-
1
-
-
0035300410
-
Expression of hypoxia-inducible factor-1α: A novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer
-
Aebersold DM, Burri P, Beer KT, et al. Expression of hypoxia-inducible factor-1α: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res 2001;61:2911-6.
-
(2001)
Cancer Res
, vol.61
, pp. 2911-2916
-
-
Aebersold, D.M.1
Burri, P.2
Beer, K.T.3
-
2
-
-
20044361991
-
2 mediate glucose deprivation-induced cytotoxicity and oxidative stress in human cancer cells
-
2 mediate glucose deprivation-induced cytotoxicity and oxidative stress in human cancer cells. J Biol Chem 2005;280:4254-63.
-
(2005)
J Biol Chem
, vol.280
, pp. 4254-4263
-
-
Ahmad, I.M.1
Aykin-Burns, N.2
Sim, J.E.3
-
3
-
-
0034896068
-
Expression of hypoxia-inducible factor-1α in epithelial ovarian tumors: Its impact on prognosis and on response to chemotherapy
-
Birner P, Schindl M, Obermair A, et al. Expression of hypoxia-inducible factor-1α in epithelial ovarian tumors: its impact on prognosis and on response to chemotherapy. Clin Cancer Res 2001;7:1661-8.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1661-1668
-
-
Birner, P.1
Schindl, M.2
Obermair, A.3
-
4
-
-
0037443587
-
Levels of hypoxia-inducible factor-1α independently predict prognosis in patients with lymph node negative breast carcinoma
-
Bos R, van der Groep P, Greijer AE, et al. Levels of hypoxia-inducible factor-1α independently predict prognosis in patients with lymph node negative breast carcinoma. Cancer 2003;97:1573-81.
-
(2003)
Cancer
, vol.97
, pp. 1573-1581
-
-
Bos, R.1
van der Groep, P.2
Greijer, A.E.3
-
5
-
-
0035479076
-
Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer
-
Brizel DM, Schroeder T, Scher RL, et al. Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer. Int J Radiat Oncol Biol Phys 2001;51:349-53.
-
(2001)
Int J Radiat Oncol Biol Phys
, vol.51
, pp. 349-353
-
-
Brizel, D.M.1
Schroeder, T.2
Scher, R.L.3
-
6
-
-
31044444974
-
Reversing hypoxic cell chemoresistance in vitro using genetic and small molecule approaches targeting hypoxia inducible factor
-
Brown LM, Cowen RL, Debray C, et al. Reversing hypoxic cell chemoresistance in vitro using genetic and small molecule approaches targeting hypoxia inducible factor. Mol Pharmacol 2006;69:411-8.
-
(2006)
Mol Pharmacol
, vol.69
, pp. 411-418
-
-
Brown, L.M.1
Cowen, R.L.2
Debray, C.3
-
7
-
-
0038293080
-
Prognostic significance of tumor oxygenation in humans
-
Evans SM, Koch CJ. Prognostic significance of tumor oxygenation in humans. Cancer Lett 2003;195:1-16.
-
(2003)
Cancer Lett
, vol.195
, pp. 1-16
-
-
Evans, S.M.1
Koch, C.J.2
-
8
-
-
13844265984
-
Cell growth-dependent coordination of lipid signaling and glycosylation is mediated by interactions between Sac1p and Dpm1p
-
Faulhammer F, Konrad G, Brankatschk B, et al. Cell growth-dependent coordination of lipid signaling and glycosylation is mediated by interactions between Sac1p and Dpm1p. J Cell Biol 2005;168:185-91.
-
(2005)
J Cell Biol
, vol.168
, pp. 185-191
-
-
Faulhammer, F.1
Konrad, G.2
Brankatschk, B.3
-
9
-
-
0022932386
-
Glucose metabolism in human gliomas: Correspondence of in situ and in vitro metabolic rates and altered energy metabolism
-
Galarraga J, Loreck DJ, Graham JF, et al. Glucose metabolism in human gliomas: correspondence of in situ and in vitro metabolic rates and altered energy metabolism. Metab Brain Dis 1986;1:279-91.
