Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity

Molecular Aspects of Medicine

Volumn 32, Issue 4-6, 2011, Pages 279-304

  Calabrese, Vittorio ^a,d   Cornelius, Carolin ^a   Cuzzocrea, Salvatore ^b,f   Iavicoli, Ivo ^e   Rizzarelli, Enrico ^a,d   Calabrese, Edward J ^c  

^a UNIVERSITY OF CATANIA   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

^c UNIVERSITY OF MASSACHUSETTS   (United States)

^d Interuniversity Consortium INBB   (Italy)

^e CATHOLIC UNIVERSITY   (Italy)

^f IRCCS CENTRO NEUROLESI BONINO PULEJO   (Italy)

Author keywords

Caloric restriction; Cellular stress response; Hormesis; Redox status; Vitagenes

Indexed keywords

ACYLCARNITINE; ANSERINE; CARNITINE; CARNOSINE; HEAT SHOCK PROTEIN 32; HEAT SHOCK PROTEIN 70; HEME OXYGENASE; HOMOCARNOSINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; POLYPHENOL DERIVATIVE; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SIRTUIN; THIOREDOXIN; TRANSCRIPTION FACTOR NRF2;

ACETYLATION; AGING; ALZHEIMER DISEASE; ARTICLE; CALORIC RESTRICTION; CELL STRESS; CELL SURVIVAL; CHRONIC FATIGUE SYNDROME; DEACETYLATION; DEGENERATIVE DISEASE; DEPRESSION; DIABETIC NEUROPATHY; DRUG MECHANISM; ENVIRONMENTAL FACTOR; GENE; GENETIC MANIPULATION; HEAT SHOCK; HOMEOSTASIS; HORMESIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LIFESPAN; LONGEVITY; MITOCHONDRION; MORBIDITY; MULTIPLE SCLEROSIS; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; NUTRIENT; OXIDATIVE STRESS; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; VITAGENE;

AGING; ANIMALS; CALORIC RESTRICTION; HORMESIS; HUMANS; LONGEVITY; OXIDATION-REDUCTION;

ANIMALIA;

EID: 81855201861     PISSN: 00982997     EISSN: 18729452     Source Type: Journal    
DOI: 10.1016/j.mam.2011.10.007     Document Type: Article

References (223)

