Protein transduction domains: Are they delivering?

Trends in Pharmacological Sciences

Volumn 24, Issue 5, 2003, Pages 213-215

  Green, Isabelle ^a   Christison, Richard ^a   Voyce, Catherine J ^a   Bundell, Ken R ^a   Lindsay, Mark A ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN; PROTEIN TRANSDUCTION DOMAIN; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; CELL TRANSPORT; CELL TYPE; FUNCTIONAL ASSESSMENT; FUTUROLOGY; HUMAN IMMUNODEFICIENCY VIRUS; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN NUCLEIC ACID INTERACTION; PROTEIN PROTEIN INTERACTION; RNA TRANSCRIPTION; SHORT SURVEY; SIGNAL TRANSDUCTION;

EID: 0038061635     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-6147(03)00076-2     Document Type: Short Survey

References (21)

1. Lindgren M., et al. Cell-penetrating peptides. Trends Pharmacol. Sci. 21:2000;99-103.
2. Wadia J.S., Dowdy S.F. Protein transduction technology. Curr. Opin. Biotechnol. 13:2002;52-56.
3. Schwarze S.R., et al. In vivo protein transduction: delivery of a biologically active protein into the mouse. Science. 285:1999;1569-1572.
4. Richard J.P., et al. Cell-penetrating peptides. A reevaluation of the mechanism of cellular uptake. J. Biol. Chem. 278:2003;585-590.
5. Leifert J.A., et al. Full-length proteins attached to the HIV tat protein transduction domain are neither transduced between cells, nor exhibit enhanced immunogenicity. Gene Ther. 9:2002;1422-1428.
6. Sandgren S., et al. Nuclear targeting of macromolecular polyanions by an HIV-Tat derived peptide. Role for cell-surface proteoglycans. J. Biol. Chem. 277:2002;38877-38883.
7. Koppelhus U., et al. Cell-dependent differential cellular uptake of PNA, peptides, and PNA-peptide conjugates. Antisense Nucleic Acid Drug Dev. 12:2002;51-63.
8. Vives E., et al. A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus. J. Biol. Chem. 272:1997;16010-16017.
9. Derossi D., et al. Cell internalization of the third helix of the Antennapedia homeodomain is receptor-independent. J. Biol. Chem. 271:1996;18188-18193.
10. Wender P.A., et al. The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters. Proc. Natl. Acad. Sci. U. S. A. 97:2000;13003-13008.
11. Derossi D., et al. Trojan peptides: the penetratin system for intracellular delivery. Trends Cell Biol. 8:1998;84-87.
12. Nagahara H., et al. Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration. Nat. Med. 4:1998;1449-1452.
13. Lundberg M., Johansson M. Is VP22 nuclear homing an artifact? Nat. Biotechnol. 19:2001;713-714.
14. Lindsay M.A. Peptide-mediated cell delivery: application in protein target validation. Curr. Opin. Pharmacol. 2:2002;587-594.
15. Cao G., et al. In vivo delivery of a Bcl-xl fusion protein containing the TAT protein transduction domain protects against ischemic brain injury and neuronal apoptosis. J. Neurosci. 22:2002;5423-5431.
16. Denicourt C., Dowdy S.F. Protein transduction technology offers novel therapeutic approach for brain ischemia. Trends Pharmacol. Sci. 2003;24.
17. Jacobson, G.M. et al. Novel NAD(P)H oxidase inhibitor suppresses angioplasty-induced superoxide and neointimal hyperplasia of rat carotid artery. Circ. Res. (in press).
18. Jo D., et al. Epigenetic regulation of gene structure and function with a cell-permeable Cre recombinase. Nat. Biotechnol. 19:2001;929-933.
19. Astriab-Fisher A., et al. Antisense inhibition of P-glycoprotein expression using peptide-oligonucleotide conjugates. Biochem. Pharmacol. 60:2000;83-90.
20. Rudolph, C. et al. Oligomers of the arginine-rich motif of the HIV-1 TAT protein are capable of transferring plasmid DNA into cells. J. Biol. Chem. (in press).
21. Torchilin V.P., et al. Cell transfection in vitro and in vivo with nontoxic TAT peptide-liposome-DNA complexes. Proc. Natl. Acad. Sci. U. S. A. 100:2003;1972-1977.