-
1
-
-
0026782895
-
Deleterious mitochondrial DNA mutations accumulate in aging human tissues
-
N. Arnheim and G. Cortopassi (1992) Deleterious mitochondrial DNA mutations accumulate in aging human tissues. Mutat Res 275 157-167.
-
(1992)
Mutat Res
, vol.275
, pp. 157-167
-
-
Arnheim, N.1
Cortopassi, G.2
-
2
-
-
0034632717
-
Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
-
S.E. Artandi, S. Chang, S.-L. Lee, S. Alson, G.J. Gottlieb, L. Chin and R.A. DePinho (2000) Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 406 641-645.
-
(2000)
Nature
, vol.406
, pp. 641-645
-
-
Artandi, S.E.1
Chang, S.2
Lee, S.-L.3
Alson, S.4
Gottlieb, G.J.5
Chin, L.6
DePinho, R.A.7
-
3
-
-
3042761646
-
BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice
-
D.J. Baker, K.B. Jeganathan, J.D. Cameron, M. Thompson, S. Juneja, A. Kopecka, et al. (2004) BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nat Genet 36 744-749.
-
(2004)
Nat Genet
, vol.36
, pp. 744-749
-
-
Baker, D.J.1
Jeganathan, K.B.2
Cameron, J.D.3
Thompson, M.4
Juneja, S.5
Kopecka, A.6
-
4
-
-
13944276264
-
Life extension in the dwarf mouse
-
A. Bartke and H. Brown-Borg (2004) Life extension in the dwarf mouse. Curr Top Dev Biol 63 189-225.
-
(2004)
Curr Top Dev Biol
, vol.63
, pp. 189-225
-
-
Bartke, A.1
Brown-Borg, H.2
-
5
-
-
0036553049
-
Consequences of growth hormone (GH) overexpression and GH resistance
-
A. Bartke, V. Chandrashekar, B. Bailey, D. Zaczek and D. Turyn (2002) Consequences of growth hormone (GH) overexpression and GH resistance. Neuropeptides 36 201-208.
-
(2002)
Neuropeptides
, vol.36
, pp. 201-208
-
-
Bartke, A.1
Chandrashekar, V.2
Bailey, B.3
Zaczek, D.4
Turyn, D.5
-
6
-
-
0036791026
-
Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect
-
M.O. Bergo, B. Gavino, J. Ross, W.K. Schmidt, C. Hong, L.V. Kendall, et al. (2002) Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect. Proc Natl Acad Sci USA 99 13049-13054.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 13049-13054
-
-
Bergo, M.O.1
Gavino, B.2
Ross, J.3
Schmidt, W.K.4
Hong, C.5
Kendall, L.V.6
-
7
-
-
14544277627
-
Telomeres and telomerase: their mechanisms of action and the effects of altering their functions
-
E.H. Blackburn (2005) Telomeres and telomerase: their mechanisms of action and the effects of altering their functions. FEBS Lett 579 859-862.
-
(2005)
FEBS Lett
, vol.579
, pp. 859-862
-
-
Blackburn, E.H.1
-
8
-
-
0030931491
-
Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
-
M.A. Blasco, H.W. Lee, M.P. Hande, E. Samper, P.M. Lansdorp, R.A. DePinho, et al. (1997) Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91 25-34.
-
(1997)
Cell
, vol.91
, pp. 25-34
-
-
Blasco, M.A.1
Lee, H.W.2
Hande, M.P.3
Samper, E.4
Lansdorp, P.M.5
DePinho, R.A.6
-
9
-
-
0025841730
-
Reduction in rate of occurrence of age-related lesions in dietary restricted laboratory mice
-
R.T. Bronson and R.D. Lipman (1991) Reduction in rate of occurrence of age-related lesions in dietary restricted laboratory mice. Growth, Development & Aging 55 169-184.
-
(1991)
Growth, Development & Aging
, vol.55
, pp. 169-184
-
-
Bronson, R.T.1
Lipman, R.D.2
-
10
-
-
13944270339
-
Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
-
J. Campisi (2005) Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 120 513-522.
-
(2005)
Cell
, vol.120
, pp. 513-522
-
-
Campisi, J.1
-
11
-
-
0037439071
-
Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brcal full-length isoform
-
L. Cao, W. Li, S. Kim, S.G. Brodie and C.X. Deng (2003) Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brcal full-length isoform. Genes Dev 17 201-213.
-
(2003)
Genes Dev
, vol.17
, pp. 201-213
-
-
Cao, L.1
Li, W.2
Kim, S.3
Brodie, S.G.4
Deng, C.X.5
-
12
-
-
3543043128
-
Essential role of limiting telomeres in the pathogenesis of Werner syndrome
-
S. Chang, A.S. Multani, N.G. Cabrera, M.L. Naylor, P. Laud, D. Lombard, et al. (2004) Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nat Genet 36 877-882.
