Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect

Proceedings of the National Academy of Sciences of the United States of America

Volumn 99, Issue 20, 2002, Pages 13049-13054

  Bergo, Martin O ^a   Gavino, Bryant ^a   Ross, Jed ^b   Schmidt, Walter K ^c   Hong, Christine ^a   Kendall, Lonnie V ^d   Mohr, Andreas ^e   Meta, Margarita ^e   Genant, Harry ^e   Jiang, Yebin ^e   Wisner, Erik R ^d   Van Bruggen, Nicholas ^b   Carano, Richard A D ^b   Michaelis, Susan ^c   Griffey, Stephen M ^d   Young, Stephen G ^a,f  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b GENENTECH INC   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f SAN FRANCISCO GENERAL HOSPITAL   (United States)

Author keywords

Brittle bones; CAAX motif; Knockout mice; Metalloproteinase

Indexed keywords

ENZYME; PROTEIN; PROTEIN PRELAMIN A; PROTEIN RCE1; PROTEIN ZMPSTE24; PROTEINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARM; ARTICLE; CELL ASSAY; CONTROLLED STUDY; CORTICAL BONE; DISEASE COURSE; DISEASE MODEL; ENZYME DEFICIENCY; FIBROBLAST; HAIR LOSS; LEG; MALNUTRITION; MAMMAL; MOUSE; MUSCLE WEAKNESS; NONHUMAN; OSTEOGENESIS IMPERFECTA; PATHOLOGIC FRACTURE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PROCESSING; TRABECULAR BONE; WEIGHT GAIN;

AGE FACTORS; ANIMALS; BACTERIAL PROTEINS; BONE AND BONES; CELL MEMBRANE; FIBROBLASTS; LAMIN TYPE A; MATRIX METALLOPROTEINASES; MEMBRANE PROTEINS; METALLOENDOPEPTIDASES; MICE; MICE, INBRED C57BL; MUSCLE WEAKNESS; MUSCLES; NUCLEAR PROTEINS; PHENOTYPE; PROTEIN PRECURSORS; PROTEIN STRUCTURE, TERTIARY; TIME FACTORS; TOMOGRAPHY, X-RAY COMPUTED;

ANIMALIA; MAMMALIA;

EID: 0036791026     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.192460799     Document Type: Article

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