1. H.M. Abdul, V. Calabrese, M. Calvani, and D.A. Butterfield Acetyl-L-carnitine-induced up-regulation of heat shock proteins protects cortical neurons against amyloid-beta peptide 1-42-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease J. Neurosci. Res. 84 2006 398 408 (Pubitemid 44126292)
2. M. Akerfelt, R.I. Morimoto, and L. Sistonen Heat shock factors: integrators of cell stress, development and lifespan Nat. Rev. Mol. Cell Biol. 11 2010 545 555
3. J. Alam, and J.L. Cook How many transcription factors does it take to turn on the heme oxygenase-1 gene? Am. J. Respir. Cell Mol. Biol. 36 2007 166 174 (Pubitemid 46233469)
4. S. Alavez, M.C. Vantipalli, D.J. Zucker, I.M. Klang, and G.J. Lithgow Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan Nature 472 2011 226 229
5. J. Anckar, and L. Sistonen SUMO: getting it on Biochem. Soc. Trans. 35 2007 1409 1413
6. J. Anckar, and L. Sistonen Regulation of HSF1 function in the heat stress response: implications in aging and disease Annu. Rev. Biochem. 80 2011 1089 1115
7. A.M. Andreou, and N. Tavernarakis Roles for SUMO modification during senescence Adv. Exp. Med. Biol. 694 2010 160 171
8. J.R. Archer, and D.E.J. Harrison L-deprenyl treatment in aged mice slightly increases life spans, and greatly reduces fecundity by aged males J. Gerontol. 51 1996 B448 B453
9. T.V. Arumugam, M. Gleichmann, S.C. Tang, and M.P. Mattson Hormesis/preconditioning mechanisms, the nervous system and aging Ageing Res. Rev. 5 2006 165 178 (Pubitemid 43766262)
10. C.E. Ash, and B.J. Merry The molecular basis by which dietary restricted feeding reduces mitochondrial reactive oxygen species generation Mech. Ageing Dev. 132 2011 43 54
11. L. Baird, and A.T. Dinkova-Kostova The cytoprotective role of the Keap1-Nrf2 pathway Arch. Toxicol. 85 2011 241 272
12. W.E. Balch, R.I. Morimoto, A. Dillin, and J.W. Kelly Adapting proteostasis for disease intervention Science 319 2008 916 919 (Pubitemid 351263754)
13. S. Banerjee Mustafi, P.K. Chakraborty, R.S. Dey, and S. Raha Heat stress upregulates chaperone heat shock protein 70 and antioxidant manganese superoxide dismutase through reactive oxygen species (ROS), p38MAPK, and Akt Cell Stress Chaperones 14 2009 579 589
14. J.A. Baur, and D.A. Sinclair Therapeutic potential of resveratrol: the in vivo evidence Rev. Drug Discov. 5 2006 493 506 (Pubitemid 44136961)
15. A.N. Begum, M.R. Jones, G.P. Lim, T. Morihara, P. Kim, D.D. Heath, C.L. Rock, M.A. Pruitt, F. Yang, B. Hudspeth, S. Hu, K.F. Faull, B. Teter, G.M. Cole, and S.A. Frautschy Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease J. Pharmacol. Exp. Ther. 326 2008 196 208 (Pubitemid 351872144)
16. D. Beher, J. Wu, S. Cumine, K.W. Kim, S.C. Lu, L. Atangan, and M. Wang Resveratrol is not a direct activator of SIRT1 enzyme activity Chem. Biol. Drug Des. 74 2009 619 624
17. N.A. Bishop, and L. Guarente Genetic links between diet and lifespan: shared mechanisms from yeast to humans Nat. Rev. Genet. 8 2007 835 844 (Pubitemid 47609089)
18. E.J. Calabrese, and L. Baldwin The dose determines the stimulation (and poison): development of a chemical hormesis database Int. J. Toxicol. 16 1997 545 559 (Pubitemid 27514585)
19. E.J. Calabrese, and L.A. Baldwin Reevaluation of the fundamental dose-response relationship - A new database suggests that the U-shaped, rather than the sigmoidal, curve predominates Bioscience 49 1999 725 732
20. E.J. Calabrese, and L.A. Baldwin Chemical hormesis: Its historical foundations as a biological hypothesis Toxicol. Pathol. 27 1999 195 216 (Pubitemid 29169509)
21. E.J. Calabrese, and L.A. Baldwin Chemical hormesis: its historical foundations as a biological hypothesis Hum. Exper. Toxicol. 19 2000 2 31
22. E.J. Calabrese, and L.A. Baldwin The marginalization of hormesis Hum. Exper. Toxicol. 19 2000 32 40
23. E.J. Calabrese, and L.A. Baldwin Radiation hormesis: its historical foundations as a biological hypothesis Hum. Exper. Toxicol. 19 2000 41 75 (Pubitemid 30195441)
24. E.J. Calabrese, and L.A. Baldwin Radiation hormesis: part 2 - the demise of a legitimate hypothesis Hum. Exper. Toxicol. 19 2000 76 84 (Pubitemid 30195442)
25. E.J. Calabrese, and L.A. Baldwin Tales of two similar hypotheses: the rise and fall of chemical and radiation hormesis Hum. Exper. Toxicol. 19 2000 85 97 (Pubitemid 30195443)
26. E.J. Calabrese, and L.A. Baldwin U-shaped dose-responses in biology, toxicology, and public health Ann. Rev. Public Health 22 2001 15 33 (Pubitemid 32452495)
27. E.J. Calabrese, and L.A. Baldwin Hormesis: U-shaped dose responses and their centrality in toxicology TiPS 22 2001 285 291 (Pubitemid 32536728)
28. E.J. Calabrese, and L.A. Baldwin Applications of hormesis in toxicology, risk assessment and chemotherapeutics Trends Pharm. Sci. 23 2002 331 337 (Pubitemid 34765630)
29. E.J. Calabrese, and L.A. Baldwin Hormesis: the dose-response revolution Ann. Rev. Pharmacol. Toxicol. 43 2003 175 197 (Pubitemid 37372639)
30. E.J. Calabrese, and R. Blain The occurrence of hormetic dose responses in the toxicological literature, the hormesis database: an overview Toxicol. Appl. Pharmacol. 202 2005 289 301 (Pubitemid 40164282)
31. E.J. Calabrese, and R. Blain The hormesis database: the occurrence of hormetic dose response in the toxicological literature Reg. Toxicol. Pharmacol. 61 2011 73 81
32. E.J. Calabrese, and W.B. Jonas Homeopathy: clarifying its relationship to hormesis Hum. Exper. Toxicol. 29 2010 531 536
33. E.J. Calabrese, and W.B. Jonas Evaluating homeopathic drugs within a biomedical framework Hum. Exper. Toxicol. 29 2010 545 549
34. E.J. Calabrese, and M.P. Mattson Hormesis provides a generalized quantitative estimate of biological plasticity J. Cell Comm. Signal. 5 2011 25 38
35. V. Calabrese, and V. Rizza Formation of propionate after short-term ethanol treatment and its interaction with the carnitine pool in rat Alcohol 19 1999 169 176 (Pubitemid 29467515)
36. V. Calabrese, M. Calvani, and D.A. Butterfield Increased formation of short-chain organic acids after chronic ethanol administration and its interaction with the carnitine pool in rat Arch. Biochem. Biophys. 431 2004 271 278 (Pubitemid 39369933)