-
(2004)
Nat Genet
, vol.36
, pp. 877-882
-
-
Chang, S.1
Multani, A.S.2
Cabrera, N.G.3
Naylor, M.L.4
Laud, P.5
Lombard, D.6
-
13
-
-
0141814680
-
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
-
H.L. Cheng, R. Mostoslavsky, S. Saito, J.P. Manis, Y. Gu, P. Patel, et al. (2003) Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci USA 100 10794-10799.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 10794-10799
-
-
Cheng, H.L.1
Mostoslavsky, R.2
Saito, S.3
Manis, J.P.4
Gu, Y.5
Patel, P.6
-
14
-
-
3242876404
-
Ataxia-telangiectasia, an evolving phenotype
-
H.H. Chun and R.A. Gatti (2004) Ataxia-telangiectasia, an evolving phenotype. DNA Repair (Amst) 3 1187-1196.
-
(2004)
DNA Repair (Amst)
, vol.3
, pp. 1187-1196
-
-
Chun, H.H.1
Gatti, R.A.2
-
15
-
-
0037123638
-
Premature aging in mice deficient in DNA repair and transcription
-
J. de Boer, J.O. Andressoo, J. de Wit, J. Huijmans, R.B. Beems, H. van Steeg, et al. (2002) Premature aging in mice deficient in DNA repair and transcription. Science 296 1276-1279.
-
(2002)
Science
, vol.296
, pp. 1276-1279
-
-
de Boer, J.1
Andressoo, J.O.2
de Wit, J.3
Huijmans, J.4
Beems, R.B.5
van Steeg, H.6
-
16
-
-
0032085182
-
A mouse model for the basal transcription/DNA repair syndrome trichothiodystrophy
-
J. de Boer, J. de Wit, H. van Steeg, R.J. Berg, H. Morreau, P. Visser, et al. (1998) A mouse model for the basal transcription/DNA repair syndrome trichothiodystrophy. Mol Cell I 981-990.
-
(1998)
Mol Cell I
, pp. 981-990
-
-
de Boer, J.1
de Wit, J.2
van Steeg, H.3
Berg, R.J.4
Morreau, H.5
Visser, P.6
-
17
-
-
0029083409
-
Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA
-
A. de Vries, C.T. van Oostrom, F.M. Hofhuis, P.M. Dortant, R.J. Berg, F.R. de Gruijl, et al. (1995) Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA. Nature 377 169-173.
-
(1995)
Nature
, vol.377
, pp. 169-173
-
-
de Vries, A.1
van Oostrom, C.T.2
Hofhuis, F.M.3
Dortant, P.M.4
Berg, R.J.5
de Gruijl, F.R.6
-
18
-
-
0034626769
-
The age of cancer
-
R.A. DePinho (2000) The age of cancer. Nature 408 248-254.
-
(2000)
Nature
, vol.408
, pp. 248-254
-
-
DePinho, R.A.1
-
19
-
-
0034732239
-
DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation
-
M.J. Difilippantonio, J. Zhu, H.T. Chen, E. Meffre, M.C. Nussenzweig, E.E. Max, et al. (2000) DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation. Nature 404 510-514.
-
(2000)
Nature
, vol.404
, pp. 510-514
-
-
Difilippantonio, M.J.1
Zhu, J.2
Chen, H.T.3
Meffre, E.4
Nussenzweig, M.C.5
Max, E.E.6
-
20
-
-
0036851242
-
Genome dynamics in aging mice
-
M.E. Dolle and J. Vijg (2002) Genome dynamics in aging mice. Genome Res 12 1732-1738.
-
(2002)
Genome Res
, vol.12
, pp. 1732-1738
-
-
Dolle, M.E.1
Vijg, J.2
-
21
-
-
85147639495
-
Increased genomic instability is not a prerequisite for shortened life span in DNA repair deficient mice.
-
in press
-
Dollé, M.E.T., Busuttil, R.A., Garcia, A.M., Wijnhoven, S., van Drunen, A., Niedernhofer, L.J., van der Horst, G., Hoeijmakers, J.H.J., van Steeg, H., and Vijg, J. Increased genomic instability is not a prerequisite for shortened life span in DNA repair deficient mice. Mutation Research, in press.
