Polymeric nanoparticle encapsulation of a naturally occurring plant scopoletin and its effects on human melanoma cell A375

Journal of Chinese Integrative Medicine

Volumn 8, Issue 9, 2010, Pages 853-862

  Khuda Bukhsh, Anisur Rahman ^a   Bhattacharyya, Soumya Sundar ^a   Paul, Saili ^a   Boujedaini, Naoual ^b  

^a UNIVERSITY OF KALYANI   (India)

^b Boiron Laboratory   (France)

Author keywords

Antineoplastic agents; Apoptosis; In vitro; Melanoma; Nanoparticles; Phytogenic; Polylactic co glycolic acid; Scopoletin

Indexed keywords

CASPASE 3; CYCLIN D1; CYCLINE; PROTEIN P53; SCOPOLETIN; STAT3 PROTEIN; SURVIVIN; COUMARIN; COUMARIN 7; COUMARIN DERIVATIVE; IMIDAZOLE DERIVATIVE; LACTIC ACID; NANOPARTICLE; POLYLACTIC ACID; POLYMER;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ATOMIC FORCE MICROSCOPY; CANCER CELL CULTURE; CLINICAL EVALUATION; DOWN REGULATION; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; DRUG UPTAKE; ENZYME INDUCTION; GELSEMIUM; HUMAN; HUMAN CELL; IN VITRO STUDY; LIGHT SCATTERING; MELANOMA; NANOENCAPSULATION; PARTICLE SIZE; SCANNING ELECTRON MICROSCOPY; DRUG EFFECTS; METABOLISM; PATHOLOGY; SKIN TUMOR; UPREGULATION;

APOPTOSIS; CASPASE 3; COUMARINS; DOWN-REGULATION; HUMANS; IMIDAZOLES; LACTIC ACID; MELANOMA; NANOPARTICLES; PARTICLE SIZE; POLYMERS; SCOPOLETIN; SKIN NEOPLASMS; UP-REGULATION;

EID: 77956846369     PISSN: 16721977     EISSN: None     Source Type: Journal    
DOI: 10.3736/jcim20100909     Document Type: Article

References (15)

1. Newman JDS, Blanchard GJ. Formation and encapsulation of gold nanoparticles using a polymeric amine reducing agent. J Nanopart Res. 2007; 9(5): 861-868.
2. Bisht S, Feldmann G, Soni S, Ravi R, Karikar C, Maitra A, Maitra A. Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): a novel strategy for human cancer therapy. J Nanobiotechnology. 2007; 5: 3. (Pubitemid 46705986)
3. Anand P, Nair HB, Sung B, Kunnumakkara AB, Yadav VR, Tekmal RR, Aggarwal BB. Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo. Biochem Pharmacol. 2010; 79(3): 330-338.
4. Allemann E. Gurny R. Doelker E. Drug loaded nanoparticles preparation methods and drug targeting tissues. Eur J Pharm Biopharm. 1993; 39(5): 173-191. (Pubitemid 23361352)
5. Bhattacharyya SS, Mandal SK, Biswas R, Paul S, Pathak S, Boujedaini N, Belon P, Khuda-Bukhsh AR. In vitro studies demonstrate anticancer activity of an alkaloid of the plant Gelsemium sempervirens. Exp Biol Med. 2008; 233(12): 1591-1601.
6. Bhattacharyya SS, Paul S, Dutta S, Boujaedaini N, Khuda-Bukhsh AR. Anti-oncogenic potentials of a plant coumarin (7-hydroxy-6-methoxy coumarin) against 7, 12-dimethylbenz[a]anthracene-induced skin papilloma in mice: the possible role of several key signal proteins. J Chin Integr Med. 2010; 8(7): 645-654. English with abstract in Chinese.
7. Bhattacharyya SS, Paul S, Khuda-Bukhsh AR. Encapsulated plant extract (Gelsemium sempervirens ) poly (lactide-co-glycolide) nanoparticles enhance cellular uptake and increase bioactivity in vitro. Exp Biol Med. 2010; 235(6): 678-688.
8. Panyam J, Dali MM, Sahoo SK, Ma W, Chakravarthi SS, Amidon GL, Levy RJ, Labhasetwar V. Labhasetwar V. Polymer degradation and in vitro release of a model protein from poly (D, L-lactide-co-glycolide) nano- and microparticles. J Control Release. 2003; 92(1-2): 173-187.
9. Fessi H, Puisieux F, Devissaguet JP, Ammoury N, Benita S. Nanocapsule formation by interfacial polymer deposition following solvent displacement. Int J Pharm. 1989; 55(1): 1-4.
10. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods. 1983; 65(1-2): 55-63. (Pubitemid 14203433)
11. Darzynkiewicz Z, Galkowski D, Zhao H. Analysis of apoptosis by cytometry using TUNEL assay. Methods. 2008; 44(3): 250-254. (Pubitemid 351296445)
12. Kawaii S, Tomono Y, Ogawa K, Sugiura M, Yano M, Yoshizawa Y. The antiproliferative effect of coumarins on several cancer cell lines. Anticancer Res. 2001; 21(2A): 917-923. (Pubitemid 32494190)
13. Ankola DD, Viswanad B, Bhardwaj V, Ramarao P, Kumar MN. Development of potent oral nanoparticulate formulation of coenzyme Q10 for treatment of hypertension: can the simple nutritional supplements be used as first line therapeutic agents for prophylaxis/therapy? Eur J Pharm Biopharm. 2007; 67(2): 361-369.
14. Kim TY, Kim DW, Chung JY, Shin SG, Kim SC, Heo DS, Kim NK, Bang YJ. Phase I and pharmacokinetic study of Genexol-PM, a cremophor-free, polymeric micelle-formulated paclitaxel, in patients with advanced malignancies. Clin Cancer Res. 2004; 10(11): 3708-3716.
15. Vasey PA, Kaye SB, Morrison R, Twelves C, Wilson P, Duncan R, Thomson AH, Murray LS, Hilditch TE, Murray T, Burtles S, Fraier D, Frigerio E, Cassidy J. Phase I clinical and pharmacokinetic study of PK1 [N-(2-hydroxypropyl) methacrylamide copolymer doxorubicin]: first member of a new class of chemotherapeutic agents-drug-polymer conjugates. Clin Cancer Res. 1999; 5(1): 83-94.