37. V. Calabrese, G. Scapagnini, A. Ravagna, C. Colombrita, F. Spadaro, D.A. Butterfield, and A.M. Giuffrida Stella Increased expression of heat shock proteins in rat brain during aging: relationship with mitochondrial function and glutathione redox state Mech. Ageing Dev. 125 2004 325 335 (Pubitemid 38438512)
38. V. Calabrese, A.M. Stella, D.A. Butterfield, and G. Scapagnini Redox regulation in neurodegeneration and longevity: role of the heme oxygenase and HSP70 systems in brain stress tolerance Antioxid. Redox Signal. 6 2004 895 913 (Pubitemid 39237943)
39. V. Calabrese, D. Boyd-Kimball, G. Scapagnini, and D.A. Butterfield Nitric oxide and cellular stress response in brain aging and neurodegenerative disorders: the role of vitagenes In Vivo 18 2004 245 267
40. V. Calabrese, C. Colombrita, E. Guagliano, M. Sapienza, A. Ravagna, V. Cardile, G. Scapagnini, A.M. Santoro, A. Mangiameli, D.A. Butterfield, A.M. Giuffrida Stella, and E. Rizzarelli Protective effect of carnosine during nitrosative stress in astroglial cell cultures Neurochem. Res. 30 2005 797 807 (Pubitemid 41413937)
41. V. Calabrese, A. Ravagna, C. Colombrita, G. Scapagnini, E. Guagliano, M. Calvani, D.A. Butterfield, and A.M. Giuffrida Stella Acetylcarnitine induces heme oxygenase in rat astrocytes and protects against oxidative stress: involvement of the transcription factor Nrf2 J. Neurosci. Res. 79 2005 509 521 (Pubitemid 40283351)
42. E.J. Calabrese, J.W. Staudenmayer, E.J. Stanek, and G.R. Hoffmann Hormesis outperforms threshold model in NCI anti-tumor drug screening data Toxicol. Sci. 94 2006 368 378 (Pubitemid 44817153)
43. V. Calabrese, D.A. Butterfield, G. Scapagnini, A.M. Stella, and M.D. Maines Redox regulation of heat shock protein expression by signaling involving nitric oxide and carbon monoxide: relevance to brain aging, neurodegenerative disorders, and longevity Antioxid. Redox Signal. 8 2006 444 477 (Pubitemid 43741315)
44. V. Calabrese, A.M. Giuffrida Stella, M. Calvani, and D.A. Butterfield Acetylcarnitine and cellular stress response: roles in nutritional redox homeostasis and regulation of longevity genes J. Nutr. Biochem. 17 2006 73 88 (Pubitemid 43082141)
45. V. Calabrese, G. Pennisi, M. Calvani, A.M. Giuffrida Stella, D.A. Butterfield, and C. Mancuso Heme oxygenase as therapeutic funnel in nutritional redox homeostasis and cellular stress response: role of acetylcarnitine C. Ritcher-Landsberg, Heat Shock Protein in Neural Cells 2006 Springer NY, USA 39 52
46. V. Calabrese, E. Guagliano, M. Sapienza, M. Panebianco, S. Calafato, E. Puleo, G. Pennisi, C. Mancuso, D.A. Butterfield, and A.G. Stella Redox regulation of cellular stress response in aging and neurodegenerative disorders: role of vitagenes Neurochem. Res. 32 2007 757 773 (Pubitemid 46481305)
47. V. Calabrese, C. Mancuso, M. Calvani, E. Rizzarelli, D.A. Butterfield, and A.M. Stella Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity Nat. Rev. Neurosci. 8 2007 766 775 (Pubitemid 47462116)
48. E.J. Calabrese, E.J. Stanek 3rd, M.A. Nascarella, and G.R. Hoffmann Hormesis predicts low-dose responses better than threshold models Int. J. Toxicol. 27 2008 369 378 (Pubitemid 352767915)
49. V. Calabrese, C. Cornelius, C. Mancuso, G. Pennisi, S. Calafato, F. Bellia, T.E. Bates, A.M. Giuffrida Stella, T. Schapira, A.T. Dinkova Kostova, and E. Rizzarelli Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity Neurochem. Res. 33 2008 2444 2471
50. V. Calabrese, T.E. Bates, C. Mancuso, C. Cornelius, B. Ventimiglia, M.T. Cambria, L. Di Renzo, A. De Lorenzo, and A.T. Dinkova-Kostova Curcumin and the cellular stress response in free radical-related diseases Mol. Nutr. Food Res. 52 2008 1062 1073
51. V. Calabrese, C. Cornelius, A.T. Dinkova-Kostova, and E.J. Calabrese Vitagenes, cellular stress response, and acetylcarnitine: relevance to hormesis Biofactors 35 2009 146 160
52. V. Calabrese, C. Cornelius, C. Mancuso, E. Barone, S. Calafato, T. Bates, E. Rizzarelli, and A.T. Kostova Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases Front. Biosci. 14 2009 376 397
53. V. Calabrese, C. Cornelius, E. Rizzarelli, J.B. Owen, A.T. Dinkova-Kostova, and D.A. Butterfield Nitric oxide in cell survival: a janus molecule Antioxid. Redox Signal. 11 2009 2717 2739
54. V. Calabrese, M. Perluigi, C. Cornelius, R. Coccia, F. Di Domenico, C. Mancuso, G. Pennisi, and A.T. Dinkova-Kostova Phenolics in aging and neurodegenerative disorders C.G. Fraga, Phenolic Compounds of Plant Origin and Health: The Biochemistry behind their Nutritional and Pharmacological Value 2009 Wiley & Sons New York
55. E.J. Calabrese, G.R. Hoffmann, E.J. Stanek III, and M.A. Nascarella Evidence of hormesis in high-throughput screening of antibacterial compounds in E. coli Hum. Exper. Toxicol. 29 2010 667 677
56. V. Calabrese, C. Cornelius, A.T. Dinkova-Kostova, E.J. Calabrese, and M.P. Mattson Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders Antioxid. Redox Signal. 13 2010 1763 1811
57. V. Calabrese, C. Cornelius, A.M. Stella, and E.J. Calabrese Cellular stress responses, mitostress and carnitine insufficiencies as critical determinants in aging and neurodegenerative disorders: role of hormesis and vitagenes Neurochem. Res. 35 2010 1880 1915
58. E.J. Calabrese Toxicology rethinks its central belief Nature 421 2003 691 692 (Pubitemid 36227604)
59. E.J. Calabrese Hormesis: from marginalization to mainstream. A case for hormesis as the default dose-response model in risk assessment Toxicol. Appl. Pharmacol. 197 2004 125 136 (Pubitemid 38639903)
60. E.J. Calabrese Historical blunders: how toxicology got the dose-response relationship half right Cell Mol. Biol. 51 2005 643 654 (Pubitemid 41803292)
61. E.J. Calabrese Paradigm lost, paradigm found: the re-emergence of hormesis as a fundamental dose response model in the toxicological sciences Environ. Poll. 138 2005 379 411
62. E.J. Calabrese Cancer biology and hormesis: human tumor cell lines commonly display hormetic (biphasic) dose responses Crit. Rev. Toxicol. 35 2005 463 582