-
Mutation Research
-
-
Dollé, M.E.T.1
Busuttil, R.A.2
Garcia, A.M.3
Wijnhoven, S.4
van Drunen, A.5
Niedernhofer, L.J.6
van der Horst, G.7
Hoeijmakers, J.H.J.8
van Steeg, H.9
Vijg, J.10
-
22
-
-
3242678797
-
Insights into aging obtained from p53 mutant mouse models
-
M. Dumble, C. Gatza, S. Tyner, S. Venkatachalam and L.A. Donehower (2004) Insights into aging obtained from p53 mutant mouse models. Ann N Y Acad Sci 1019 171-177.
-
(2004)
Ann N Y Acad Sci
, vol.1019
, pp. 171-177
-
-
Dumble, M.1
Gatza, C.2
Tyner, S.3
Venkatachalam, S.4
Donehower, L.A.5
-
23
-
-
0013839230
-
Werner's syndrome: caricature of aging a genetic model for the study of degenerative diseases
-
C.J. Epstein, G.M. Martin and A.G. Motulsky (1965) Werner's syndrome: caricature of aging a genetic model for the study of degenerative diseases. Trans Assoc Am Physicians 78 73-81.
-
(1965)
Trans Assoc Am Physicians
, vol.78
, pp. 73-81
-
-
Epstein, C.J.1
Martin, G.M.2
Motulsky, A.G.3
-
24
-
-
0037673950
-
Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome
-
M. Eriksson, W.T. Brown, L.B. Gordon, M.W. Glynn, J. Singer, L. Scott, et al. (2003) Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature 423 293-298.
-
(2003)
Nature
, vol.423
, pp. 293-298
-
-
Eriksson, M.1
Brown, W.T.2
Gordon, L.B.3
Glynn, M.W.4
Singer, J.5
Scott, L.6
-
25
-
-
2942547771
-
Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice
-
S. Espejel, M. Martin, P. Klatt, J. Martin-Caballero, J.M. Flores and M.A. Blasco (2004) Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice. EMBO Rep 5 503-509.
-
(2004)
EMBO Rep
, vol.5
, pp. 503-509
-
-
Espejel, S.1
Martin, M.2
Klatt, P.3
Martin-Caballero, J.4
Flores, J.M.5
Blasco, M.A.6
-
26
-
-
0024465870
-
Mutator phenotype of Werner syndrome is characterized by extensive deletions
-
K. Fukuchi, G.M. Martin and R.J. Monnat Jr. (1989) Mutator phenotype of Werner syndrome is characterized by extensive deletions. Proc Natl Acad Sci USA 86 5893-5897.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 5893-5897
-
-
Fukuchi, K.1
Martin, G.M.2
Monnat, R.J.3
-
27
-
-
0028033989
-
The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase
-
S. Gangloff, J.P. McDonald, C. Bendixen, L. Arthur and R. Rothstein (1994) The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase. Mol Cell Biol 14 8391-8398.
-
(1994)
Mol Cell Biol
, vol.14
, pp. 8391-8398
-
-
Gangloff, S.1
McDonald, J.P.2
Bendixen, C.3
Arthur, L.4
Rothstein, R.5
-
28
-
-
0037112844
-
“Super p53” mice exhibit enhanced DNA damage response, are tumor resistant and age normally
-
I. Garcia-Cao, M. Garcia-Cao, J. Martin-Caballero, L.M. Criado, P. Klatt, J.M. Flores, et al. (2002) “Super p53” mice exhibit enhanced DNA damage response, are tumor resistant and age normally. Embo J 21 6225-6235.
-
(2002)
Embo J
, vol.21
, pp. 6225-6235
-
-
Garcia-Cao, I.1
Garcia-Cao, M.2
Martin-Caballero, J.3
Criado, L.M.4
Klatt, P.5
Flores, J.M.6
-
29
-
-
0030691121
-
Hierarchical deterioration of body systems in Werner's syndrome: implications for normal ageing
-
M. Goto (1997) Hierarchical deterioration of body systems in Werner's syndrome: implications for normal ageing. Mech Ageing Dev 98 239-254.
-
(1997)
Mech Ageing Dev
, vol.98
, pp. 239-254
-
-
Goto, M.1
-
30
-
-
11244320353
-
The nuclear lamina comes of age
-
Y. Gruenbaum, A. Margalit, R.D. Goldman, D.K. Shumaker and K.L. Wilson (2005) The nuclear lamina comes of age. Nat Rev Mol Cell Biol 6 21-31.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 21-31
-
-
Gruenbaum, Y.1
Margalit, A.2
Goldman, R.D.3
Shumaker, D.K.4
Wilson, K.L.5
-
31
-
-
0031433517
-
Growth retardation and leaky SCID phenotype of Ku70-deficient mice
-
Y. Gu, K.J. Seidl, G.A. Rathbun, C. Zhu, J.P. Manis, N. van der Stoep, et al. (1997) Growth retardation and leaky SCID phenotype of Ku70-deficient mice. Immunity 7 653-665.
