanism of physical activity: a new theoretic framework. Med Hypotheses 72(5), 527-32 (2009)
208. S. I. Rattan: Hormetic modulation of aging and longevity by mild heat stress. Dose Response 3(4), 533-46 (2005)
209. A. Salminen and K. Kaarniranta: ER stress and hormetic regulation of the aging process. Ageing Res Rev 9(3), 211-7 (2010)
210. I. Martins, L. Galluzzi and G. Kroemer: Hormesis, cell death and aging. Aging (Albany NY) 3(9), 821-8 (2011)
211. F. P. Perez, X. Zhou, J. Morisaki and D. Jurivich: Electromagnetic field therapy delays cellular senescence and death by enhancement of the heat shock response. Exp Gerontol 43(4), 307-16 (2008)
212. I. R. Bell and M. Koithan: Models for the study of whole systems. Integrative Cancer Therapies 5(4), 293-307 (2006)
213. S. M. Antelman, A. R. Caggiula, S. Gershon, D. J. Edwards, M. C. Austin, S. Kiss and D. Kocan: Stressorinduced oscillation. A possible model of the bidirectional symptoms in PTSD. Annals of the New York Academy of Sciences 821, 296-304 (1997)
214. S. M. Antelman, A. R. Caggiula, D. Kocan, S. Knopf, D. Meyer, D. J. Edwards and H. Barry, 3rd: One experience with 'lower' or 'higher' intensity stressors, respectively enhances or diminishes responsiveness to haloperidol weeks later: implications for understanding drug variability. Brain Research 566(1-2), 276-83 (1991)
215. A. Danese and B. S. McEwen: Adverse childhood experiences, allostasis, allostatic load, and age-related disease. Physiol Behav 106(1), 29-39 (2012)
216. B. S. McEwen: The neurobiology of stress: from serendipity to clinical relevance. Brain Res 886(1-2), 172-189 (2000)
217. B. S. McEwen: Allostasis, allostatic load, and the aging nervous system: role of excitatory amino acids and excitotoxicity. Neurochem Res 25(9-10), 1219-31 (2000)
218. B. S. McEwen: Protective and damaging effects of stress mediators: central role of the brain. Dialogues Clin Neurosci 8(4), 367-81 (2006)
219. NC Bell, C Minelli, J Tompkins, MM Stevens, AG Shard: Emerging techniques for submicrometer particle sizing applied to stober silica. Langmuir 28(29), 10860-10872 (2012)
220. L. Richter, V. Charwat, C. Jungreuthmayer, F. Bellutti, H. Brueckl and P. Ertl: Monitoring cellular stress responses to nanoparticles using a lab-on-a-chip. Lab Chip 11(15), 2551-60 (2011)
221. C. M. Witt, Luedtke R, Baur R, Willich SN.: Homeopathic Medical Practice: Long-term results of a Cohort Study with 3981 Patients. BMC Public Health 5(1), 115 epub (2005)
222. M. Haidvogl, Riley DS, Heger M, Brien S, Jong M, Fischer M, Lewith GT, Jansen G, Thurneysen AE.: Homeopathic and conventional treatment for acute respiratory and ear complaints: a comparative study on outcome in the primary care setting. BMC Complement Altern Med 2(7), 7 (2007)
223. A. L. Barabasi: Linked. How everything is connected to everything else and what it means for business, science, and everyday life. Plume, Cambridge, MA (2003)
224. A. L. Barabasi, N. Gulbahce and J. Loscalzo: Network medicine: a network-based approach to human disease. Nat Rev Genet 12(1), 56-68 (2011)
225. J. Loscalzo and A. L. Barabasi: Systems biology and the future of medicine. Wiley Interdiscip Rev Syst Biol Med 3(6), 619-27 (2011)
226. M. Vidal, M. E. Cusick and A. L. Barabasi: Interactome networks and human disease. Cell 144, 986-98 (2011)
227. A. R. Stebbing: Interpreting 'dose-response' curves using homeodynamic data: with an improved explanation for hormesis. Dose Response 7(3), 221-33 (2009)
228. R. P. Juster, G. Bizik, M. Picard, G. Arsenault-Lapierre, S. Sindi, L. Trepanier, M. F. Marin, N. Wan, Z. Sekerovic, C. Lord, A. J. Fiocco, P. Plusquellec, B. S. McEwen and S. J. Lupien: A transdisciplinary perspective of chronic stress in relation to psychopathology throughout life span development. Dev Psychopathol23(3), 725-76 (2011)
229. R. P. Juster, B. S. McEwen and S. J. Lupien: Allostatic load biomarkers of chronic stress and impact on health and cognition. Neurosci Biobehav Rev 35(1), 2-16 (2010)
230. B. S. McEwen: Physiology and neurobiology of stress and adaptation: central role of the brain. Physiol Rev 87(3), 873-904 (2007)
231. F. J. Kelling, F. Ialenti and C. J. Den Otter: Background odour induces adaptation and sensitization of olfactory receptors in the antennae of houseflies. Medical & Veterinary Entomology 16(2), 161-9 (2002)
