Time-dependent sensitization: The odyssey of a scientific heresy from the laboratory to the door of the clinic

Molecular Psychiatry

Volumn 5, Issue 4, 2000, Pages 350-356

  Antelman, S M ^a,b   Levine, J ^a,b   Gershon, S ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Antidepressants; Evolution; Immunological memory; Post traumatic stress disorder; Pulsed therapy; Sensitization; Stress

Indexed keywords

AMFEBUTAMONE; AMITRIPTYLINE; AMPHETAMINE; ANTIDEPRESSANT AGENT; BENZODIAZEPINE; CELL RECEPTOR; CENTRAL STIMULANT AGENT; CITALOPRAM; CLENBUTEROL; CLOMIPRAMINE; COCAINE; CORTICOTROPIN RELEASING FACTOR DERIVATIVE; CYTOKINE; DESIPRAMINE; DIAZEPAM; DOPAMINE; DOPAMINE AUTORECEPTOR; ESTROGEN; FLUMAZENIL; HALOPERIDOL; IMIPRAMINE; METYRAPONE; MORPHINE; N METHYL BETA CARBOLINE 3 CARBOXAMIDE; NEUROLEPTIC AGENT; NORADRENALIN; PHENELZINE; SODIUM CHLORIDE; TRIAZOLAM; UNINDEXED DRUG;

ANIMAL EXPERIMENT; BEHAVIOR; CLINICAL TRIAL; DEPRESSION; DRUG EXPOSURE; DRUG MECHANISM; DRUG SENSITIZATION; DRUG TARGETING; ELECTROCONVULSIVE THERAPY; HUMAN; IMMUNOLOGICAL MEMORY; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PULSATILE DRUG RELEASE; REVIEW; STIMULUS RESPONSE; STRESS;

EID: 0033923796     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4000721     Document Type: Review

References (68)