-
(1997)
Immunity
, vol.7
, pp. 653-665
-
-
Gu, Y.1
Seidl, K.J.2
Rathbun, G.A.3
Zhu, C.4
Manis, J.P.5
van der Stoep, N.6
-
32
-
-
0035964315
-
Does oxidative damage to DNA increase with age?
-
M.L. Hamilton, H. Van Remmen, J.A. Drake, H. Yang, Z.M. Guo, K. Kewitt, et al. (2001) Does oxidative damage to DNA increase with age? Proc Natl Acad Sci USA 98 10469-10474.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 10469-10474
-
-
Hamilton, M.L.1
Van Remmen, H.2
Drake, J.A.3
Yang, H.4
Guo, Z.M.5
Kewitt, K.6
-
33
-
-
25444501240
-
Aneuploidy-cancer predis-position syndromes: a new link between the mitotic spindle checkpoint and cancer
-
S. Hanks and N. Rahman (2005) Aneuploidy-cancer predis-position syndromes: a new link between the mitotic spindle checkpoint and cancer. Cell Cycle 4 225-227.
-
(2005)
Cell Cycle
, vol.4
, pp. 225-227
-
-
Hanks, S.1
Rahman, N.2
-
34
-
-
0037470542
-
Aging and genome maintenance: lessons from the mouse?
-
P. Hasty, J. Campisi, J. Hoeijmakers, H. van Steeg and J. Vijg (2003) Aging and genome maintenance: lessons from the mouse? Science 299 1355-1359.
-
(2003)
Science
, vol.299
, pp. 1355-1359
-
-
Hasty, P.1
Campisi, J.2
Hoeijmakers, J.3
van Steeg, H.4
Vijg, J.5
-
35
-
-
4544377929
-
Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity
-
P. Hasty and J. Vijg (2004) Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity. Aging Cell 3 55-65.
-
(2004)
Aging Cell
, vol.3
, pp. 55-65
-
-
Hasty, P.1
Vijg, J.2
-
36
-
-
0035902108
-
Genome maintenance mechanisms for preventing cancer
-
J.H. Hoeijmakers (2001) Genome maintenance mechanisms for preventing cancer. Nature 411 366-374.
-
(2001)
Nature
, vol.411
, pp. 366-374
-
-
Hoeijmakers, J.H.1
-
37
-
-
1542267804
-
Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification
-
T. Hosaka, W.H. Biggs 3rd, D. Tieu, A.D. Boyer, N.M. Varki, W.K. Cavenee, et al. (2004) Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. Proc Natl Acad Sci USA 101 2975-2980.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 2975-2980
-
-
Hosaka, T.1
Biggs, W.H.2
Tieu, D.3
Boyer, A.D.4
Varki, N.M.5
Cavenee, W.K.6
-
38
-
-
13944256856
-
Fitness cost of extended lifespan in Caenorhabditis elegans
-
N.L. Jenkins, G. McColl and G.J. Lithgow (2004) Fitness cost of extended lifespan in Caenorhabditis elegans. Proc Biol Sci 271 2523-2526.
-
(2004)
Proc Biol Sci
, vol.271
, pp. 2523-2526
-
-
Jenkins, N.L.1
McColl, G.2
Lithgow, G.J.3
-
39
-
-
0042911521
-
Functional genetic analysis of mouse chromosome 11
-
B.T. Kile, K.E. Hentges, A.T. Clark, H. Nakamura, A.P. Salinger, B. Liu, et al. (2003) Functional genetic analysis of mouse chromosome 11. Nature 425 81-86.
-
(2003)
Nature
, vol.425
, pp. 81-86
-
-
Kile, B.T.1
Hentges, K.E.2
Clark, A.T.3
Nakamura, H.4
Salinger, A.P.5
Liu, B.6
-
40
-
-
13944262937
-
Understanding the odd science of aging
-
T.B. Kirkwood (2005) Understanding the odd science of aging. Cell 120 437-447.
-
(2005)
Cell
, vol.120
, pp. 437-447
-
-
Kirkwood, T.B.1
-
41
-
-
0020070207
-
Cytogerontology since 1881: a reappraisal of August Weismann and a review of modern progress
-
T.B. Kirkwood and T. Cremer (1982) Cytogerontology since 1881: a reappraisal of August Weismann and a review of modern progress. Hum Genet 60 101-121.
