Comparison of human duodenum and Caco-2 gene expression profiles for 12,000 gene sequences tags and correlation with permeability of 26 drugs

Pharmaceutical Research

Volumn 19, Issue 10, 2002, Pages 1400-1416

  Sun, Duxin ^a,b   Lennernas, Hans ^c   Welage, Lynda S ^a   Barnett, Jeffery L ^d   Landowski, Christopher P ^a   Foster, David ^a   Fleisher, David ^a   Lee, Kyung Dall ^a   Amidon, Gordon L ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

^c UPPSALA UNIVERSITY   (Sweden)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Gene expression; GeneChip ; In vivo in vitro correlation; Permeability; Transporter

Indexed keywords

ABC TRANSPORTER; AMOXICILLIN; ATENOLOL; CARRIER PROTEIN; CEFALEXIN; CIMETIDINE; CREATINE; CYCLOSPORIN; DESIPRAMINE; DRUG CARRIER; ENALAPRIL; FUROSEMIDE; GLUCOSE; GLUCOSE TRANSPORTER; HYDROCHLOROTHIAZIDE; KETOPROFEN; LEUCINE; LEVODOPA; LISINOPRIL; LOSARTAN; MANNITOL; METOPROLOL; NAPROXEN; PHENAZONE; PHENYLALANINE; PIROXICAM; PROPRANOLOL; RANITIDINE; TERBUTALINE; VERAPAMIL;

ARTICLE; CELL CULTURE; CELL STRAIN CACO 2; COMPUTER ANALYSIS; COMPUTER PROGRAM; DEVICE; DRUG ABSORPTION; DRUG PENETRATION; DUODENUM; FEMALE; GENE EXPRESSION; GENE SEQUENCE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; JEJUNUM; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; SEQUENCE TAGGED SITE;

NON-PROGRAMMATIC;

ADULT; CACO-2 CELLS; DUODENUM; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PERMEABILITY; PHARMACEUTICAL PREPARATIONS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE TAGGED SITES;

EID: 0036805724     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020483911355     Document Type: Article

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