232. H. C. Lunt, M. J. Barwood, J. Corbett and M. J. Tipton: 'Cross-adaptation': habituation to short repeated cold-water immersions affects the response to acute hypoxia in humans. J Physiol 588(Pt 18), 3605-13 (2010)
233. P. Csermely, V. Agoston and S. Pongor: The efficiency of multi-target drugs: The network approach might help drug design. Trends Pharmacol Sci 26(4), 178-82 (2005)
234. P. Csermely, T. Korcsmaros, I. A. Kovacs, M. S. Szalay and C. Soti: Systems biology of molecular chaperone networks. Novartis Found Symp 291, 45-54; discussion 54-8, 137-40 (2008)
235. S. B. Brien, H. Harrison, J. Daniels and G. Lewith: Monitoring improvement in health during homeopathic intervention. Development of an assessment tool based on Hering's Law of Cure: The Hering's Law Assessment Tool (HELAT). Homeopathy101(1), 28-37 (2012)
236. A. Vasquez, R. Dobrin, D. Sergi, J. P. Eckmann, Z. N. Oltvai and A. L. Barabasi: The topological relationship between the large-scale attributes and local interaction patterns of complex networks. Proceedings of the National Academy of Sciences of the United States of America 101(52), 17940-17945 (2004)
237. S. M. Antelman and A. R. Caggiula: Oscillation follows drug sensitization: implications. Critical Reviews in Neurobiology 10(1), 101-17 (1996)
238. T. Randolph: Specific adaptation. Annals of Allergy 40, 333-345 (1978)
239. E. Chen, M. D. Hanson, L. Q. Paterson, M. J. Griffin, H. A. Walker and G. E. Miller: Socioeconomic status and inflammatory processes in childhood asthma: The role of psychological stress. J Allergy Clin Immunol 117(5), 1014-20 (2006)
240. G. Miller and E. Chen: Unfavorable socioeconomic conditions in early life presage expression of proinflammatory phenotype in adolescence. Psychosom Med 69(5), 402-9 (2007)
241. H. E. Covington, 3rd and K. A. Miczek: Repeated social-defeat stress, cocaine or morphine. Effects on behavioral sensitization and intravenous cocaine selfadministration "binges". Psychopharmacology 158(4), 388-98 (2001)
242. N. M. Avena, C. A. Carrillo, L. Needham, S. F. Leibowitz and B. G. Hoebel: Sugar-dependent rats show enhanced intake of unsweetened ethanol. Alcohol 34(2-3), 203-9 (2004)
243. N. M. Avena and B. G. Hoebel: A diet promoting sugar dependency causes behavioral cross-sensitization to a low dose of amphetamine. Neuroscience 122(1), 17-20 (2003)
244. N. M. Avena and B. G. Hoebel: Amphetaminesensitized rats show sugar-induced hyperactivity (crosssensitization) and sugar hyperphagia. Pharmacol Biochem Behav 74(3), 635-9 (2003)
245. P. Rada, N. M. Avena and B. G. Hoebel: Daily bingeing on sugar repeatedly releases dopamine in the accumbens shell. Neuroscience 134(3), 737-44 (2005)
246. S. R. Dube, V. J. Felitti, M. Dong, W. H. Giles and R. F. Anda: The impact of adverse childhood experiences on health problems: evidence from four birth cohorts dating back to 1900. Prev Med 37(3), 268-77 (2003)
247. L. Klein: Miasms and Nosodes. Narayana Publishers, Toronto, ON Canada (2009)
248. D. Crews, R. Gillette, S. V. Scarpino, M. Manikkam, M. I. Savenkova and M. K. Skinner: Epigenetic transgenerational inheritance of altered stress responses. Proc Natl Acad Sci U S A (2012)
249. A. M. Hayes, Laurenceau JP, Feldman G, Strauss JL, Cardaciotto L.: Change is not always linear: The study of nonlinear and discontinuous patterns of change in psychotherapy. Clin Psychol Rev 27(6), 715-23 (2007)
250. T. Hollenstein: State space grids: analyzing dynamics across development. International Journal of Behavioral Development 31(4), 384-96 (2007)
251. P. Bak: How Nature Works: The Science of Self-Organized Criticality. Copernicus Press, New York, NY (1996)
252. W. C. Abraham: Metaplasticity: Tuning synapses and networks for plasticity. Nat Rev Neurosci 9(5), 387 (2008)
253. R. Sankaran: The Synergy in Homoeopathy. Homoeopathic Medical Publishers, Mumbai, India (2012)
254. D. S. Coffey: Self-organization, complexity, and chaos: The new biology for medicine. Nature Medicine 4(8), 882-885 (1998)
255. A. Garfinkel, M. L. Spano, W. L. Ditto, J. N. Weiss: Controlling cardiac chaos. Science 257(5074), 1230-5 (1992)
