Enhancement of curcumin oral absorption and pharmacokinetics of curcuminoids and curcumin metabolites in mice

Cancer Chemotherapy and Pharmacology

Volumn 69, Issue 3, 2012, Pages 679-689

  Zhongfa, Liu ^a,b   Chiu, Ming ^a   Wang, Jiang ^a   Chen, Wei ^a   Yen, Winston ^a   Fan Havard, Patty ^c   Yee, Lisa D ^a   Chan, Kenneth K ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c UNIVERSITY AT BUFFALO   (United States)

Author keywords

Curcumin metabolites; Curcuminoids; LC MS MS; Nano emulsion curcumin (NEC); Pharmacokinetics

Indexed keywords

CREMOPHOR; CURCUMIN; CURCUMIN METABOLITE; CURCUMIN O GLUCURONIDE; CURCUMIN O SULFATE; CURCUMINOID DERIVATIVE; DEMETHOXYCURCUMIN; DIDEMETHOXYCURCUMIN; DRUG METABOLITE; MACROGOL; METHYLCELLULOSE; TETRAHYDROCURCUMIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DRUG ABSORPTION; DRUG CLEARANCE; DRUG DOSAGE FORM COMPARISON; DRUG ELIMINATION; DRUG FORMULATION; DRUG HALF LIFE; DRUG STRUCTURE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; MOUSE; NANOEMULSION; NONHUMAN; PHARMACOLOGICAL PARAMETERS; PRIORITY JOURNAL; SUSPENSION; SUSTAINED RELEASE FORMULATION; TIME TO MAXIMUM PLASMA CONCENTRATION;

ABSORPTION; ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CURCUMIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG STABILITY; EMULSIONS; MICE; MICE, INBRED STRAINS; MICROSCOPY, ELECTRON, TRANSMISSION; MOLECULAR STRUCTURE; MOUTH MUCOSA; NANOPARTICLES; PARTICLE SIZE; SOLUBILITY; SURFACE PROPERTIES; TANDEM MASS SPECTROMETRY;

EID: 84859741795     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-011-1749-y     Document Type: Article

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