The chaperone-dependent ubiquitin ligase CHIP targets HIF-1α for degradation in the presence of methylglyoxal

PLoS ONE

Volumn 5, Issue 11, 2010, Pages

  Bento, Carla Figueira ^a,b   Fernandes, Rosa ^a   Ramalho, José ^a   Marques, Carla ^a   Shang, Fu ^c   Taylor, Allen ^c   Pereira, Paulo ^a  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c TUFTS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXY TERMINUS OF HEAT SHOCK PROTEIN 70 INTERACTING PROTEIN; CELL PROTEIN; CHAPERONE; CHIP PROTEIN; GLUCOSE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LACTOYLGLUTATHIONE LYASE; METHYLGLYOXAL; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; HEAT SHOCK PROTEIN 40; HEAT SHOCK PROTEIN 70; HYPOXIA INDUCIBLE FACTOR 1; STUB1 PROTEIN, HUMAN; VHL PROTEIN, HUMAN; VON HIPPEL LINDAU PROTEIN;

ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; DOWN REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HYDROXYLATION; HYPOXIA; MOLECULAR MECHANICS; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN STABILITY; PROTEIN TARGETING; TRANSCRIPTION INITIATION; ANIMAL; CELL HYPOXIA; CELL LINE; CELL STRAIN COS1; CELL STRAIN HEK293; CERCOPITHECUS; DRUG EFFECT; GENETICS; INTRACELLULAR SPACE; METABOLISM; MUTATION; PROTEIN BINDING; RNA INTERFERENCE; TUMOR CELL LINE; UBIQUITINATION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL HYPOXIA; CELL LINE; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; COS CELLS; GLUCOSE; HEK293 CELLS; HSP40 HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; INTRACELLULAR SPACE; LACTOYLGLUTATHIONE LYASE; MOLECULAR CHAPERONES; MUTATION; PROTEIN BINDING; PYRUVALDEHYDE; RNA INTERFERENCE; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 78649753203     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0015062     Document Type: Article

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