1. Darwin C. On the Origin of Species by Means of Natural Selection or the Preservation of Favoured Races in the Struggle for Life. Appleton: New York, 1889, pp 295-29G.
2. Planck M. Scientific Autobiography and Other Papers. Philosophical Library: New York, 1949, pp 33-34.
3. Antelman SM, Chiodo LA. Repeated antidepressant treatments induce a long-lasting dopamine autoreceptor subsensitivity: is daily treatment necessary for clinical efficacy? Psychopharmacol Bull 1981; 17: 92-94.
4. Chiodo LA, Antelman SM. Electroconvulsive shock: progressive dopamine autoreceptor subsensitivity independent of repeated treatment. Science 1980; 210: 799-801.
5. Chiodo LA, Antolman SM. Repeated tricyclics induce a progressive dopamine autoreceptor subsensitivity independent of daily drug treatment. Nature 1980; 287: 451-454.
6. Antelman SM, DeGiovanni LA, Kocan D et al. Amitriptyline sensitization of a serotonin-mediated behavior depends on the passage of time and not repeated treatment. Life Sei 1983; 33: 1727-1730.
7. Lace JW, Antelman SM. Cortical beta-adrenergic subsensitivity after desmethylimipramine may depend on the passage of time rather than daily treatment. Drain Res 1983; 278: 359-361.
8. Antelman SM, Chiodo LA, DeGiovanni LA. Antidepressant and dopamine autoreceptors: implications for both a novel means of treating depression and understanding bipolar illness. In: Costa E, Racagni G (eds). Typical and Atypical Antidepressants, Molecular Mechanisms. Raven Press: New York, 1982.
9. Antelman SM. Is it possible that drugs have been given the wrong way for centuries? In: Sen AK and Lee T (cds). Receptors and Ligands in Psychiatry. Cambridge Press: Cambridge, 1988.
10. Dziedzicka-Wasylewska M, Rogoz Z. Time-dependent effects of antidepressant drugs on the low dose of apomorphine-induced locomotor hypoactivity in rats. Polish J Pharmacol 1997; 49: 337-343.
11. Antelman SM, Eichler AJ, Black CA et al. Interchangeability of stress and amphetamine in sensitization. Science 1980; 207: 329-331.
12. Antelman SM, Chiodo LA. Amphetamine as a Stressor. In: Creese I (ed), Stimulants: Neurochemical, Behavioral and Clinical Perspectives. Raven Press: New York, 1983.
13. Paulson PE, Robinson TE. Amphetamine-induced time-dependent sensitization of dopamine neurotransmission in the dorsal and ventral striatum: a microdialysis study in behaving rats. Synapse 1995; 19: 56-65.
14. Schmidt ED, Tilders FJ, Janszen AW et al. Intermittent cocaine exposure causes delayed and long-lasting sensitization of cocaineinduced ACTH secretion in rats. Eur J Pharmacol 1995; 285: 317-321.
15. Antelman SM, Kocan D, Edwards DJ et al. Anticonvulsant and other effects of diazepam grow with time after a single treatment. Pharmacol Biochem Beh 1989; 33: 31-39.
16. Smith RB, Kroboth PD, Folan MM et al. Pharmacodynamic design and evaluation of novel dual release formulations of triazolam. Int J Clin Pharmacol Therapeut Toxicol 1993; 35: 422-429.
17. Deny CL, Kroboth PD, Pittenger AL et al. Pharmacokinetics and pharmacodynamics of triazolam after two intermittent doses in obese and normal-weight men. J Clin Psychopharmacol 1995; 15: 197-205.
18. Kroboth PD, McAuley JW, Derry CL. Time-dependent sensitization to triazolam? An observation in three studies. J Clin Psychopharmacol 1995; 15: 192-196.
19. Antelman SM, Caggiula AR, Kocan D et al. One experience with 'lower' or 'higher' intensity Stressors, respectively enhances or diminishes responsiveness to haloperidol weeks later: implications for understanding drug variability. Brain Res 1991; 566: 276-283.
20. Caggiula AR, Antelman SM, Palmer AM et al. The effects of ethanol on striatal dopamine and frontal cortical D-[3H]aspartate efflux oscillate with repeated treatment: relevance to individual differences in drug responsiveness. Neuropsychopharmacology 1996; 15: 125-132.
21. Pollock J, Kornetsky C. Reexpression of morphine-induced oral stereotypy six months after last morphine sensitizing dose. Pharmacol Biochem Beh 1996; 53: 67-71.
