Magnesium phosphate nanoparticles can be efficiently used in vitro and in vivo as non-viral vectors for targeted gene delivery

Journal of Biomedical Nanotechnology

Volumn 5, Issue 1, 2009, Pages 106-114

  Bhakta, Gajadhar ^a   Shrivastava, Anju ^a   Maitra, Amarnath ^a  

^a UNIVERSITY OF DELHI   (India)

Author keywords

Gene delivery; Liver targeting; Magnesium phosphate nanoparticles; Non viral vectors; pSV gal; Transfection efficiency

Indexed keywords

GENE DELIVERY; LIVER TARGETING; MAGNESIUM PHOSPHATE NANOPARTICLES; NON-VIRAL VECTORS; TRANSFECTION EFFICIENCY;

AMINES; CALCIUM; CELL PROLIFERATION; CROSSLINKING; GENE TRANSFER; LIVER; MAGNESIUM; MAGNESIUM PRINTING PLATES; MICROEMULSIONS; NANOPARTICLES; NUCLEIC ACIDS; ORGANIC ACIDS; PHOSPHATES; VECTORS;

CALCIUM PHOSPHATE;

1 (3 DIMETHYLAMINOPROPYL) 3 ETHYLCARBODIIMIDE; BETA GALACTOSIDASE; MAGNESIUM; NANOPARTICLE; PLASMID DNA; POLYACRYLIC ACID; PYRANOSIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CELL STRAIN COS7; CELL STRAIN HEK293; CELL STRAIN MCF 7; CELL VIABILITY; CONTROLLED STUDY; CROSS LINKING; CYTOTOXICITY; EMBRYO; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIVER; LUNG; MICROEMULSION; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; SINGLE DRUG DOSE; SPLEEN;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; CRYSTALLIZATION; DNA, VIRAL; DRUG CARRIERS; GENE TARGETING; GENETIC VECTORS; MACROMOLECULAR SUBSTANCES; MAGNESIUM COMPOUNDS; MATERIALS TESTING; MOLECULAR CONFORMATION; NANOPARTICLES; PHOSPHATES; SURFACE PROPERTIES; TRANSFECTION;

EID: 67649822589     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2009.029     Document Type: Article

References (43)

