Calcium based non-viral gene delivery: An overview of methodology and applications

Acta Medica Iranica

Volumn 48, Issue 3, 2010, Pages 133-141

  Khosravi Darani, Kianoush ^a   Mozafari, Mohamaad Reza ^b   Rashidi, Ladan ^c   Mohammadi, Mehrdad ^a  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MONASH UNIVERSITY   (Australia)

^c Institute of Standard and Industrial Research of Iran   (Iran)

Author keywords

Calcium phosphate; Gene transfer techniques; Nanoparticles; Transfection

Indexed keywords

CALCIUM PHOSPHATE; CARBOXYLIC ACID POLYMER; CHITOSAN; DNA; LIPOPLEX; LIPOSOME; MACROGOL; NANOPARTICLE; POLYACRYLIC ACID; POLYASPARTIC ACID; POLYMER; UNCLASSIFIED DRUG;

BIOCOMPATIBILITY; CYTOTOXICITY; DRUG COATING; DRUG FORMULATION; DRUG STABILITY; ENDOCYTOSIS; GENE TRANSFER; GENETIC TRANSFECTION; LIPOSOMAL GENE DELIVERY SYSTEM; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PRECIPITATION; REVIEW;

ANIMALS; CALCIUM PHOSPHATES; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; LIPIDS; NANOPARTICLES;

EID: 77955124676     PISSN: 00446025     EISSN: 00446025     Source Type: Journal    
DOI: None     Document Type: Review

References (95)