63. E.J. Calabrese Hormesis: why it is important to toxicology and toxicologists Environ. Toxicol. Chem. 27 2008 1451 1474 (Pubitemid 351961969)
64. E.J. Calabrese Another California milestone: the first application of hormesis in litigation and regulation Int. J. Toxicol. 27 2008 31 33 (Pubitemid 351302266)
65. E.J. Calabrese Pharmacological enhancement of neuronal survival Crit. Rev. Toxicol. 38 2008 349 389 (Pubitemid 351574460)
66. E.J. Calabrese Hormesis and medicine Br. J. Clin. Pharmacol. 66 2008 594 617
67. E.J. Calabrese Astrocytes: adaptive responses to low doses of neurotoxins Crit. Rev. Toxicol. 38 2008 463 471 (Pubitemid 351883148)
68. E.J. Calabrese P-Glycoprotein efflux transporter activity often displays biphasic dose-response relationships Crit. Rev. Toxicol. 38 2008 473 487 (Pubitemid 351883149)
69. E.J. Calabrese Hormesis and homeopathy: introduction Hum. Exper. Toxicol. 29 2010 527 529
70. J. Cates, G.C. Graham, N. Omattage, E. Pavesich, I. Setliff, J. Shaw, C.L. Smith, and O. Lipan Sensing the heat stress by mammalian cells BMC Biophys. 4 2011 16
71. S. Cenci Proteostasis as a signaling device and therapeutic target D. Milardi, E. Rizzarelli, Neurodegeneration: Metallostasis and Proteostasis 2011 RSC Book London
72. Y. Chen, L. Yang, and T.J. Lee Oroxylin A inhibition of lipopolysaccharide-induced iNOS and COX-2 gene expression via suppression of nuclear factor-kappaB activation Biochem. Pharmacol. 59 2000 1445 1457 (Pubitemid 30177363)
73. C.Y. Chen, J.H. Jang, M.H. Li, and Y.J. Surh Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells Biochem. Biophys. Res. Commun. 331 2005 993 1000
74. R.J. Colman, R.M. Anderson, S.C. Johnson, E.K. Kastman, K.J. Kosmatka, T.M. Beasley, D.B. Allison, C. Cruzen, H.A. Simmons, J.W. Kemnitz, and R. Weindruch Caloric restriction delays disease onset and mortality in rhesus monkeys Science 325 2009 201 204
75. C. Corona, V. Frazzini, E. Silvestri, R. Lattanzio, R. La Sorda, M. Piantelli, L.M. Canzoniero, D. Ciavardelli, E. Rizzarelli, and S.L. Sensi Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice PLoS One 6 2011 e17971
76. T. Criswell, K. Leskov, S. Miyamoto, G. Luo, and D.A. Boothman Transcription factors activated in mammalian cells after clinically relevant doses of ionizing radiation Oncogene 22 2003 5813 5827 (Pubitemid 37176702)
77. D. Cuthbertson, K. Smith, J. Babraj, G. Leese, T. Waddell, P. Atherton, H. Wackerhage, P.M. Taylor, and M.J. Rennie Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle FASEB J. 19 2005 422 424 (Pubitemid 40316537)
78. S. Cuzzocrea, B. Zingarelli, E. Gilad, P. Hake, A.L. Salzman, and C. Szabo Protective effect of melatonin in carrageenan-induced models of local inflammation: relationship to its inhibitory effect on nitric oxide production and its peroxynitrite scavenging activity J. Pineal Res. 23 1997 106 116 (Pubitemid 127731745)
79. S. Cuzzocrea, A.P. Caputi, and B. Zingarelli Peroxynitrite-mediated DNA strand breakage activates poly (ADP-ribose) synthetase and causes cellular energy depletion in carrageenan-induced pleurisy Immunology 93 1998 96 101 (Pubitemid 28133101)
80. N. Dali-Youcef, M. Lagouge, S. Froelich, C. Koehl, K. Schoonjans, and J. Auwerx Sirtuins: the 'magnificent seven', function, metabolism and longevity Ann. Med. 39 2007 335 345
81. B. Dancsó, Z. Spiró, M.A. Arslan, M.T. Nguyen, D. Papp, P. Csermely, and C. Soti The heat shock connection of metabolic stress and dietary restriction Curr. Pharm. Biotechnol. 11 2010 139 145
82. R. Di Paola, D. Impellizzeri, A.T. Salinaro, E. Mazzon, F. Bellia, M. Cavallaro, C. Cornelius, G. Vecchio, V. Calabrese, E. Rizzarelli, and S. Cuzzocrea Administration of carnosine in the treatment of acute spinal cord injury Biochem. Pharmacol. 82 2011 1478 1489
83. A.T. Dinkova-Kostova, and P. Talalay Relation of structure of curcumin analogs to their potencies as inducers of Phase 2 detoxification enzymes Carcinogenesis 20 1999 911 914 (Pubitemid 29191875)
84. A.T. Dinkova-Kostova, and P. Talalay Persuasive evidence that quinone reductase type 1 (DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen Free Radic. Biol. Med. 29 2000 231 240
85. A.T. Dinkova-Kostova, and X.J. Wang Induction of the Keap1/Nrf2/ARE pathway by oxidizable diphenols Chem. Biol. Interact. 192 2011 101 106
86. A.T. Dinkova-Kostova The isothiocyanate sulforaphane induces the phase 2 response by signaling of the Keap1-Nrf2-ARE pathway: implications for dietary protection against cancer Y.J. Surh, Z. Dong, E. Cadenas, L. Packer, Dietary Modulation of Cell Signaling Pathways 2008 CRC Press Boca Raton 205 229
87. D. Dobrota, T. Fedorova, S. Stvolinsky, E. Babusikova, K. Likavcanova, A. Drgova, A. Strapkova, and A. Boldyrev Carnosine protects the brain of rats and Mongolian gerbils against ischemic injury: after-stroke-effect Neurochem. Res. 30 2005 1283 1288 (Pubitemid 41772274)
88. S. Dukic-Stefanovic, R. Schinzel, P. Riederer, and G. Munch AGES in brain ageing: AGE-inhibitors as neuroprotective and anti-dementia drugs? Biogerontology 2 2001 19 34 (Pubitemid 32780866)
89. J. Dutta, Y. Fan, N. Gupta, G. Fan, and C. Gelinas Current insights into the regulation of programmed cell death by NF-κB Oncogene 25 2006 6800 6816 (Pubitemid 44657853)
90. A.A. Falcon, S. Chen, M.S. Wood, and J.P. Aris Acetyl-coenzyme A synthetase 2 is a nuclear protein required for replicative longevity in Saccharomyces cerevisiae Mol. Cell. Biochem. 333 2010 99 108
91. A.F. Fernandez, and M.F. Fraga The effects of the dietary polyphenol resveratrol on human healthy aging and lifespan Epigenetics 6 2011 870 874
92. J.C. Fierro-Gonzalez, M. Gonzalez-Barrios, A. Miranda-Vizuete, and P. Swoboda The thioredoxin TRX-1 regulates adult lifespan extension induced by dietary restriction in Caenorhabditis elegans Biochem. Biophys. Res. Commun. 406 2011 478 482
93. L.W. Finley, W. Haas, V. Desquiret-Dumas, D.C. Wallace, V. Procaccio, S.P. Gygi, and M.C. Haigis Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity PLoS One 6 2011 e23295
94. L. Fontana, and S. Klein Aging, adiposity, and calorie restriction JAMA 297 2007 986 994 (Pubitemid 46380237)
