-
1
-
-
84882515412
-
-
Pharma SNP Consortium of the Japan Pharmaceutical Manufacturers Association
-
Pharma SNP Consortium of the Japan Pharmaceutical Manufacturers Association. (Internet at http://www.jpma.or.jp/12english/publications/pub019b_genome;http:/.
-
-
-
-
2
-
-
0347136014
-
The genetic polymorphism of drug transporters: Functional analysis approaches
-
Ishikawa T, Tsuji A, Inui K, Sai Y, Anzai N, Wada M, et al. The genetic polymorphism of drug transporters: Functional analysis approaches. Pharmacogenomics 2004, 5:189-199.
-
(2004)
Pharmacogenomics
, vol.5
, pp. 189-199
-
-
Ishikawa, T.1
Tsuji, A.2
Inui, K.3
Sai, Y.4
Anzai, N.5
Wada, M.6
-
3
-
-
84882504021
-
-
SNP Consortium Ltd
-
SNP Consortium Ltd. (Internet at http://snp.cshl.org.).
-
-
-
-
4
-
-
84882545319
-
-
National Center for Biotechnology Information Entrez SNP interface
-
National Center for Biotechnology Information Entrez SNP interface. (Internet at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=Limits&DB=snp.).
-
-
-
-
6
-
-
0033487121
-
Second AAPS-NIH frontier symposium: Membrane transporters drug therapy. American Association of Pharmaceutical Sciences
-
Internet at
-
Pang DC, Amidon GL, Preusch PC, Sadée W. Second AAPS-NIH frontier symposium: Membrane transporters drug therapy. American Association of Pharmaceutical Sciences. AAPS PharmSci 1999, 1:E7. Internet at. http://www.aapsj.org/view.asp?art=ps010205.
-
(1999)
AAPS PharmSci
, vol.1
-
-
Pang, D.C.1
Amidon, G.L.2
Preusch, P.C.3
Sadée, W.4
-
9
-
-
0040112968
-
-
Kluwer Academic/Plenum Publishers, New York, A. GL, S.-A. W (Eds.)
-
Membrane transporters as drug targets 1999, Kluwer Academic/Plenum Publishers, New York. A. GL, S.-A. W (Eds.).
-
(1999)
Membrane transporters as drug targets
-
-
-
10
-
-
0003890246
-
Principles and models of biological transport
-
Springer-Verlag, New York
-
Friedman MH Principles and models of biological transport 1986, Springer-Verlag, New York.
-
(1986)
-
-
Friedman, M.H.1
-
11
-
-
0003923044
-
Channels, carriers, and pumps: An introduction to membrane transport
-
Academic Press, New York
-
Stein WD Channels, carriers, and pumps: An introduction to membrane transport 1990, Academic Press, New York.
-
(1990)
-
-
Stein, W.D.1
-
12
-
-
0001903482
-
Bacterial transport as an import mechanism and target for antimicrobials
-
Marcel Dekker, Inc., New York, G. NH (Ed.)
-
Hancock REW Bacterial transport as an import mechanism and target for antimicrobials. Drug transport in antimi-crobial and anticancer chemotherapy 1995, 1204-1210. Marcel Dekker, Inc., New York. G. NH (Ed.).
-
(1995)
Drug transport in antimi-crobial and anticancer chemotherapy
, pp. 1204-1210
-
-
Hancock, R.E.W.1
-
13
-
-
84882469418
-
Biomembrane transport
-
Academic Press, San Diego
-
Van Winkle LJ Biomembrane transport 1999, Academic Press, San Diego.
-
(1999)
-
-
Van, W.L.J.1
-
14
-
-
0003974063
-
Basic transport phenomena in biomed-ical engineering
-
Taylor & Frances Publishers, Philadelphia
-
Fournier RL Basic transport phenomena in biomed-ical engineering 1999, Taylor & Frances Publishers, Philadelphia.
-
(1999)
-
-
Fournier, R.L.1
-
15
-
-
0004244842
-
Equations of membrane biophysics
-
Academic Press, New York
-
Lakshminarayanaiah N Equations of membrane biophysics 1984, Academic Press, New York.
-
(1984)
-
-
Lakshminarayanaiah, N.1
-
16
-
-
0018750834
-
Digoxin-quinidine inter-action
-
Hager WD, Fenster P, Mayersohn M, Perrier D, Graves P, Marcus FI, et al. Digoxin-quinidine inter-action. N Engl J Med 1979, 300:513-517.
-
(1979)
N Engl J Med
, vol.300
, pp. 513-517
-
-
Hager, W.D.1
Fenster, P.2
Mayersohn, M.3
Perrier, D.4
Graves, P.5
Marcus, F.I.6
-
17
-
-
33751385411
-
Solute diffusion in lipid bilayer membranes: An atomic level study by molecular dynamics simulation
-
Bassolino-Klimas D, Alper HE, Stouch TR. Solute diffusion in lipid bilayer membranes: An atomic level study by molecular dynamics simulation. Biochem-istry 1993, 32:1494-1501.
-
(1993)
Biochem-istry
, vol.32
, pp. 1494-1501
-
-
Bassolino-klimas, D.1
Alper, H.E.2
Stouch, T.R.3
-
18
-
-
0029896615
-
Drug-membrane interactions studied by molecular dynamics simula-tion: Size dependence of diffusion
-
Bassolino D, Alper H, Stouch TR. Drug-membrane interactions studied by molecular dynamics simula-tion: Size dependence of diffusion. Drug Des Discov 1996, 13:334-339.
-
(1996)
Drug Des Discov
, vol.13
, pp. 334-339
-
-
Bassolino, D.1
Alper, H.2
Stouch, T.R.3
-
19
-
-
2342505916
-
Permeation of small molecules through a lipid bilayer: A computer simulation study
-
Bemporad D, Essex JW, Luttmann C. Permeation of small molecules through a lipid bilayer: A computer simulation study. J Phys Chem B 2004, 108:S156-S162.
-
(2004)
J Phys Chem B
, vol.108
-
-
Bemporad, D.1
Essex, J.W.2
Luttmann, C.3
-
20
-
-
3042813458
-
Computer sim-ulation of small molecule permeation across a lipid bilayer: Dependence on bilayer properties solute volume size and cross-sectional area
-
Bemporad D, Luttmann C, Essex JW. Computer sim-ulation of small molecule permeation across a lipid bilayer: Dependence on bilayer properties solute volume size and cross-sectional area. Biophys J 2004, 87:519-525.
-
(2004)
Biophys J
, vol.87
, pp. 519-525
-
-
Bemporad, D.1
Luttmann, C.2
Essex, J.W.3
-
21
-
-
0003955925
-
Exploring QSAR fundamentals and applications in chemistry and biology
-
American Chemical Society, Washington, DC
-
Hansch C, Leo A Exploring QSAR fundamentals and applications in chemistry and biology 1995, American Chemical Society, Washington, DC.
-
(1995)
-
-
Hansch, C.1
Leo, A.2
-
22
-
-
84882495718
-
Absorption, distribution, and metabolism of drugs
-
Academic Press, New York, T. JG (Ed.)
-
Austel B, Kutter R Absorption, distribution, and metabolism of drugs. Quantitative structure/activity relationships. Medicinal chemistry monographs 1983, vol 19:787-791. Academic Press, New York. T. JG (Ed.).
-
(1983)
Quantitative structure/activity relationships. Medicinal chemistry monographs
, vol.19
, pp. 787-791
-
-
Austel, B.1
Kutter, R.2
-
23
-
-
0031024064
-
Immobilized artificial membranes - screens for drug membrane interactions
-
Yang CY, Cai SJ, Liu H, Pidgeon C Immobilized artificial membranes - screens for drug membrane interactions. Adv Drug Del. Rev 1997, 23:708-717.
-
(1997)
Adv Drug Del. Rev
, vol.23
, pp. 708-717
-
-
Yang, C.Y.1
Cai, S.J.2
Liu, H.3
Pidgeon, C.4
-
24
-
-
0029991481
-
Immobilized artificial mem-brane chromatography: Measurements of membrane partition coefficient and predicting drug membrane permeability
-
Ong S, Liu H, Pidgeon C. Immobilized artificial mem-brane chromatography: Measurements of membrane partition coefficient and predicting drug membrane permeability. J Chromatogr A 1996, 728:521-526.
-
(1996)
J Chromatogr A
, vol.728
, pp. 521-526
-
-
Ong, S.1
Liu, H.2
Pidgeon, C.3
-
25
-
-
0031024171
-
Experimental and computational approaches to esti-mates solubility and permeability in drug discovery and development settings
-
Lipinski CA, Lombardo F, Dominy BW, Feeney PJ. Experimental and computational approaches to esti-mates solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 1997, 23:141.
-
(1997)
Adv Drug Deliv Rev
, vol.23
, pp. 141
-
-
Lipinski, C.A.1
Lombardo, F.2
Dominy, B.W.3
Feeney, P.J.4
-
26
-
-
0008932795
-
Tetracycline uptake and efflux in bacteria
-
Marcel Dekker, Inc., New York, G. NH (Ed.)
-
Chopra I Tetracycline uptake and efflux in bacteria. Drug transport in antimicrobial and anticancer chemotherapy 1995, 2129-2139. Marcel Dekker, Inc., New York. G. NH (Ed.).
-
(1995)
Drug transport in antimicrobial and anticancer chemotherapy
, pp. 2129-2139
-
-
Chopra, I.1
-
27
-
-
0032959549
-
Phase I clinical and pharmacokinetic study of PK1 [N-(2-hydroxypropyl) -methacylamide copolymer doxorubicin]: First member of a new class of chemotherapeutic
-
Vasey PA, Kaye SB, Morrison R, Twelves C, Wilson P, Duncan R, et al. Phase I clinical and pharmacokinetic study of PK1 [N-(2-hydroxypropyl) -methacylamide copolymer doxorubicin]: First member of a new class of chemotherapeutic. Clin Cancer Res 1999, 5:265-270.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 265-270
-
-
Vasey, P.A.1
Kaye, S.B.2
Morrison, R.3
Twelves, C.4
Wilson, P.5
Duncan, R.6
-
28
-
-
0031965514
-
Uptake and intracellular distribution of 4-amino-fluorescein-labelled poly (L-lysine citramide imide) in K562 cells
-
Abdellaoui K, Boustta M, Morjani H, Vert M. Uptake and intracellular distribution of 4-amino-fluorescein-labelled poly (L-lysine citramide imide) in K562 cells. J Drug Target 1998, 5:39-42.
-
(1998)
J Drug Target
, vol.5
, pp. 39-42
-
-
Abdellaoui, K.1
Boustta, M.2
Morjani, H.3
Vert, M.4
-
29
-
-
0031777867
-
Recent advances in intestinal macro-molecular drug delivery via receptor-mediated trans-port pathways
-
Swaan PW. Recent advances in intestinal macro-molecular drug delivery via receptor-mediated trans-port pathways. Pharm Res 1998, 15:1690-1698.
-
(1998)
Pharm Res
, vol.15
, pp. 1690-1698
-
-
Swaan, P.W.1
-
30
-
-
0017585201
-
Gentamicin disposition and tissue accumulation on multiple dosing
-
Schentag JJ, Jusko WJ, Vance JW, Cumbo TJ, Abrutyn E, DeLattre M, Gerbracht LM. Gentamicin disposition and tissue accumulation on multiple dosing. J Pharmacokinet Biopharm 1977, 5:2285-2293.
