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Volumn , Issue , 2006, Pages 601-618

Mouse Models of Accelerated Aging

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EID: 84882814675     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012369391-4/50050-3     Document Type: Chapter
Times cited : (2)

References (80)
  • 1
    • 0026782895 scopus 로고
    • Deleterious mitochondrial DNA mutations accumulate in aging human tissues
    • N. Arnheim and G. Cortopassi (1992) Deleterious mitochondrial DNA mutations accumulate in aging human tissues. Mutat Res 275 157-167.
    • (1992) Mutat Res , vol.275 , pp. 157-167
    • Arnheim, N.1    Cortopassi, G.2
  • 2
    • 0034632717 scopus 로고    scopus 로고
    • Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
    • S.E. Artandi, S. Chang, S.-L. Lee, S. Alson, G.J. Gottlieb, L. Chin and R.A. DePinho (2000) Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 406 641-645.
    • (2000) Nature , vol.406 , pp. 641-645
    • Artandi, S.E.1    Chang, S.2    Lee, S.-L.3    Alson, S.4    Gottlieb, G.J.5    Chin, L.6    DePinho, R.A.7
  • 3
    • 3042761646 scopus 로고    scopus 로고
    • BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice
    • D.J. Baker, K.B. Jeganathan, J.D. Cameron, M. Thompson, S. Juneja, A. Kopecka, et al. (2004) BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nat Genet 36 744-749.
    • (2004) Nat Genet , vol.36 , pp. 744-749
    • Baker, D.J.1    Jeganathan, K.B.2    Cameron, J.D.3    Thompson, M.4    Juneja, S.5    Kopecka, A.6
  • 4
    • 13944276264 scopus 로고    scopus 로고
    • Life extension in the dwarf mouse
    • A. Bartke and H. Brown-Borg (2004) Life extension in the dwarf mouse. Curr Top Dev Biol 63 189-225.
    • (2004) Curr Top Dev Biol , vol.63 , pp. 189-225
    • Bartke, A.1    Brown-Borg, H.2
  • 5
    • 0036553049 scopus 로고    scopus 로고
    • Consequences of growth hormone (GH) overexpression and GH resistance
    • A. Bartke, V. Chandrashekar, B. Bailey, D. Zaczek and D. Turyn (2002) Consequences of growth hormone (GH) overexpression and GH resistance. Neuropeptides 36 201-208.
    • (2002) Neuropeptides , vol.36 , pp. 201-208
    • Bartke, A.1    Chandrashekar, V.2    Bailey, B.3    Zaczek, D.4    Turyn, D.5
  • 6
    • 0036791026 scopus 로고    scopus 로고
    • Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect
    • M.O. Bergo, B. Gavino, J. Ross, W.K. Schmidt, C. Hong, L.V. Kendall, et al. (2002) Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect. Proc Natl Acad Sci USA 99 13049-13054.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13049-13054
    • Bergo, M.O.1    Gavino, B.2    Ross, J.3    Schmidt, W.K.4    Hong, C.5    Kendall, L.V.6
  • 7
    • 14544277627 scopus 로고    scopus 로고
    • Telomeres and telomerase: their mechanisms of action and the effects of altering their functions
    • E.H. Blackburn (2005) Telomeres and telomerase: their mechanisms of action and the effects of altering their functions. FEBS Lett 579 859-862.
    • (2005) FEBS Lett , vol.579 , pp. 859-862
    • Blackburn, E.H.1
  • 8
    • 0030931491 scopus 로고    scopus 로고
    • Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
    • M.A. Blasco, H.W. Lee, M.P. Hande, E. Samper, P.M. Lansdorp, R.A. DePinho, et al. (1997) Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91 25-34.
    • (1997) Cell , vol.91 , pp. 25-34
    • Blasco, M.A.1    Lee, H.W.2    Hande, M.P.3    Samper, E.4    Lansdorp, P.M.5    DePinho, R.A.6
  • 9
    • 0025841730 scopus 로고
    • Reduction in rate of occurrence of age-related lesions in dietary restricted laboratory mice
    • R.T. Bronson and R.D. Lipman (1991) Reduction in rate of occurrence of age-related lesions in dietary restricted laboratory mice. Growth, Development & Aging 55 169-184.
