Glucose-induced O 2 consumption activates hypoxia inducible factors 1 and 2 in rat insulin-secreting pancreatic beta-cells

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Bensellam, Mohammed ^a   Duvillié, Bertrand ^b   Rybachuk, Galyna ^a   Laybutt, D Ross ^c   Magnan, Christophe ^d   Guiot, Yves ^a   Pouysségur, Jacques ^e   Jonas, Jean Christophe ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b INSERM   (France)

^c ST VINCENT S HOSPITAL   (Australia)

^d Groupe Hospitalier Pitié Salpêtrière   (France)

^e UNIVERSITÉ CÔTE D'AZUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENOMEDULLIN; CALCIUM ION; COBALT CHLORIDE; GLUCOSE; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2; HYPOXIA INDUCIBLE FACTOR 2ALPHA; INSULIN; MESSENGER RNA; OXYGEN; PIMONIDAZOLE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CALCIUM; ENDOTHELIAL PAS DOMAIN CONTAINING PROTEIN 1; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CELL HYPOXIA; CELL LEVEL; CELL NUCLEUS; CELL STIMULATION; COMPLEX FORMATION; CONTROLLED STUDY; DIABETES MELLITUS; GENE ACTIVATION; GENE EXPRESSION; GENE LOCATION; GENE TARGETING; GLYCOLYSIS; IN VITRO STUDY; INSULIN RELEASE; MALE; MOUSE; NONHUMAN; OXYGEN CONCENTRATION; OXYGEN CONSUMPTION; PANCREAS ISLET BETA CELL; RAT; ANIMAL; DRUG EFFECT; FEMALE; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; KINETICS; METABOLISM; MITOCHONDRION; PATHOLOGY; SECRETION;

MUS; RATTUS;

ADRENOMEDULLIN; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CALCIUM; CELL HYPOXIA; DIABETES MELLITUS; FEMALE; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; GLUCOSE; GLYCOLYSIS; HYPOXIA-INDUCIBLE FACTOR 1; INSULIN; INSULIN-SECRETING CELLS; KINETICS; MALE; MICE; MITOCHONDRIA; OXYGEN; RATS; RNA, MESSENGER;

EID: 84855303456     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0029807     Document Type: Article

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