-
(1977)
J Pharmacokinet Biopharm
, vol.5
, pp. 2285-2293
-
-
Schentag, J.J.1
Jusko, W.J.2
Vance, J.W.3
Cumbo, T.J.4
Abrutyn, E.5
DeLattre, M.6
Gerbracht, L.M.7
-
31
-
-
0020077075
-
Aminoglycoside nephrotoxic-ity -a tale of two transports
-
Whelton A, Solez K. Aminoglycoside nephrotoxic-ity -a tale of two transports. J Lab Clin Med 1982, 99:E7.
-
(1982)
J Lab Clin Med
, vol.99
-
-
Whelton, A.1
Solez, K.2
-
32
-
-
0020003714
-
Effect of basic amino acids and amino-glycosides on 3H-gentamicin uptake in cortical slices of rat and human kidney
-
Bennett WM, Plamp CE, Elliott WC, Parker RA, Porter GA. Effect of basic amino acids and amino-glycosides on 3H-gentamicin uptake in cortical slices of rat and human kidney. J Lab Clin Med 1982, 99:7-9.
-
(1982)
J Lab Clin Med
, vol.99
, pp. 7-9
-
-
Bennett, W.M.1
Plamp, C.E.2
Elliott, W.C.3
Parker, R.A.4
Porter, G.A.5
-
34
-
-
0030754510
-
Once-daily dosing of aminogly-cosides: Review and recommendations for clinical practice
-
Freeman CD, Nicolau DP, Belliveau PP, Nightingale CH. Once-daily dosing of aminogly-cosides: Review and recommendations for clinical practice. J Antimicrob Chemother 1997, 39:289-306.
-
(1997)
J Antimicrob Chemother
, vol.39
, pp. 289-306
-
-
Freeman, C.D.1
Nicolau, D.P.2
Belliveau, P.P.3
Nightingale, C.H.4
-
35
-
-
2942536119
-
Aminoglycoside toxicity: Daily versus thrice-weekly dosing for treatment of mycobacterial diseases
-
Peloquin CA, Berning SE, Nitta AT, Simone PM, Goble M, Huitt GA, Iseman MD, Cook JL, Curran-Everett D. Aminoglycoside toxicity: Daily versus thrice-weekly dosing for treatment of mycobacterial diseases. Clin Infect Dis 2004, 38:1238-1241.
-
(2004)
Clin Infect Dis
, vol.38
, pp. 1238-1241
-
-
Peloquin, C.A.1
Berning, S.E.2
Nitta, A.T.3
Simone, P.M.4
Goble, M.5
Huitt, G.A.6
Iseman, M.D.7
Cook, J.L.8
Curran-everett, D.9
-
36
-
-
4744348954
-
Molecular aspects of renal han-dling of aminoglycosides and strategies for prevent-ing the nephrotoxicity
-
Nagai J, Takano M. Molecular aspects of renal han-dling of aminoglycosides and strategies for prevent-ing the nephrotoxicity. Drug Metab Pharmacokinet 2004, 19:12624-12637.
-
(2004)
Drug Metab Pharmacokinet
, vol.19
, pp. 12624-12637
-
-
Nagai, J.1
Takano, M.2
-
37
-
-
0022539382
-
Kinetics of gen-tamicin uptake release in the rat. Comparison of inner ear tissues and fluids with other organs
-
Tran Ba Huy P, Bernard P, Schacht J. Kinetics of gen-tamicin uptake release in the rat. Comparison of inner ear tissues and fluids with other organs. J Clin Invest 1986, 77:135-141.
-
(1986)
J Clin Invest
, vol.77
, pp. 135-141
-
-
Tran, B.H.P.1
Bernard, P.2
Schacht, J.3
-
38
-
-
0036636358
-
Hearing loss and nephro-toxicity in long-term aminoglycoside treatment of patients with tuberculosis
-
de Jager P, van Altena R. Hearing loss and nephro-toxicity in long-term aminoglycoside treatment of patients with tuberculosis. Int J Tuberc Lung Dis 2002, 6:4875-4884.
-
(2002)
Int J Tuberc Lung Dis
, vol.6
, pp. 4875-4884
-
-
de, J.P.1
van, A.R.2
-
39
-
-
0029448668
-
Vector-mediated delivery of opiod peptides to the brain
-
Bickel U, Pardridge WM. Vector-mediated delivery of opiod peptides to the brain. NIDA Res Monogr 1995, 154:1-13.
-
(1995)
NIDA Res Monogr
, vol.154
, pp. 1-13
-
-
Bickel, U.1
Pardridge, W.M.2
-
40
-
-
84882514750
-
Combined use of carboxyl-directed protein pegylation and vector-mediated blood-brain barrier drug delivery system optimizes brain uptake of brain-derived neur
-
Pardridge WM, Wu D, Sakane T. Combined use of carboxyl-directed protein pegylation and vector-mediated blood-brain barrier drug delivery system optimizes brain uptake of brain-derived neur. Pharm Res 1998, 15:437-496.
-
(1998)
Pharm Res
, vol.15
, pp. 437-496
-
-
Pardridge, W.M.1
Wu, D.2
Sakane, T.3
-
41
-
-
0042899083
-
Blood-brain barrier drug targeting: The future of brain drug development
-
Pardridge WM. Blood-brain barrier drug targeting: The future of brain drug development. Mol Interv 2003, 3:229-256.
-
(2003)
Mol Interv
, vol.3
, pp. 229-256
-
-
Pardridge, W.M.1
-
42
-
-
0042899083
-
Blood-brain barrier drug targeting: The future of brain drug development
-
Pardridge WM. Blood-brain barrier drug targeting: The future of brain drug development. Mol Interv 2003, 3:51.
-
(2003)
Mol Interv
, vol.3
, pp. 51
-
-
Pardridge, W.M.1
-
43
-
-
0035286685
-
The potential use of receptor-mediated endocytosis for oral drug delivery
-
Russell-Jones GJ. The potential use of receptor-mediated endocytosis for oral drug delivery. Adv Drug Deliv Rev 2001, 46:113-128.
-
(2001)
Adv Drug Deliv Rev
, vol.46
, pp. 113-128
-
-
Russell-jones, G.J.1
-
44
-
-
0034058526
-
Bidirectional transcytosis of IgG by the rat neonatal Fc recep-tor expressed in a rat kidney cell line: A system to study protein transport across epithelia
-
McCarthy KM, Yoong Y, Simister NE. Bidirectional transcytosis of IgG by the rat neonatal Fc recep-tor expressed in a rat kidney cell line: A system to study protein transport across epithelia. J Cell Sci 2000, 113:3-25.
-
(2000)
J Cell Sci
, vol.113
, pp. 3-25
-
-
McCarthy, K.M.1
Yoong, Y.2
Simister, N.E.3
-
45
-
-
0027374509
-
Transcytosis of placen-tal alkaline phosphatase-polymeric immunoglobulin receptor fusion proteins is regulated by mutations of Ser664
-
Apodaca G, Mostov KE. Transcytosis of placen-tal alkaline phosphatase-polymeric immunoglobulin receptor fusion proteins is regulated by mutations of Ser664. J Biol Chem 1993, 268:221-244.
-
(1993)
J Biol Chem
, vol.268
, pp. 221-244
-
-
Apodaca, G.1
Mostov, K.E.2
-
46
-
-
0026784945
-
Antennapedia homeobox as a signal for the cellular internalization and nuclear addressing of a small exogenous peptide
-
Perez F, Joliot A, Bloch-Gallego E, Zahraoui A, Triller A, Prochiantz A. Antennapedia homeobox as a signal for the cellular internalization and nuclear addressing of a small exogenous peptide. J Cell Sci 1992, 102:83-94.
-
(1992)
J Cell Sci
, vol.102
, pp. 83-94
-
-
Perez, F.1
Joliot, A.2
Bloch-gallego, E.3
Zahraoui, A.4
Triller, A.5
Prochiantz, A.6
-
47
-
-
0034739894
-
Effi-cient intracellular delivery of GFP by homeodomains of Drosophila Fushi-tarazu and Engrailed proteins
-
Han K, Jeon MJ, Kim KA, Park J, Choi SY. Effi-cient intracellular delivery of GFP by homeodomains of Drosophila Fushi-tarazu and Engrailed proteins. Mol Cells 2000, 10:193-206.
-
(2000)
Mol Cells
, vol.10
, pp. 193-206
-
-
Han, K.1
Jeon, M.J.2
Kim, K.A.3
Park, J.4
Choi, S.Y.5
-
48
-
-
0035204427
-
A peptide carrier for the delivery of biologically active proteins into mammalian cells
-
Morris MC, Depollier J, Mery J, Heitz F, Divita G. A peptide carrier for the delivery of biologically active proteins into mammalian cells. Nat Biotechnol 2001, 19:826-834.
-
(2001)
Nat Biotechnol
, vol.19
, pp. 826-834
-
-
Morris, M.C.1
Depollier, J.2
Mery, J.3
Heitz, F.4
Divita, G.5
-
49
-
-
0035137639
-
Protein transduction: An alternative to genetic inter-vention?
-
Ford KG, Souberbielle BE, Darling D, Farzaneh F. Protein transduction: An alternative to genetic inter-vention?. Gene Ther 2001, 8:559-577.
-
(2001)
Gene Ther
, vol.8
, pp. 559-577
-
-
Ford, K.G.1
Souberbielle, B.E.2
Darling, D.3
Farzaneh, F.4
-
50
-
-
0034296675
-
Characterization of a class of cationic peptides able to facilitate efficient protein transduction in vitro and in vivo
-
Mi Z, Mai J, Lu X, Robbins PD. Characterization of a class of cationic peptides able to facilitate efficient protein transduction in vitro and in vivo. Mol Ther 2000, 2:148-155.
-
(2000)
Mol Ther
, vol.2
, pp. 148-155
-
-
Mi, Z.1
Mai, J.2
Lu, X.3
Robbins, P.D.4
-
51
-
-
0141907727
-
Cellular uptake of the Tat peptide: An endo-cytosis mechanism following ionic interactions
-
Vives E. Cellular uptake of the Tat peptide: An endo-cytosis mechanism following ionic interactions. J Mol Recognit 2003, 16:156-162.
-
(2003)
J Mol Recognit
, vol.16
, pp. 156-162
-
-
Vives, E.1
-
52
-
-
0041816277
-
Antennapedia and HIV transactivator of transcription (TAT) "protein transduction domains" promote endocytosis of high molecular weight cargo upon binding
-
Console S, Marty C, Garcia-Echeverria C, Schwendener R, Ballmer-Hofer K. Antennapedia and HIV transactivator of transcription (TAT) "protein transduction domains" promote endocytosis of high molecular weight cargo upon binding. J Biol Chem 2003, 278:677-686.
-
(2003)
J Biol Chem
, vol.278
, pp. 677-686
-
-
Console, S.1
Marty, C.2
Garcia-echeverria, C.3
Schwendener, R.4
Ballmer-hofer, K.5
-
53
-
-
0038061635
-
Protein transduction domains: Are they delivering?
-
Green I, Christison R, Voyce CJ, Bundell KR, Lindsay MA. Protein transduction domains: Are they delivering?. Trends Pharmacol Sci 2003, 24:1538-1544.
-
(2003)
Trends Pharmacol Sci
, vol.24
, pp. 1538-1544
-
-
Green, I.1
Christison, R.2
Voyce, C.J.3
Bundell, K.R.4
Lindsay, M.A.5
-
54
-
-
5644276383
-
Delivery of bioactive molecules into the cell: The Trojan horse approach
-
Dietz GP, Bahr M. Delivery of bioactive molecules into the cell: The Trojan horse approach. Mol Cell Neurosci 2004, 27:159-170.
