The conclusions on the effectiveness of homeopathy highly depend on the set of analyzed trials

Journal of Clinical Epidemiology

Volumn 61, Issue 12, 2008, Pages 1197-1204

  Ludtke R ^a   Rutten, A L B ^b  

^a Karl und Veronica Carstens Stiftung   (Germany)

^b Artsenvereniging voor homeopathie VHAN ^*  (Netherlands)

Author keywords

Heterogeneity; Homeopathy; Meta analysis; Randomized clinical trials; Selection bias; Sensitivity analysis

Indexed keywords

PLACEBO;

HOMEOPATHY; HUMAN; PRIORITY JOURNAL; PUBLICATION; REVIEW; RUNNING; SAMPLE SIZE; SENSITIVITY ANALYSIS;

DATA INTERPRETATION, STATISTICAL; HOMEOPATHY; HUMANS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RESEARCH DESIGN; TREATMENT OUTCOME;

EID: 54049092358     PISSN: 08954356     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jclinepi.2008.06.015     Document Type: Review

References (52)

1. Shang A., Huwiler-Muntener K., Nartey L., Juni P., Dorig S., Sterne J.A., et al. Are the clinical effects of homoeopathy placebo effects? Comparative study of placebo-controlled trials of homoeopathy and allopathy. Lancet 366 (2005) 726-732
2. Linde K., Scholz M., Ramirez G., Clausius N., Melchart D., and Jonas W.B. Impact of study quality on outcome in placebo-controlled trials of homeopathy. J Clin Epidemiol 52 (1999) 631-636
3. Fisher P., Berman B., Davidson J., Reilly D., and Thompson T. Are the clinical effects of homoeopathy placebo effects?. [letter]. Lancet 366 (2005) 2082-2083
4. 4.2.4 [updated March 2005]. In: Higgins J., and Green S. (Eds). Cochrane handbook for systematic reviews of interventions (2005), John Wiley & Sons, Ltd., Chichester, UK
5. Thompson S.G. Why and how sources of heterogeneity should be investigated. In: Egger M., Smith G.D., and Altman D. (Eds). Systematic Reviews in Health Care (2001), BMJ Publishing Group, London 157-175
6. Rottey E.E.D., Verleye G.B., and Liagre R.L.P. Het effect van een homeopathische bereiding van micro-organismen bij de preventie von griepsymtomen-Een gerandomiseerd dubbel-blind onderzoek in de huisartspraktijk. Tijdschr Integ Geneeskunde 11 (1995) 54-58
7. Vickers A.J., Fisher P., Wyllie S.E., and Rees R. Homeopathic Arnica 30X is ineffective for muscle soreness after long-distance running-a randomized, double-blind, placebo-controlled trial. Clin J Pain 14 (1998) 227-231
8. Papp R., Schuback G., Beck E., Burkard G., Bengel J., Lehrl S., et al. Oscillococcinum in patients with influenza-like syndromes: a placebo controlled double-blind evaluation. Br Homeopath J 87 2 (1998) 69-76
9. Schmidt J.M., and Ostermayr B. Does a homeopathic ultramolecular dilution of Thyroidinum 30CH affect the decrease of body weight reduction in fasting patients?-A randomised placebo-controlled double-blind trial. Homeopathy 91 (2002) 197-206
10. Labrecque M., Audet D., Latulippe L., and Drouin J. Homeopathic treatment of plantar warts. Can Med Assoc J 146 (1992) 1749-1753
11. Jacobs J., Jiménez L.M., Malthouse S., Chapman E., Crothers D., Masuk M., et al. Homeopathic treatment of acute childhood diarrhea-results from a clinical trial in Nepal. J Alternat Complement Med 6 2 (2000) 131-139
12. Weiser M., and Clasen B.P.E. Randomisierte plazebokontrollierte Doppelblindstudie zur Untersuchung der klinischen Wirksamkeit der homöopathischen Euphorbium compositum-Nasentropfen S bei chronischer Sinusitis. Forsch Komplementärmed 1 (1994) 251-259