-
(1986)
Metab Brain Dis
, vol.1
, pp. 279-291
-
-
Galarraga, J.1
Loreck, D.J.2
Graham, J.F.3
-
10
-
-
0035860147
-
Relation of hypoxia inducible factor 1α and 2α in operable non-small celllung cancer to angiogenic molecular profile of tumors and survival
-
Giatromanolaki A, Koukourakis M, Sivridis E, et al. Relation of hypoxia inducible factor 1α and 2α in operable non-small celllung cancer to angiogenic molecular profile of tumors and survival. Br J Cancer 2001;85:881-90.
-
(2001)
Br J Cancer
, vol.85
, pp. 881-890
-
-
Giatromanolaki, A.1
Koukourakis, M.2
Sivridis, E.3
-
11
-
-
0036468251
-
Metabolic changes detected by in vivo magnetic resonance studies of HEPA-1 wild-type tumors and tumors deficient in hypoxia-inducible factor-1beta (HIF-1beta): Evidence of an anabolic role for the HIF-1 pathway
-
Griffiths JR, McSheehy PM, Robinson SP, et al. Metabolic changes detected by in vivo magnetic resonance studies of HEPA-1 wild-type tumors and tumors deficient in hypoxia-inducible factor-1beta (HIF-1beta): evidence of an anabolic role for the HIF-1 pathway. Cancer Res 2002;62:688-95.
-
(2002)
Cancer Res
, vol.62
, pp. 688-695
-
-
Griffiths, J.R.1
McSheehy, P.M.2
Robinson, S.P.3
-
12
-
-
30344487247
-
Reoxygenation of human coronary smooth muscle cells suppresses HIF-1alpha gene expression and augments radiation-induced growth delay and apoptosis
-
Grumann T, Arab A, Bode C, et al. Reoxygenation of human coronary smooth muscle cells suppresses HIF-1alpha gene expression and augments radiation-induced growth delay and apoptosis. Strahlenther Onkol 2006;182:16-21.
-
(2006)
Strahlenther Onkol
, vol.182
, pp. 16-21
-
-
Grumann, T.1
Arab, A.2
Bode, C.3
-
13
-
-
0348134741
-
Redistribution of intracellular oxygen in hypoxia by nitric oxide: Effect on HIF1alpha
-
Hagen T, Taylor CT, Lam F, et al. Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha. Science 2003;302:1975-8.
-
(2003)
Science
, vol.302
, pp. 1975-1978
-
-
Hagen, T.1
Taylor, C.T.2
Lam, F.3
-
15
-
-
0029775242
-
Association between tumor hypoxia and malignant progression inadvanced cancer of the uterine cervix
-
Höckel M, Schlenger K, Aral B, et al. Association between tumor hypoxia and malignant progression inadvanced cancer of the uterine cervix. Cancer Res 1996;56:4509-15.
-
(1996)
Cancer Res
, vol.56
, pp. 4509-4515
-
-
Höckel, M.1
Schlenger, K.2
Aral, B.3
-
16
-
-
0035925098
-
Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects
-
Höckel M, Vaupel P, Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst 2001;93:266-76.
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 266-276
-
-
Höckel, M.1
Vaupel, P.2
-
17
-
-
27944502154
-
Breast carcinomas fulfill the Warburg hypothesis and provide metabolic markers of cancer prognosis
-
Isidoro A, Casado E, Redondo A, et al. Breast carcinomas fulfill the Warburg hypothesis and provide metabolic markers of cancer prognosis. Carcinogenesis 2005;26:2095-104.
-
(2005)
Carcinogenesis
, vol.26
, pp. 2095-2104
-
-
Isidoro, A.1
Casado, E.2
Redondo, A.3
-
18
-
-
3142622930
-
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway
-
Kung AL, Zabludoff SD, France DS, et al. Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway. Cancer Cell 2004;6:33-43.