    • (1991) Growth, Development & Aging , vol.55 , pp. 169-184
    • Bronson, R.T.1    Lipman, R.D.2
  • 10
    • 13944270339 scopus 로고    scopus 로고
    • Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
    • J. Campisi (2005) Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 120 513-522.
    • (2005) Cell , vol.120 , pp. 513-522
    • Campisi, J.1
  • 11
    • 0037439071 scopus 로고    scopus 로고
    • Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brcal full-length isoform
    • L. Cao, W. Li, S. Kim, S.G. Brodie and C.X. Deng (2003) Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brcal full-length isoform. Genes Dev 17 201-213.
    • (2003) Genes Dev , vol.17 , pp. 201-213
    • Cao, L.1    Li, W.2    Kim, S.3    Brodie, S.G.4    Deng, C.X.5
  • 12
    • 3543043128 scopus 로고    scopus 로고
    • Essential role of limiting telomeres in the pathogenesis of Werner syndrome
    • S. Chang, A.S. Multani, N.G. Cabrera, M.L. Naylor, P. Laud, D. Lombard, et al. (2004) Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nat Genet 36 877-882.
    • (2004) Nat Genet , vol.36 , pp. 877-882
    • Chang, S.1    Multani, A.S.2    Cabrera, N.G.3    Naylor, M.L.4    Laud, P.5    Lombard, D.6
  • 13
    • 0141814680 scopus 로고    scopus 로고
    • Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
    • H.L. Cheng, R. Mostoslavsky, S. Saito, J.P. Manis, Y. Gu, P. Patel, et al. (2003) Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci USA 100 10794-10799.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 10794-10799
    • Cheng, H.L.1    Mostoslavsky, R.2    Saito, S.3    Manis, J.P.4    Gu, Y.5    Patel, P.6
  • 14
    • 3242876404 scopus 로고    scopus 로고
    • Ataxia-telangiectasia, an evolving phenotype
    • H.H. Chun and R.A. Gatti (2004) Ataxia-telangiectasia, an evolving phenotype. DNA Repair (Amst) 3 1187-1196.
    • (2004) DNA Repair (Amst) , vol.3 , pp. 1187-1196
    • Chun, H.H.1    Gatti, R.A.2
  • 16
    • 0032085182 scopus 로고    scopus 로고
    • A mouse model for the basal transcription/DNA repair syndrome trichothiodystrophy
    • J. de Boer, J. de Wit, H. van Steeg, R.J. Berg, H. Morreau, P. Visser, et al. (1998) A mouse model for the basal transcription/DNA repair syndrome trichothiodystrophy. Mol Cell I 981-990.
    • (1998) Mol Cell I , pp. 981-990
    • de Boer, J.1    de Wit, J.2    van Steeg, H.3    Berg, R.J.4    Morreau, H.5    Visser, P.6
  • 17
    • 0029083409 scopus 로고
    • Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA
    • A. de Vries, C.T. van Oostrom, F.M. Hofhuis, P.M. Dortant, R.J. Berg, F.R. de Gruijl, et al. (1995) Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA. Nature 377 169-173.
    • (1995) Nature , vol.377 , pp. 169-173
    • de Vries, A.1    van Oostrom, C.T.2    Hofhuis, F.M.3    Dortant, P.M.4    Berg, R.J.5    de Gruijl, F.R.6
  • 18
    • 0034626769 scopus 로고    scopus 로고
    • The age of cancer
    • R.A. DePinho (2000) The age of cancer. Nature 408 248-254.
    • (2000) Nature , vol.408 , pp. 248-254
    • DePinho, R.A.1
  • 19
    • 0034732239 scopus 로고    scopus 로고
    • DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation
    • M.J. Difilippantonio, J. Zhu, H.T. Chen, E. Meffre, M.C. Nussenzweig, E.E. Max, et al. (2000) DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation. Nature 404 510-514.
