Ameliorating effect of microdoses of a potentized homeopathic drug, Arsenicum Album, on arsenic-induced toxicity in mice

BMC Complementary and Alternative Medicine

Volumn 3, Issue , 2003, Pages

  Mallick, Palash ^a   Chakrabarti Mallick, Jayati ^a   Guha, Bibhas ^a   Khuda Bukhsh, A R ^a  

^a UNIVERSITY OF KALYANI   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ARSENIC; ARSENIC TRIOXIDE; ASPARTATE AMINOTRANSFERASE; GLUTATHIONE TRANSFERASE; GROUND WATER;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARSENIC POISONING; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BANGLADESH; BIOACCUMULATION; BIOCHEMISTRY; CLINICAL PROTOCOL; CONTROLLED STUDY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME LOCALIZATION; HOMEOPATHY; INDIA; LIVER; MOUSE; NONHUMAN; PLANT; REVIEW; SAFETY; TISSUE DISTRIBUTION; WATER CONTAMINATION; WATER SUPPLY; WATER TREATMENT;

ADMINISTRATION, ORAL; ALANINE TRANSAMINASE; ANIMALS; ARSENIC; ARSENICALS; ASPARTATE AMINOTRANSFERASES; DRUG ADMINISTRATION SCHEDULE; DRUG TOLERANCE; GLUTATHIONE; HOMEOPATHY; LIVER; MICE; POISONING;

EID: 20244385773     PISSN: 14726882     EISSN: None     Source Type: Journal    
DOI: 10.1186/1472-6882-3-7     Document Type: Review

References (39)

