The possible mechanisms underlying the impairment of hif-1α pathway signaling in hyperglycemia and the beneficial effects of certain therapies

International Journal of Medical Sciences

Volumn 10, Issue 10, 2013, Pages 1412-1421

  Xiao, Haijuan ^a   Gu, Zhenyang ^b   Wang, Guoxing ^c   Zhao, Tongfeng ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b CHINESE PLA GENERAL HOSPITAL   (China)

^c ZHEJIANG UNIVERSITY   (China)

Author keywords

Alpha (HIF 1 ); Hyperglycemia; Hypoxia inducible factor; Methylglyoxal (MGO); Prolyl hydroxylases (PHDs); Reactive oxidative species (ROS); Therapy

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ANGIOTENSIN II; ARGININE; CHEMOKINE RECEPTOR CXCR4; CYTOCHROME C OXIDASE; DEFEROXAMINE; DIMETHYLOXALYLGLYCINE; E1A ASSOCIATED P300 PROTEIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUCOSE; HEAT SHOCK PROTEIN 40; HEAT SHOCK PROTEIN 70; HYPERGLYCEMIC AGENT; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1BETA; ICOSAPENTAENOIC ACID; INSULIN; METALLOTHIONEIN; METHYLGLYOXAL; NITRIC OXIDE; PROTEASOME; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; SOMATOMEDIN B; SOMATOMEDIN C; STROMAL CELL DERIVED FACTOR 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULOTROPIN; VON HIPPEL LINDAU PROTEIN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE;

DIABETES MELLITUS; ENZYME ACTIVITY; GENE OVEREXPRESSION; GENE THERAPY; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLYCOLYSIS; HUMAN; HYPERGLYCEMIA; HYPOXIA; NONHUMAN; OSMOLARITY; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN SYNTHESIS; REVIEW; SIGNAL TRANSDUCTION; TRANSACTIVATION; ANIMAL; GENETICS; METABOLISM;

ANIMALS; HUMANS; HYPERGLYCEMIA; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; PROLYL HYDROXYLASES; PYRUVALDEHYDE; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84883173615     PISSN: 14491907     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijms.5630     Document Type: Review

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