-
(2004)
Mol Cell Neurosci
, vol.27
, pp. 159-170
-
-
Dietz, G.P.1
Bahr, M.2
-
55
-
-
0035542854
-
Molecular transporters for pep-tides: Delivery of a cardioprotective e-PKC agonist peptide into cells intact ischemic heart using a transport system R (7)
-
Chen L, Wright LR, Chen CH, Oliver SF, Wender PA, Mochly-Rosen D. Molecular transporters for pep-tides: Delivery of a cardioprotective e-PKC agonist peptide into cells intact ischemic heart using a transport system R (7). Chem Biol 2001, 8:1492-1500.
-
(2001)
Chem Biol
, vol.8
, pp. 1492-1500
-
-
Chen, L.1
Wright, L.R.2
Chen, C.H.3
Oliver, S.F.4
Wender, P.A.5
Mochly-rosen, D.6
-
56
-
-
0037349932
-
Cell-permeable peptides improve cellular uptake and therapeutic gene delivery of replication-deficient viruses in cells and in vivo
-
Gratton JP, Yu J, Griffith JW, Babbitt RW, Scotland RS, Hickey R, Giordano FJ, Sessa WC. Cell-permeable peptides improve cellular uptake and therapeutic gene delivery of replication-deficient viruses in cells and in vivo. Nat Med 2003, 9:622-627.
-
(2003)
Nat Med
, vol.9
, pp. 622-627
-
-
Gratton, J.P.1
Yu, J.2
Griffith, J.W.3
Babbitt, R.W.4
Scotland, R.S.5
Hickey, R.6
Giordano, F.J.7
Sessa, W.C.8
-
58
-
-
0037212701
-
Tight junction proteins
-
Gonzalez-Mariscal L, Betanzos A, Nava P, Jaramillo BE. Tight junction proteins. Prog Biophys Mol Biol 2003, 81:576-582.
-
(2003)
Prog Biophys Mol Biol
, vol.81
, pp. 576-582
-
-
Gonzalez-mariscal, L.1
Betanzos, A.2
Nava, P.3
Jaramillo, B.E.4
-
59
-
-
0034306505
-
Enhancing paracellular permeability by modulating epithe-lial tight junctions
-
Ward PD, Tippin TK, Thakker DR. Enhancing paracellular permeability by modulating epithe-lial tight junctions. Pharm Sci Technol Today 2000, 3:90-105.
-
(2000)
Pharm Sci Technol Today
, vol.3
, pp. 90-105
-
-
Ward, P.D.1
Tippin, T.K.2
Thakker, D.R.3
-
60
-
-
0034049537
-
N-Trimethylated chitosan chloride (TMC) improves the intestinal permeation of the pep-tide drug buserelin in vitro (Caco-2 cells) and in vivo (rats)
-
Thanou M, Florea BI, Langemeyer MW, Verhoef JC, Juninger HE. N-Trimethylated chitosan chloride (TMC) improves the intestinal permeation of the pep-tide drug buserelin in vitro (Caco-2 cells) and in vivo (rats). Pharm Res 2000, 17:51.
-
(2000)
Pharm Res
, vol.17
, pp. 51
-
-
Thanou, M.1
Florea, B.I.2
Langemeyer, M.W.3
Verhoef, J.C.4
Juninger, H.E.5
-
61
-
-
0036709081
-
Blood-brain barrier disruption following the internal carotid arterial per-fusion of alkyl glycerols
-
Lee HJ, Zhang Y, Pardridge WM. Blood-brain barrier disruption following the internal carotid arterial per-fusion of alkyl glycerols. J Drug Target 2002, 10:59-73.
-
(2002)
J Drug Target
, vol.10
, pp. 59-73
-
-
Lee, H.J.1
Zhang, Y.2
Pardridge, W.M.3
-
62
-
-
0036846813
-
Enhanced permeability of molecular weight markers poorly bioavailable compounds across Caco-2 cell monolayers using the absorption enhancer zonula occludens t
-
Cox DS, Raje S, Gao HL, Salama NN, Eddington ND. Enhanced permeability of molecular weight markers poorly bioavailable compounds across Caco-2 cell monolayers using the absorption enhancer zonula occludens t. Pharm Res 2002, 19:1277-1285.
-
(2002)
Pharm Res
, vol.19
, pp. 1277-1285
-
-
Cox, D.S.1
Raje, S.2
Gao, H.L.3
Salama, N.N.4
Eddington, N.D.5
-
63
-
-
1942466467
-
The effect of Δ G on the transport and oral absorption of macromolecules
-
Salama NN, Fasano A, Thakar M, Eddington ND. The effect of Δ G on the transport and oral absorption of macromolecules. J Pharm Sci 2004, 93:23712-23719.
-
(2004)
J Pharm Sci
, vol.93
, pp. 23712-23719
-
-
Salama, N.N.1
Fasano, A.2
Thakar, M.3
Eddington, N.D.4
-
64
-
-
11844272009
-
The impact of Δ G on the oral bioavailability of low bioavailable therapeutic agents
-
Salama NN, Fasano A, Thakar M, Eddington ND. The impact of Δ G on the oral bioavailability of low bioavailable therapeutic agents. J Pharmacol Exp Ther 2005, 312:717-722.
-
(2005)
J Pharmacol Exp Ther
, vol.312
, pp. 717-722
-
-
Salama, N.N.1
Fasano, A.2
Thakar, M.3
Eddington, N.D.4
-
65
-
-
0031972453
-
Molecular and structural features of the proton-coupled oligopep-tide transporter superfamily
-
Fei Y-J, Ganapathy V, Leibach F. Molecular and structural features of the proton-coupled oligopep-tide transporter superfamily. Prog Nucleic Acid Res Mol Biol 1998, 58:728-732.
-
(1998)
Prog Nucleic Acid Res Mol Biol
, vol.58
, pp. 728-732
-
-
Fei, Y.-J.1
Ganapathy, V.2
Leibach, F.3
-
68
-
-
0031800792
-
Role of organic cation transporters in drug absorption and elimination
-
Zhang L, Brett CM, Giacomini KM. Role of organic cation transporters in drug absorption and elimination. Annu Rev Pharmacol Toxicol 1998, 38:339-347.
-
(1998)
Annu Rev Pharmacol Toxicol
, vol.38
, pp. 339-347
-
-
Zhang, L.1
Brett, C.M.2
Giacomini, K.M.3
-
69
-
-
84882507970
-
Hepatic canalicular mem-brane 4: Expression of the multidrug resistance genes in the liver
-
Silverman JA, Schrenk D. Hepatic canalicular mem-brane 4: Expression of the multidrug resistance genes in the liver. FASEB J 1997, 11:265-271.
-
(1997)
FASEB J
, vol.11
, pp. 265-271
-
-
Silverman, J.A.1
Schrenk, D.2
-
70
-
-
0029940766
-
Role of multidrug resistance protein (MRP) in glutathione S-conjugate transport in mammalian cells
-
Muller M, de Vries EGE, Jansen PLM. Role of multidrug resistance protein (MRP) in glutathione S-conjugate transport in mammalian cells. J Hepatol 1996, 24(suppl 1):35109-35114.
-
(1996)
J Hepatol
, vol.24
, Issue.SUPPL. 1
, pp. 35109-35114
-
-
Muller, M.1
de, V.E.G.E.2
Jansen, P.L.M.3
-
71
-
-
0030978107
-
Functional expression of the rat liver canalicular iso-form of the multidrug resistance-associated protein
-
Madon J, Eckhardt U, Gerloff T, Stieger B, Meier PJ. Functional expression of the rat liver canalicular iso-form of the multidrug resistance-associated protein. FEBS Lett 1997, 406:213-215.
-
(1997)
FEBS Lett
, vol.406
, pp. 213-215
-
-
Madon, J.1
Eckhardt, U.2
Gerloff, T.3
Stieger, B.4
Meier, P.J.5
-
72
-
-
0030725999
-
Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver
-
Meier PJ, Eckhardt U, Schroeder A, Hagenbuch B, Stieger B. Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver. Hepatology 1997, 26:85-131.
-
(1997)
Hepatology
, vol.26
, pp. 85-131
-
-
Meier, P.J.1
Eckhardt, U.2
Schroeder, A.3
Hagenbuch, B.4
Stieger, B.5
-
73
-
-
0032961331
-
Evidence for overlapping substrate specificity between large neutral amino acid (LNAA) dipeptide (hPEPT1) transporters for PD 158473 an NMDA antagonist
-
Surendran N, Covitz KM, Han H, Sadée W, Oh GM, Amidon GL, et al. Evidence for overlapping substrate specificity between large neutral amino acid (LNAA) dipeptide (hPEPT1) transporters for PD 158473 an NMDA antagonist. Pharm Res 1999, 16:1123-1129.
-
(1999)
Pharm Res
, vol.16
, pp. 1123-1129
-
-
Surendran, N.1
Covitz, K.M.2
Han, H.3
Sadée, W.4
Oh, G.M.5
Amidon, G.L.6
-
74
-
-
0009504438
-
The transporter factsbook
-
Academic Press, San Diego
-
Griffith J, Sansom C The transporter factsbook 1998, Academic Press, San Diego.
-
(1998)
-
-
Griffith, J.1
Sansom, C.2
-
75
-
-
0011912916
-
Cellular and biochemical aspects of multidrug resistance
-
Marcel Dekker, Inc, New York, G. NH (Ed.)
-
Ambudkar SV, Pastan I, Gottesman MM Cellular and biochemical aspects of multidrug resistance. Drug transport in antimi-crobial and anticancer chemotherapy 1995, 357-362. Marcel Dekker, Inc, New York. G. NH (Ed.).
-
(1995)
Drug transport in antimi-crobial and anticancer chemotherapy
, pp. 357-362
-
-
Ambudkar, S.V.1
Pastan, I.2
Gottesman, M.M.3
-
76
-
-
0032900953
-
Biochemical cellular and pharmacological aspects of the multidrug trans-porter
-
Ambudkar SV, Dey S, Hrycyna CA, Ramachandra M, Pastan I, Gottesman MM. Biochemical cellular and pharmacological aspects of the multidrug trans-porter. Annu Rev Pharmacol Toxicol 1999, 39:89-109.
-
(1999)
Annu Rev Pharmacol Toxicol
, vol.39
, pp. 89-109
-
-
Ambudkar, S.V.1
Dey, S.2
Hrycyna, C.A.3
Ramachandra, M.4
Pastan, I.5
Gottesman, M.M.6
-
77
-
-
0344825356
-
P-Glycoprotein: From genomics to mechanism
-
Ambudkar SV, Kimchi-Sarfaty C, Sauna ZE, Gottesman MM. P-Glycoprotein: From genomics to mechanism. Oncogene 2003, 22:1-44.
-
(2003)
Oncogene
, vol.22
, pp. 1-44
-
-
Ambudkar, S.V.1
Kimchi-sarfaty, C.2
Sauna, Z.E.3
Gottesman, M.M.4
-
78
-
-
0035823075
-
Structure of MsbA from E. coli: A homolog of the multidrug resistance ATP bind-ing cassette (ABC) transporters
-
Chang G, Roth CB. Structure of MsbA from E. coli: A homolog of the multidrug resistance ATP bind-ing cassette (ABC) transporters. Science 2001, 293:346-358.
-
(2001)
Science
, vol.293
, pp. 346-358
-
-
Chang, G.1
Roth, C.B.2
-
79
-
-
0038799725
-
Structure of MsbA from Vibrio cholera: A multidrug resistance ABC transporter homolog in a closed conformation
-
Chang G. Structure of MsbA from Vibrio cholera: A multidrug resistance ABC transporter homolog in a closed conformation. J Mol Biol 2003, 330:27-31.