-
(2004)
Cancer Cell
, vol.6
, pp. 33-43
-
-
Kung, A.L.1
Zabludoff, S.D.2
France, D.S.3
-
19
-
-
27644477840
-
Effect of low glutamine/glucose on hypoxia-induced elevation of hypoxia-inducible factor-1alpha in human pancreatic cancer MiaPaCa-2 and human prostatic cancer DU-145 cells
-
Kwon SJ, Lee YJ. Effect of low glutamine/glucose on hypoxia-induced elevation of hypoxia-inducible factor-1alpha in human pancreatic cancer MiaPaCa-2 and human prostatic cancer DU-145 cells. Clin Cancer Res 2005;11:4694-700.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 4694-4700
-
-
Kwon, S.J.1
Lee, Y.J.2
-
20
-
-
1642387020
-
Hypoxia-inducible factor (HIF-1) alpha: Its protein stability and biological functions
-
Lee JW, Bae SH, Jeong JW, et al. Hypoxia-inducible factor (HIF-1) alpha: its protein stability and biological functions. Exp Mol Med 2004;36:1-12.
-
(2004)
Exp Mol Med
, vol.36
, pp. 1-12
-
-
Lee, J.W.1
Bae, S.H.2
Jeong, J.W.3
-
21
-
-
0038407274
-
2-deoxy-D-glucose-induced cytotoxicity and radiosensitization in tumor cells is mediated via disruptions in thiol metabolism
-
Lin X, Zhang F, Bradbury CM, et al. 2-deoxy-D-glucose-induced cytotoxicity and radiosensitization in tumor cells is mediated via disruptions in thiol metabolism. Cancer Res 2003;63:3413-7.
-
(2003)
Cancer Res
, vol.63
, pp. 3413-3417
-
-
Lin, X.1
Zhang, F.2
Bradbury, C.M.3
-
22
-
-
32444433450
-
Hypoxia-induced energy stress regulates mRNA translation and cell growth
-
Liu L, Cash TP, Jones RG, et al. Hypoxia-induced energy stress regulates mRNA translation and cell growth. Mol Cell 2006;21:521-31.
-
(2006)
Mol Cell
, vol.21
, pp. 521-531
-
-
Liu, L.1
Cash, T.P.2
Jones, R.G.3
-
23
-
-
20544465985
-
Regulation of transcription and translation by hypoxia
-
Liu L, Simon C. Regulation of transcription and translation by hypoxia. Cancer Biol Ther 2004;3:492-7.
-
(2004)
Cancer Biol Ther
, vol.3
, pp. 492-497
-
-
Liu, L.1
Simon, C.2
-
24
-
-
0037189542
-
Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis
-
Lu H, Forbes RA, Verma A. Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis. J Biol Chem 2002;277:23111-5.
-
(2002)
J Biol Chem
, vol.277
, pp. 23111-23115
-
-
Lu, H.1
Forbes, R.A.2
Verma, A.3
-
25
-
-
0442313668
-
Greater cell cycle inhibition and cytotoxicity induced by 2 deoxy-D-glucose in tumor cells treated under hypoxic vs aerobic conditions
-
Maher JC, Krishan A, Lampidis TJ. Greater cell cycle inhibition and cytotoxicity induced by 2 deoxy-D-glucose in tumor cells treated under hypoxic vs aerobic conditions. Cancer Chemother Pharmacol 2004;53:116-22.
-
(2004)
Cancer Chemother Pharmacol
, vol.53
, pp. 116-122
-
-
Maher, J.C.1
Krishan, A.2
Lampidis, T.J.3
-
26
-
-
0346027211
-
Regulation of hypoxia-inducible factor-1alpha by nitric oxide through mitochondria-dependent and -independent pathways
-
Mateo J, Garcia-Lecea M, Cadenas S, et al. Regulation of hypoxia-inducible factor-1alpha by nitric oxide through mitochondria-dependent and -independent pathways. Biochem J 2003;376:537-44.
-
(2003)
Biochem J
, vol.376
, pp. 537-544
-
-
Mateo, J.1
Garcia-Lecea, M.2
Cadenas, S.3
-
27
-
-
33748199697
-
Endogenous hypoxia markers in locally advanced cancers of the uterine cervix: Reality or wishful thinking?