1. Wyrozumska P, Stebelska K, Grzybek M, Sikorski AF. Synthetic vectors for genetic drug delivery. In: Mozafari MR, editors. Nanocarrier Technologies: Frontiers of Nanotherapy. The Netherlands: Springer; 2006. p. 139-175.
2. Romano G, Pacilio C, Giordano A. Gene transfer technology in therapy: current applications and future goals. Stem Cells 1999;17(4):191-202.
3. Tomanin R, Scarpa M. Why do we need new gene therapy viral vectors? Characteristics, limitations and future perspectives of viral vector transduction. Curr Gene Ther 2004;4(4):357-372.
4. Khosravi-Darani K, Sadeghi-Zadeh M. Comparison of nonviral systems for gene delivery vehicles. Tabib-e-Shargh J 2005;7(2):149-158. [in Persian]
5. Graham FL, van der Eb AJ. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 1973;52(2):456-467.
6. Xu H, Miller J, Liang BT. High-efficiency gene transfer into cardiac myocytes. Nucleic Acids Res 1992;20(23):6425-6426.
7. Yang YW, Yang JC. Calcium phosphate as a gene carrier: electron microscopy. Biomaterials 1997;18(3):213-7.
8. Shen H, Tan J, Saltzman WM. Surface-mediated gene transfer from nanocomposites of controlled texture. Nat Mater 2004;3(8):569-574.
9. Truong-Le VL, Walsh SM, Schweibert E, Mao HQ, Guggino WB, August JT, Leong KW. Gene transfer by DNA-gelatin nanospheres. Arch Biochem Biophys 1999;361(1):47-56.
10. Urabe M, Kume A, Tobita K, Ozawa K. DNA/calcium phosphate precipitates mixed with medium are stable and maintain high transfection efficiency. Anal Biochem 2000;278(1):91-92.
11. Kulkarni VI, Shenoy VS, Dodiya SS, Rajyaguru TH, Murthy RR. Role of calcium in gene delivery. Expert Opin Drug Deliv 2006;3(2):235-245.
12. Frey A, Neutra MR, Robey FA. Peptomer aluminum oxide nanoparticle conjugates as systemic and mucosal vaccine candidates: synthesis and characterization of a conjugate derived from the C4 domain of HIV-1MN gp120. Bioconjug Chem 1997;8(3):424-433.
13. Kneuer C, Sameti M, Bakowsky U, Schiestel T, Schirra H, Schmidt H, et al. A nonviral DNA delivery system based on surface modified silica-nanoparticles can efficiently transfect cells in vitro. Bioconjug Chem 2000;11(6):926-932.
14. Zhang S, Gonsalves KE. Preparation and characterization of thermally stable nanohydroxyapatite. J Mater Sci Mater Med 1997;8(1):25-8.
15. Cheng FY, Su CH, Yang YS, Yeh CS, Tsai CY, Wu CL, et al. Characterization of aqueous dispersions of Fe3O4 nanoparticles and their biomedical and their biomedical applications. Biomaterials 2005;26(7):729-38.
16. Kakizawa Y, Miyata K, Furukawa S, Kataoka K. Sizecontrolled formation of a calcium phosphate-based organicinorganic hybrid vector for gene delivery using poly(ethylene glycol)-block-poly(aspartic acid). Adv Mater 2004;16(8):699-702.
17. Madry H, Reszka R, Bohlender J, Wagner J. Efficacy of cationic liposome-mediated gene transfer to mesangial cells in vitro and in vivo. J Mol Med 2001;79(4):184-189.
18. Schmidt HT, Gray BL, Wingert PA, Ostafin AE. Assembly of aqueous-cored calcium phosphate nanoparticles for drug delivery. Chem Mat 2004;16:4942-4947.
19. Yu D, Wong J, Matsuda Y, Fox JL, Higuchi WI, Otsuka M. Self-setting hydroxyapatite cement: a novel skeletal drugdelivery system for antibiotics. J Pharm Sci 1992;81(6):529-531.
20. Morçöl T, Nagappan P, Nerenbaum L, Mitchell A, Bell SJ. Calcium phosphate-PEG-insulin-casein (CAPIC) particles asoral delivery systems for insulin. Int J Pharm 2004;277(1-2):91-97.
21. Matsumoto T, Okazaki M, Inoue M, Yamaguchi S, Kusunose T, Toyonaga T, et al. Hydroxyapatite particles as a controlled release carrier of protein. Biomaterials 2004;25(17):3807-3812.
22. Joosten U, Joist A, Frebel T, Brandt B, Diederichs S, von Eiff C. Evaluation of an in situ setting injectable calcium phosphate as a new carrier material for gentamicin in the treatment of chronic osteomyelitis: studies in vitro and in vivo. Biomaterials 2004;25(18):4287-4295.