-
(2003)
J Mol Biol
, vol.330
, pp. 27-31
-
-
Chang, G.1
-
80
-
-
0037052565
-
The E. coli BtuCD struc-ture: A framework for ABC transporter architecture and mechanism
-
Locher KP, Lee AT, Rees DC. The E. coli BtuCD struc-ture: A framework for ABC transporter architecture and mechanism. Science 2002, 296:463-467.
-
(2002)
Science
, vol.296
, pp. 463-467
-
-
Locher, K.P.1
Lee, A.T.2
Rees, D.C.3
-
81
-
-
1842426089
-
Towards P-glycoprotein structure-activity relation-ships
-
Chap 20, Wiley-VCH Verlag GmbH & Co, Weinheim, V. de Waterbeemd H, L.-D. H, A. P (Eds.) Drug bioavailability -Estimation of solubility, permeability, absorption and bioavaila-bility
-
Seelig A, Landwojtowicz E, Fischer H, Blatter XL Towards P-glycoprotein structure-activity relation-ships. Methods and Principles of Medicinal Chemistry 2003, vol 18:1680-1688. Chap 20, Wiley-VCH Verlag GmbH & Co, Weinheim. V. de Waterbeemd H, L.-D. H, A. P (Eds.).
-
(2003)
Methods and Principles of Medicinal Chemistry
, vol.18
, pp. 1680-1688
-
-
Seelig, A.1
Landwojtowicz, E.2
Fischer, H.3
Blatter, X.L.4
-
82
-
-
0032518454
-
A general pattern for substrate recognition by P-glycoprotein
-
Seelig A. A general pattern for substrate recognition by P-glycoprotein. Eur J Biochem 1998, 251:1310-1319.
-
(1998)
Eur J Biochem
, vol.251
, pp. 1310-1319
-
-
Seelig, A.1
-
84
-
-
0036316392
-
Three dimensional structure of a bacterial oxalate transporter
-
Hirai T, Heymann JAW, Shi D, Sarker R, Maloney PC, Subramaniam S. Three dimensional structure of a bacterial oxalate transporter. Nat Struct Biol 2002, 9:239-261.
-
(2002)
Nat Struct Biol
, vol.9
, pp. 239-261
-
-
Hirai, T.1
Heymann, J.A.W.2
Shi, D.3
Sarker, R.4
Maloney, P.C.5
Subramaniam, S.6
-
85
-
-
0041353145
-
Structure and mechanism of the lactose permease of Escherichia coli
-
Abramson J, Smirnova I, Kasho V, Verner G, Kaback HR, Iwata S. Structure and mechanism of the lactose permease of Escherichia coli. Science 2003, 301:1524-1531.
-
(2003)
Science
, vol.301
, pp. 1524-1531
-
-
Abramson, J.1
Smirnova, I.2
Kasho, V.3
Verner, G.4
Kaback, H.R.5
Iwata, S.6
-
86
-
-
0041489951
-
Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coli
-
Huang Y, Lemieux MJ, Song J, Auer M, Wang DN. Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coli. Science 2003, 301:408-451.
-
(2003)
Science
, vol.301
, pp. 408-451
-
-
Huang, Y.1
Lemieux, M.J.2
Song, J.3
Auer, M.4
Wang, D.N.5
-
87
-
-
0031662109
-
5'-Amino acid esters of antiviral nucle-osides acyclovir and AZT are absorbed by the intestinal PEPT1 peptide transporter
-
Han H, de Vrueh RL, Rhie JK, Covitz KM, Smith PL, Lee CP, et al. 5'-Amino acid esters of antiviral nucle-osides acyclovir and AZT are absorbed by the intestinal PEPT1 peptide transporter. Pharm Res 1998, 15:431-460.
-
(1998)
Pharm Res
, vol.15
, pp. 431-460
-
-
Han, H.1
de, V.R.L.2
Rhie, J.K.3
Covitz, K.M.4
Smith, P.L.5
Lee, C.P.6
-
88
-
-
0033812228
-
Transport of valganciclovir a ganciclovir prodrug via pep-tide transporters PEPT1 and PEPT2
-
Sugawara M, Huang W, Fei YJ, Leibach FH, Ganapathy V, Ganapathy ME. Transport of valganciclovir a ganciclovir prodrug via pep-tide transporters PEPT1 and PEPT2. J Pharm Sci 1900, 89:781-789.
-
(1900)
J Pharm Sci
, vol.89
, pp. 781-789
-
-
Sugawara, M.1
Huang, W.2
Fei, Y.J.3
Leibach, F.H.4
Ganapathy, V.5
Ganapathy, M.E.6
-
89
-
-
0034933504
-
Valganciclovir
-
Curran M, Noble S Valganciclovir. Drugs 2001, 61:100-108.
-
(2001)
Drugs
, vol.61
, pp. 100-108
-
-
Curran, M.1
Noble, S.2
-
90
-
-
0033807143
-
Valganciclovir results in improved oral absorption of ganciclovir in liver transplant patients
-
Pescovitz MD, Rabkin J, Merion RM, Paya CV, Pirsch J, Freeman RB, et al. Valganciclovir results in improved oral absorption of ganciclovir in liver transplant patients. Antimicrob Agents Chemother 2000, 44:75-78.
-
(2000)
Antimicrob Agents Chemother
, vol.44
, pp. 75-78
-
-
Pescovitz, M.D.1
Rabkin, J.2
Merion, R.M.3
Paya, C.V.4
Pirsch, J.5
Freeman, R.B.6
-
91
-
-
4644328982
-
XP13512 [(+/-) -1-([(α-isobutanoyloxyethoxy) carbonyl]aminomethyl) -1-cyclohexane acetic acid] a novel gabapentin prodrug: I. Design synthesis enzymatic
-
Cundy KC, Branch R, Chernov-Rogan T, Dias T, Estrada T, Hold K, et al. XP13512 [(+/-) -1-([(α-isobutanoyloxyethoxy) carbonyl]aminomethyl) -1-cyclohexane acetic acid] a novel gabapentin prodrug: I. Design synthesis enzymatic. J Pharmacol Exp Ther 2004, 311:1667-1677.
-
(2004)
J Pharmacol Exp Ther
, vol.311
, pp. 1667-1677
-
-
Cundy, K.C.1
Branch, R.2
Chernov-rogan, T.3
Dias, T.4
Estrada, T.5
Hold, K.6
-
92
-
-
4644251930
-
XP13512 [(+/-) -1-([(α-isobutanoyloxyethoxy) carbonyl]aminomethyl) -1-cyclohexane acetic acid]a novel gabapentin prodrug: II. Improved oral bioavailabili
-
Cundy KC, Annamalai T, Bu L, De Vera J, Estrela J, Luo W, et al. XP13512 [(+/-) -1-([(α-isobutanoyloxyethoxy) carbonyl]aminomethyl) -1-cyclohexane acetic acid]a novel gabapentin prodrug: II. Improved oral bioavailabili. J Pharmacol Exp Ther 2004, 311:391-395.
-
(2004)
J Pharmacol Exp Ther
, vol.311
, pp. 391-395
-
-
Cundy, K.C.1
Annamalai, T.2
Bu, L.3
De, V.J.4
Estrela, J.5
Luo, W.6
-
93
-
-
0033328139
-
The contribution of P-glycoprotein to phar-macokinetic drug-drug interactions
-
Yu DK. The contribution of P-glycoprotein to phar-macokinetic drug-drug interactions. J Clin Pharma-col 1999, 39:525-547.
-
(1999)
J Clin Pharma-col
, vol.39
, pp. 525-547
-
-
Yu, D.K.1
-
94
-
-
0032823160
-
Intestinal secretion of intra-venous talinolol is inhibited by luminal R-verapamil
-
Gramatte T, Oertel R. Intestinal secretion of intra-venous talinolol is inhibited by luminal R-verapamil. Clin Pharmacol Ther 1999, 66:361-398.
-
(1999)
Clin Pharmacol Ther
, vol.66
, pp. 361-398
-
-
Gramatte, T.1
Oertel, R.2
-
95
-
-
84882481133
-
Inhibition of the CYP3A4-mediated metabolism and P-glycoprotein-mediated transport of the HIV-1 protease inhibitor saquinavir by grapefruit juice components
-
Eagling VA, Profit L, Black DJ. Inhibition of the CYP3A4-mediated metabolism and P-glycoprotein-mediated transport of the HIV-1 protease inhibitor saquinavir by grapefruit juice components. Br J Clin Pharmacol 1999, 48:7468-7485.
-
(1999)
Br J Clin Pharmacol
, vol.48
, pp. 7468-7485
-
-
Eagling, V.A.1
Profit, L.2
Black, D.J.3
-
96
-
-
0032904977
-
Grapefruit juice activates P-glycoprotein-mediated drug transport
-
Soldner A, Christians U, Susanto M, Wacher VJ, Silverman JA, Benet LZ. Grapefruit juice activates P-glycoprotein-mediated drug transport. Pharm Res 1999, 16:1793-1800.
-
(1999)
Pharm Res
, vol.16
, pp. 1793-1800
-
-
Soldner, A.1
Christians, U.2
Susanto, M.3
Wacher, V.J.4
Silverman, J.A.5
Benet, L.Z.6
-
97
-
-
0002886177
-
Physiology and pharmacology of the blood-brain barrier
-
Springer-Verlag, New York, B. MWB (Ed.)
-
Physiology and pharmacology of the blood-brain barrier. Handbook of experimental pharmacology 1992, vol 103. Springer-Verlag, New York. B. MWB (Ed.).
-
(1992)
Handbook of experimental pharmacology
, vol.103
-
-
-
98
-
-
0003620711
-
Physiology of the cerebrospinal fluid and blood-brain barrier
-
8, CRC Press, Boca Raton, FL
-
Davson H, Segal M Physiology of the cerebrospinal fluid and blood-brain barrier 1996, 8, CRC Press, Boca Raton, FL.
-
(1996)
-
-
Davson, H.1
Segal, M.2
-
99
-
-
0028229150
-
Disruption of the mouse mdr1a P-glycoprotein gene leads to deficiency in the blood-brain barrier and to increased sensitivity to drugs
-
Schinkel AH, Smit JJ, van Tellingen O, Beijnen JH, Wagenaar E, van Deemter L, et al. Disruption of the mouse mdr1a P-glycoprotein gene leads to deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 1994, 77:419-430.
-
(1994)
Cell
, vol.77
, pp. 419-430
-
-
Schinkel, A.H.1
Smit, J.J.2
van, T.O.3
Beijnen, J.H.4
Wagenaar, E.5
van, D.L.6
-
100
-
-
4243801613
-
Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins
-
Schinkel AH, Mayer U, Wagenaar E, Mol CA, van Deemter L, Smit JJ, et al. Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins. Proc Natl Acad Sci USA 1997, 94:1091-1098.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 1091-1098
-
-
Schinkel, A.H.1
Mayer, U.2
Wagenaar, E.3
Mol, C.A.4
van, D.L.5
Smit, J.J.6
-
101
-
-
0029892497
-
P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs
-
Schinkel AH, Wagenaar E, Mol CA, Van Deemter L. P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J Clin Invest 1996, 97:461-492.
-
(1996)
J Clin Invest
, vol.97
, pp. 461-492
-
-
Schinkel, A.H.1
Wagenaar, E.2
Mol, C.A.3
Van, D.L.4
-
102
-
-
0033833430
-
Increased drug delivery to the brain by P-glycoprotein inhibition
-
Sadeque AJM, Wandel C, He H, Shah S, Wood AJJ. Increased drug delivery to the brain by P-glycoprotein inhibition. Clin Pharmacol Ther 2000, 68:252-261.