-
(1982)
Hum Genet
, vol.60
, pp. 101-121
-
-
Kirkwood, T.B.1
Cremer, T.2
-
42
-
-
22344456832
-
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
-
G.C. Kujoth, A. Hiona, T.D. Pugh, S. Someya, K. Panzer, S.E. Wohlgemuth, T. Hofer, A.Y. Seo, R. Sullivan, W.A. Jobling, J.D. Morrow, H. Van Remmen, J.M. Sedivy, T. Yamasoba, M. Tanokura, R. Weindruch, C. Leeuwenburgh and T.A. Prolla (2005) Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science 309 481-484.
-
(2005)
Science
, vol.309
, pp. 481-484
-
-
Kujoth, G.C.1
Hiona, A.2
Pugh, T.D.3
Someya, S.4
Panzer, K.5
Wohlgemuth, S.E.6
Hofer, T.7
Seo, A.Y.8
Sullivan, R.9
Jobling, W.A.10
Morrow, J.D.11
Van Remmen, H.12
Sedivy, J.M.13
Yamasoba, T.14
Tanokura, M.15
Weindruch, R.16
Leeuwenburgh, C.17
Prolla, T.A.18
-
43
-
-
0035826797
-
Mice lacking DNA topoisomerase IIIbeta develop to maturity but show a reduced mean lifespan
-
K.Y. Kwan and J.C. Wang (2001) Mice lacking DNA topoisomerase IIIbeta develop to maturity but show a reduced mean lifespan. Proc Natl Acad Sci USA 98 5717-5721.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 5717-5721
-
-
Kwan, K.Y.1
Wang, J.C.2
-
45
-
-
0035266463
-
Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase
-
M. Lebel, R.D. Cardiff and P. Leder (2001) Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase. Cancer Res 61 1816-1819.
-
(2001)
Cancer Res
, vol.61
, pp. 1816-1819
-
-
Lebel, M.1
Cardiff, R.D.2
Leder, P.3
-
46
-
-
0032573157
-
A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity
-
M. Lebel and P. Leder (1998) A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity. Proc Natl Acad Sci USA 95 13097-13102.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 13097-13102
-
-
Lebel, M.1
Leder, P.2
-
47
-
-
0942268166
-
DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy
-
A.R. Lehmann (2003) DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy. Biochimie 85 1101-1111.
-
(2003)
Biochimie
, vol.85
, pp. 1101-1111
-
-
Lehmann, A.R.1
-
48
-
-
0034737004
-
Rothmund-Thomson syndrome due to RECQ4 helicase mutations: report and clinical and molecular comparisons with Bloom syndrome and Werner syndrome
-
N.M. Lindor, Y. Furuichi, S. Kitao, A. Shimamoto, C. Arndt and S. Jalal (2000) Rothmund-Thomson syndrome due to RECQ4 helicase mutations: report and clinical and molecular comparisons with Bloom syndrome and Werner syndrome. Am J Med Genet 90 223-228.
-
(2000)
Am J Med Genet
, vol.90
, pp. 223-228
-
-
Lindor, N.M.1
Furuichi, Y.2
Kitao, S.3
Shimamoto, A.4
Arndt, C.5
Jalal, S.6
-
49
-
-
22544466685
-
Genomic instability in laminopathy-based premature aging
-
B. Liu, J. Wang, K.M. Chan, W.M. Tjia, W. Deng, X. Guan, J.D. Huang, K.M. Li, P.Y. Chau, D.J. Chen, D. Pei, A.M. Pendas, J. Cadinanos, C. Lopez-Otin, H.F. Tse, C. Hutchison, J. Chen, Y. Cao, K.S. Cheah, K. Tryggvason and Z. Zhou (2005) Genomic instability in laminopathy-based premature aging. Nat Med 11 780-785.
-
(2005)
Nat Med
, vol.11
, pp. 780-785
-
-
Liu, B.1
Wang, J.2
Chan, K.M.3
Tjia, W.M.4
Deng, W.5
Guan, X.6
Huang, J.D.7
Li, K.M.8
Chau, P.Y.9
Chen, D.J.10
Pei, D.11
Pendas, A.M.12
Cadinanos, J.13
Lopez-Otin, C.14
Tse, H.F.15
Hutchison, C.16
Chen, J.17
Cao, Y.18
Cheah, K.S.19
Tryggvason, K.20
Zhou, Z.21
more..
-
50
-
-
17544402913
-
Mutations in the WRN gene in mice accelerate mortality in a p53-null background
-
D.B. Lombard, C. Beard, B. Johnson, R.A. Marciniak, J. Dausman, R. Bronson, et al. (2000) Mutations in the WRN gene in mice accelerate mortality in a p53-null background. Mol Cell Biol 20 3286-3291.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 3286-3291
-
-
Lombard, D.B.1
Beard, C.2
Johnson, B.3
Marciniak, R.A.4
Dausman, J.5
Bronson, R.6
-
51
-
-
13944249618
-
DNA repair, genome stability, and aging
-
D.B. Lombard, K.F. Chua, R. Mostoslavsky, S. Franco, M. Gostissa and F.W. Alt (2005) DNA repair, genome stability, and aging. Cell 120 497-512.