95. M. Galli, F. Van Gool, and O. Leo Sirtuins and inflammation: friends or foes? Biochem. Pharmacol. 81 2011 569 576
96. Z. Gerhart-Hines, J.T. Rodgers, O. Bare, C. Lerin, S.H. Kim, R. Mostoslavsky, F.W. Alt, Z. Wu, and P. Puigserver Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha EMBO J. 26 2007 1913 1923 (Pubitemid 46624046)
97. S. Ghosh, and M.S. Hayden New regulators of NF-κB in inflammation Nat. Rev. Immunol. 8 2008 837 848
98. A.A. Goldberg, S.D. Bourque, P. Kyryakov, C. Gregg, T. Boukh-Viner, A. Beach, M.T. Burstein, G. Machkalyan, V. Richard, S. Rampersad, D. Cyr, S. Milijevic, and V.I. Titorenko Effect of calorie restriction on the metabolic history of chronologically aging yeast Exp. Gerontol. 44 2009 555 571
99. A.A. Goldberg, P. Kyryakov, S.D. Bourque, and V.I. Titorenko Xenohormetic, hormetic and cytostatic selective forces driving longevity at the ecosystemic level Aging (Albany, NY) 2 2010 461 470
100. G.I. Grasso, G. Arena, F. Bellia, G. Maccarrone, M. Parrinello, A. Pietropaolo, G. Vecchio, and E. Rizzarelli Intramolecular weak interactions in the thermodynamic stereoselectivity of copper(II) complexes with carnosine-trehalose conjugates Chemistry 17 2011 9448 9455
101. J.L. Green, F.J. Sawaya, and A.L. Dollar The effects of caloric restriction on health and longevity Curr. Treat. Options Cardiovasc. Med. 13 2011 326 334
102. K.L. Guan, and Y. Xiong Regulation of intermediary metabolism by protein acetylation Trends Biochem. Sci. 36 2011 108 116
103. L. Guarente, and H. Franklin Epstein lecture: sirtuins, aging, and medicine N. Engl. J. Med. 364 2011 2235 2244
104. S.C. Gupta, J.H. Kim, R. Kannappan, S. Reuter, P.M. Dougherty, and B.B. Aggarwal Role of nuclear factor κB-mediated inflammatory pathways in cancer-related symptoms and their regulation by nutritional agents Exp. Biol. Med. (Maywood) 236 2011 658 671
105. J.M. Gutteridge, and B. Halliwell Antioxidants: molecules, medicines, and myths Biochem. Biophys. Res. Commun. 393 2010 561 564
106. B. Halliwell Biochemistry of oxidative stress Biochem. Soc. Trans. 35 2007 1147 1150
107. M.N. Harvie, M. Pegington, M.P. Mattson, J. Frystyk, B. Dillon, G. Evans, J. Cuzick, S.A. Jebb, B. Martin, R.G. Cutler, T.G. Son, S. Maudsley, O.D. Carlson, J.M. Egan, A. Flyvbjerg, and A. Howell The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women Int. J. Obes. (Lond.) 35 2011 714 727
108. M.S. Hayden, and S. Ghosh Shared principles in NF-κB signaling Cell 132 2008 344 362
109. J.D. Hayes, and M. McMahon NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer Trends Biochem. Sci. 34 2009 176 188
110. M. Helenius, M. Hanninen, S.K. Lehtinen, and A. Salminen Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-κB Biochem. J. 318 1996 603 608 (Pubitemid 26305964)
111. A. Hiona, and C. Leeuwenburgh Effects of age and caloric restriction on brain neuronal cell death/survival Ann. NY Acad. Sci. 1019 2004 96 105 (Pubitemid 38951291)
112. A.R. Hipkiss, J.E. Preston, D.T. Himsworth, V.C. Worthington, M. Keown, J. Michaelis, J. Lawrence, A. Mateen, L. Allende, P.A. Eagles, and N.J. Abbott Pluripotent protective effects of carnosine, a naturally occurring dipeptide Ann. NY Acad. Sci. 854 1998 37 53 (Pubitemid 29022791)
113. A.R. Hipkiss Could carnosine or related structures suppress Alzheimer's disease? J. Alzheimer's Dis. 11 2007 229 240 (Pubitemid 47010978)
114. A.R. Hipkiss Carnosine and its possible roles in nutrition and health Adv. Food Nutr. Res. 57 2009 87 154
115. A.R. Hipkiss Carnosine, diabetes and Alzheimer's disease Expert Rev. Neurother. 9 2009 583 585
116. A.R. Hipkiss On the enigma of carnosine's anti-ageing actions Exp. Gerontol. 44 2009 237 242
117. A.R. Hipkiss Aging, proteotoxicity, mitochondria, glycation, NAD and carnosine: possible inter-relationships and resolution of the oxygen paradox Front. Aging Neurosci. 2 2010 10
118. J.O. Holloszy, and L. Fontana Caloric restriction in humans Exp. Gerontol. 42 2007 709 712 (Pubitemid 47058857)
119. Y. Horio, T. Hayashi, A. Kuno, and R. Kunimoto Cellular and molecular effects of sirtuins in health and disease Clin. Sci. (Lond.) 121 2011 191 203
120. K. Huber, and G. Superti-Furga After the grape rush: sirtuins as epigenetic drug targets in neurodegenerative disorders Bioorg. Med. Chem. 19 2011 3616 3624
121. S. Janssens, and J. Tschopp Signals from within: the DNA-damage-induced NF-κB response Cell Death Differ. 13 2006 773 784
122. A. Jazwa, and A. Cuadrado Targeting heme oxygenase-1 for neuroprotection and neuroinflammation in neurodegenerative diseases Curr. Drug Targets 11 2010 1517 1531
123. L.L. Jones, D.A. McDonald, and P.R. Borum Acylcarnitines: role in brain Prog. Lipid. Res. 49 2010 61 75
124. K.A. Jung, and M.K. Kwak The Nrf2 system as a potential target for the development of indirect antioxidants Molecules 15 2010 7266 7291
125. T.W. Kensler, N. Wakabayashi, and S. Biswal Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway Annu. Rev. Pharmacol. Toxicol. 47 2007 89 116
126. J. Kerner, K. Lee, and C.L. Hoppel Post-translational modifications of mitochondrial outer membrane proteins Free Radic. Res. 45 2011 16 28
127. H.J. Kim, K.W. Kim, B.P. Yu, and H.Y. Chung The effect of age on cyclooxygenase-2 gene expression: NF-κB activation and IkappaBalpha degradation Free Radic. Biol. Med. 28 2000 683 692
128. T. Kitamuro, K. Takahashi, K. Ogawa, R. Udono-Fujimori, K. Takeda, K. Furuyama, M. Nakayama, J. Sun, H. Fujita, W. Hida, T. Hattori, K. Shirato, K. Igarashi, and S. Shibahara Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells J. Biol. Chem. 278 2003 9125 9133 (Pubitemid 36800393)
129. K. Kitani, C. Minami, K. Isobe, K. Maehara, S. Kanai, G.O. Ivy, and M.C. Carrillo Why (-)deprenyl prolongs survivals of experimental animals: increase of anti-oxidant enzymes in brain and other body tissues as well as mobilization of various humoral factors may lead to systemic anti-aging effects Mech. Ageing Dev. 123 2002 1087 1100 (Pubitemid 34603092)
130. K. Kitani, S. Kanai, K. Miyasaka, M.C. Carillo, and G.O. Ivy Dose-dependency of life span prolongation of F344/DuCrj rats injected with (-)deprenyl Biogerontology 6 2005 297 302 (Pubitemid 43193659)
