Calcium mediates high glucose-induced HIF-1α and VEGF expression in cultured rat retinal Müller cells through CaMKII-CREB pathway

Acta Pharmacologica Sinica

Volumn 33, Issue 8, 2012, Pages 1030-1036

  Li, Jun ^a   Zhao, Shu Zhi ^a   Wang, Pei Pei ^b   Yu, Song Ping ^b   Zheng, Zhi ^a   Xu, Xun ^a  

^a SHANGHAI FIRST PEOPLE S HOSPITAL   (China)

^b Lishui City Center Hospital   (China)

Author keywords

CaMKII; CREB; diabetic retinopathy; hyperglycemia; retinal M ller cells

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; BAPTA AM; BETA ACTIN; CALCIUM; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM CHELATING AGENT; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUCOSE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; UNCLASSIFIED DRUG; VASCULOTROPIN; HIF1A PROTEIN, RAT; VASCULAR ENDOTHELIAL GROWTH FACTOR A, RAT; VASCULOTROPIN A;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; DIABETIC RETINOPATHY; DRUG EFFECT; ENZYME PHOSPHORYLATION; GENETIC TRANSFECTION; MUELLER CELL; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; CELL CULTURE; DRUG EFFECTS; GENE EXPRESSION REGULATION; MACROGLIA; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; CALCIUM; CALCIUM CHELATING AGENTS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CELLS, CULTURED; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; EPENDYMOGLIAL CELLS; GENE EXPRESSION REGULATION; GLUCOSE; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84864656536     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2012.61     Document Type: Article

References (34)