-
(2005)
Cell
, vol.120
, pp. 497-512
-
-
Lombard, D.B.1
Chua, K.F.2
Mostoslavsky, R.3
Franco, S.4
Gostissa, M.5
Alt, F.W.6
-
52
-
-
1042266548
-
Modulation of mammalian life span by the short isoform of p53
-
B. Maier, W. Gluba, B. Bernier, T. Turner, K. Mohammad, T. Guise, et al. (2004) Modulation of mammalian life span by the short isoform of p53. Genes Dev 18 306-319.
-
(2004)
Genes Dev
, vol.18
, pp. 306-319
-
-
Maier, B.1
Gluba, W.2
Bernier, B.3
Turner, T.4
Mohammad, K.5
Guise, T.6
-
53
-
-
13944280713
-
Genetic modulation of senescent phenotypes in Homo sapiens
-
G.M. Martin (2005) Genetic modulation of senescent phenotypes in Homo sapiens. Cell 120 523-532.
-
(2005)
Cell
, vol.120
, pp. 523-532
-
-
Martin, G.M.1
-
54
-
-
0033581704
-
The p66shc adaptor protein controls oxidative stress response and life span in mammals
-
E. Migliaccio, M. Giorgio, S. Mele, G. Pelicci, P. Reboldi, P.P. Pandolfi, et al. (1999) The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature 402 309-313.
-
(1999)
Nature
, vol.402
, pp. 309-313
-
-
Migliaccio, E.1
Giorgio, M.2
Mele, S.3
Pelicci, G.4
Reboldi, P.5
Pandolfi, P.P.6
-
55
-
-
1342264308
-
Mammalian SIRT1 represses forkhead transcription factors
-
M.C. Motta, N. Divecha, M. Lemieux, C. Kamel, D. Chen, W. Gu, et al. (2004) Mammalian SIRT1 represses forkhead transcription factors. Cell 116 551-563.
-
(2004)
Cell
, vol.116
, pp. 551-563
-
-
Motta, M.C.1
Divecha, N.2
Lemieux, M.3
Kamel, C.4
Chen, D.5
Gu, W.6
-
56
-
-
0037673940
-
A progeroid syndrome in mice is caused by defects in A-type lamins
-
L.C. Mounkes, S. Kozlov, L. Hernandez, T. Sullivan and C.L. Stewart (2003) A progeroid syndrome in mice is caused by defects in A-type lamins. Nature 423 298-301.
-
(2003)
Nature
, vol.423
, pp. 298-301
-
-
Mounkes, L.C.1
Kozlov, S.2
Hernandez, L.3
Sullivan, T.4
Stewart, C.L.5
-
57
-
-
0029778191
-
Requirement for Ku80 in growth and immunoglobulin V(D)J recombination
-
A. Nussenzweig, C. Chen, V. da Costa Soares, M. Sanchez, K. Sokol, M.C. Nussenzweig, et al. (1996) Requirement for Ku80 in growth and immunoglobulin V(D)J recombination. Nature 382 551-555.
-
(1996)
Nature
, vol.382
, pp. 551-555
-
-
Nussenzweig, A.1
Chen, C.2
da Costa Soares, V.3
Sanchez, M.4
Sokol, K.5
Nussenzweig, M.C.6
-
58
-
-
7244239317
-
Hutchinson-Gilford progeria syndrome
-
R.L. Pollex and R.A. Hegele (2004) Hutchinson-Gilford progeria syndrome. Clin Genet 66 375-381.
-
(2004)
Clin Genet
, vol.66
, pp. 375-381
-
-
Pollex, R.L.1
Hegele, R.A.2
-
59
-
-
0033010781
-
Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase
-
M. Poot, K.A. Gollahon and P.S. Rabinovitch (1999) Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase. Hum Genet 104 10-14.
-
(1999)
Hum Genet
, vol.104
, pp. 10-14
-
-
Poot, M.1
Gollahon, K.A.2
Rabinovitch, P.S.3
-
60
-
-
2642631746
-
p107 is a suppressor of retinoblastoma development in pRb-deficient mice
-
E. Robanus-Maandag, M. Dekker, M. van der Valk, M.L. Carrozza, J.C. Jeanny, J.H. Dannenberg, et al. (1998) p107 is a suppressor of retinoblastoma development in pRb-deficient mice. Genes Dev 12 1599-1609.