1. Das D, Chatterjee A, Samanta G, Mondal BK, Roy Chowdhury T, Chowdhury PP, Chanda C, Basu G, Lodh D and Nandi S et al.: Arsenic contamination in ground water in six districts of West Bengal, India: the biggest arsenic calamity in the world. Analyst 1994, 119:168N-170N.
2. Das D, Chatterjee A, Mondal BK, Samanta G, Chanda C and Chakraborti D: Arsenic in ground water in six districts of West Bengal, India. The biggest arsenic calamity in the world. Part 2. Arsenic concentration in drinking water, hair, nail, urine, skin-scale and liver tissue (biopsy) of the affected people. Analyst 1995, 120:917-924.
3. Chakraborty AK and Saha KC: Arsenical dermatosis from tube well water in West Bengal. Indian J Med Res 1987, 85:326-334.
4. Das D, Samanta G, Mondal BK, Roy Chowdhury T, Chanda C, Chowdhury PP, Bose GK and Chakraborti D: Arsenic in ground water in six districts of West Bengal, India. Environmental Geochemistry and Health 1996, 18:5-15.
5. Luo ZD, Zhang YM, Ma L, Zhang GY, He X, Wilson R, Byrd DM, Griffiths JG, Lai S and He L et al.: Chronic arsenicism and cancer in inner Mongolia - consequences of well-water arsenic levels greater than 50 μg/l. In: Arsenic: Exposure and Health Effects Edited by: Abernathy CO, Calderon RL, Chppel WR. London, Chapman and Hall; 1997:55-68.
6. Niu S, Cao S and Shen E: The status of arsenic poisoning in China. In: Arsenic: Exposure and Health Effects Edited by: Abernathy CO, Calderon RL, Chppel WR. London, Chapman and Hall; 1997:78-83.
7. Choprapawon C and Rodcline A: Chronic arsenic poisoning in Ronpibool Nakhon Sri Thammarat, the southern province of Thailand. In: Arsenic: Exposure and Health Effects Edited by: Abernathy CO, Calderon RL, Chppel WR. London, Chapman and Hall; 1997:69-77.
8. Bencko V: Health aspects of burning coal with a high arsenic content: the central Slovakia experience. In: Arsenic: Exposure and Health Effects Edited by: Abernathy CO, Calderon RL, Chppel WR. London, Chapman and Hall; 1997:84-92.
9. Cebrian ME, Albores A, Aguilar M and Blakely E: Chronic arsenic poisoning in the north of Mexico. Hum Toxicol 1983, 2:121-133.
10. Mitra K, Kundu SN and Khuda-Bukhsh AR: Efficacy of a potentized homoeopathic drug (Arsenicum Album-30) in reducing toxic effects produced by arsenic trioxide in mice: I. On rate of accumulation of arsenic in certain vital organs. Comp Ther Med 1998, 6:178-184.
11. Mitra K, Kundu SN and Khuda-Bukhsh AR: Efficacy of a potentized homoeopathic drug (Arsenicum Album-30) in reducing toxic effects produced by arsenic trioxide in mice: II. On alterations of body weight, tissue weight and total protein. Comp Ther Med 1999, 7:24-34.
12. Datta S, Mallick P and Khuda-Bukhsh AR: Efficacy of a potentized homeopathic drug (Arsenicum Album-30) in reducing genotoxic effects produced by arsenic trioxide in mice: I. Comparative studies of pre-, post- and combined pre- and postoral administration and comparative efficacy of two microdoses. Comp Ther Med 1999, 7:62-75.
13. Datta S, Mallick P and Khuda-Bukhsh AR: Efficacy of a potentized homeopathic drug (Arsenicum Album-30) in reducing genotoxic effects produced by arsenic trioxide in mice: II. Comparative efficacy of an antibiotic, actinomycin D alone and in combination with either of two microdoses. Comp Ther Med 1999, 7:156-163.
14. Kundu SN, Mitra K and Khuda-Bukhsh AR: Efficacy of a potentized homoeopathic drug (Arsenicum Album-30) in reducing cytotoxic effects produced by arsenic trioxide in mice: III. Enzymatic changes and recovery of tissue damage in liver. Comp Ther Med 2000, 8:76-81.
15. Kundu SN, Mitra K and Khuda-Bukhsh AR: Efficacy of a potentized homoeopathic drug (Arsenicum Album-30) in reducing cytotoxic effects produced by arsenic trioxide in mice: IV. Pathological changes, protein profiles and content of DNA and RNA. Comp Ther Med 2000, 8:157-175.
16. Khuda-Bukhsh AR: The efficacy of potentized homeopathic drug in combating arsenic poisoning. Pers Cytol Genet 2001, 10:231-239.
17. Cazin JC, Cazin M, Gaborit JL, Chaoui A, Boiron J, Belon P, Cherruault Y and Papapanayotou C: A study of the effect of decimal and centesimal dilutions of arsenic on the retention and mobilization of arsenic in the rat. Human Toxicol 1987, 6:315-320.
18. Bergmeyer HU and Bernt E.: In Methods of Enzymatic analysis Volume 2. Edited by: Bergmeyer HU. New York, Academic Press; 1974:735.
19. Lowry OH, Rosebrough NJ, Farr AL and Randall RJ: Protein measurement with Folin phenol reagent. J Biol Chem 1951, 193:265-275.
20. Ellman GL: Tissue sulfhydryl groups. Arch Biochem Biophys 1959, 82:70-77.
21. Guha Mazumder DN, Das Gupta J, Santra A, Pal A, Ghose A, Sarkar S, Chattopadhaya N and Chakraborti D: Non-cancer effects of chronic arsenicosis with special reference to liver damage. In: Arsenic: Exposure and Health Effects Edited by: Abernathy CO, Calderon RL, Chppel WR. London, Chapman and Hall; 1997:113-123.
22. Timbrell JA: In: Principles of biochemical toxicology London, Taylor & Francis Ltd; 1991.
23. Boiron J, Belon P, Abecassis J, Cazin JC and Gaborit JL: Effects of arsenicum album 7 cH in rats poisoned by arsenic: quantitative study, statistical value of results. In: Proc 35th Congress of the Liga Homoeopathica Internationalis London, Faculty of Homoeopathy; 1982:308-319.
24. Boiron J, Abecassis J and Belon P: In: Aspects of research in homoeopathy. Editions Boiron 1983, I:1-79.
25. Linde K, Jonas WB, Melchart D, Worku F, Wagnert H and Eitel F: Critical review and meta-analysis of serial agitated dilutions in experimental toxicology. Hum Exp toxicol 1994, 13:481-492.
26. Rey L: Thermoluminiscence of ultra-high dilutions of lithium chloride and sodium chloride. Physica A 2003, 323:67-74.
27. Khuda-Bukhsh AR: Potentized homoeopathic drugs act through regulation of gene-expression: a hypothesis to explain their mechanism and pathways of action in vivo. Comp Ther Med 1997, 5:43-46.
28. J. Chakrabarti, SJ Biswas and AR Khuda-Bukhsh: Cytogenetical effects of ultrasound in mice and their modulations by Actinomycin D and a homeopathic drug, Arnica-30. Indian J Exp Biol 2001, 39:1235-1242.
29. SJ Biswas and AR Khuda-Bukhsh: Effect of homeopathic drug, Chelidonium, in amelioration of p-DAB induced hepatocarcinogenesis in mice. BMC Compl & Alter Med 2002:2-4.
30. Biswas SJ and Khuda-Bukhsh AR: Microdoses of Chelidonium majus ameliorate genotoxicity and modulate enzymatic changes during azo dye induced hepatocarcinogenesis in mice. Cancer Detection and Prevention 2003 in press.
31. Khuda-Bukhsh AR: Towards understanding molecular mechanisms of action of homeopathic drugs: An overview. Mol Cell Biochem 2003 in press.
32. van Wijk R and Wiegant FAC: In: Cultured mammalian cells in homoeopathy research: the simila priciple of self-recovery. Utrecht, the Netherlands, Utrecht University 1994:1-230.
33. Weigant FAC, van Rijn J and van Wijk R: Enhancement of the stress response by minute amounts of cadmium in sensitized Reuber H35 hepatoma cells. Toxicology 1997, 116:27-37.
34. van Wijk R and Wiegant FAC: Homoeopathy and the mammalian cel, I: programmed cell recovery and new therapeutic strategies. In: Homeopathy - a critical appraisal Edited by: Ernst E, Hahn EG. Butterworth-Heinemann, Reed Educational and Professional Publishers Ltd; 1998:180-186.
35. Khuda Bukhsh AR and Maity S: Alteration of cytogenetical effects by oral administration of a homeopathic drug, Ruta Graveolens in mice exposed to sub lethal X-irradiation. The Berlin J Res Hom 1991, 1:264-274.
36. Khuda-Bukhsh AR and Banik S: Assessment of cytogenetical damage in X-irradiated mice and their alterations by oral administrations of potentized homeopathic drug, Ginseng- 200. The Berlin J Res Hom 1991, 1:254-263.
37. Banik S and Khuda-Bukhsh AR: Alterations of cytogenetical and haematological effects by ultra-low doses of Ginseng in whole-body X-irradiated mice. The Nucleus 1996, 49:28-35.
38. Datta S, Mallick P and Khuda Bukhsh AR: Comparative efficacy of two microdoses of a potentized homeopathic drug, Cadmium Sulphoricum, in reducing cytogenetical effects produced by cadmium chloride in mice: A time-course study. BMC Compl & Alter Med 2001, 1:9.
39. Matsumoto J: Molecular mechanism of biological responses to homeopathic medicines. Med Hypotheses 1995, 45:292-296.