-
Mayer A, Hockel M, Vaupel P. Endogenous hypoxia markers in locally advanced cancers of the uterine cervix: reality or wishful thinking? Strahlenther Onkol 2006;182:501-10.
-
(2006)
Strahlenther Onkol
, vol.182
, pp. 501-510
-
-
Mayer, A.1
Hockel, M.2
Vaupel, P.3
-
29
-
-
2342611976
-
Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: Role of reoxygenation, free radicals, and stress granules
-
Moeller BJ, Cao Y, Li CY, et al. Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. Cancer Cell 2004;5:429-41.
-
(2004)
Cancer Cell
, vol.5
, pp. 429-441
-
-
Moeller, B.J.1
Cao, Y.2
Li, C.Y.3
-
30
-
-
0031762534
-
Relevance of oxygen in radiation oncology. Mechanisms of action, correlation to low hemoglobin levels
-
Molls M, Stadler P, Becker A, et al. Relevance of oxygen in radiation oncology. Mechanisms of action, correlation to low hemoglobin levels. Strahlenther Onkol 1998;174:Suppl:13-6.
-
(1998)
Strahlenther Onkol
, vol.174
, Issue.SUPPL.
, pp. 13-16
-
-
Molls, M.1
Stadler, P.2
Becker, A.3
-
31
-
-
26444466467
-
Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study
-
Nordsmark M, Bentzen SM, Rudat V, et al. Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study. Radiother Oncol 2005;77:18-24.
-
(2005)
Radiother Oncol
, vol.77
, pp. 18-24
-
-
Nordsmark, M.1
Bentzen, S.M.2
Rudat, V.3
-
32
-
-
33748136112
-
Influence of pretreatment polarographically measured oxygenation levels in spontaneous canine tumors treated with radiation therapy
-
Rohrer Bley C, Ohlerth S, Roos M, et al. Influence of pretreatment polarographically measured oxygenation levels in spontaneous canine tumors treated with radiation therapy. Strahlenther Onkol 2006;182:518-24.
-
(2006)
Strahlenther Onkol
, vol.182
, pp. 518-524
-
-
Rohrer Bley, C.1
Ohlerth, S.2
Roos, M.3
-
33
-
-
33748178991
-
A clinical study of hypoxia using endogenous hypoxic markers and polarographic oxygen electrodes
-
Sakata K, Someya M, Nagakura H, et al. A clinical study of hypoxia using endogenous hypoxic markers and polarographic oxygen electrodes. Strahlenther Onkol 2006;182:511-7.
-
(2006)
Strahlenther Onkol
, vol.182
, pp. 511-517
-
-
Sakata, K.1
Someya, M.2
Nagakura, H.3
-
34
-
-
0034017489
-
Development of a hypoxia-responsive vector for tumor-specific gene therapy
-
Shibata T, Giaccia AJ, Brown JM. Development of a hypoxia-responsive vector for tumor-specific gene therapy. Gene Ther 2000;7:493-8.
-
(2000)
Gene Ther
, vol.7
, pp. 493-498
-
-
Shibata, T.1
Giaccia, A.J.2
Brown, J.M.3
-
35
-
-
23844485492
-
Reduced expression of hypoxia-inducible factor-1alpha in perinecrotic regions of solid tumors
-
Sobhanifar S, Aquino-Parsons C, Stanbridge EJ, et al. Reduced expression of hypoxia-inducible factor-1alpha in perinecrotic regions of solid tumors. Cancer Res 2005;65:7259-66.
-
(2005)
Cancer Res
, vol.65
, pp. 7259-7266
-
-
Sobhanifar, S.1
Aquino-Parsons, C.2
Stanbridge, E.J.3
-
36
-
-
23644437291
-
Radiosensitization by 6-aminonicotinamide and 2-deoxy D glucose in human cancer cells
-
Varshney R, Dwarakanath B, Jain V. Radiosensitization by 6-aminonicotinamide and 2-deoxy D glucose in human cancer cells. Int J Radiat Biol 2005;81:397-408.