22. Martin P, Soubrie P, Simon P. Does a single priming injection of clenbuterol alter behavioral response to beta-adrenoceptor agonists and antagonists in mice through a time-dependent process? Eur J Pharmacol 1985; 115: 91-96.
23. Pollock BG, Perel J, Shostak M et al. Understanding the response lag to tricyclics. I. Application of pulse-loading regimens with intravenous clomipramine. Psychopharmacol Bull 1986; 22: 214-229.
24. Pollock BG, Perel J, Nathan SR et al. Acute antidepressant effect following pulse loading with intravenous and oral clomipramine. Arch Gen Psychiat 1989; 46: 29-35.
25. Dube S, Perel JM, Miewald J et al. Antidepressant response to oral pulse loading with clomipramine (abstract). Biol Psychiat 1996; 39: 623.
26. Schmidt ED, Janszen AW, Wouterlood FG et al. Interleukin-1induced long-lasting changes in hypothalamic corticotropin-releasing hormone (CRH)-neurons and hyperresponsiveness of the hypothalamus-pituitary-adrenal axis. J Neurosci 1995; 15: 7417-7426.
27. Schmidt ED, Binnekade AW, Janszen AW et al. Short Stressor induced long-lasting increases of vasopressin stores in hypothalamic corticotropin-releasing hormone (CRH) neurons in adult rats. J Neuroendocrinol 1996; 8: 703-712.
28. Denicoff KD, Durkin TM, Lotze MT et al. The neuroendocrine effects of interleukin-2 treatment. J Clin Endocrinol Metab 1989; 69: 402-410.
29. Hayley S, Brebner K, Lacosta S et al. Sensitization to the effects of tumor necrosis factor-alpha: neuroendocrine, central monoamine and behavioral variations. J Neurosci 1999; 19: 5654-5665.
30. Stanford SC, Little HJ, Null DJ et al. A single dose of FG7142 causes long-term increases in mouse cortical β-adrenoceptors. Eur J Pharmacol 1986; 134: 313-319.
31. Antelman SM, Knopf S, Kocan D et al. Persistent sensitization of clonidine-induced hypokinesia following one exposure to a Stressor: possible relevance to panic disorder and its treatment. Psychopharmacology 1989; 98: 97-101.
32. Tarn SP, Hache RJ, Deeley RG. Estrogen memory effect in human hepatocytes during repeated cell division without hormone. Science 1986; 234: 1234-1237.
33. Hache RJ, Tarn SP, Cochrane A et al. Long-term effects of estrogen on avian liver: estrogen-inducible switch in expression of nuclear, hormone-binding proteins. Mol Cell Biol 1987; 7: 3538-3547.
34. Burch JBE, Evans MI. Chromatin structural transitions and the phenomenon of vitellogenin gene memory in chickens. Mol Cell Biol 1986; 6: 1886-1893.
35. Schmidt ED, Janszen AW, Binnekade AW et al. Transient suppression of resting corticosterone levels induces sustained increase of AVP stores in hypothalamic CRH-neurons of rats. J Neurocndocrinol 1997; 0: 69-77.
36. Antelman SM, Kocan D, Edwards DJ et al. Behavioral effects of a single neuroleptic treatment grows with the passage of time. Brain Res 1986; 385: 58-67.
37. Meil W, See RE. Single preexposure to fluphenazinc produces persisting behavioral sensitization accompanied by tolerance to fluphenazine-induccd striatal dopamine overflow in rats. Pharmacol Biochem Beh 1994; 48: 605-612.
38. Antelman SM. Time-dependent sensitization as the cornerstone for a new approach to pharmacotherapy: drugs as foreign/stressful stimuli. Drug Dev Res 1988; 14: 1-30.
39. Williams SA, Wesnes K, Oliver SD et al. Absence of effect of Sertraline on time-based sensitization of cognitive impairment with haloperidol. J Clin Psychiat 1996; 57 (suppl 1): 7-11.
40. Caggiula AR, Antelman SM, Aul E et al. Prior stress attenuates the analgesic response but sensitizes the corticosterone and cortical dopamine responses to stress 10 days later. Psychopharmacology 1989; 99: 233-237.
41. Antelman SM, Kocan D, Knopf S et al. One brief exposure to a psychological Stressor induces long-lasting, time-dependent sensitization of both the cataleptic and neurochemical responses to haloperidol. Life Sei 1992; 51: 261-266.
42. 2 autoreceptors. Eur J Pharmacol 1997; 337: 291-296.
43. Antelman SM, Caggiula AR. Oscillation follows drug sensitization: implications. Crit Revs Neurobiol 1996; 10: 101-117.