-
(2000)
Clin Pharmacol Ther
, vol.68
, pp. 252-261
-
-
Sadeque, A.J.M.1
Wandel, C.2
He, H.3
Shah, S.4
Wood, A.J.J.5
-
103
-
-
0033616684
-
Choroid plexus epithe-lial expression of MDR1 P-glycoprotein and multi-drug resistance-associated protein contribute to the blood-cerebrospinal fluid drug-per
-
Rao VV, Dahlheimer JL, Bardgett ME, Snyder AZ, Finch RA, Sartorelli AC, et al. Choroid plexus epithe-lial expression of MDR1 P-glycoprotein and multi-drug resistance-associated protein contribute to the blood-cerebrospinal fluid drug-per. Proc Natl Acad Sci USA 1999, 96:610-620.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 610-620
-
-
Rao, V.V.1
Dahlheimer, J.L.2
Bardgett, M.E.3
Snyder, A.Z.4
Finch, R.A.5
Sartorelli, A.C.6
-
104
-
-
0041837255
-
Blood-brain barrier efflux transport
-
Golden PL, Pollack GM. Blood-brain barrier efflux transport. J Pharm Sci. 2003, 92:597-600.
-
(2003)
J Pharm Sci.
, vol.92
, pp. 597-600
-
-
Golden, P.L.1
Pollack, G.M.2
-
105
-
-
0036844903
-
Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate car-rier gene in hu
-
Rothem L, Ifergan I, Kaufman Y, Priest DG, Jansen G, Assaraf YG. Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate car-rier gene in hu. Biochem J 2002, 367:610-615.
-
(2002)
Biochem J
, vol.367
, pp. 610-615
-
-
Rothem, L.1
Ifergan, I.2
Kaufman, Y.3
Priest, D.G.4
Jansen, G.5
Assaraf, Y.G.6
-
106
-
-
0037195066
-
Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals
-
Ishida S, Lee J, Thiele DJ, Herskowitz I. Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals. Proc Natl Acad Sci USA 2002, 99:616-620.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 616-620
-
-
Ishida, S.1
Lee, J.2
Thiele, D.J.3
Herskowitz, I.4
-
107
-
-
3242734736
-
Increased expression of the copper efflux transporter ATP7A mediates resistance to cisplatin carboplatin and oxaliplatin in ovarian cancer cells
-
Samimi G, Safaei R, Katano K, Holzer AK, Rochdi M, Tomioka M, Goodman M, Howell SB. Increased expression of the copper efflux transporter ATP7A mediates resistance to cisplatin carboplatin and oxaliplatin in ovarian cancer cells. Clin Cancer Res 2004, 10:1154-1159.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 1154-1159
-
-
Samimi, G.1
Safaei, R.2
Katano, K.3
Holzer, A.K.4
Rochdi, M.5
Tomioka, M.6
Goodman, M.7
Howell, S.B.8
-
108
-
-
0346103812
-
Lustrous insights into cisplatin accumu-lation: Copper transporters
-
Gary Kruh. Lustrous insights into cisplatin accumu-lation: Copper transporters. Clin Cancer Res 2003, 9:781-789.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 781-789
-
-
Gary, K.1
-
109
-
-
2442566926
-
Expression of copper-transporting P-type adenosine triphosphatase (ATP7B) in human hepatocellular carcinoma
-
Sugeno H, Takebayashi Y, Higashimoto M, Ogura Y, Shibukawa G, Kanzaki A, et al. Expression of copper-transporting P-type adenosine triphosphatase (ATP7B) in human hepatocellular carcinoma. Anti-cancer Res 2004, 24:1145-1150.
-
(2004)
Anti-cancer Res
, vol.24
, pp. 1145-1150
-
-
Sugeno, H.1
Takebayashi, Y.2
Higashimoto, M.3
Ogura, Y.4
Shibukawa, G.5
Kanzaki, A.6
-
110
-
-
18744432281
-
HIV-1 protease inhibitors and the MDR1 multidrug transporter
-
Lee CGL, Gottesman MM. HIV-1 protease inhibitors and the MDR1 multidrug transporter. J Clin Invest 1998, 101:2811-2815.
-
(1998)
J Clin Invest
, vol.101
, pp. 2811-2815
-
-
Lee, C.G.L.1
Gottesman, M.M.2
-
111
-
-
0032860574
-
Nuclear targeting peptide scaffolds for lipofection of nondividing mammalian cells
-
Subramanian A, Ranganathan P, Diamond SL. Nuclear targeting peptide scaffolds for lipofection of nondividing mammalian cells. Nat Biotechnol 1999, 17:315-323.
-
(1999)
Nat Biotechnol
, vol.17
, pp. 315-323
-
-
Subramanian, A.1
Ranganathan, P.2
Diamond, S.L.3
-
112
-
-
0034192228
-
Fetal mitochondrial heart and skeletal muscle damage in Erythroce-bus patas monkeys exposed in utero to 3-azido-3'-deoxythymidine
-
Gerschenson M, Erhart SW, Paik CY, St Claire MC, Nagashima K, Skopets B, et al. Fetal mitochondrial heart and skeletal muscle damage in Erythroce-bus patas monkeys exposed in utero to 3-azido-3'-deoxythymidine. AIDS Res Hum Retroviruses 2000, 1 6:324-333.
-
(2000)
AIDS Res Hum Retroviruses
, pp. 324-333
-
-
Gerschenson, M.1
Erhart, S.W.2
Paik, C.Y.3
St, C.M.C.4
Nagashima, K.5
Skopets, B.6
-
113
-
-
0028817865
-
Hepatic failure lactic acidosis due to fialuridine (FIAU) an investi-gational nucleoside analogue for chronic hepatitis B
-
McKenzie R, Fried MW, Sallie R, Conjeevaram H, Di Bisceglie AM, Park Y, et al. Hepatic failure lactic acidosis due to fialuridine (FIAU) an investi-gational nucleoside analogue for chronic hepatitis B. N Engl J Med 1995, 333:1203-1211.
-
(1995)
N Engl J Med
, vol.333
, pp. 1203-1211
-
-
McKenzie, R.1
Fried, M.W.2
Sallie, R.3
Conjeevaram, H.4
Di, B.A.M.5
Park, Y.6
-
114
-
-
0036174438
-
Assessment of mitochondrial toxicity in human cells treated with tenofovir: Comparison with other nucleoside reverse transcriptase inhibitors
-
Birkus G, Hitchcock MJ, Cihlar T. Assessment of mitochondrial toxicity in human cells treated with tenofovir: Comparison with other nucleoside reverse transcriptase inhibitors. Antimicrob Agents Chemother 2002, 46:239-245.
-
(2002)
Antimicrob Agents Chemother
, vol.46
, pp. 239-245
-
-
Birkus, G.1
Hitchcock, M.J.2
Cihlar, T.3
-
115
-
-
0033214905
-
Mouse transporter protein a membrane pro-tein that regulates cellular multidrug resistance is localized to lysosomes
-
Cabrita MA, Hobman TC, Hogue DL, King KM, Cass CE. Mouse transporter protein a membrane pro-tein that regulates cellular multidrug resistance is localized to lysosomes. Cancer Res 1999, 59:543-552.
-
(1999)
Cancer Res
, vol.59
, pp. 543-552
-
-
Cabrita, M.A.1
Hobman, T.C.2
Hogue, D.L.3
King, K.M.4
Cass, C.E.5
-
116
-
-
0029902695
-
Renal secretion of organic anions and cations
-
Pritchard JB, Miller DS. Renal secretion of organic anions and cations. Kidney Int 1996, 49:478-485.
-
(1996)
Kidney Int
, vol.49
, pp. 478-485
-
-
Pritchard, J.B.1
Miller, D.S.2
-
117
-
-
0035066252
-
Trans-porters involved in the elimination of drugs in the kidney: Organic anion transporters and organic cation transporters
-
Dresser MJ, Leabman MK, Giacomini KM. Trans-porters involved in the elimination of drugs in the kidney: Organic anion transporters and organic cation transporters. J Pharm Sci 2001, 90:8.
-
(2001)
J Pharm Sci
, vol.90
, pp. 8
-
-
Dresser, M.J.1
Leabman, M.K.2
Giacomini, K.M.3
-
118
-
-
0242637653
-
Nucleo-side tranporters in disposition and targeting of nucleoside analogs in the kidney
-
Mangravite LM, Badagnani I, Giacomini KM. Nucleo-side tranporters in disposition and targeting of nucleoside analogs in the kidney. Eur J Pharmacol 2003, 479:491-502.
-
(2003)
Eur J Pharmacol
, vol.479
, pp. 491-502
-
-
Mangravite, L.M.1
Badagnani, I.2
Giacomini, K.M.3
-
119
-
-
0033514320
-
Inhibition of P-glycoprotein-mediated drug transport: A unifying mechanism to explain the inter-action between digoxin and quinidine
-
Fromm MF, Kim RB, Stein CM, Wilkinson GR, Roden DM. Inhibition of P-glycoprotein-mediated drug transport: A unifying mechanism to explain the inter-action between digoxin and quinidine. Circulation 1999, 99:4028-4033.
-
(1999)
Circulation
, vol.99
, pp. 4028-4033
-
-
Fromm, M.F.1
Kim, R.B.2
Stein, C.M.3
Wilkinson, G.R.4
Roden, D.M.5
-
120
-
-
0032848316
-
P-glycoprotein system as a determinant of drug inter-actions: The case of digoxin-verapamil
-
Verschraagen M, Koks CH, Schellens JH, Beijnen JH. P-glycoprotein system as a determinant of drug inter-actions: The case of digoxin-verapamil. Pharmacol Res 1999, 40:2517-2524.
-
(1999)
Pharmacol Res
, vol.40
, pp. 2517-2524
-
-
Verschraagen, M.1
Koks, C.H.2
Schellens, J.H.3
Beijnen, J.H.4
-
121
-
-
0029007730
-
Digoxin-quinidine and digoxin-amiodarone interactions: Frequency of occurrence and monitoring in Australian repatriation hospitals
-
Freitag D, Bebee R, Sunderland B. Digoxin-quinidine and digoxin-amiodarone interactions: Frequency of occurrence and monitoring in Australian repatriation hospitals. J Clin Pharm Ther 1995, 20:231-237.
-
(1995)
J Clin Pharm Ther
, vol.20
, pp. 231-237
-
-
Freitag, D.1
Bebee, R.2
Sunderland, B.3
-
122
-
-
0036380025
-
Mechanisms of clinically relevant drug interactions associated with tacrolimus
-
Christians U, Jacobsen W, Benet LZ, Lampen A. Mechanisms of clinically relevant drug interactions associated with tacrolimus. Clin Pharmacokinet 2002, 41:3900-3905.
-
(2002)
Clin Pharmacokinet
, vol.41
, pp. 3900-3905
-
-
Christians, U.1
Jacobsen, W.2
Benet, L.Z.3
Lampen, A.4
-
123
-
-
0036694282
-
AIDS Clinical Trial Group Protocol 398 investigators
-
Clin Phar-macol Ther
-
Pfister M, Labbe L, Lu JF, Hammer SM, Mellors J, Bennett KK, Rosenkranz S, Sheiner LB, AIDS Clinical Trial Group Protocol 398 investigators. Effect of coad-ministration of nelfinavir indinavir and saquinavir on the pharmacokinetics of amprenavir. Clin Phar-macol Ther 2002, 72:1739-1753.