131. K. Kitani, S. Kanai, K. Miyasaka, M.C. Carillo, and G.O. Ivy The necessity of having a proper dose of (-)deprenyl (D) to prolong the life spans of rats explains discrepancies among different studies in the past Ann. NY Acad. Sci. 1067 2006 375 382 (Pubitemid 43806347)
132. M. Kobayashi, and M. Yamamoto Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species Adv. Enzyme Regul. 46 2006 113 140 (Pubitemid 44301353)
133. T. Kuhn The Structure of Scientific Revolutions 1996 University of Chicago Press Chicago
134. E.J. Lesnefsky, D. He, S. Moghaddas, and C.L. Hoppel Reversal of mitochondrial defects before ischemia protects the aged heart FASEB J. 20 2006 1543 1545
135. M. Lu, H.E. Kim, C.R. Li, S. Kim, I.J. Kwak, Y.J. Lee, S.S. Kim, J.Y. Moon, C.H. Kim, D.K. Kim, H.S. Kang, and J.S. Park Two distinct disulfide bonds formed in human heat shock transcription factor 1 act in opposition to regulate its DNA binding activity Biochemistry 47 2008 6007 6015 (Pubitemid 351770030)
136. M. Lucanic, J.M. Held, M.C. Vantipalli, I.M. Klang, J.B. Graham, B.W. Gibson, G.J. Lithgow, and M.S. Gill N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans Nature 473 2011 226 229
137. T.D. Luckey Hormesis with Ionizing Radiation 1980 CRC Press Boca Raton, FL, USA
138. M.D. Maines The heme oxygenase system: a regulator of second messenger gases Annu. Rev. Pharmacol. Toxicol. 37 1997 517 554 (Pubitemid 27238886)
139. W. Mair, and A. Dillin Aging and survival: the genetics of life span extension by dietary restriction Annu. Rev. Biochem. 77 2008 727 754
140. C. Mancuso, M. Perluigi, C. Cini, C. De Marco, A.M. Giuffrida Stella, and V. Calabrese Heme oxygenase and cyclooxygenase in the central nervous system: a functional interplay J. Neurosci. Res. 84 2006 1385 1391 (Pubitemid 44687398)
141. C. Mancuso, G. Scapagnini, D. Curr, A.M. Giuffrida Stella, C. De Marco, D.A. Butterfield, and V. Calabrese Mitochondrial dysfunction, free radical generation and cellular stress response in neurodegenerative disorders Front. Biosci. 12 2007 1107 1123 (Pubitemid 46846882)
142. C. Mancuso Heme oxygenase and its products in the nervous system Antioxid. Redox Signal. 6 2004 878 887 (Pubitemid 39237941)
143. M.P. Mattson Dietary factors, hormesis and health Ageing Res. Rev. 7 2008 43 48
144. M.P. Mattson Hormesis and disease resistance: activation of cellular stress response pathways Hum. Exper. Toxicol. 27 2008 155 162
145. C.M. McCay, M.F. Crowell, and L.A. Maynard The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935 Nutrition 5 1989 155 171
146. M.A. McDaniel, S.F. Maier, and G.O. Einstein ''Brain-specific'' nutrients: a memory cure? Nutrition 19 2003 957 975
147. G.A. McFarland, and R. Holliday Retardation of the senescence of cultured human diploid fibroblasts by carnosine Exp. Cell Res. 212 1994 167 175 (Pubitemid 24216690)
148. C. Mingorance, R. Rodriguez-Rodriguez, M.L. Justo, M.D. Herrera, and M.A. de Sotomayor Pharmacological effects and clinical applications of propionyl-L-carnitine Nutr. Rev. 69 2011 279 290
149. E. Morselli, G. Mariño, M.V. Bennetzen, T. Eisenberg, E. Megalou, S. Schroeder, S. Cabrera, P. Bénit, P. Rustin, A. Criollo, O. Kepp, L. Galluzzi, S. Shen, S.A. Malik, M.C. Maiuri, Y. Horio, C. López- Otín, J.S. Andersen, N. Tavernarakis, F. Madeo, and G. Kroemer Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome J. Cell Biol. 192 2011 615 629
150. H. Motohashi, and M. Yamamoto Nrf2-Keap1 defines a physiologically important stress response mechanism Trends Mol. Med. 10 2004 549 557 (Pubitemid 39433824)
151. R. Motterlini, R. Foresti, R. Bassi, V. Calabrese, J.E. Clark, and C.J. Green Endothelial Heme oxygenase-1 induction by hypoxia: modulation by inducible nitric oxide synthase (iNOS) and S-nitrosothiols J. Biol. Chem. 275 2000 13613 13620 (Pubitemid 30257429)
152. H. Nakano, A. Nakajima, S. Sakon-Komazawa, J.H. Piao, X. Xue, and K. Okumura Reactive oxygen species mediate crosstalk between NF-κB and JNK Cell Death Differ. 13 2006 730 737
153. M. Nakayama, K. Takahashi, T. Kitamuro, K. Yasumoto, D. Katayose, K. Shirato, Y. Fujii-Kuriyama, and S. Shibahara Repression of heme oxygenase-1 by hypoxia in vascular endothelial cells Biochem. Biophys. Res. Commun. 271 2000 665 671 (Pubitemid 30444685)
154. V.G. Nicoletti, A.M. Santoro, G. Grasso, L.I. Vagliasindi, M.L. Giuffrida, C. Cuppari, V.S. Purrello, A.M. Stella, and E. Rizzarelli Carnosine interaction with nitric oxide and astroglial cell protection J. Neurosci. Res. 85 2007 2239 2245 (Pubitemid 47172155)
155. R.C. Noland, T.R. Koves, S.E. Seiler, H. Lum, R.M. Lust, O. Ilkayeva, R.D. Stevens, F.G. Hegardt, and D.M. Muoio Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control J. Biol. Chem. 284 2009 22840 22852
156. S. Okinaga, K. Takahashi, K. Takeda, M. Yoshizawa, H. Fujita, H. Sasaki, and S. Shibahara Regulation of human heme oxygenase-1 gene expression under thermal stress Blood 87 1996 5074 5084 (Pubitemid 26189848)
157. K. Ono, M. Ikemoto, T. Kawarabayashi, M. Ikeda, T. Nishinakagawa, M. Hosokawa, M. Shoji, M. Takahashi, and M. Nakashima A chemical chaperone, sodium 4-phenylbutyric acid, attenuates the pathogenic potency in human alpha-synuclein A30P + A53T transgenic mice Parkinsonism Relat. Disord. 15 2009 649 654
158. O. Ozden, S.H. Park, H.S. Kim, H. Jiang, M.C. Coleman, D.R. Spitz, and D. Gius Acetylation of MnSOD directs enzymatic activity responding to cellular nutrient status or oxidative stress Aging (Albany, NY) 3 2011 102 107
159. K. Pahan, F.G. Sheikh, A.M. Namboodiri, and I. Singh Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages J. Clin. Invest. 100 1997 2671 2679 (Pubitemid 28007534)
160. A. Paine, B. Eiz-Vesper, R. Blasczyk, and S. Immenschuh Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential Biochem. Pharmacol. 80 2010 1895 1903
161. S.H. Panowski, S. Wolff, H. Aguilaniu, J. Durieux, and A. Dillin PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans Nature 447 2007 550 555 (Pubitemid 46868041)
162. Pkala, J., Patkowska-Sokoła, B., Bodkowski, R., Jamroz, D., Nowakowski, P., Lochyński, S., Librowski, T., Carnitine, L., in press. Metabolic functions and meaning in humans life. Curr. Drug Metab.