13. Walach H., Haeusler W., Lowes T., Mussbach D., Schamell U., Springer W., et al. Classical homeopathic treatment of chronic headaches. Cephalalgia 17 (1997) 119-126
14. Jacobs J., Jiménez L.M., Gloyd S.S., Gale J.L., and Crothers D. Treatment of acute childhood diarrhea with homoeopathic medicine: a randomized clinical trial in Nicaragua. Pediatrics 93 (1994) 719-725
15. Jacobs J., Springer D.A., and Crothers D. Homeopathic treatment of acute otitis media in children: a preliminary randomized placebo-controlled trial. Pediatr Infect Dis J (2001) 177-183
16. Hart O., Mullee M.A., Lewith G., and Miller J. Double-blind, placebo-controlled, randomized clinical trial of homoeopathic arnica C30 for pain and infection after total abdominal hysterectomy. J Royal Soc Med 90 (1997) 73-78
17. Wiesenauer M., Häussler S., and Gaus W. Pollinosis-Therapie mit Galphimia glauca. MMW Fortschr Med 101 (1983) 811-814
18. Zell J., Connert W.D., Mau J., and Feuerstake G. Behandlung von akuten Sprunggelenksdistorsionen-Doppelblindstudie zum Wirksamkeitsnachweis eines homöopathischen Salbenpräparats. MMW Fortschr Med 106 5 (1988) 96-100
19. Böhmer D., and Ambrus P. Behandlung von Sportverletzungen mit Traumeel-Salbe-Kontrollierte Doppelblindstudie. Biol Medizin 21 4 (1992) 260-268
20. Vickers A.J., Fisher P., Smith C., Wyllie S.E., and Lewith G.T. Homoeopathy for delayed onset muscle soreness-a randomised double blind placebo controlled trial. Brit J Sports Med 31 (1997) 304-307
21. Jawara N., Lewith G.T., Vickers A., Mullee M.A., and Smith C. Homoeopathic Arnica and Rhus toxicodendron for delayed onset muscle soreness-a pilot for a randomized, double-blind, placebo-controlled trial. Brit Hom J 86 1 (1997) 10-15
22. Chapman E.H., Weintraub R.J., and Milburn M.A. Homeopathic treatment of mild traumatic brain injury-a randomised, double-blind, placebo-controlled clinical trial. J Head Trauma Rehabil 14 (1999) 521-542
23. Tveiten D., Bruset S., Borchgrevink C.F., and Norseth J. Effects of the homeopathic remedy Arnica D30 on marathon runners: a randomized, double-blind study during the 1995 Oslo Marathon. Complem Ther Med 6 2 (1998) 71-74
24. Stevinson C., Devaraj V.S., and Fountain-Barber A. Homeopathic arnica for prevention of pain and bruising: randomized placebo-controlled trial in hand surgery. J R Soc Med 96 (2003) 60-65
25. Lepaisant C. Essai thérapeutique en homéopathie: traitement des tensions mammaires et mastodynies du syndrome prémenstruel. Rev Fr Gynécol Obstét 90 2 (1995) 94-97
26. Chapman E.H., Angelica J., Spitalny G., and Strauss M. Results of a study of the homoeopathic treatment of PMS. J Am Inst Hom 87 (1994) 14-21
27. Egger M. Study characteristics of homoeopathy studies. Available from: (2005). http://www.ispm.unibe.ch/downloads/Lancet_Homoeopathy [cited 06.03.2006]
28. Hasselblad V., and Hedges L. Meta-analysis of screening and diagnostic tests. Psychol Bull 117 (1995) 167-178
29. Egger M., Smith G.D., Schneider M., and Minder C. Bias in meta-analysis detected by a simple, graphical test. British Med J 315 (1997) 629-634
30. Thompson S.G., and Sharp S.J. Explaining heterogeneity in meta-anaysis: a comparison of methods. Statist Med 18 (1999) 2693-2708
31. Fleiss J. The statistical basis of meta-analysis. Stat Meth Med Res 2 (1993) 121-145