-
(2002)
Effect of coad-ministration of nelfinavir indinavir and saquinavir on the pharmacokinetics of amprenavir
, vol.72
, pp. 1739-1753
-
-
Pfister, M.1
Labbe, L.2
Lu, J.F.3
Hammer, S.M.4
Mellors, J.5
Bennett, K.K.6
Rosenkranz, S.7
Sheiner, L.B.8
-
124
-
-
0000006828
-
Pharmacokinetic interaction of digoxin with an herbal extract from St. John's wort (Hypericum perforatum)
-
Johne A, Brockmoller J, Bauer S, Maurer A, Langheinrich M, Roots I. Pharmacokinetic interaction of digoxin with an herbal extract from St. John's wort (Hypericum perforatum). Clin Pharmacol Ther 1999, 66:741-750.
-
(1999)
Clin Pharmacol Ther
, vol.66
, pp. 741-750
-
-
Johne, A.1
Brockmoller, J.2
Bauer, S.3
Maurer, A.4
Langheinrich, M.5
Roots, I.6
-
125
-
-
0034620261
-
Herb-drug interactions
-
Fugh-Berman A Herb-drug interactions. Lancet 2000, 355:14298-14302.
-
(2000)
Lancet
, vol.355
, pp. 14298-14302
-
-
Fugh-berman, A.1
-
126
-
-
0034620261
-
Herb-drug interactions
-
See also erratum and comment
-
Fugh-Berman A Herb-drug interactions. Lancet 2000, 355:4661-4669. See also erratum and comment.
-
(2000)
Lancet
, vol.355
, pp. 4661-4669
-
-
Fugh-berman, A.1
-
127
-
-
0005582691
-
Transcription of the mul-tidrug resistance gene MDR1: A therapeutic target
-
Scotto KW, Johnson RA. Transcription of the mul-tidrug resistance gene MDR1: A therapeutic target. Mol Interv 2001, 1:5087-5089.
-
(2001)
Mol Interv
, vol.1
, pp. 5087-5089
-
-
Scotto, K.W.1
Johnson, R.A.2
-
130
-
-
0029027893
-
Controlled trial of dexverapamil a modulator of multidrug resistance in lymphomas refractory to EPOCH chemotherapy
-
Wilson WH, Bates SE, Fojo A, Bryant G, Zhan Z, Regis J, et al. Controlled trial of dexverapamil a modulator of multidrug resistance in lymphomas refractory to EPOCH chemotherapy. J Clin Oncol 1995, 12:873-877.
-
(1995)
J Clin Oncol
, vol.12
, pp. 873-877
-
-
Wilson, W.H.1
Bates, S.E.2
Fojo, A.3
Bryant, G.4
Zhan, Z.5
Regis, J.6
-
131
-
-
0033179095
-
Frequency clinical significance of the expression of mul-tidrug resistance proteins MDR1/P-glycoprotein MRP1 and LRP in acute myeloid leukemia: A Southwest On
-
Leith CP, Kopecky KJ, Chen IM, Eijdems L, Slovak ML, McConnell TS, et al. Frequency clinical significance of the expression of mul-tidrug resistance proteins MDR1/P-glycoprotein MRP1 and LRP in acute myeloid leukemia: A Southwest On. Blood 1999, 94:635-644.
-
(1999)
Blood
, vol.94
, pp. 635-644
-
-
Leith, C.P.1
Kopecky, K.J.2
Chen, I.M.3
Eijdems, L.4
Slovak, M.L.5
McConnell, T.S.6
-
132
-
-
84882511567
-
Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremor
-
Allen JD, van Loevezijn A, Lakhai JM, van der Valk M, van Tellingen O, Reid G, et al. Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremor. Mol Cancer Ther 1902, 1:1099-1105.
-
(1902)
Mol Cancer Ther
, vol.1
, pp. 1099-1105
-
-
Allen, J.D.1
van, L.A.2
Lakhai, J.M.3
van, D.V.M.4
van, T.O.5
Reid, G.6
-
133
-
-
0029926220
-
The multidrug-resistance gene in gene therapy of cancer and hematopoietic disorders
-
Licht T, Pastan I, Gottesman MM, Herrmann F. The multidrug-resistance gene in gene therapy of cancer and hematopoietic disorders. Ann Hematol 1996, 72:716-723.
-
(1996)
Ann Hematol
, vol.72
, pp. 716-723
-
-
Licht, T.1
Pastan, I.2
Gottesman, M.M.3
Herrmann, F.4
-
134
-
-
0034096096
-
Chemoprotection of hematopoietic cells by a mutant P-glycoprotein resistant to a potent chemosensi-tizer of multidrug-resistant cancers
-
Hafkemeyer P, Licht T, Pastan I, Gottesman MM. Chemoprotection of hematopoietic cells by a mutant P-glycoprotein resistant to a potent chemosensi-tizer of multidrug-resistant cancers. Hum Gene Ther 2000, 11:4890-4897.
-
(2000)
Hum Gene Ther
, vol.11
, pp. 4890-4897
-
-
Hafkemeyer, P.1
Licht, T.2
Pastan, I.3
Gottesman, M.M.4
-
135
-
-
84882543824
-
Multidrug resistance efflux
-
Cambridge University Press, London, B.-S. JK, B. S, S. CJ, W. FB (Eds.)
-
Lewis K Multidrug resistance efflux. Transport of molecules across microbial membranes. 58th Symposium of the Soci-ety for General Microbiology, University of Leeds, September 1999 1999, 1649-1654. Cambridge University Press, London. B.-S. JK, B. S, S. CJ, W. FB (Eds.).
-
(1999)
Transport of molecules across microbial membranes. 58th Symposium of the Soci-ety for General Microbiology, University of Leeds, September 1999
, pp. 1649-1654
-
-
Lewis, K.1
-
136
-
-
84882544321
-
Classification of mem-brane transporters
-
Kluwer Academic/Plenum Publishers, New York, A. GL, S.-A. W (Eds.)
-
Sadée W, Graul RC, Lee AY Classification of mem-brane transporters. Membrane transporters as drug targets 1999, 397-421. Kluwer Academic/Plenum Publishers, New York. A. GL, S.-A. W (Eds.).
-
(1999)
Membrane transporters as drug targets
, pp. 397-421
-
-
Sadée, W.1
Graul, R.C.2
Lee, A.Y.3
-
137
-
-
0031823433
-
Genomics and drugs: Finding the optimal drug for the right patient
-
Sadée W. Genomics and drugs: Finding the optimal drug for the right patient. Pharm Res 1998, 15:269-281.
-
(1998)
Pharm Res
, vol.15
, pp. 269-281
-
-
Sadée, W.1
-
138
-
-
0033569516
-
Pharmacogenomics: Trans-lating functional genomics into rational therapeutics
-
Evans WE, Relling MV. Pharmacogenomics: Trans-lating functional genomics into rational therapeutics. Science 1999, 286:552-557.
-
(1999)
Science
, vol.286
, pp. 552-557
-
-
Evans, W.E.1
Relling, M.V.2
-
139
-
-
84882556528
-
Pharmacogenomics of drug transporters: The next drug delivery challenge
-
Lee VH, Sporty JL, Fandy TE. Pharmacogenomics of drug transporters: The next drug delivery challenge. Adv Drug Deliv Rev 1901, 50(suppl 1):301-306.
-
(1901)
Adv Drug Deliv Rev
, vol.50
, Issue.SUPPL. 1
, pp. 301-306
-
-
Lee, V.H.1
Sporty, J.L.2
Fandy, T.E.3
-
140
-
-
0011896592
-
Human proton/oligopeptide transporter (POT) genes: Identification of putative human genes using bioinformatics
-
Botka CW, Wittig TW, Graul RC, Nielsen CU, Higaka K, Amidon GL, Sadée W Human proton/oligopeptide transporter (POT) genes: Identification of putative human genes using bioinformatics. AAPS PharmSci 2000, 2:E16.
-
(2000)
AAPS PharmSci
, vol.2
-
-
Botka, C.W.1
Wittig, T.W.2
Graul, R.C.3
Nielsen, C.U.4
Higaka, K.5
Amidon, G.L.6
Sadée, W.7
-
141
-
-
2642672835
-
Evolutionary origins of mul-tidrug and drug-specific efflux pumps in bacteria
-
Saier MH Jr, Paulsen IT, Sliwinski MK, Pao SS, Skurray RA, Nikaido H. Evolutionary origins of mul-tidrug and drug-specific efflux pumps in bacteria. FASEB J 1998, 12:179-183.
-
(1998)
FASEB J
, vol.12
, pp. 179-183
-
-
Saier, M.H.J.1
Paulsen, I.T.2
Sliwinski, M.K.3
Pao, S.S.4
Skurray, R.A.5
Nikaido, H.6
-
142
-
-
84882475035
-
Evolutionary origins of transmembrane transport systems
-
Cambridge University Press, London
-
Saier MH Jr, Tseng T-T Evolutionary origins of transmembrane transport systems. Transport of molecules across microbial membranes. 58th Symposium of the Society for General Microbiology, University of Leeds, September 1999 1999, 813-851. Cambridge University Press, London.
-
(1999)
Transport of molecules across microbial membranes. 58th Symposium of the Society for General Microbiology, University of Leeds, September 1999
, pp. 813-851
-
-
Saier, M.H.J.1
Tseng, T.-T.2
-
143
-
-
0032478498
-
Microbial genome analyses: Global comparisons of transport capabilities based on phylogenies bioenergetics and substrate specificities
-
Paulsen IT, Sliwinski MK, Saier MH Jr. Microbial genome analyses: Global comparisons of transport capabilities based on phylogenies bioenergetics and substrate specificities. J Mol Biol 1998, 277:133-141.
-
(1998)
J Mol Biol
, vol.277
, pp. 133-141
-
-
Paulsen, I.T.1
Sliwinski, M.K.2
Saier, M.H.J.3
-
144
-
-
0032560586
-
Unified inventory of established and putative transporters encoded within the com-plete genome of Saccharomyces cerevisiae
-
Paulsen IT, Sliwinski MK, Nelissen B, Goffeau A, Saier MH Jr. Unified inventory of established and putative transporters encoded within the com-plete genome of Saccharomyces cerevisiae. FEBS Lett 1998, 430:338-345.
-
(1998)
FEBS Lett
, vol.430
, pp. 338-345
-
-
Paulsen, I.T.1
Sliwinski, M.K.2
Nelissen, B.3
Goffeau, A.4
Saier, M.H.J.5
-
145
-
-
84882507953
-
-
Internet
-
Internet at http://www.chem.qmul.ac.uk/iubmb/mtp.
-
-
-
-
146
-
-
84882490811
-
-
Internet
-
Internet at http://www.gene.ucl.ac.uk/nomenclature.
-
-
-
-
147
-
-
7644238424
-
The ABCs of solute car-riers: Physiological pathological and therapeutic implications of human membrane transport proteins Introduction
-
Hediger MA, Romero MF, Peng JB, Rolfs A, Takanaga H, Bruford EA. The ABCs of solute car-riers: Physiological pathological and therapeutic implications of human membrane transport proteins Introduction. Pflugers Arch 2004, 447:134-138.
-
(2004)
Pflugers Arch
, vol.447
, pp. 134-138
-
-
Hediger, M.A.1
Romero, M.F.2
Peng, J.B.3
Rolfs, A.4
Takanaga, H.5
Bruford, E.A.6
-
148
-
-
84882528048
-
-
Internet
-
Internet at http://www.tcdb.org.
-
-
-
-
149
-
-
0031000180
-
The first genome from the third domain of life
-
Clayton RA, White O, Ketchum KA, Venter JC. The first genome from the third domain of life. Nature 1997, 387:1019-1020.