23. Paul W, Sharma CP. Development of porous spherical hydroxyapatite granules: application towards protein delivery. J Mater Sci Mater Med 1999;10(7):383-8.
24. Tolou H. Administration of oligonucleotides to cultured cells by calcium phosphate precipitation method. Anal Biochem 1993;215(1):156-158.
25. Chen C, Okayama H. High-efficiency transformation of mammalian cells by plasmid DNA. Mol Cell Biol 1987;7(8):2745-2782.
26. Jordan M, Wurm F. Transfection of adherent and suspended cells by calcium phosphate. Methods 2004;33(2):136-143.
27. Orrantia E, Chang PL. Intracellular distribution of DNA internalized through calcium phosphate precipitation. Exp Cell Res 1990;190(2):170-4.
28. Seelos C. A critical parameter determining the aging of DNAcalcium-phosphate precipitates. Anal Biochem 1997;245(1):109-11.
29. Zhang Y, Kohler N, Zhang M. Surface modification of superparamagnetic magnetite nanoparticles and their intracellular uptake. Biomaterials 2002;23(7):1553-1561.
30. Roy I, Mitra S, Maitra A, Mozumdar S. Calcium phosphate nanoparticles as novel non-viral vectors for targeted gene delivery. Int J Pharm 2003;250(1):25-33.
31. Lopata MA, Cleveland DW, Sollner-Webb B. High level transient expression of a chloramphenicol acetyl transferase gene by DEAE-dextran mediated DNA transfection coupled with a dimethyl sulfoxide or glycerol shock treatment. Nucleic Acids Res 1984;12(14):5707-5717.
32. Frost E, Williams J. Mapping temperature-sensitive and hostrange mutations of adenovirus type 5 by marker rescue. Virology 1978;91(1):39-50.
33. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning: A Laboratory Manual. 3rd ed. New York: Cold Spring Harbor Press; 2001.
34. Jordan M, Schallhorn A, Wurm FM. Transfecting mammalian cells: optimization of critical parameters affecting calciumphosphate precipitate formation. Nucleic Acids Res 1996;24(4):596-601.
35. Zhdanov RI, Bogdaneko EV, Zarubina TV, Dominiva SI, Krivstov GG, Borisenko AS, et al. New lipid and glycolipidbased nanosystems for targeted gene delivery: cholenims, glycoclipids and chitosan. In: Mozafari MR, editor. Nanomaterials and Nanosystems for Biomedical Applications. Netherlands: Springer; 2007. p. 27-53.
36. Wilson SP, Smith LA. Addition of glycerol during DNA exposure enhances calcium phosphate transfection. Anal Biochem 1997;246(1):148-150.
37. Mozafari MR, Reed CJ, Rostron C, Kocum C, Piskin E. Construction of stable anionic liposome-plasmid particles using the heating method: a preliminary investigation. Cell Mol Biol Lett 2002;7(3):923-927.
38. O'Mahoney JV, Adams TE. Optimization of experimental variables influencing reporter gene expression in hepatoma cells following calcium phosphate transfection. DNA Cell Biol 1994;13(12):1227-1232.
39. Wilson SP, Liu F, Wilson PR, Housley PR. Optimization of calcium phosphate transfection for bovine chromaffin cells: relationship to calcium phosphate precipitate formation. Anal Biochem 1995;226(2):212-220.
40. Luo D, Saltzman WM. Synthetic DNA delivery systems. Nat Biotechnol 2000;18(1):33-37.
41. Chowdhury EH, Kunou M, Nagaoka M, Kundu AK, Hoshiba T, Akaike T. High-efficiency gene delivery for expression in mammalian cells by nanoprecipitates of Ca-Mg phosphate. Gene 2004;341:77-82.
42. Kakizawa Y, Kataoka K. Block copolymer self-assembly into monodispersive nanoparticles with hybrid core of antisense DNA and calcium phosphate. Langmuir 2002;18:4539-4543.
43. Strain AJ, Wyllie AH. The uptake and stability of simianvirus-40 DNA after calcium phosphate transfection of CV-1 cells. Biochem J 1984;218(2):475-482.
44. Welzel T, Radtke I, Meyer-Zaika W, Heumann R, Epple M. Transfection of cells with custom-made calcium phosphate nanoparticles coated with DNA. J Materials Chem 2004;14(14):2213-2217.
45. Prabha S, Zhou WZ, Panyam J, Labhasetwar V. Sizedependency of nanoparticle-mediated gene transfection: studies with fractionated nanoparticles. Int J Pharm 2002;244(1-2):105-115.
46. Washbourne P, McAllister AK. Techniques for gene transfer into neurons. Curr Opin Neurobiol 2002;12(5):566-573.