32. Higgins J.P., and Thompson S.G. Quantifying heterogeneity in a meta-analysis. Stat Med 21 (2002) 1539-1558
33. Ernst E., and Barnes J. Are homoeopathic remedies effective for delayed-onset muscle soreness?-a systematic review of placebo-controlled trials. Perfusion 11 (1998) 4-8
34. Linde K., and Jonas W. Are the clinical effects of homoeopathy placebo effects?. [letter]. Lancet 366 (2005) 2081-2082
35. Shang A., Jüni P., Sterne J.A.C., Huwiler-Müntener K., and Egger M. Author's reply. Lancet 366 (2005) 2083-2085
36. Egger M., Smith G.D., and Phillips A.N. Meta analysis: principles and procedures. BMJ 315 (1997) 1533-1537
37. Higgins J.P.T., Thompson S.G., Deeks J.J., and Altman D.G. Measuring inconsistency in meta-analyses. Br Med J 327 (2003) 557-560
38. McAuley L., Pham B., Tugwell P., and Moher D. Does the inclusion of grey literature influence estimates of intervention effectiveness reported in meta-analyses?. Lancet 356 (2000) 1228-1231
39. Chan A., Hjobartsson A., Haahr M., Gotzsche P., and Altman D. Empirical evidence for selective reporting of outcomes in randomized trials: comparison of protocols to published articles. JAMA 291 (2004) 2457-2465
40. Pham B., Klassen T.P., Lawson M.L., and Moher D. Language of publication restrictions in systematic reviews gave different results depending on whether the intervention was conventional or complementary. J Clin Epidemiol 58 (2005) 769-776
41. Moher D., Fortin P., Jadad A.R., Juni P., Klassen T., Le Lorier J., et al. Completeness of reporting of trials published in languages other than English: implications for conduct and reporting of systematic reviews. Lancet 347 (1996) 363-366
42. Klassen T.P., Pham B., Lawson M.L., and Moher D. For randomized controlled trials, the quality of reports of complementary and alternative medicine was as good as reports of conventional medicine. J Clin Epidemiol 58 (2005) 763-768
43. Linde K., Clausius N., Ramirez G., Melchart D., Eitel F., Hedges L., et al. Are the clinical effects of homoeopathy placebo effects?-a meta-analysis of placebo-controlled trials. Lancet 350 (1997) 834-843
44. Dean M.E. The trials of homeopathy (2004), KVC-Verlag, Essen
45. de Lange-de-Klerk E.S.M., Blommers J., Kuik D.J., Bezemer P.D., and Feenstra L. Effects of homoeopathic medicines on daily burden of symptoms in children with recurrent upper respiratory tract infections. BMJ 309 (1994) 1329-1332
46. Reilly D.T., Taylor M.A., Beattie N.G.M., Campbell J.H., McSharry C., Aitchison T.C., et al. Is evidence for homoeopathy reproducible?. Lancet 344 (1994) 1601-1606
47. Reilly D.T., Taylor M.A., McSharry C., and Aitchison T. Is homoeopathy a placebo response?-Controlled trial of homoeopathic potency-with pollen in hayfever as model. Lancet 2 (1986) 881-886
48. Hofmeyr G.J., Piccioni V., and Blauhof P. Postpartum homoeopathic Arnica montana-a potency-finding pilot study. Br J Clin Pract 44 (1990) 619-621
49. Vandenbroucke J.P., and de Craen A.J. Alternative medicine: a "mirror image" for scientific reasoning in conventional medicine. Ann Intern Med 135 (2001) 507-513
50. Quine W.V. Ontological relativity and other essays (1969), Columbia University Press, New York
51. Vandenbroucke J.P. Homoeopathy and "the growth of truth. Lancet 366 (2005) 691-692
52. Gezondheidsraad. Alternatieve Behandelwijzen en Wetenschappelijk Onderzoek [Alternative treatments and scientific research]. Den Haag; 1993.