-
(1998)
Genes Dev
, vol.12
, pp. 1599-1609
-
-
Robanus-Maandag, E.1
Dekker, M.2
van der Valk, M.3
Carrozza, M.L.4
Jeanny, J.C.5
Dannenberg, J.H.6
-
61
-
-
0033525558
-
Longevity, stress response, and cancer in aging telomerase-deficient mice
-
K.L. Rudolph, S. Chang, H.W. Lee, M. Blasco, G.J. Gottlieb, C. Greider, et al. (1999) Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell 96 701-712.
-
(1999)
Cell
, vol.96
, pp. 701-712
-
-
Rudolph, K.L.1
Chang, S.2
Lee, H.W.3
Blasco, M.4
Gottlieb, G.J.5
Greider, C.6
-
62
-
-
0037365789
-
ATM and related protein kinases: safeguarding genome integrity
-
Y. Shiloh (2003) ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer 3 155-168.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 155-168
-
-
Shiloh, Y.1
-
63
-
-
25144516017
-
Recombination at mammalian telomeres: An alternative mechanism for telomere protection and elongation
-
M. Tarsounas and S.C. West (2005) Recombination at mammalian telomeres: An alternative mechanism for telomere protection and elongation. Cell Cycle 4
-
(2005)
Cell Cycle
, vol.4
-
-
Tarsounas, M.1
West, S.C.2
-
64
-
-
0037470501
-
The endocrine regulation of aging by insulin-like signals
-
M. Tatar, A. Bartke and A. Antebi (2003) The endocrine regulation of aging by insulin-like signals. Science 299 1346-1351.
-
(2003)
Science
, vol.299
, pp. 1346-1351
-
-
Tatar, M.1
Bartke, A.2
Antebi, A.3
-
65
-
-
2642580016
-
Premature ageing in mice expressing defective mitochondrial DNA polymerase
-
A. Trifunovic, A. Wredenberg, M. Falkenberg, J.N. Spelbrink, A.T. Rovio, C.E. Bruder, et al. (2004) Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429 417-423.
-
(2004)
Nature
, vol.429
, pp. 417-423
-
-
Trifunovic, A.1
Wredenberg, A.2
Falkenberg, M.3
Spelbrink, J.N.4
Rovio, A.T.5
Bruder, C.E.6
-
66
-
-
0037011958
-
p53 mutant mice that display early ageing-associated phenotypes
-
S.D. Tyner, S. Venkatachalam, J. Choi, S. Jones, N. Ghebranious, H. Igelmann, et al. (2002) p53 mutant mice that display early ageing-associated phenotypes. Nature 415 45-53.
-
(2002)
Nature
, vol.415
, pp. 45-53
-
-
Tyner, S.D.1
Venkatachalam, S.2
Choi, J.3
Jones, S.4
Ghebranious, N.5
Igelmann, H.6
-
67
-
-
0035289717
-
Chromosomal stability and the DNA double-stranded break connection
-
D.C. Van Gent, J.H. Hoeijmakers and R. Kanaar (2001) Chromosomal stability and the DNA double-stranded break connection. Nat Rev Genet 2 196-206.
-
(2001)
Nat Rev Genet
, vol.2
, pp. 196-206
-
-
Van Gent, D.C.1
Hoeijmakers, J.H.2
Kanaar, R.3
-
68
-
-
25644440744
-
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation
-
I. Varela, J. Cadinanos, A.M. Pendas, A. Gutierrez-Fernandez, A.R. Folgueras, L.M. Sanchez, Z. Zhou, F.J. Rodriguez, C.L. Stewart, J.A. Vega, K. Tryggvason, J.M. Freije and C. Lopez-Otin (2005) Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation. Nature 437 564-568.
-
(2005)
Nature
, vol.437
, pp. 564-568
-
-
Varela, I.1
Cadinanos, J.2
Pendas, A.M.3
Gutierrez-Fernandez, A.4
Folgueras, A.R.5
Sanchez, L.M.6
Zhou, Z.7
Rodriguez, F.J.8
Stewart, C.L.9
Vega, J.A.10
Tryggvason, K.11
Freije, J.M.12
Lopez-Otin, C.13
-
69
-
-
0037198009
-
Large genome rearrangements as a primary cause of aging
-
J. Vijg and M.E. Dollé (2002) Large genome rearrangements as a primary cause of aging. Mech Ageing Dev 123 907-915.
-
(2002)
Mech Ageing Dev
, vol.123
, pp. 907-915
-
-
Vijg, J.1
Dollé, M.E.2
-
71
-
-
0032827888
-
Deletion of Ku86 causes early onset of senescence in mice
-
H. Vogel, D.S. Lim, G. Karsenty, M. Finegold and P. Hasty (1999) Deletion of Ku86 causes early onset of senescence in mice. Proc Natl Acad Sci USA 96 10770-10775.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 10770-10775
-
-
Vogel, H.1
Lim, D.S.2
Karsenty, G.3
Finegold, M.4
Hasty, P.5
-
73
-
-
0024324482
-
A hyper-recombination mutation in S. cerevisiae identifies a novel eukaryotic topoisomerase
-
J.W. Wallis, G. Chrebet, G. Brodsky, M. Rolfe and R. Rothstein (1989) A hyper-recombination mutation in S. cerevisiae identifies a novel eukaryotic topoisomerase. Cell 58 409-419.
