N-trimethylated chitosan chloride (tmc) improves the intestinal permeation of the peptide drug buserelin in vitro (caco-2 cells) and in vivo (rats)

Pharmaceutical Research

Volumn 17, Issue 1, 2000, Pages 27-31

  Thanou, M ^a   Florea, B I ^a   Langemeyer M W E ^a   Verhoef, J C ^a   Junginger, H E ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Buserelin; Caco 2 cells; Chitosan HCl; Intestinal absorption in vivo; Intraduodenal administration; N trimethyl chitosan chloride

Indexed keywords

BUSERELIN ACETATE; CHITOSAN DERIVATIVE; PEPTIDE DERIVATIVE; SEACURE 244; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; INTESTINE MUCOSA; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BIOLOGICAL TRANSPORT; BUSERELIN; CACO-2 CELLS; CHITIN; CHITOSAN; DRUG CARRIERS; HUMANS; HYDROGEN-ION CONCENTRATION; INTESTINAL ABSORPTION; MALE; RATS; RATS, WISTAR;

EID: 0034049537     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007558206506     Document Type: Article

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