47. Lasic DD. Templeton NS. Liposomes in gene therapy. Adv Drug Deliv Rev 1996; 20: 221-226.
48. Ishii N, Fukushima J, Kaneko T, Okada E, Tani K, Tanaka SI, et al. Cationic liposomes are a strong adjuvant for a DNA vaccine of human immunodeficiency virus type 1. AIDS Res Hum Retroviruses 1997;13(16):1421-1428.
49. Tang MX, Redemann CT, Szoka FC Jr. In vitro gene delivery by degraded polyamidoamine dendrimers. Bioconjug Chem 1996;7(6):703-714.
50. Loyter A, Scangos G, Juricek D, Keene D, Ruddle FH. Mechanisms of DNA entry into mammalian cells. II. Phagocytosis of calcium phosphate DNA co-precipitate visualized by electron microscopy. Exp Cell Res 1982;139(1):223-234.
51. Loyter A, Scangos GA, Ruddle FH. Mechanisms of DNA uptake by mammalian cells: fate of exogenously added DNA monitored by the use of fluorescent dyes. Proc Natl Acad Sci U S A 1982;79(2):422-4226.
52. Lechardeur D, Verkman AS, Lukacs GL. Intracellular routing of plasmid DNA during non-viral gene transfer. Adv Drug Deliv Rev 2005;57(5):755-6753.
53. Sokolova VV, Radtke I, Heumann R, Epple M. Effective transfection of cells with multi-shell calcium phosphate-DNA nanoparticles. Biomaterials 2006;27(16):3147-3153.
54. Bisht S, Bhakta G, Mitra S, Maitra A. pDNA loaded calcium phosphate nanoparticles: highly efficient non-viral vector for gene delivery. Int J Pharm 2005;288(1):157-168.
55. Paine PL, Moore LC, Horowitz SB. Nuclear envelope permeability. Nature 1975;254(5496):109-114.
56. Zhu SH, Huang BY, Zhou KC, Huang SP, Liu F, Li YM, et al. Hydroxyapatite nanoparticles as a novel gene carrier. J Nanoparticle Res 2004;6(2):307-311.
57. Maitra A. Calcium phosphate nanoparticles: secondgeneration nonviral vectors in gene therapy. Expert Rev Mol Diagn 2005;5(6):893-905.
58. Cullis PR, Chonn A. Recent advances in liposome technologies and their applications for systemic gene delivery. Adv Drug Deliv Rev 1998;30(1-3):73-83.
59. Fenske DB, MacLachlan I, Cullis PR. Stabilized plasmid-lipid particles: a systemic gene therapy vector. Methods Enzymol 2002;346:36-71.
60. Alton EW, Geddes DM. Gene therapy for cystic fibrosis: a clinical perspective. Gene Ther 1995;2(2):88-95.
61. Liu Y, Liggitt D, Zhong W, Tu G, Gaensler K, Debs R. Cationic liposome-mediated intravenous gene delivery. J Biol Chem 1995;270(42):24864-24870.
62. Smith JG, Walzem RL, German JB. Liposomes as agents of DNA transfer. Biochim Biophys Acta 1993;1154(3-4):327-40.
63. Zabner J, Fasbender AJ, Moninger T, Poellinger KA, Welsh MJ. Cellular and molecular barriers to gene transfer by a cationic lipid. J Biol Chem 1995;270(32):18997-9007.
64. Bonté F, Juliano RL. Interactions of liposomes with serum proteins. Chem Phys Lipids 1986;40(2-4):359-72.
65. Oku N, Yamazaki Y, Matsuura M, Sugiyama M, HasegawaM, Nango M. A novel non-viral gene transfer system, polycation liposomes. Adv Drug Deliv Rev 2001;52(3):209-218.
66. Deol P, Khuller GK. Lung specific stealth liposomes: stability, biodistribution and toxicity of liposomal antitubercular drugs in mice. Biochim Biophys Acta 1997;1334(2-3):161-172.
67. Lechardeur D, Sohn KJ, Haardt M, Joshi PB, Monck M, Graham RW, et al. Metabolic instability of plasmid DNA in the cytosol: a potential barrier to gene transfer. Gene Ther 1999;6(4):482-497.
68. Filion MC, Phillips NC. Toxicity and immunomodulatory activity of liposomal vectors formulated with cationic lipids toward immune effector cells. Biochim Biophys Acta 1997;1329(2):345-356.
69. Khosravi-Darani K, Mozafari MR. The Second Generation of Anionic Liposome for Gene Therapy. Tabib-e-Shargh 2005;7(1):71-79.
70. Gao X, Huang L. Potentiation of cationic liposome-mediated gene delivery by polycations. Biochemistry 1996;35(3):1027-1036.
71. Hagstrom JE, Sebestyen MG, Budker V, Ludtke JJ, Fritz JD, Wolff JA. Complexes of non-cationic liposomes and histone H1 mediate efficient transfection of DNA without encapsulation. Biochim Biophys Acta 1996;1284(1):47-55.