    • (2000) Nature , vol.404 , pp. 510-514
    • Difilippantonio, M.J.1    Zhu, J.2    Chen, H.T.3    Meffre, E.4    Nussenzweig, M.C.5    Max, E.E.6
  • 20
    • 0036851242 scopus 로고    scopus 로고
    • Genome dynamics in aging mice
    • M.E. Dolle and J. Vijg (2002) Genome dynamics in aging mice. Genome Res 12 1732-1738.
    • (2002) Genome Res , vol.12 , pp. 1732-1738
    • Dolle, M.E.1    Vijg, J.2
  • 23
    • 0013839230 scopus 로고
    • Werner's syndrome: caricature of aging a genetic model for the study of degenerative diseases
    • C.J. Epstein, G.M. Martin and A.G. Motulsky (1965) Werner's syndrome: caricature of aging a genetic model for the study of degenerative diseases. Trans Assoc Am Physicians 78 73-81.
    • (1965) Trans Assoc Am Physicians , vol.78 , pp. 73-81
    • Epstein, C.J.1    Martin, G.M.2    Motulsky, A.G.3
  • 24
    • 0037673950 scopus 로고    scopus 로고
    • Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome
    • M. Eriksson, W.T. Brown, L.B. Gordon, M.W. Glynn, J. Singer, L. Scott, et al. (2003) Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature 423 293-298.
    • (2003) Nature , vol.423 , pp. 293-298
    • Eriksson, M.1    Brown, W.T.2    Gordon, L.B.3    Glynn, M.W.4    Singer, J.5    Scott, L.6
  • 25
    • 2942547771 scopus 로고    scopus 로고
    • Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice
    • S. Espejel, M. Martin, P. Klatt, J. Martin-Caballero, J.M. Flores and M.A. Blasco (2004) Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice. EMBO Rep 5 503-509.
    • (2004) EMBO Rep , vol.5 , pp. 503-509
    • Espejel, S.1    Martin, M.2    Klatt, P.3    Martin-Caballero, J.4    Flores, J.M.5    Blasco, M.A.6
  • 26
    • 0024465870 scopus 로고
    • Mutator phenotype of Werner syndrome is characterized by extensive deletions
    • K. Fukuchi, G.M. Martin and R.J. Monnat Jr. (1989) Mutator phenotype of Werner syndrome is characterized by extensive deletions. Proc Natl Acad Sci USA 86 5893-5897.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 5893-5897
    • Fukuchi, K.1    Martin, G.M.2    Monnat, R.J.3
  • 27
    • 0028033989 scopus 로고
    • The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase
    • S. Gangloff, J.P. McDonald, C. Bendixen, L. Arthur and R. Rothstein (1994) The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase. Mol Cell Biol 14 8391-8398.
    • (1994) Mol Cell Biol , vol.14 , pp. 8391-8398
    • Gangloff, S.1    McDonald, J.P.2    Bendixen, C.3    Arthur, L.4    Rothstein, R.5
  • 28
    • 0037112844 scopus 로고    scopus 로고
    • “Super p53” mice exhibit enhanced DNA damage response, are tumor resistant and age normally
    • I. Garcia-Cao, M. Garcia-Cao, J. Martin-Caballero, L.M. Criado, P. Klatt, J.M. Flores, et al. (2002) “Super p53” mice exhibit enhanced DNA damage response, are tumor resistant and age normally. Embo J 21 6225-6235.
    • (2002) Embo J , vol.21 , pp. 6225-6235
    • Garcia-Cao, I.1    Garcia-Cao, M.2    Martin-Caballero, J.3    Criado, L.M.4    Klatt, P.5    Flores, J.M.6
  • 29
    • 0030691121 scopus 로고    scopus 로고
    • Hierarchical deterioration of body systems in Werner's syndrome: implications for normal ageing
    • M. Goto (1997) Hierarchical deterioration of body systems in Werner's syndrome: implications for normal ageing. Mech Ageing Dev 98 239-254.
    • (1997) Mech Ageing Dev , vol.98 , pp. 239-254
    • Goto, M.1
  • 33
    • 25444501240 scopus 로고    scopus 로고
    • Aneuploidy-cancer predis-position syndromes: a new link between the mitotic spindle checkpoint and cancer
    • S. Hanks and N. Rahman (2005) Aneuploidy-cancer predis-position syndromes: a new link between the mitotic spindle checkpoint and cancer. Cell Cycle 4 225-227.
