Silica nanoparticles administered at the maximum tolerated dose induce genotoxic effects through an inflammatory reaction while gold nanoparticles do not

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 745, Issue 1-2, 2012, Pages 38-50

  Downs, Thomas R ^a   Crosby, Meredith E ^a,c   Hu, Ting ^a   Kumar, Shyam ^b   Sullivan, Ashley ^a   Sarlo, Katherine ^a   Reeder, Bob ^a   Lynch, Matt ^a   Wagner, Matthew ^a   Mills, Tim ^a   Pfuhler, Stefan ^a  

^a PROCTER AND GAMBLE COMPANY   (United States)

^b BioReliance Corporation   (United States)

^c ASTRAZENECA   (United Kingdom)

Author keywords

Genotoxicity testing; Inflammation; Nanoparticles; Oxidative stress

Indexed keywords

GOLD NANOPARTICLE; INTERLEUKIN 6; NANOPARTICLE; SILICON DIOXIDE; SILICON DIOXIDE NANOPARTICLE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BLOOD CELL; CELL DAMAGE; CELL DEATH; COMET ASSAY; CONTROLLED STUDY; CYTOKINE RELEASE; DNA DAMAGE; GENOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; LIVER INJURY; LUNG INJURY; MALE; MAXIMUM TOLERATED DOSE; MICRONUCLEUS; MICRONUCLEUS TEST; NEUTROPHILIA; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; RETICULOCYTE;

ANIMALS; COMET ASSAY; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; GOLD; HUMANS; INFLAMMATION; LIVER; LUNG; MALE; MAXIMUM TOLERATED DOSE; MICRONUCLEUS TESTS; MUTAGENS; NANOSTRUCTURES; PARTICLE SIZE; QUARTZ; RATS; RATS, WISTAR; SILICON DIOXIDE;

RATTUS NORVEGICUS;

EID: 84860467500     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2012.03.012     Document Type: Article

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