44. Antelman SM, Caggiula AR, Knopf S et al. Amphetamine or haloperidol 2 weeks earlier antagonized the plasma corticosterone response to amphetamine: evidence for the stressful/foreign nature of drugs. Psychopharmacology 1992; 107: 331-336.
45. Vandijken HH, DeGoeji DC, Sutanto W et al. Short inescapable stress produces long-lasting changes in the brain-pituitary-adrenal axis of adult male rats. Neuroendocrinology 1993; 58: 57-64.
46. Sutanto W, Oitzl MS, Rots NY et al. Corticosteroid receptor plasticity in the central nervous system of various rat models. Endocr Regul 1992; 20: 111-118.
47. Liberzon I, Krstov M, Young EA. Stress-restress: effects on ACTH and fast feedback. Psychoncuroendocrinology 1997; 22: 443-453.
48. Persoons JH, Moos NM, Broug-Holub E et al. Acute and long-term effects of Stressors on pulmonary immune functions. Am f Respir Cell Mol Biol 1997; 17: 203-208.
49. Antelman SM, Cunnick JE, Lysle DT et al. Immobilization 12 days (but not one hour) earlier enhanced 2-deoxy-D-glucose-induced immunosuppression: evidence for stressor-induced time-dependent sensitization of the immune system. Prog Neuro-Psychopharmacol Biol Psychiat 1990; 14: 579-590.
50. Klatzo I, Spatz M. Studies on experimental ischemia in mongolian gerbils. In: Zulch KJ, Kaufman W, Hossman KA, Hossman V (eds). Brain and Heart Infarct II. Springer-Verlag: New York, 1979.
51. Fuller JL, Collins RL. Temporal patterns of sensitization for audiogenie seizures in SJL/mice. Dev Psychobiol 1968; 1: 185-188.
52. Vandijken HH, van der Heyden JA, Mos J et al. Inescapable footshocks induce progressive and long-lasting behavioural changes in male rats. Physiol Behav 1992; 51: 787-794.
53. Robinson TE. Stimulant drugs and stress: factors influencing individual differences in the susceptibility to sensitization. In: Kalivas PW, Barnes CD (eds). Sensitization of the A'ervous System. Telford Press: NJ, 1988.
54. Koolhaas JM, DeBoer SF, DeRutter AJ et al. Social stress in rats and mice. Acta Physiol Scand SuppI 1997; C40: 69-72.
55. Malhotra S, Santosh PJ. Loading dose imipramine-neu- approach to pharmacotherapy of melancholic depression. J Psychiat Res 1996; 30: 51-58.
56. Sallcc FR, Vrindavanam NS, Deas-Nesmith D et al. Pulse intravenous clomipramine for depressed adolescents: double-blind, controlled trial. Am J Psychiat 1997; 154: 668-673.
57. Jagadeesh HN, Gangadhar BN, Janakiramaiah DK et al. Time dependent therapeutic effects of single electroconvulsive therapy (ECT) in endogenous depression. J Affect Dis 1992; 24: 291-296.
58. Antelman SM, Gershon S. Clinical application of time-dependent sensitization to antideprcssant therapy. Prog Neuro-Psychopharmacol Biol Psychiat 1998; 22: 65-78.
59. Deuschle M, Schmider J, Weber B et al. Pulse-dosing and conventional application of doxepine: effects on psychopathology and hypothalamus-pituitary-adrenal (HPA) system. J Clin Psychopharmacol 1997; 17: 156-160.
60. Yuille MR, Houlston RS, Catovsky D. Anticipation in familial chronic lymphocytic leukaemia. Leukemia 1998; 12: 1696-1698.
61. Farquhar J, Gajdusek DC. Kuru. Raven Press: New York, 1981, pp 44, 260.
62. Archibald HC, Tuddenham RO. Persistent stress reaction after combat: a twenty year follow-up. Arch Gen Psychiat 1965; 12: 475-481.
63. Yehuda R, Antelman SM. Criteria for rationally evaluating animal models of posttraumatic stress disorder. Biol Psychiat 1993; 33: 479-186.
64. Antelman SM, Caggiula AR, Gershon S et al. Stressor-induced oscillation: a possible model of the bidirectional symptoms in PTSD. Ann NY Acad Sei 1997; 821: 296-304.
65. Elwood JM, Jopson J. Melanoma and sun exposure: an overview of published studies. Int J Cancer 1997; 73: 198-203.
66. Sotelo J. Multiple viral pathogenicity: another paradigm in medical research. Perspectives Biol Med 1996; 39: 507-513.
67. Marks IM. Fears, Phobias, and Rituals. Oxford University Press: New York, 1987, p 249.
68. Keynes JM. The General Theory of Employment Interest and Money. Harcourt-Brace: New York, 1936, p viii.