    • (2005) Cell Cycle , vol.4 , pp. 225-227
    • Hanks, S.1    Rahman, N.2
  • 35
    • 4544377929 scopus 로고    scopus 로고
    • Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity
    • P. Hasty and J. Vijg (2004) Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity. Aging Cell 3 55-65.
    • (2004) Aging Cell , vol.3 , pp. 55-65
    • Hasty, P.1    Vijg, J.2
  • 36
    • 0035902108 scopus 로고    scopus 로고
    • Genome maintenance mechanisms for preventing cancer
    • J.H. Hoeijmakers (2001) Genome maintenance mechanisms for preventing cancer. Nature 411 366-374.
    • (2001) Nature , vol.411 , pp. 366-374
    • Hoeijmakers, J.H.1
  • 37
    • 1542267804 scopus 로고    scopus 로고
    • Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification
    • T. Hosaka, W.H. Biggs 3rd, D. Tieu, A.D. Boyer, N.M. Varki, W.K. Cavenee, et al. (2004) Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. Proc Natl Acad Sci USA 101 2975-2980.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 2975-2980
    • Hosaka, T.1    Biggs, W.H.2    Tieu, D.3    Boyer, A.D.4    Varki, N.M.5    Cavenee, W.K.6
  • 38
    • 13944256856 scopus 로고    scopus 로고
    • Fitness cost of extended lifespan in Caenorhabditis elegans
    • N.L. Jenkins, G. McColl and G.J. Lithgow (2004) Fitness cost of extended lifespan in Caenorhabditis elegans. Proc Biol Sci 271 2523-2526.
    • (2004) Proc Biol Sci , vol.271 , pp. 2523-2526
    • Jenkins, N.L.1    McColl, G.2    Lithgow, G.J.3
  • 40
    • 13944262937 scopus 로고    scopus 로고
    • Understanding the odd science of aging
    • T.B. Kirkwood (2005) Understanding the odd science of aging. Cell 120 437-447.
    • (2005) Cell , vol.120 , pp. 437-447
    • Kirkwood, T.B.1
  • 41
    • 0020070207 scopus 로고
    • Cytogerontology since 1881: a reappraisal of August Weismann and a review of modern progress
    • T.B. Kirkwood and T. Cremer (1982) Cytogerontology since 1881: a reappraisal of August Weismann and a review of modern progress. Hum Genet 60 101-121.
    • (1982) Hum Genet , vol.60 , pp. 101-121
    • Kirkwood, T.B.1    Cremer, T.2
  • 43
    • 0035826797 scopus 로고    scopus 로고
    • Mice lacking DNA topoisomerase IIIbeta develop to maturity but show a reduced mean lifespan
    • K.Y. Kwan and J.C. Wang (2001) Mice lacking DNA topoisomerase IIIbeta develop to maturity but show a reduced mean lifespan. Proc Natl Acad Sci USA 98 5717-5721.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 5717-5721
    • Kwan, K.Y.1    Wang, J.C.2
  • 45
    • 0035266463 scopus 로고    scopus 로고
    • Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase
    • M. Lebel, R.D. Cardiff and P. Leder (2001) Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase. Cancer Res 61 1816-1819.
    • (2001) Cancer Res , vol.61 , pp. 1816-1819
    • Lebel, M.1    Cardiff, R.D.2    Leder, P.3
  • 46
    • 0032573157 scopus 로고    scopus 로고
    • A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity
    • M. Lebel and P. Leder (1998) A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity. Proc Natl Acad Sci USA 95 13097-13102.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 13097-13102
    • Lebel, M.1    Leder, P.2
  • 47
    • 0942268166 scopus 로고    scopus 로고
    • DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy
    • A.R. Lehmann (2003) DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy. Biochimie 85 1101-1111.
