Systems toxicology used in nanotoxicology: Mechanistic insights into the hepatotoxicity of nano-copper particles from toxicogenomics

Journal of Nanoscience and Nanotechnology

Volumn 10, Issue 12, 2010, Pages 8527-8537

  Yang, Baohua ^a   Wang, Quanjun ^a   Lei, Ronghui ^b   Wu, Chunqi ^a   Shi, Chang ^a   Wang, Qingxiu ^a   Yuan, Ye ^a   Wang, Ying ^c   Luo, Yongwei ^a   Hu, Zhonghui ^a   Ma, Huazhi ^a   Liao, Mingyang ^a  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^b XI'AN JIAOTONG UNIVERSITY   (China)

^c JINZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Copper nanoparticles; Microarray; Nanomaterials; Nanotoxicology; Systems toxicology; Toxicogenomics

Indexed keywords

COPPER NANOPARTICLES; NANOMATERIALS; NANOTOXICOLOGY; SYSTEMS TOXICOLOGY; TOXICOGENOMICS;

AMINO ACIDS; ANTHROPOMETRY; BIOCHEMISTRY; COPPER; LIVER; MICROARRAYS; NANOPARTICLES; NANOSTRUCTURED MATERIALS; RATS; RISK ASSESSMENT; SIGNAL TRANSDUCTION; TISSUE; TOXICITY;

GENE EXPRESSION;

COPPER; METAL NANOPARTICLE;

ANALYSIS OF VARIANCE; ANIMAL; ARTICLE; ATOMIC FORCE MICROSCOPY; CHEMISTRY; CLUSTER ANALYSIS; DNA MICROARRAY; DRUG EFFECT; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETICS; LIVER; MALE; METABOLISM; METHODOLOGY; NECROSIS; PARTICLE SIZE; PATHOLOGY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TOXIC HEPATITIS; TOXICOGENETICS; WISTAR RAT;

ANALYSIS OF VARIANCE; ANIMALS; CLUSTER ANALYSIS; COPPER; DRUG-INDUCED LIVER INJURY; GENE EXPRESSION; GENE EXPRESSION PROFILING; LIVER; MALE; METABOLIC NETWORKS AND PATHWAYS; METAL NANOPARTICLES; MICROSCOPY, ATOMIC FORCE; NECROSIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PARTICLE SIZE; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TOXICOGENETICS;

EID: 79952111940     PISSN: 15334880     EISSN: None     Source Type: Journal    
DOI: 10.1166/jnn.2010.2481     Document Type: Conference Paper

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