1. D. C. Gorecki, "Dressed-up" naked plasmids: Emerging vectors for non-viral gene therapy. Discov. Med. 6, 191 (2006).
2. S. D. Li and L. Huang, Gene therapy progress and prospects: Non-viral gene therapy by systemic delivery. Gene. Ther. 13, 1313 (2006).
3. I. S. Zuhom, J. B. Engberts, and D. Hoekstra, Gene delivery by cationic lipid vectors: Overcoming cellular barriers. Eur. Biophys. J. 36, 349 (2007).
4. P. P. Karmali and A. Chaudhuri, Cationic liposomes as non-viral carriers of gene medicines: Resolved issues, open questions, and future promises. Med. Res. Rev. 27, 696 (2007).
5. L. Wasungu and D. Hoekstra, Cationic lipids, lipoplexes and intracellular delivery of genes. J. Control Release 116, 255 (2006).
6. M. J. Tiera, F. O. Winnik, and J. C. Fernandes, Synthetic and natural polycations for gene therapy: State of the art and new perspectives. Curr. Gene. Ther. 6, 59 (2006).
7. B. Demeneix and J. P. Behr, Polyethylenimine (PEI). Adv. Genet. 53, 217 (2005).
8. C. Dufes, I. F. Uchegbu, and A. G. Schatzlein, Dendrimers in gene delivery. Adv. Drug. Deliv. Rev. 57, 2177 (2005).
9. D. Lechardeur and G. L. Lukacs, Nucleocytoplasmic transport of plasmid DNA: A perilous journey from the cytoplasm to the nucleus. Hum. Gene. Ther. 17, 882 (2006).
10. A. Maitra, Calcium phosphate nanoparticles: Second generation non-viral vectors in gene therapy. Expert Rev. Mol. Diagn. 5, 893 (2005).
11. K. Tan, P. Cheang, I. A. Ho, P. Y. Lam, and K. M. Hui, Nanosized bioceramic particles could function as efficient gene delivery vehicles with target specificity for the spleen. Gene. Ther. 14, 828 (2007).
12. M. Ravi Kumar, G. Hellermann, R. F. Lockey, and S. S. Mohapatra, Nanoparticle-mediated gene delivery: State of the art. Expert Opin. Biol. Ther. 4, 1213 (2004).
13. A. K. Salem, P. C. Searson, and K. W. Leong, Multifunctional nanorods for gene delivery. Nat. Mater. 2, 668 (2003).
14. X. Li, Y. Peng, and X. Qu, Carbon nanotubes selective destabilization of duplex and triplex DNA and inducing B-A transition in solution. Nucleic Acids Res. 34, 3670 (2006).
15. J. Dobson, Gene therapy progress and prospects: Magnetic nanoparticle-based gene delivery. Gene. Ther. 13, 283 (2006).
16. B. Nemery, Metal toxicity and the respiratory tract. Eur. Respir. J. 3, 202 (1990).
17. M. F. Wendland, Applications of manganese-enhanced magnetic resonance imaging (MEMRI) to imaging of the heart. NMR Biomed. 17, 581 (2004).
18. M. R. Mozafari and A. Omri, Importance of divalent cations in nanolipoplex gene delivery. J. Pharm. Sci. 96, 1955 (2007).
19. T. Jefferson, M. Rudin, and C. Di Pietrantoni, 2004 Adverse events after immunisation with aluminium-containing DTP vaccines: Systematic review of the evidence. Lancet. Infect. Dis. 4, 84 (2007).
20. FDI Commission. Mouthrinses and dental caries. Int. Dent. J. 52, 337 (2002).
21. A. I. Alayash, F. D'Agnillo, and P. W. Buehler, First-generation blood substitutes: What have we learned? Biochemical and physiological perspectives. Expert Opin. Biol. Ther. 7, 665 (2007).
22. A. Vinu, M. Miyahara, and K. Ariga, Assemblies of biomaterials in mesoporous media. J. Nanosci. Nanotechnol. 6, 1510 (2006).
23. M. P. Ginebra, T. Traykova, and J. A. Planell, Calcium phosphate cements as bone drug delivery systems: A review. J. Control Release 113, 102 (2006).
24. G. Valenti, G. Procino, G. Tamma, M. Carmosino, and M. Svelto, Minireview: Aquaporin 2 trafficking. Endocrinology 146, 5063 (2005).
25. D. Rotin, V. Kanelis, and L. Schild, Trafficking and cell surface stability of ENaC. Am. J. Physiol. Renal. Physiol. 281, F391 (2001).
26. I. Roy, S. Mitra, A. N. Maitra, and S. Mozumdar, Calcium phosphate nanoparticles as novel non-viral vectors for targeted gene delivery. Int. J. Pharm. 250, 25 (2003).
27. G. Bhakta, S. Mitra, and A. Maitra, DNA encapsulated magnesium and manganous phosphate nanoparticles: Potential non-viral vectors for gene delivery. Biomaterials 26, 2157 (2005).
28. J. R. D. Sambrook, Molecular cloning, a laboratory manual. 2, 1.32 (2001).
29. E. Landi, G. Logroscino, L. Proietti, A. Tampieri, M. Sandri, and S. Sprio, Biomimetic Mg-substituted hydroxyapatite: From synthesis to in vivo behaviour. J. Mater. Sci. Mater. Med. 19, 239 (2008).
30. H. S. Ryu, K. S. Hong, J. K. Lee, D. J. Kim, J. H. Lee, B. S. Chang, D. H. Lee, C. K. Lee, and S. S. Chung, Magnesia-doped HA/beta-TCP ceramics and evaluation of their biocompatibility. Biomaterials 25, 393 (2004).
31. http://www.pacifichealth.com/gras-list.html.
32. S. Bisht, G. Bhakta, S. Mitra, and A. Maitra, pDNA loaded calcium phosphate nanoparticles: Highly efficient non-viral vector for gene delivery. Int. J. Pharm. 288, 157 (2005).
33. M. X. Tang, C. T. Redemann, and F. C. Szoka, Jr., In vitro gene delivery by degraded polyamidoamine dendrimers. Bioconjug. Chem. 7, 703 (1996).
34. G. J. Phillips, Green fluorescent protein-a bright idea for the study of bacterial protein localization. FEMS Microbiol. Lett. 204, 9 (2001).
35. V. P. Torchilin, Multifunctional nanocarriers. Adv. Drug Deliv. Rev. 58, 1532 (2006).
36. S. Kommareddy, S. B. Tiwari, and M. M. Amiji, Long-circulating polymeric nanovectors for tumor-selective gene delivery. Technol. Cancer Res. Treat. 4, 615 (2005).
37. J. Wu, M. H. Nantz, and M. A. Zern, Targeting hepatocytes for drug and gene delivery: Emerging novel approaches and applications. Front Biosci. 1;7:d717-25 (2002).
38. R. W. Herzog, Recent advances in hepatic gene transfer: More efficacy and less immunogenicity. Curr. Opin. Drug Discov. Devel. 8, 199 (2005).
39. D. P. Sarkar, K. Ramani, and S. K. Tyagi, Targeted gene delivery by virosomes. Methods Mol. Biol. 199, 163 (2002).
40. C. Di Campli, J. Wu, and M. A. Zern, Targeting of therapeutics to the liver: Liposomes and viral vectors. Alcohol. Clin. Exp. Res. 23, 950 (1999).
41. Y. H. Ni, In vivo hepatic gene therapy. Acta Paediatr. Taiwan. 42, 191 (2001).
42. E. Suleymanoglu, Phospholipid-nucleic acid recognition: Energetics of DNA-Mg2+-phosphatidylcholine ternary complex formation and its further compaction as a gene delivery formulation. J. Pharm. Sci. Technol. 60, 218 (2006).
43. A. M. Lam and P. R. Cullis, Calcium ion enhances the transfection potency of plasmid DNA-Cationic Liposome complexes. Biochim. Biophy. Acta 1463, 279 (2000).