163. Pereira, C.V., Lebiedzinska, M., Wieckowski, M.R., Oliveira, P.J., in press. Regulation and protection of mitochondrial physiology by sirtuins. Mitochondrion.
164. R.T. Peters, S.M. Liao, and T. Maniatis IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex Mol. Cell. 5 2000 513 522
165. C.A. Piantadosi, C.M. Withers, R.R. Bartz, N.C. MacGarvey, P. Fu, T.E. Sweeney, K.E. Welty-Wolf, and H.B. Suliman Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression J. Biol. Chem. 286 2011 16374 16385
166. H.F. Poon, V. Calabrese, M. Calvani, and D.A. Butterfield Proteomics analyses of specific protein oxidation and protein expression in aged rat brain and its modulation by L-acetylcarnitine: insights into the mechanisms of action of this proposed therapeutic agent for CNS disorders associated with oxidative stress Antioxid. Redox Signal. 8 2006 381 394 (Pubitemid 43741310)
167. J.E. Preston, A.R. Hipkiss, D.T. Himsworth, I.A. Romero, and J.N. Abbott Toxic effects of beta-amyloid(25-35) on immortalised rat brain endothelial cell: protection by carnosine, homocarnosine and beta-alanine Neurosci. Lett. 242 1998 105 108 (Pubitemid 28083003)
168. H.J. Prochaska, M.J. De Long, and P. Talalay On the mechanisms of induction of cancer-protective enzymes: a unifying proposal Proc. Natl. Acad. Sci. USA 82 1985 8232 8236 (Pubitemid 16171068)
169. H.J. Prochaska, A.B. Santamaria, and P. Talalay Rapid detection of inducers of enzymes that protect against carcinogens Proc. Natl. Acad. Sci. USA 89 1992 2394 2398
170. D. Pubill, E. Verdaguer, F.X. Sureda, A. Camins, M. Pallas, J. Camarasa, and E. Escubedo Carnosine prevents methamphetamine-induced gliosis but not dopamine terminal loss in rats Eur. J. Pharmacol. 448 2002 165 168 (Pubitemid 34874583)
171. A. Raffaello, and R. Rizzuto Mitochondrial longevity pathways Biochim. Biophys. Acta 1813 2011 260 268
172. O. Rahat, N. Maoz, and H.Y. Cohen Multiple pathways regulating the calorie restriction response in yeast J. Gerontol. A Biol. Sci. Med. Sci. 66 2011 163 169
173. S. Reuter, S.C. Gupta, B. Park, A. Goel, and B.B. Aggarwal Epigenetic changes induced by curcumin and other natural compounds Genes Nutr. 6 2011 93 108
174. M.G. Rosca, H. Lemieux, and C.L. Hoppel Mitochondria in the elderly: Is acetylcarnitine a rejuvenator? Adv. Drug. Deliv. Rev. 61 2009 1332 1342
175. W.W. Ruehl, T.L. Entriken, B.A. Muggenburg, D.S. Bruyette, W.G. Grifftim, and F.F. Hahn Treatment with L-deprenyl prolongs life in elderly dogs Life Sci. 61 1997 1037 1044 (Pubitemid 27371342)
176. M.N. Sack Caloric excess or restriction mediated modulation of metabolic enzyme acetylation-proposed effects on cardiac growth and function Biochim. Biophys. Acta 1813 2011 1279 1285
177. M.G. Salgo, E. Bermudez, G.L. Squadrito, and W.A. Pryor Peroxynitrite causes DNA damage and oxidation of thiols in rat thymocytes Arch. Biochem. Biophys. 322 1995 500 505
178. A. Salminen, and K. Kaarniranta NF-κB signaling in the aging process J. Clin. Immunol. 29 2009 397 405
179. A. Salminen, and K. Kaarniranta SIRT1 regulates the ribosomal DNA locus: epigenetic candles twinkle longevity in the Christmas tree Biochem. Biophys. Res. Commun. 378 2009 6 9
180. A. Salminen, J. Huuskonen, J. Ojala, A. Kauppinen, K. Kaarniranta, and T. Suuronen Activation of innate immunity system during aging: NF-κB signaling is the molecular culprit of inflamm-aging Ageing Res. Rev. 7 2008 83 105 (Pubitemid 351418294)
181. A. Salminen, J. Ojala, J. Huuskonen, A. Kauppinen, T. Suuronen, and K. Kaarniranta Interaction of aging-associated signaling cascades: inhibition of NF-κB signaling by longevity factors FoxOs and SIRT1 Cell. Mol. Life Sci. 65 2008 1049 1058
182. D. Salvemini, E. Mazzon, L. Dugo, D.P. Riley, I. Serraino, A.P. Caputi, and S. Cuzzocrea Pharmacological manipulation of the inflammatory cascade by the superoxide dismutase mimetic, M40403 Br. J. Pharmacol. 132 2001 815 827 (Pubitemid 32193638)
183. T. Satoh, and S.A. Lipton Redox regulation of neuronal survival mediated by electrophilic compounds Trends Neurosci. 30 2007 37 45 (Pubitemid 44960491)
184. T. Satoh, S. Saitoh, M. Hosaka, and K. Kosaka Simple ortho- and para-hydroquinones as compounds neuroprotective against oxidative stress in a manner associated with specific transcriptional activation Biochem. Biophys. Res. Commun. 379 2009 537 541
185. G. Scapagnini, C. Colombrita, M. Amadio, V. D'Agata, E. Arcelli, M. Sapienza, A. Quattrone, and V. Calabrese Curcumin activates defensive genes and protects neurons against oxidative stress Antioxid. Redox Signal. 8 2006 395 403 (Pubitemid 43741311)
186. H.M. Schipper, W. Song, H. Zukor, J.R. Hascalovici, and D. Zeligman Heme oxygenase-1 and neurodegeneration: expanding frontiers of engagement J. Neurochem. 110 2009 469 485
187. H.M. Schipper Heme oxygenase-1 in Alzheimer disease: a tribute to Moussa Youdim J. Neural Transm. 118 2011 381 387
188. H. Schulz Ueber Hefegifte. Pflugers Archiv fur die gesamte Physiologie des Menschen und der Tiere 42 1888 517 541
189. S. Shibahara The heme oxygenase dilemma in cellular homeostasis: new insights for the feedback regulation of heme catabolism Tohoku J. Exp. Med. 200 2003 167 186 (Pubitemid 37406931)
190. T. Shimada, T. Kawai, K. Takeda, M. Matsumoto, J. Inoue, Y. Tatsumi, A. Kanamaru, and S. Akira IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases Int. Immunol. 11 1999 1357 1362 (Pubitemid 29355675)
191. T. Shimazu, M.D. Hirschey, J.Y. Huang, L.T. Ho, and E. Verdin Acetate metabolism and aging: an emerging connection Mech. Ageing Dev. 131 2010 511 516
192. T. Shinkawa, K. Tan, M. Fujimoto, N. Hayashida, K. Yamamoto, E. Takaki, R. Takii, R. Prakasam, S. Inouye, V. Mezger, and A. Nakai Heat shock factor 2 is required for maintaining proteostasis against febrile range thermal stress and polyglutamine aggregation Mol. Biol. Cell. 22 2011 3571 3583
193. C.M. Southam, and J. Ehrlich Effects of extract of western red-cedar heartwood on certain wood-decaying fungi in culture Phytopathology 33 1943 517 524