    • (2003) Biochimie , vol.85 , pp. 1101-1111
    • Lehmann, A.R.1
  • 48
    • 0034737004 scopus 로고    scopus 로고
    • Rothmund-Thomson syndrome due to RECQ4 helicase mutations: report and clinical and molecular comparisons with Bloom syndrome and Werner syndrome
    • N.M. Lindor, Y. Furuichi, S. Kitao, A. Shimamoto, C. Arndt and S. Jalal (2000) Rothmund-Thomson syndrome due to RECQ4 helicase mutations: report and clinical and molecular comparisons with Bloom syndrome and Werner syndrome. Am J Med Genet 90 223-228.
    • (2000) Am J Med Genet , vol.90 , pp. 223-228
    • Lindor, N.M.1    Furuichi, Y.2    Kitao, S.3    Shimamoto, A.4    Arndt, C.5    Jalal, S.6
  • 52
  • 53
    • 13944280713 scopus 로고    scopus 로고
    • Genetic modulation of senescent phenotypes in Homo sapiens
    • G.M. Martin (2005) Genetic modulation of senescent phenotypes in Homo sapiens. Cell 120 523-532.
    • (2005) Cell , vol.120 , pp. 523-532
    • Martin, G.M.1
  • 54
    • 0033581704 scopus 로고    scopus 로고
    • The p66shc adaptor protein controls oxidative stress response and life span in mammals
    • E. Migliaccio, M. Giorgio, S. Mele, G. Pelicci, P. Reboldi, P.P. Pandolfi, et al. (1999) The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature 402 309-313.
    • (1999) Nature , vol.402 , pp. 309-313
    • Migliaccio, E.1    Giorgio, M.2    Mele, S.3    Pelicci, G.4    Reboldi, P.5    Pandolfi, P.P.6
  • 55
    • 1342264308 scopus 로고    scopus 로고
    • Mammalian SIRT1 represses forkhead transcription factors
    • M.C. Motta, N. Divecha, M. Lemieux, C. Kamel, D. Chen, W. Gu, et al. (2004) Mammalian SIRT1 represses forkhead transcription factors. Cell 116 551-563.
    • (2004) Cell , vol.116 , pp. 551-563
    • Motta, M.C.1    Divecha, N.2    Lemieux, M.3    Kamel, C.4    Chen, D.5    Gu, W.6
  • 56
    • 0037673940 scopus 로고    scopus 로고
    • A progeroid syndrome in mice is caused by defects in A-type lamins
    • L.C. Mounkes, S. Kozlov, L. Hernandez, T. Sullivan and C.L. Stewart (2003) A progeroid syndrome in mice is caused by defects in A-type lamins. Nature 423 298-301.
    • (2003) Nature , vol.423 , pp. 298-301
    • Mounkes, L.C.1    Kozlov, S.2    Hernandez, L.3    Sullivan, T.4    Stewart, C.L.5
  • 58
    • 7244239317 scopus 로고    scopus 로고
    • Hutchinson-Gilford progeria syndrome
    • R.L. Pollex and R.A. Hegele (2004) Hutchinson-Gilford progeria syndrome. Clin Genet 66 375-381.
    • (2004) Clin Genet , vol.66 , pp. 375-381
    • Pollex, R.L.1    Hegele, R.A.2
  • 59
    • 0033010781 scopus 로고    scopus 로고
    • Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase
    • M. Poot, K.A. Gollahon and P.S. Rabinovitch (1999) Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase. Hum Genet 104 10-14.
    • (1999) Hum Genet , vol.104 , pp. 10-14
    • Poot, M.1    Gollahon, K.A.2    Rabinovitch, P.S.3
  • 61
    • 0033525558 scopus 로고    scopus 로고
    • Longevity, stress response, and cancer in aging telomerase-deficient mice
    • K.L. Rudolph, S. Chang, H.W. Lee, M. Blasco, G.J. Gottlieb, C. Greider, et al. (1999) Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell 96 701-712.
    • (1999) Cell , vol.96 , pp. 701-712
    • Rudolph, K.L.1    Chang, S.2    Lee, H.W.3    Blasco, M.4    Gottlieb, G.J.5    Greider, C.6
  • 62
    • 0037365789 scopus 로고    scopus 로고
    • ATM and related protein kinases: safeguarding genome integrity
    • Y. Shiloh (2003) ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer 3 155-168.