256. S. J. Schiff, K. Jerger, D. H. Duong, T. Chang, M. L. Spano and W. L. Ditto: Controlling chaos in the brain. Nature 370, 615-20 (1994)
257. S. J. Guastello, Koopmans, M, Pincus, D.: Chaos and Complexity in Psychology: The Theory of Nonlinear Dynamical Systems. Cambridge University Press, New York, NY (2009)
258. S. Kauffman: At Home in the Universe. The Search for the Laws of Self-Organization and Complexity. Oxford University Press, NY (1995)
259. R. Papp, et al.: Oscillococcinum in patients with influenza-like syndromes: a placebo-controlled double blind evaluation. British Homeopathy Journal 87, 69-76 (1998)
260. J. P. Ferley, D. Zmirou, D. D'Adhemar and F. Balducci: A controlled evaluation of a homoeopathic preparation in the treatment of influenza-like syndromes. British Journal of Clinical Pharmacology 27(3), 329-35 (1989)
261. A. Berchieri, Jr., W. C. Turco, J. B. Paiva, G. H. Oliveira and E. V. Sterzo: Evaluation of isopathic treatment of Salmonella enteritidis in poultry. Homeopathy 95(2), 94-7 (2006)
262. P. Colin: An epidemiological study of a homeopathic practice. British Homoeopathic Journal 89(3), 116-21 (2000)
263. G. Vithoulkas: The Science of Homeopathy. Grove Weidenfeld, N.Y. (1980)
264. H. Möllinger, Schneider, R., Walach, H.: Homeopathic pathogenetic trials produce specific symptoms different from placebo. Forsch Komplementmed 16(2), 105-10 (2009)
265. H. Walach, Möllinger H, Sherr J, Schneider R.: Homeopathic pathogenetic trials produce more specific than non-specific symptoms: results from two double-blind placebo controlled trials. J Psychopharmacol 22(5), 543-52 (2008)
266. J. Sherr: Dynamic Materia Medica. Syphilis: A Study of Syphilitic Miasm through Remedies. Dynamis Books, Great Malvern Worcestershire, England (2002)
267. P. Vijayakar: Genetic Materia Medica: Tri-miasmatic Materia Medica. Preeti Vijayakar Mumbai, India (2008)
268. J. Scholten: Homeopathy and the Elements. Stichting Alonnissos, Utrecht, the Netherlands (1996)
269. M. Oberbaum, Singer SR, Vithoulkas G.: The colour of the homeopathic improvement: The multidimensional nature of the response to homeopathic therapy. Homeopathy 94(3), 196-9 (2005)
270. A. Banerjee, S. Pathak, S. J. Biswas, S. Roy-Karmakar, N. Boujedaini, P. Belon and A. R. Khuda-Bukhsh: Chelidonium majus 30C and 200C in induced hepato-toxicity in rats. Homeopathy 99(3), 167-76 (2010)
271. P. Endler, K. Thieves, C. Reich, P. Matthiessen, L. Bonamin, C. Scherr and S. Baumgartner: Repetitions of fundamental research models for homeopathically prepared dilutions beyond 10(-23): a bibliometric study. Homeopathy 99(1), 25-36 (2010)
272. P. C. Endler, Schulte, J.: Ultra High Dilution. Physiology and Physics. In: Kluwer Academic Publishers, Dordrecht, The Netherlands (1994)
273. M. Frass, C. Dielacher, M. Linkesch, C. Endler, I. Muchitsch, E. Schuster and A. Kaye: Influence of potassium dichromate on tracheal secretions in critically ill patients. Chest 127(3), 936-41 (2005)
274. P. Bellavite, A. Conforti, M. Marzotto, P. Magnani, M. Cristofoletti, D. Olioso and M. E. Zanolin: Testing homeopathy in mouse emotional response models: pooled data analysis of two series of studies. Evid Based Complement Alternat Med 2012, 954374 (2012)
275. M. Abu-Asab, H. Amri, M. Koithan and J. Shaver: A systems biology approach: parsimony phylogenetics. Forsch Komplementarmed 19(Supplement 1), 42-48 (2012)
276. E. Antman, S. Weiss and J. Loscalzo: Systems pharmacology, pharmacogenetics, and clinical trial design in network medicine. Wiley Interdisciplinary Reviews-Systems Biology and Medicine 4(4), 367-383 (2012)
277. C. A. Hidalgo, N. Blumm, A. L. Barabasi and N. A. Christakis: A dynamic network approach for the study of human phenotypes. PLoS Comput Biol 5(4), e1000353 (2009)
278. M. V. Yigit, A. Moore and Z. Medarova: Magnetic nanoparticles for cancer diagnosis and therapy. Pharm Res, 29(5), 1180-8 (2012)
279. M. Koithan, M. Verhoef, I. R. Bell, C. Ritenbaugh, M. White and A. Mulkins: The process of whole person healing: "unstuckness" and beyond. J Altern Complement Med 13(6), 659-68 (2007)
280. B. L. Fredrickson and M. F. Losada: Positive affect and the complex dynamics of human flourishing. American Psychologist 60(7), 678-86 (2005) Medicine