-
(1997)
Nature
, vol.387
, pp. 1019-1020
-
-
Clayton, R.A.1
White, O.2
Ketchum, K.A.3
Venter, J.C.4
-
150
-
-
0032540874
-
Complete genome sequence of Treponema pallidum the syphilis spiro-chete
-
Fraser CM, Norris SJ, Weinstock GM, White O, Sutton GG, Dodson R, et al. Complete genome sequence of Treponema pallidum the syphilis spiro-chete. Science 1998, 281:117-125.
-
(1998)
Science
, vol.281
, pp. 117-125
-
-
Fraser, C.M.1
Norris, S.J.2
Weinstock, G.M.3
White, O.4
Sutton, G.G.5
Dodson, R.6
-
151
-
-
84882510890
-
-
Internet. A list of known human transporters is given under the heading EGAD Cellular Roles/Metabolism/Transport
-
Internet at www.tigr.org. A list of known human transporters is given under the heading EGAD Cellular Roles/Metabolism/Transport.
-
-
-
-
152
-
-
33947243477
-
Human membrane transporter database: A Web-accessible relational database for drug transport studies and pharmacogenomics
-
See also
-
Yan Q, Sadée W Human membrane transporter database: A Web-accessible relational database for drug transport studies and pharmacogenomics. AAPS PharmSci 2000, 2:E20. See also. http://www.aapspharmsci.org/view.asp?art=ps020320&pdf=yes;http://lab .digibench.net/transporter.
-
(2000)
AAPS PharmSci
, vol.2
-
-
Yan, Q.1
Sadée, W.2
-
153
-
-
55449129212
-
A semiauto-mated approach to gene discovery through expressed sequence tag data mining: Discovery of new human transporter genes
-
Brown S, Chang JL, Sadée W, Babbitt PC. A semiauto-mated approach to gene discovery through expressed sequence tag data mining: Discovery of new human transporter genes. AAPS PharmSci 2003, 5:E1.
-
(2003)
AAPS PharmSci
, vol.5
-
-
Brown, S.1
Chang, J.L.2
Sadée, W.3
Babbitt, P.C.4
-
154
-
-
0037446295
-
Drug sensitivity and resistance genes in cancer chemotherapy: A chemogenomics approach
-
Huang Y, Sadée W. Drug sensitivity and resistance genes in cancer chemotherapy: A chemogenomics approach. Drug Discov Today 2003, 8:101-119.
-
(2003)
Drug Discov Today
, vol.8
, pp. 101-119
-
-
Huang, Y.1
Sadée, W.2
-
155
-
-
3042655528
-
Membrane transporters and channels: Role of the transportome in cancer chemosensitivity and chemoresistance
-
Huang Y, Anderle P, Bussey KJ, Barbacioru C, Shankavaram U, Dai Z, Reinhold WC, Papp A, Weinstein JN, Sadée W. Membrane transporters and channels: Role of the transportome in cancer chemosensitivity and chemoresistance. Cancer Res 2004, 64:243-253.
-
(2004)
Cancer Res
, vol.64
, pp. 243-253
-
-
Huang, Y.1
Anderle, P.2
Bussey, K.J.3
Barbacioru, C.4
Shankavaram, U.5
Dai, Z.6
Reinhold, W.C.7
Papp, A.8
Weinstein, J.N.9
Sadée, W.10
-
156
-
-
5144226212
-
Mining our ABCs: Pharmacoge-nomic approach for evaluating transporter function in cancer drug resistance
-
Ross DD, Doyle LA. Mining our ABCs: Pharmacoge-nomic approach for evaluating transporter function in cancer drug resistance. Cancer Cell 2004, 6:1995-2004.
-
(2004)
Cancer Cell
, vol.6
, pp. 1995-2004
-
-
Ross, D.D.1
Doyle, L.A.2
-
157
-
-
5144226566
-
Predicting drug sensitivity and resistance: Profiling ABC trans-porter genes in cancer cells
-
Szakacs G, Annereau JP, Lababidi S, Shankavaram U, Arciello A, Bussey KJ, Reinhold W, Guo Y, Kruh GD, Reimers M, Weinstein JN, Gottesman MM. Predicting drug sensitivity and resistance: Profiling ABC trans-porter genes in cancer cells. Cancer Cell 2004, 6:1086-1099.
-
(2004)
Cancer Cell
, vol.6
, pp. 1086-1099
-
-
Szakacs, G.1
Annereau, J.P.2
Lababidi, S.3
Shankavaram, U.4
Arciello, A.5
Bussey, K.J.6
Reinhold, W.7
Guo, Y.8
Kruh, G.D.9
Reimers, M.10
Weinstein, J.N.11
Gottesman, M.M.12
-
158
-
-
5144226566
-
Predicting drug sensitivity and resistance: Profiling ABC trans-porter genes in cancer cells
-
Comment in
-
Szakacs G, Annereau JP, Lababidi S, Shankavaram U, Arciello A, Bussey KJ, Reinhold W, Guo Y, Kruh GD, Reimers M, Weinstein JN, Gottesman MM. Predicting drug sensitivity and resistance: Profiling ABC trans-porter genes in cancer cells. Cancer Cell 2004, 6:417-425. Comment in.
-
(2004)
Cancer Cell
, vol.6
, pp. 417-425
-
-
Szakacs, G.1
Annereau, J.P.2
Lababidi, S.3
Shankavaram, U.4
Arciello, A.5
Bussey, K.J.6
Reinhold, W.7
Guo, Y.8
Kruh, G.D.9
Reimers, M.10
Weinstein, J.N.11
Gottesman, M.M.12
-
159
-
-
0036805724
-
Comparison of human duodenum Caco-2 gene expression profiles for 12000 gene sequences tags and correlation with permeability of 26 drugs
-
Sun D, Lennernäs H, Welage LS, Barnett JL, Landowski CP, Foster D, Fleisher D, Lee KD, Amidon GL. Comparison of human duodenum Caco-2 gene expression profiles for 12000 gene sequences tags and correlation with permeability of 26 drugs. Pharm Res 2002, 19:184-193.
-
(2002)
Pharm Res
, vol.19
, pp. 184-193
-
-
Sun, D.1
Lennernäs, H.2
Welage, L.S.3
Barnett, J.L.4
Landowski, C.P.5
Foster, D.6
Fleisher, D.7
Lee, K.D.8
Amidon, G.L.9
-
160
-
-
0024292717
-
An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene
-
Choi KH, Chen CJ, Kriegler M, Roninson IB. An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene. Cell 1988, 53:555-565.
-
(1988)
Cell
, vol.53
, pp. 555-565
-
-
Choi, K.H.1
Chen, C.J.2
Kriegler, M.3
Roninson, I.B.4
-
161
-
-
0024362996
-
P-glycoprotein gene (MDR1) cDNA from human adrenal: Normal P-glycoprotein carries Gly185 with an altered pat-tern of multidrug resistance
-
Kioka N, Tsubota J, Kakehi Y, Komano T, Gottesman MM, Pastan I, et al. P-glycoprotein gene (MDR1) cDNA from human adrenal: Normal P-glycoprotein carries Gly185 with an altered pat-tern of multidrug resistance. Biochem Biophys Res Commun 1989, 162:15-40.
-
(1989)
Biochem Biophys Res Commun
, vol.162
, pp. 15-40
-
-
Kioka, N.1
Tsubota, J.2
Kakehi, Y.3
Komano, T.4
Gottesman, M.M.5
Pastan, I.6
-
162
-
-
84882488321
-
Genetic polymorphism in MDR-1: A tool for examining allelic expression in normal cells unselected drug-selected cells and human tumors
-
Mickley LA, Lee JS, Weng Z, Zhan Z, Alvarez M, Wilson W, et al. Genetic polymorphism in MDR-1: A tool for examining allelic expression in normal cells unselected drug-selected cells and human tumors. Blood 1998, 91:29-58.
-
(1998)
Blood
, vol.91
, pp. 29-58
-
-
Mickley, L.A.1
Lee, J.S.2
Weng, Z.3
Zhan, Z.4
Alvarez, M.5
Wilson, W.6
-
163
-
-
0030963724
-
Identification of a P-glycoprotein-deficient subpopulation in the CF-1 mouse strain using a restriction fragment length poly-morphism
-
Umbenhauer DR, Lankas GR, Pippert TR, Wise LD, Cartwright ME, Hall SJ, et al. Identification of a P-glycoprotein-deficient subpopulation in the CF-1 mouse strain using a restriction fragment length poly-morphism. Toxicol Appl Pharmacol 1997, 146:959-963.
-
(1997)
Toxicol Appl Pharmacol
, vol.146
, pp. 959-963
-
-
Umbenhauer, D.R.1
Lankas, G.R.2
Pippert, T.R.3
Wise, L.D.4
Cartwright, M.E.5
Hall, S.J.6
-
164
-
-
0034724324
-
Functional polymor-phisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression an
-
Hoffmeyer S, Burk O, von Richter O, Arnold HP, Brockmoller J, Johne A, et al. Functional polymor-phisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression an. Proc Natl Acad Sci USA 2000, 97:487-491.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 487-491
-
-
Hoffmeyer, S.1
Burk, O.2
von, R.O.3
Arnold, H.P.4
Brockmoller, J.5
Johne, A.6
-
165
-
-
1442277718
-
The role of MDR1 genetic polymorphisms in interindividual variability in P-glycoprotein expression and function
-
Woodahl EL, Ho RJ. The role of MDR1 genetic polymorphisms in interindividual variability in P-glycoprotein expression and function. Curr Drug Metab 2004, 5:S33-S40.
-
(2004)
Curr Drug Metab
, vol.5
-
-
Woodahl, E.L.1
Ho, R.J.2
-
166
-
-
3042772026
-
Identification of functionally variant MDR1 alleles among European Americans and African Americans
-
Kim RB, Leake BF, Choo EF, Dresser GK, Kubba SV, Schwarz UI, et al. Identification of functionally variant MDR1 alleles among European Americans and African Americans. Clin Pharmacol Ther 2001, 70:E16.
-
(2001)
Clin Pharmacol Ther
, vol.70
-
-
Kim, R.B.1
Leake, B.F.2
Choo, E.F.3
Dresser, G.K.4
Kubba, S.V.5
Schwarz, U.I.6
-
167
-
-
84882496268
-
Swiss HIV Cohort Study
-
Fellay J, Marzolini C, Meaden ER, Back DJ, Buclin T, Chave JP, et al. Swiss HIV Cohort Study. Lancet 2002, 359:265-274.
-
(2002)
Lancet
, vol.359
, pp. 265-274
-
-
Fellay, J.1
Marzolini, C.2
Meaden, E.R.3
Back, D.J.4
Buclin, T.5
Chave, J.P.6
-
168
-
-
84882496268
-
Swiss HIV Cohort Study
-
Comment in
-
Fellay J, Marzolini C, Meaden ER, Back DJ, Buclin T, Chave JP, et al. Swiss HIV Cohort Study. Lancet 2002, 359:2114. Comment in.
-
(2002)
Lancet
, vol.359
, pp. 2114
-
-
Fellay, J.1
Marzolini, C.2
Meaden, E.R.3
Back, D.J.4
Buclin, T.5
Chave, J.P.6
-
169
-
-
84882496268
-
Swiss HIV Cohort Study
-
Fellay J, Marzolini C, Meaden ER, Back DJ, Buclin T, Chave JP, et al. Swiss HIV Cohort Study. Lancet 2002, 359:252-274.
-
(2002)
Lancet
, vol.359
, pp. 252-274
-
-
Fellay, J.1
Marzolini, C.2
Meaden, E.R.3
Back, D.J.4
Buclin, T.5
Chave, J.P.6
-
170
-
-
84882523056
-
Pharmacogenetics of membrane transporters investigators
-
Kroetz DL, Pauli-Magnus C, Hodges LM, Huang CC, Kawamoto M, Johns SJ, et al. Pharmacogenetics of membrane transporters investigators. Pharmacoge-netics 2003, 13:573-592.