    • (2003) Nat Rev Cancer , vol.3 , pp. 155-168
    • Shiloh, Y.1
  • 63
    • 25144516017 scopus 로고    scopus 로고
    • Recombination at mammalian telomeres: An alternative mechanism for telomere protection and elongation
    • M. Tarsounas and S.C. West (2005) Recombination at mammalian telomeres: An alternative mechanism for telomere protection and elongation. Cell Cycle 4
    • (2005) Cell Cycle , vol.4
    • Tarsounas, M.1    West, S.C.2
  • 64
    • 0037470501 scopus 로고    scopus 로고
    • The endocrine regulation of aging by insulin-like signals
    • M. Tatar, A. Bartke and A. Antebi (2003) The endocrine regulation of aging by insulin-like signals. Science 299 1346-1351.
    • (2003) Science , vol.299 , pp. 1346-1351
    • Tatar, M.1    Bartke, A.2    Antebi, A.3
  • 67
    • 0035289717 scopus 로고    scopus 로고
    • Chromosomal stability and the DNA double-stranded break connection
    • D.C. Van Gent, J.H. Hoeijmakers and R. Kanaar (2001) Chromosomal stability and the DNA double-stranded break connection. Nat Rev Genet 2 196-206.
    • (2001) Nat Rev Genet , vol.2 , pp. 196-206
    • Van Gent, D.C.1    Hoeijmakers, J.H.2    Kanaar, R.3
  • 69
    • 0037198009 scopus 로고    scopus 로고
    • Large genome rearrangements as a primary cause of aging
    • J. Vijg and M.E. Dollé (2002) Large genome rearrangements as a primary cause of aging. Mech Ageing Dev 123 907-915.
    • (2002) Mech Ageing Dev , vol.123 , pp. 907-915
    • Vijg, J.1    Dollé, M.E.2
  • 73
    • 0024324482 scopus 로고
    • A hyper-recombination mutation in S. cerevisiae identifies a novel eukaryotic topoisomerase
    • J.W. Wallis, G. Chrebet, G. Brodsky, M. Rolfe and R. Rothstein (1989) A hyper-recombination mutation in S. cerevisiae identifies a novel eukaryotic topoisomerase. Cell 58 409-419.
    • (1989) Cell , vol.58 , pp. 409-419
    • Wallis, J.W.1    Chrebet, G.2    Brodsky, G.3    Rolfe, M.4    Rothstein, R.5
  • 74
    • 12644266319 scopus 로고    scopus 로고
    • Disruption of mouse ERCCI results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence
    • G. Weeda, I. Donker, J. de Wit, H. Morreau, R. Janssens, C.J. Vissers, et al. (1997) Disruption of mouse ERCCI results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence. Curr Biol 7 427-439.
    • (1997) Curr Biol , vol.7 , pp. 427-439
    • Weeda, G.1    Donker, I.2    de Wit, J.3    Morreau, H.4    Janssens, R.5    Vissers, C.J.6
  • 76
    • 0000055057 scopus 로고
    • Pleiotropy, natural selection, and the evolution of senescence
    • G.C. Williams (1957) Pleiotropy, natural selection, and the evolution of senescence. Evolution 11 398-411.
    • (1957) Evolution , vol.11 , pp. 398-411
    • Williams, G.C.1
  • 78
    • 0037421896 scopus 로고    scopus 로고
    • Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing
    • K.K. Wong, R.S. Maser, R.M. Bachoo, J. Menon, D.R. Carrasco, Y. Gu, et al. (2003) Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature 421 643-648.
    • (2003) Nature , vol.421 , pp. 643-648
    • Wong, K.K.1    Maser, R.S.2    Bachoo, R.M.3    Menon, J.4    Carrasco, D.R.5    Gu, Y.6
  • 79
    • 0029844048 scopus 로고    scopus 로고
    • Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma
    • Y. Xu, T. Ashley, E.E. Brainerd, R.T. Bronson, M.S. Meyn and D. Baltimore (1996) Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev 10 2411-2422.
    • (1996) Genes Dev , vol.10 , pp. 2411-2422
    • Xu, Y.1    Ashley, T.2    Brainerd, E.E.3    Bronson, R.T.4    Meyn, M.S.5    Baltimore, D.6


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