Novel roles for insulin receptor (IR) in adipocytes and skeletal muscle cells via new and unexpected substrates

Cellular and Molecular Life Sciences

Volumn 70, Issue 16, 2013, Pages 2815-2834

  Ramalingam, Latha ^a   Oh, Eunjin ^a   Thurmond, Debbie C ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adipose tissue; Insulin receptor; Insulin receptor substrate; Insulin signaling; Longevity; Metabolism; Mitogenesis; Skeletal muscle

Indexed keywords

ADAPTOR PROTEIN; ADIPOSE PROTEIN 2; BINDING PROTEIN; CAVEOLIN 1; CAVEOLIN 3; CBL PROTEIN; CYCLIC AMP BINDING PROTEIN; GRB 2 ASSOCIATED BINDER 1 PROTEIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; JANUS KINASE 1; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; MUNC18 PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN SHC; SIRTUIN; SNARE PROTEIN; SOMATOMEDIN RECEPTOR; STAT5B PROTEIN; TRANSCRIPTION FACTOR FOXO; UNCLASSIFIED DRUG;

ADIPOCYTE; AGING; CELL TYPE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; DOWN REGULATION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE LOCATION; GENE MUTATION; GENE STRUCTURE; GLUCOSE HOMEOSTASIS; GLUCOSE TRANSPORT; HUMAN; INSULIN RECEPTOR GENE; INSULIN RESISTANCE; KNOCKOUT MOUSE; LIFESPAN; LONGEVITY; MITOGENESIS; MUSCLE CELL; NONHUMAN; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATOR GENE; REVIEW; SIGNAL TRANSDUCTION; SKELETAL MUSCLE CELL;

ADIPOCYTES; ANIMALS; HUMANS; INSULIN; MUSCLE CELLS; MUSCLE, SKELETAL; RECEPTOR, INSULIN;

EID: 84881134459     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-012-1176-1     Document Type: Review

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