72. Ibáñez M, Gariglio P, Chávez P, Santiago R, Wong C, Baeza I. Spermidine-condensed DNA and cone-shaped lipids improve delivery and expression of exogenous DNA transfer by liposomes. Biochem Cell Biol 1996;74(5):633-643.
73. Mizuguchi H, Nakagawa T, Nakanishi M, Imazu S, Nakagawa S, Mayumi T. Efficient gene transfer into mammalian cells using fusogenic liposome. Biochem Biophys Res Commun 1996;218(1):402-407.
74. Li S, Huang L. In vivo gene transfer via intravenous administration of cationic lipid-protamine-DNA (LPD) complexes. Gene Ther 1997;4(9):891-900.
75. Perez-Terzic C, Pyle J, Jaconi M, Stehno-Bittel L, Clapham DE. Conformational states of the nuclear pore complex induced by depletion of nuclear Ca2+ stores. Science 1996;273(5283):1875-1877.
76. Zaitsev SV, Haberland A, Otto A, Vorob'ev VI, Haller H, Böttger M. H1 and HMG17 extracted from calf thymus nuclei are efficient DNA carriers in gene transfer. Gene Ther 1997;4(6):586-592.
77. Lam AM, Cullis PR. Calcium enhances the transfection potency of plasmid DNA-cationic liposome complexes. Biochim Biophys Acta 2000;1463(2):279-290.
78. Kharakoz DP, Khusainova RS, Gorelov AV, Dawson KA. Stoichiometry of dipalmitoylphosphatidylcholine-DNA interaction in the presence of Ca2+: a temperature-scanning ultrasonic study. FEBS Lett 1999;446(1):27-29.
79. Lappalainen K, Jääskeläinen I, Syrjänen K, Urtti A, Syrjänen S. Comparison of cell proliferation and toxicity assays using two cationic liposomes. Pharm Res 1994;11(8):1127-31.
80. Anwer K, Bailey A, Sullivan SM. Targeted gene delivery: a two-pronged approach. Crit Rev Ther Drug Carrier Syst 2000;17(4):377-424.
81. Gulati M, Bajad S, Singh S, Ferdous AJ, Singh M. Development of liposomal amphotericin B formulation. J Microencapsul 1998;15(2):137-51.
82. Tardi PG, Boman NL, Cullis PR. Liposomal doxorubicin. J Drug Target 1996;4(3):129-140.
83. Perrie Y, Gregoriadis G. Liposome-entrapped plasmid DNA: characterisation studies. Biochim Biophys Acta 2000;1475(2):125-132.
84. Patil SD, Rhodes DG. Influence of divalent cations on the conformation of phosphorothioate oligodeoxynucleotides: a circular dichroism study. Nucleic Acids Res 2000;28(12):2439-2445.
85. Lakkaraju A, Dubinsky JM, Low WC, Rahman YE. Neurons are protected from excitotoxic death by p53 antisense oligonucleotides delivered in anionic liposomes. J Biol Chem 2001;276(34):32000-32007.
86. Wilson RW, Bloomfield VA. Counterion-induced condensation of deoxyribonucleic acid. a light-scattering study. Biochemistry 1979;18(11):2192-2196.
87. Zareie MH, Mozafari MR, Hasirci V, Piskin E. Scanning tunnelling microscopy investigation of liposome-DNA-Ca2+ complexes. J Liposome Res 1997;7(4):491-502.
88. Mozafari MR, Zareie MH, Piskin E, Hasirci V. Formation of supramolecular structures by negatively charged liposomes in the presence of nucleic acids and divalent cations. Drug Deliv 1998;5(2):135-41.
89. Mozafari MR, Hasirci V. Mechanism of calcium ion induced multilamellar vesicle-DNA interaction. J Microencapsul 1998;15(1):55-65.
90. McManus JJ, Radler JO, Dawson KA. Does calcium turn a zwitterionic lipid cationic? J Phys Chem B 2003a;107(36):9869-9875.
91. McManus JJ, Radler JO, Dawson KO. Phase behavior of DPPC in a DNA-calcium-zwitterionic lipid complex studied by small-angle X-ray scattering. Langmuir 2003b;19(23):9630-9637.
92. Bailey AL, Sullivan SM. Efficient encapsulation of DNA plasmids in small neutral liposomes induced by ethanol and calcium. Biochim Biophys Acta 2000;1468(1-2):239-252.
93. Patil SD, Rhodes DG, Burgess DJ. Anionic liposomal delivery system for DNA transfection. AAPS J 2004;6(4):e29.
94. Reston JT, Gould-Fogerite S, Mannino RJ. Potentiation of DNA mediated gene transfer in NIH3T3 cells by activators of protein kinase C. Biochim Biophys Acta 1991;1088(2):270-276.
95. Eanes ED, Meyer JL. The maturation of crystalline calcium phosphates in aqueous suspensions at physiologic pH. Calcif Tissue Res 1977;23(3):259-269