1. Bishara NB, Ding H. Glucose enhances expression of TRPC1 and calcium entry in endothelial cells. Am J Physiol heart Circ Physiol 2010; 298: h171-8.
2. 2+ responses triggered by purinergic stimulation in retinal neurons and microglia. Brain Res 2010; 1316: 129-38.
3. i in renal proximal tubular cells. Kidney Int 1998; 54: 1206-13. (Pubitemid 28449907)
4. Santiago AR, Rosa SC, Santos PF, Cristovao AJ, Barber AJ, Ambrosio AF. Elevated glucose changes the expression of ionotropic glutamate receptor subunits and impairs calcium homeostasis in retinal neural cells. Invest ophthalmol Vis Sci 2006; 47: 4130-7. (Pubitemid 46044332)
5. Kohn EC, Alessandro R, Spoonster J, Wersto RP, Liotta LA. Angio-genesis: role of calcium-mediated signal transduction. Proc natl Acad Sci u S A 1995; 92: 1307-11.
6. Kim JH, Yu YS, Kim DH, Lee TG, Moon DW, Kim KW. In situ calcium mapping in the mouse retina via time-of-flight secondary ion mass spectrometry: modulation of retinal angiogenesis by calcium ion in development and oxygen-induced retinopathy. Biochem Cell Biol 2008; 86: 459-67.
7. Gariano RF, Gardner TW. Retinal angiogenesis in development and disease. nature 2005; 438: 960-6. (Pubitemid 43093962)
8. Koyama Y, Matsuzaki S, Gomi F, Yamada K, Katayama T, Sato K, et al. Induction of amyloid beta accumulation by ER calcium disruption and resultant upregulation of angiogenic factors in ARPE19 cells. Invest ophthalmol Vis Sci 2008; 49: 2376-83.
9. Cordeiro S, Seyler S, Stindl J, Milenkovic VM, Strauss O. heat-sensitive TRPV channels in retinal pigment epithelial cells: regulation of VEGF-A secretion. Invest Ophthalmol Vis Sci 2010; 51: 6001-8.
10. Swiatek-De Lange M, Stampfl A, Hauck SM, Zischka H, Gloeckner CJ, et al. Membrane-initiated effects of progesterone on calcium dependent signaling and activation of VEGF gene expression in retinal glial cells. glia 2007; 55: 1061-73. (Pubitemid 47066746)
11. 2+ channels in retinal pigment epithelial cells regulate vascular endothelial growth factor secretion rates in health and disease. Mol Vis 2007; 13: 443-56. (Pubitemid 46502439)
12. Zhang B, Ma JX. SERPInA3K prevents oxidative stress induced necrotic cell death by inhibiting calcium overload. PLoS one 2008; 3: e4077.
13. 2+ oscillations. Science 1998; 279: 227-30. (Pubitemid 28103880)
14. Mayr B, Montminy M. Transcriptional regulation by the phosphoryla-tion-dependent factor CREB. nat Rev Mol Cell Biol 2001; 2: 599-609. (Pubitemid 33674011)
15. Lonze BE, Ginty DD. Function and regulation of CREB family transcription factors in the nervous system. neuron 2002; 35: 605-23. (Pubitemid 35229980)
16. Wu D, Zhau HE, Huang WC, Iqbal S, Habib FK, Sartor O, et al. cAMP-responsive element-binding protein regulates vascular endothelial growth factor expression: implication in human prostate cancer bone metastasis. oncogene 2007; 26: 5070-7. (Pubitemid 47206947)
17. Pierce EA, Avery RL, Foley ED, Aiello LP, Smith LE. Vascular endo-thelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization. Proc natl Acad Sci USA 1995; 92: 905-9.
18. Hicks D, Courtois Y. The growth and behaviour of rat retinal Muller cells in vitro. 1. An improved method for isolation and culture. Exp Eye Res 1990; 51: 119-29. (Pubitemid 20265829)
19. hu h, Zhang R, Zhang Y, Xia Z, hu Y. Role of CREB in the regulatory action of sarsasapogenin on muscarinic M1 receptor density during cell aging. FEBS Lett 2010; 584: 1549-52.
20. West AE, Chen WG, Dalva MB, Dolmetsch RE, Kornhauser JM, Shaywitz AJ, et al. Calcium regulation of neuronal gene expression. Proc natl Acad Sci u S A 2001; 98: 11024-31. (Pubitemid 32928677)
21. Torii S, Okamura N, Suzuki Y, Ishizawa T, Yasumoto K, Sogawa K. Cyclic AMP represses the hypoxic induction of hypoxia-inducible factors in PC12 cells. J Biochem 2009; 146: 839-44.
22. Dobroff AS, Wang H, Melnikova VO, Villares GJ, Zigler M, Huang L, et al. Silencing cAMP-response element-binding protein (CREB) identifes CYR61 as a tumor suppressor gene in melanoma. J Biol Chem 2009; 284: 26194-206.
23. Ferris FL, 3rd, Davis MD, Aiello LM. Treatment of diabetic retinopathy. n Engl J Med 1999; 341: 667-78. (Pubitemid 29399047)
24. Kowluru RA, Tang J, Kern TS. Abnormalities of retinal metabolism in diabetes and experimental galactosemia. VII. Effect of long-term administration of antioxidants on the development of retinopathy. Diabetes 2001; 50: 1938-42. (Pubitemid 33641616)
25. Ke Q, Costa M. Hypoxia-inducible factor-1 (HIF-1). Mol Pharmacol 2006; 70: 1469-80.
26. Semenza GL. Hypoxia-inducible factor 1 (HIF-1) pathway. Sci STKE 2007; 2007: cm8.
27. Wang J, Xu X, Elliott MH, Zhu M, Le YZ. Muller cell-derived VEGF is essential for diabetes-induced retinal inflammation and vascular leakage. Diabetes 2010; 59: 2297-305.
28. Lin M, Chen Y, Jin J, hu Y, Zhou KK, Zhu M, et al. Ischaemia-induced retinal neovascularisation and diabetic retinopathy in mice with conditional knockout of hypoxia-inducible factor-1 in retinal Muller cells. Diabetologia 2011; 54: 1554-66.
29. Hui AS, Bauer AL, Striet JB, Schnell PO, Czyzyk-Krzeska MF. Calcium signaling stimulates translation of HIF-alpha during hypoxia. FASEB J 2006; 20: 466-75. (Pubitemid 44933323)
30. 2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 trans criptional activity in cells subjected to intermittent hypoxia. J Biol Chem 2005; 280: 4321-8.
31. 2+/calmodulin-dependent protein kinase II. J Biol Chem 2001; 276: 3719-22.
32. Tombes RM, grant S, Westin Eh, Krystal g. g1 cell cycle arrest and apoptosis are induced in nIh 3T3 cells by Kn-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase). Cell Growth Differ 1995; 6: 1063-70.
33. Takeda H, Kitaoka Y, Hayashi Y, Kumai T, Munemasa Y, Fujino H, et al. Calcium/calmodulin-dependent protein kinase II regulates the phos-phoryl ation of CREB in NMDA-induced retinal neurotoxicity. Brain Res 2007; 1184: 306-15. (Pubitemid 350160572)
34. Fan W, Li X, Cooper NG. CaMKIIalphaB mediates a survival response in retinal ganglion cells subjected to a glutamate stimulus. Invest ophthalmol Vis Sci 2007; 48: 3854-63. (Pubitemid 351261127)