-
(2003)
Pharmacoge-netics
, vol.13
, pp. 573-592
-
-
Kroetz, D.L.1
Pauli-magnus, C.2
Hodges, L.M.3
Huang, C.C.4
Kawamoto, M.5
Johns, S.J.6
-
171
-
-
84882523056
-
Pharmacogenetics of membrane transporters investigators
-
Erratum in
-
Kroetz DL, Pauli-Magnus C, Hodges LM, Huang CC, Kawamoto M, Johns SJ, et al. Pharmacogenetics of membrane transporters investigators. Pharmacogenetics 2003, 13:701. Erratum in.
-
(2003)
Pharmacogenetics
, vol.13
, pp. 701
-
-
Kroetz, D.L.1
Pauli-magnus, C.2
Hodges, L.M.3
Huang, C.C.4
Kawamoto, M.5
Johns, S.J.6
-
172
-
-
0037246432
-
Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine
-
Zamber CP, Lamba JK, Yasuda K, Farnum J, Thummel K, Schuetz JD, Schuetz EG. Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine. Pharmacogenetics 2003, 13:116-125.
-
(2003)
Pharmacogenetics
, vol.13
, pp. 116-125
-
-
Zamber, C.P.1
Lamba, J.K.2
Yasuda, K.3
Farnum, J.4
Thummel, K.5
Schuetz, J.D.6
Schuetz, E.G.7
-
173
-
-
3042651340
-
Diflomotecan pharmacokinetics in relation to ABCG2 421C>A genotype
-
Sparreboom A, Gelderblom H, Marsh S, Ahluwalia R, Obach R, Principe P, Twelves C, Verweij J, McLeod HL. Diflomotecan pharmacokinetics in relation to ABCG2 421C>A genotype. Clin Pharmacol Ther 2004, 76:465-468.
-
(2004)
Clin Pharmacol Ther
, vol.76
, pp. 465-468
-
-
Sparreboom, A.1
Gelderblom, H.2
Marsh, S.3
Ahluwalia, R.4
Obach, R.5
Principe, P.6
Twelves, C.7
Verweij, J.8
McLeod, H.L.9
-
174
-
-
4444381535
-
ABCG2 phar-macogenetics: Ethnic differences in allele frequency and assessment of influence on irinotecan disposition
-
De Jong FA, Marsh S, Mathijssen RH, King C, Verweij J, Sparreboom A, McLeod HL. ABCG2 phar-macogenetics: Ethnic differences in allele frequency and assessment of influence on irinotecan disposition. Clin Cancer Res 2004, 10:459-462.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 459-462
-
-
De, J.F.A.1
Marsh, S.2
Mathijssen, R.H.3
King, C.4
Verweij, J.5
Sparreboom, A.6
McLeod, H.L.7
-
175
-
-
2342644918
-
Expression up-regulation and transport activity of the multidrug-resistance protein Abcg2 at the mouse blood-brain barrier
-
Cisternino S, Mercier C, Bourasset F, Roux F, Scherrmann JM. Expression up-regulation and transport activity of the multidrug-resistance protein Abcg2 at the mouse blood-brain barrier. Cancer Res 2004, 64:375-388.
-
(2004)
Cancer Res
, vol.64
, pp. 375-388
-
-
Cisternino, S.1
Mercier, C.2
Bourasset, F.3
Roux, F.4
Scherrmann, J.M.5
-
176
-
-
0036865724
-
Identification of genetic variations of the human organic cation trans-porter hOCT1 and their functional consequences
-
Kerb R, Brinkmann U, Chatskaia N, Gorbunov D, Gorboulev V, Mornhinweg E, et al. Identification of genetic variations of the human organic cation trans-porter hOCT1 and their functional consequences. Pharmacogenetics 2002, 12:E20.
-
(2002)
Pharmacogenetics
, vol.12
-
-
Kerb, R.1
Brinkmann, U.2
Chatskaia, N.3
Gorbunov, D.4
Gorboulev, V.5
Mornhinweg, E.6
-
177
-
-
0036020986
-
Polymorphisms in a human kidney xenobiotic transporter OCT2 exhibit altered function
-
Leabman MK, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, et al. Polymorphisms in a human kidney xenobiotic transporter OCT2 exhibit altered function. Pharmacogenetics 2002, 12:E1.
-
(2002)
Pharmacogenetics
, vol.12
-
-
Leabman, M.K.1
Huang, C.C.2
Kawamoto, M.3
Johns, S.J.4
Stryke, D.5
Ferrin, T.E.6
-
178
-
-
0036865711
-
Polymorphisms affecting function of the human organic cation transporter hOCT1 (SLC22A1): What are the consequences?
-
Schinkel AH, Jonker JW. Polymorphisms affecting function of the human organic cation transporter hOCT1 (SLC22A1): What are the consequences?. Phar-macogenetics 2002, 12:356-363.
-
(2002)
Phar-macogenetics
, vol.12
, pp. 356-363
-
-
Schinkel, A.H.1
Jonker, J.W.2
-
179
-
-
0035929574
-
Polymor-phisms in OATP-C: Identification of multiple allelic variants associated with altered transport activity among European-and African-Americans
-
Tirona RG, Leake BF, Merino G, Kim RB. Polymor-phisms in OATP-C: Identification of multiple allelic variants associated with altered transport activity among European-and African-Americans. J Biol Chem 2001, 276:4294-4301.
-
(2001)
J Biol Chem
, vol.276
, pp. 4294-4301
-
-
Tirona, R.G.1
Leake, B.F.2
Merino, G.3
Kim, R.B.4
-
180
-
-
0038209381
-
Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: Consequences for pravastatin pharmacokinetics
-
Nishizato Y, Ieiri I, Suzuki H, Kimura M, Kawabata K, Hirota T, et al. Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: Consequences for pravastatin pharmacokinetics. Clin Pharmacol Ther 2003, 73:129-137.
-
(2003)
Clin Pharmacol Ther
, vol.73
, pp. 129-137
-
-
Nishizato, Y.1
Ieiri, I.2
Suzuki, H.3
Kimura, M.4
Kawabata, K.5
Hirota, T.6
-
181
-
-
0037131885
-
Pharmacogenomics of organic anion-transporting polypeptides (OATP)
-
Tirona RG, Kim RB. Pharmacogenomics of organic anion-transporting polypeptides (OATP). Adv Drug Deliv Rev 2002, 54:105-107.
-
(2002)
Adv Drug Deliv Rev
, vol.54
, pp. 105-107
-
-
Tirona, R.G.1
Kim, R.B.2
-
183
-
-
0038612980
-
Natural variation in human membrane transporter genes reveals evolu-tionary and functional constraints
-
Leabman MK, Huang CC, De Young J, Carlson EJ, Taylor TR, de la Cruz M, et al. Natural variation in human membrane transporter genes reveals evolu-tionary and functional constraints. Proc Natl Acad Sci USA 2003, 100:1400-1416.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 1400-1416
-
-
Leabman, M.K.1
Huang, C.C.2
De, Y.J.3
Carlson, E.J.4
Taylor, T.R.5
de, L.C.M.6
-
184
-
-
10744229920
-
Functional genetic diversity in the concentrative nucleoside transporter CNT1in human populations
-
Gray JH, Mangravite LM, Owen RP, Urban TJ, Chan W, Carlson EJ, et al. Functional genetic diversity in the concentrative nucleoside transporter CNT1in human populations. Mol Pharmacol 2004, 65:519-529.
-
(2004)
Mol Pharmacol
, vol.65
, pp. 519-529
-
-
Gray, J.H.1
Mangravite, L.M.2
Owen, R.P.3
Urban, T.J.4
Chan, W.5
Carlson, E.J.6
-
185
-
-
84882507263
-
Drug bioavailability - estimation of sol-ubility, permeability, absorption and bioavailability
-
Wiley-VCH Verlag GmbH & Co., Weinheim
-
Van de Waterbeemd H, Lennernäs H, Artursson P Drug bioavailability - estimation of sol-ubility, permeability, absorption and bioavailability. Methods and principles of medicinal chemistry 2003, vol 18. Wiley-VCH Verlag GmbH & Co., Weinheim.
-
(2003)
Methods and principles of medicinal chemistry
, vol.18
-
-
Van, D.W.H.1
Lennernäs, H.2
Artursson, P.3
-
186
-
-
0037212497
-
Hydrogen bonding descrip-tors in the prediction of human in vivo intestinal permeability
-
Winiwarter S, Ax F, Lennernäs H, Hallberg A, Pettersson C, Karlen A. Hydrogen bonding descrip-tors in the prediction of human in vivo intestinal permeability. J Mol Graph Model 2003, 21:224-231.
-
(2003)
J Mol Graph Model
, vol.21
, pp. 224-231
-
-
Winiwarter, S.1
Ax, F.2
Lennernäs, H.3
Hallberg, A.4
Pettersson, C.5
Karlen, A.6
-
187
-
-
0031872134
-
Predicting drug absorption from molecular surface properties based on molecular dynamics simulations
-
Krarup LH, Christensen IT, Hovgaard L, Frokjaer S. Predicting drug absorption from molecular surface properties based on molecular dynamics simulations. Pharm Res 1998, 15:1749-1756.
-
(1998)
Pharm Res
, vol.15
, pp. 1749-1756
-
-
Krarup, L.H.1
Christensen, I.T.2
Hovgaard, L.3
Frokjaer, S.4
-
188
-
-
0036844787
-
Predicting blood-brain barrier partitioning of organic molecules using membrane-interaction QSAR analysis
-
Iyer M, Mishru R, Han Y, Hopfinger AJ. Predicting blood-brain barrier partitioning of organic molecules using membrane-interaction QSAR analysis. Pharm Res 2002, 19:88-94.
-
(2002)
Pharm Res
, vol.19
, pp. 88-94
-
-
Iyer, M.1
Mishru, R.2
Han, Y.3
Hopfinger, A.J.4
-
189
-
-
84882562250
-
Computational methods to predict biopharmaceutical properties
-
Internet at
-
Bolger MB Computational methods to predict biopharmaceutical properties. AAPS meeting, Indianapolis 2000, Internet at. http://www.simulations-plus.com/pdf_files/aaps_2000_report.pdf.
-
(2000)
AAPS meeting, Indianapolis
-
-
Bolger, M.B.1
-
190
-
-
84882488076
-
-
KnowItAll ADME/Tox Blood-Brain Barrier Permeability Predictor
-
KnowItAll ADME/Tox Blood-Brain Barrier Permeability Predictor. (Internet at http://biorad.com/pages/SAD/collateral/predictors_blood_brain_barrier.pd f.).
-
-
-
-
191
-
-
0028948839
-
A theoretical basis for a biopharmaceutic drug clas-sification the correlation of in vitro drug product dissolution and in vivo bioavailability
-
Amidon GL, Lennernäs H, Shah VP, Crison JR. A theoretical basis for a biopharmaceutic drug clas-sification the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm Res 1995, 12:3473-3478.
-
(1995)
Pharm Res
, vol.12
, pp. 3473-3478
-
-
Amidon, G.L.1
Lennernäs, H.2
Shah, V.P.3
Crison, J.R.4
-
192
-
-
18944373550
-
In silico strategies for modeling membrane transporter function
-
Chang C, Ray A, Swaan P. In silico strategies for modeling membrane transporter function. Drug Discov Today 2005, 10:11-19.
-
(2005)
Drug Discov Today
, vol.10
, pp. 11-19
-
-
Chang, C.1
Ray, A.2
Swaan, P.3
|