194. Speakman, J.R., Mitchell, S.E., 2011. Caloric restriction. Mol. Asp. Med. doi:10.1016/j.mam.2011.07.001.
195. S.R. Spencer, C.A. Wilczak, and P. Talalay Induction of glutathione transferases and NAD(P)H:quinone reductase by fumaric acid derivatives in rodent cells and tissues Cancer Res. 50 1990 7871 7875
196. A.R.D. Stebbing Hormesis - the stimulation of growth by low-levels of inhibitors Sci. Total Environ. 22 1982 213 234 (Pubitemid 12138176)
197. R. Stocker Antioxidant activities of bile pigments Antioxid. Redox Signal. 6 2004 841 849 (Pubitemid 39237937)
198. S. Stoll, U. Hafner, B. Kranzlin, and W.E. Muller Chronic treatment of Syrian hamsters with low-dose selegiline increases life span in females but not males Neurobiol. Aging 18 1997 205 211 (Pubitemid 27355938)
199. S. Stvolinsky, M. Kukley, D. Dobrota, V. Mezesova, and A. Boldyrev Carnosine protects rats under global ischemia Brain Res. Bull. 53 2000 445 448 (Pubitemid 32000822)
200. K. Taguchi, H. Motohashi, and M. Yamamoto Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution Genes Cells 16 2011 123 140
201. K. Takahashi, M. Nakayama, K. Takeda, H. Fujia, and S. Shibahara Suppression of heme oxygenase-1 mRNA expression by interferon-gamma in human glioblastoma cells J. Neurochem. 72 1999 2356 2361 (Pubitemid 29242185)
202. S.C. Tang, T.V. Arumugam, R.G. Cutler, D.G. Jo, T. Magnus, S.L. Chan, M.R. Mughal, R.S. Telljohann, M. Nassar, X. Ouyang, A. Calderan, P. Ruzza, A. Guiotto, and M.P. Mattson Neuroprotective actions of a histidine analogue in models of ischemic stroke J. Neurochem. 101 2007 729 736 (Pubitemid 46633326)
203. J. Taunton, C.A. Hassig, and S.L. Schreiber A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p Science 272 1996 408 411 (Pubitemid 26138177)
204. G. Traina, G. Federighi, M. Macchi, R. Bernardi, M. Durante, and M. Brunelli Modulation of myelin basic protein gene expression by acetyl-L-carnitine Mol. Neurobiol. 44 2011 1 6
205. A. Vassilopoulos, K.S. Fritz, D.R. Petersen, and D. Gius The human sirtuin family: evolutionary divergences and functions Hum. Genomics 5 2011 485 496
206. M.H. Vendelbo, and K.S. Nair Mitochondrial longevity pathways Biochim. Biophys. Acta 1813 2011 634 644
207. E. Vivoli, L. Di Cesare Mannelli, A. Salvicchi, A. Bartolini, A. Koverech, R. Nicolai, P. Benatti, and C. Ghelardini Acetyl-L-carnitine increases artemin level and prevents neurotrophic factor alterations during neuropathy Neuroscience 167 2010 1168 1174
208. G.R. Wagner, and R.M. Payne Mitochondrial acetylation and diseases of aging J. Aging Res. 2011 2011 234875
209. D.C. Wallace Why do we still have a maternally inherited mitochondrial DNA? Insights from evolutionary medicine Annu. Rev. Biochem. 76 2007 781 821
210. D.C. Wallace Mitochondria as chi Genetics 179 2008 727 735
211. D.C. Wallace Mitochondrial DNA mutations in disease and aging Environ. Mol. Mutagen. 51 2010 440 450
212. D.C. Wallace The epigenome and the mitochondrion: bioenergetics and the environment Genes Dev. 24 2010 1571 1573
213. Q. Wang, Y. Zhang, C. Yang, H. Xiong, Y. Lin, J. Yao, H. Li, L. Xie, W. Zhao, Y. Yao, Z.B. Ning, R. Zeng, Y. Xiong, K.L. Guan, S. Zhao, and G.P. Zhao Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux Science 327 2010 1004 1007
214. E. Wenzel, and V. Somoza Metabolism and bioavailability of trans-resveratrol Mol. Nutr. Food Res. 49 2005 472 481 (Pubitemid 40780394)
215. S.D. Westerheide, J.D. Bosman, B.N. Mbadugha, T.L. Kawahara, G. Matsumoto, S. Kim, W. Gu, J.P. Devlin, R.B. Silverman, and R.I. Morimoto Celastrols as inducers of the heat shock response and cytoprotection J. Biol. Chem. 279 2004 56053 56060 (Pubitemid 40066613)
216. S.D. Westerheide, J. Anckar, S.M.Jr. Stevens, L. Sistonen, and R.I. Morimoto Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1 Science 323 2009 1063 1066
217. A. Wierinckx, J. Brevé, D. Mercier, M. Schultzberg, B. Drukarch, and A.M. Van Dam Detoxication enzyme inducers modify cytokine production in rat mixed glial cells J. Neuroimmunol. 166 2005 132 143 (Pubitemid 41074663)
218. R.S. Zee, C.B. Yoo, D.R. Pimentel, D.H. Perlman, J.R. Burgoyne, X. Hou, M.E. McComb, C.E. Costello, R.A. Cohen, and M.M. Bachschmid Redox regulation of sirtuin-1 by S-glutathiolation Antioxid. Redox Signal. 13 2010 1023 1032
219. J. Zhao, N. Kobori, J. Aronowski, and P.K. Dash Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents Neurosci. Lett. 393 2006 108 112 (Pubitemid 41821089)
220. J. Zhao, A.N. Moore, J.B. Redell, and P.K. Dash Enhancing expression of Nrf2-driven genes protects the blood brain barrier after brain injury J. Neurosci. 27 2007 10240 10248 (Pubitemid 47450456)
221. X. Zhao, G. Sun, J. Zhang, R. Strong, P.K. Dash, Y.W. Kan, J.C. Grotta, and J. Aronowski Transcription factor Nrf2 protects the brain from damage produced by intracerebral hemorrhage Stroke 38 2007 3280 3286 (Pubitemid 350175749)
222. S. Zhao, W. Xu, W. Jiang, W. Yu, Y. Lin, T. Zhang, J. Yao, L. Zhou, Y. Zeng, H. Li, Y. Li, J. Shi, W. An, S.M. Hancock, F. He, L. Qin, J. Chin, P. Yang, X. Chen, Q. Lei, Y. Xiong, and K.L. Guan Regulation of cellular metabolism by protein lysine acetylation Science 327 2010 1000 1004
223. E.J. Calabrese, K.A. Bachmann, A.J. Bailer, P.M. Bolger, J. Borak, L. Cai, N. Cedergreen, M.G. Cherian, C.C. Chiueh, T.W. Clarkson, R.R. Cook, D.M. Diamond, D.J. Doolittle, M.A. Dorato, S.O. Duke, L. Feinendegen, D.E. Gardner, R.W. Hart, K.L. Hastings, A.W. Hayes, G.R. Hoffmann, J.A. Ives, Z. Jaworowski, T.E. Johnson, W.B. Jonas, N.E. Kaminski, J.G. Keller, J.E. Klaunig, T.B. Knudsen, W.J. Kozumbo, T. Lettieri, S.-Z. Liu, A. Maisseu, K.I. Maynard, E.J. Masoro, R.O. McClellan, H.M. Mehendale, C. Mothersill, D.B. Newlin, H.N. Nigg, F.W. Oehme, R.F. Phalen, M.A. Philbert, S.I.S. Rattan, J.E. Riviere, J. Rodricks, R.M. Sapolsky, B.R. Scott, C. Seymour, D.A. Sinclair, J. Smith-Sonneborn, E.T. Snow, L. Spear, D.E. Stevenson, Y. Thomas, M. Tubiana, G.M. Williams, and M.P. Mattson Biological stress response terminology: integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework Toxicol. Appl. Pharmacol. 222 2007 122 128 (Pubitemid 46970781)