-
(2005)
Int J Radiat Biol
, vol.81
, pp. 397-408
-
-
Varshney, R.1
Dwarakanath, B.2
Jain, V.3
-
37
-
-
31744438176
-
Impact of haemoglobin levels on tumor oxygenation: The higher, the better?
-
Vaupel P, Mayer A, Höckel M. Impact of haemoglobin levels on tumor oxygenation: the higher, the better? Strahlenther Onkol 2006;182:63-71.
-
(2006)
Strahlenther Onkol
, vol.182
, pp. 63-71
-
-
Vaupel, P.1
Mayer, A.2
Höckel, M.3
-
38
-
-
1542316344
-
Cell-type-specific association of hypoxia-inducible factor-1alpha (HIF-1alpha) protein accumulation and radiobiologic tumor hypoxia
-
Vordermark D, Katzer A, Baier K, et al. Cell-type-specific association of hypoxia-inducible factor-1alpha (HIF-1alpha) protein accumulation and radiobiologic tumor hypoxia. Int J Radiat Oncol Biol Phys 2004;58:1242-50.
-
(2004)
Int J Radiat Oncol Biol Phys
, vol.58
, pp. 1242-1250
-
-
Vordermark, D.1
Katzer, A.2
Baier, K.3
-
39
-
-
27144439058
-
Glucose requirement for hypoxic accumulation of hypoxia-inducible factor-1alpha (HIF-1alpha)
-
Vordermark D, Kraft P, Katzer A, et al. Glucose requirement for hypoxic accumulation of hypoxia-inducible factor-1alpha (HIF-1alpha). Cancer Lett 2005;230:122-33.
-
(2005)
Cancer Lett
, vol.230
, pp. 122-133
-
-
Vordermark, D.1
Kraft, P.2
Katzer, A.3
-
40
-
-
0037227501
-
Similar radiation sensitivities of acutely and chronically hypoxic cells in HT 1080 fibrosarcoma xenografts
-
Vordermark D, Menke DR, Brown JM. Similar radiation sensitivities of acutely and chronically hypoxic cells in HT 1080 fibrosarcoma xenografts. Radiat Res 2003;159:94-101.
-
(2003)
Radiat Res
, vol.159
, pp. 94-101
-
-
Vordermark, D.1
Menke, D.R.2
Brown, J.M.3
-
41
-
-
0035215945
-
Green fluorescent protein is a suitable reporter of tumor hypoxia despite an oxygen requirement for chromophore formation
-
Vordermark D, Shibata T, Brown JM. Green fluorescent protein is a suitable reporter of tumor hypoxia despite an oxygen requirement for chromophore formation. Neoplasia 2001;3:527-34.
-
(2001)
Neoplasia
, vol.3
, pp. 527-534
-
-
Vordermark, D.1
Shibata, T.2
Brown, J.M.3
-
42
-
-
4444369682
-
Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha
-
Welsh S, Williams R, Kirkpatrick L, et al. Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha. Mol Cancer Ther 2004;3:233-44.
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 233-244
-
-
Welsh, S.1
Williams, R.2
Kirkpatrick, L.3
-
43
-
-
0346689991
-
Hexokinase II and VEGF expression in liver tumors: Correlation with hypoxia-inducible factor-1α and its significance
-
Yasuda S, Arii S, Mori A, et al. Hexokinase II and VEGF expression in liver tumors: correlation with hypoxia-inducible factor-1α and its significance. J Hepatol 2004;40:117-23.
-
(2004)
J Hepatol
, vol.40
, pp. 117-123
-
-
Yasuda, S.1
Arii, S.2
Mori, A.3
-
44
-
-
15444362131
-
Glucose deprivation increases mRNA stability of vascular endothelial growth factor through activation of AMP-activated protein kinase in DU145 prostate carcinoma
-
Yun H, Lee M, Kim SS, et al. Glucose deprivation increases mRNA stability of vascular endothelial growth factor through activation of AMP-activated protein kinase in DU145 prostate carcinoma. J Biol Chem 2005;280:9963-72.
-
(2005)
J Biol Chem
, vol.280
, pp. 9963-9972
-
-
Yun, H.1
Lee, M.2
Kim, S.S.3
|