-
(1989)
Cell
, vol.58
, pp. 409-419
-
-
Wallis, J.W.1
Chrebet, G.2
Brodsky, G.3
Rolfe, M.4
Rothstein, R.5
-
74
-
-
12644266319
-
Disruption of mouse ERCCI results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence
-
G. Weeda, I. Donker, J. de Wit, H. Morreau, R. Janssens, C.J. Vissers, et al. (1997) Disruption of mouse ERCCI results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence. Curr Biol 7 427-439.
-
(1997)
Curr Biol
, vol.7
, pp. 427-439
-
-
Weeda, G.1
Donker, I.2
de Wit, J.3
Morreau, H.4
Janssens, R.5
Vissers, C.J.6
-
75
-
-
27544480902
-
Accelerated aging pathology in ad libitum fed Xpd(TTD) mice is accompanied by features suggestive of caloric restriction
-
S.W. Wijnhoven, R.B. Beems, M. Roodbergen, J. van den Berg, P.H. Lohman, K. Diderich, G.T. van der Horst, J. Vijg, J.H. Hoeijmakers and H. van Steeg (2005) Accelerated aging pathology in ad libitum fed Xpd(TTD) mice is accompanied by features suggestive of caloric restriction. DNA Repair 4 1314-1324.
-
(2005)
DNA Repair
, vol.4
, pp. 1314-1324
-
-
Wijnhoven, S.W.1
Beems, R.B.2
Roodbergen, M.3
van den Berg, J.4
Lohman, P.H.5
Diderich, K.6
van der Horst, G.T.7
Vijg, J.8
Hoeijmakers, J.H.9
van Steeg, H.10
-
76
-
-
0000055057
-
Pleiotropy, natural selection, and the evolution of senescence
-
G.C. Williams (1957) Pleiotropy, natural selection, and the evolution of senescence. Evolution 11 398-411.
-
(1957)
Evolution
, vol.11
, pp. 398-411
-
-
Williams, G.C.1
-
77
-
-
0030626770
-
Aging of the female reproductive system: a window into brain aging
-
discussion 303–305
-
P.M. Wise, M.L. Kashon, K.M. Krajnak, K.L. Rosewell, A. Cai, K. Scarbrough, et al. (1997) Aging of the female reproductive system: a window into brain aging. Recent Prog Horm Res 52 279-303. discussion 303–305
-
(1997)
Recent Prog Horm Res
, vol.52
, pp. 279-303
-
-
Wise, P.M.1
Kashon, M.L.2
Krajnak, K.M.3
Rosewell, K.L.4
Cai, A.5
Scarbrough, K.6
-
78
-
-
0037421896
-
Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing
-
K.K. Wong, R.S. Maser, R.M. Bachoo, J. Menon, D.R. Carrasco, Y. Gu, et al. (2003) Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature 421 643-648.
-
(2003)
Nature
, vol.421
, pp. 643-648
-
-
Wong, K.K.1
Maser, R.S.2
Bachoo, R.M.3
Menon, J.4
Carrasco, D.R.5
Gu, Y.6
-
79
-
-
0029844048
-
Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma
-
Y. Xu, T. Ashley, E.E. Brainerd, R.T. Bronson, M.S. Meyn and D. Baltimore (1996) Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev 10 2411-2422.
-
(1996)
Genes Dev
, vol.10
, pp. 2411-2422
-
-
Xu, Y.1
Ashley, T.2
Brainerd, E.E.3
Bronson, R.T.4
Meyn, M.S.5
Baltimore, D.6
-
80
-
-
15844409553
-
Positional cloning of the Werner's syndrome gene
-
C.E. Yu, J. Oshima, Y.H. Fu, E.M. Wijsman, F. Hisama, R. Alisch, et al. (1996) Positional cloning of the Werner's syndrome gene. Science 272
-
(1996)
Science
, vol.272
-
-
Yu, C.E.1
Oshima, J.2
Fu, Y.H.3
Wijsman, E.M.4
Hisama, F.5
Alisch, R.6
|