A novel, multifunctional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes

Molecular and Cellular Biology

Volumn 18, Issue 2, 1998, Pages 872-879

  Ribon, Vered ^a,b   Printen, John A ^a,b   Hoffman, Noah G ^c   Kay, Brian K ^d   Saltiel, Alan R ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b PFIZER INC   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTE; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CELL STRAIN 3T3; FIBROBLAST; GROWTH REGULATION; HORMONAL REGULATION; MITOGENICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN PHOSPHORYLATION; SEQUENCE HOMOLOGY; ANIMAL; CHEMISTRY; ISOLATION AND PURIFICATION; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

CARRIER PROTEIN; CBL PROTEIN; CBL PROTEIN, MOUSE; FYN PROTEIN, MOUSE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; INSULIN RECEPTOR; ONCOPROTEIN; PROTEIN; PROTEIN KINASE FYN; PROTEIN TYROSINE KINASE; TYROSINE; UBIQUITIN PROTEIN LIGASE;

3T3 CELLS; ADIPOCYTES; ANIMALS; CARRIER PROTEINS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; MICE; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-CBL; PROTO-ONCOGENE PROTEINS C-CRK; PROTO-ONCOGENE PROTEINS C-FYN; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; TYROSINE; UBIQUITIN-PROTEIN LIGASES;

EID: 0031594145     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.18.2.872     Document Type: Article

References (46)

1. Andoniou, C. E., C. B. F. Thien, and W. Y. Langdon. 1994. Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene. EMBO J. 13:4515-4523.
2. Araki, E., M. A. Lipes, M. E. Patti, J. C. Bruning, B. Haag, R. S. Johnson, and R. C. Kahn. 1994. Alternative pathway of insulin signaling in mice with targeted disruption of the IRS-1 gene. Nature (London) 372:186-190.
3. Backer, J. M., M. G. Mayers, Jr., S. E. Shoelson, D. J. Chin, X.-J. Sun, M. Miralpeix, H. Patrick, B. Margolis, E. Y. Skolnik, J. Schlessinger, and M. F. White. 1992. Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation. EMBO J. 11:3469-3479.
4. Birge, R. B., E. J. Fajardo, C. Reichman, S. E. Shoelson, Z. Songyang, L. C. Cantley, and H. Hanafusa. 1993. Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts. Mol. Cell. Biol. 13:4648-4656.
5. Blake, T., K. Heath, and W. Langdon. 1993. The truncation that generated the v-cbl oncogene reveals an ability for nuclear transport, DNA binding and acute transformation. EMBO J. 12:2017-2026.
6. Blake, T., M. Shapiro, H. Morse, and W. Langdon. 1991. The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif. Oncogene 6:653-657.
7. Bruning, J. C., J. Winnay, B. Cheatham, and C. R. Kahn. 1997. Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells. Mol. Cell. Biol. 17:1513-1521.
8. Buday, L., A. Khwaja, S. Sipeki, A. Farago, and J. Downward. 1996. Interactions of Cbl with two adapter proteins, Grb2 and Crk, upon T cell activation. J. Biol. Chem. 271:6159-6163.
9. Chomcynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
10. de Herreros, A. G., and M. J. Birnbaum. 1989. The acquisition of increased insulin-responsive hexose transporter in 3T3-L1 adipocytes correlates with expression of a novel transporter gene. J. Biol. Chem. 264:19994-19999.
11. Donovan, J. A., R. L. Wagner, W. Y. Langdon, and L. E. Samelson. 1994. The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor. J. Biol. Chem. 269:22921-22924.
12. Feller, M. S., B. Knudsen, and H. Hanafusa. 1995. Cellular proteins binding to the first src homology 3 (SH3) domain of the proto-oncogene product c-Crk indicates Crk-specific signaling pathways. Oncogene 10:1465-1473.
13. Fukazawa, T., S. Miyake, V. Band, and H. Band. 1996. Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins. J. Biol. Chem. 271:14554-14559.
14. Fukazawa, T., K. A. Reedquist, T. Traub, S. Soltoff, G. Panchamoorthy, B. Druker, L. Cantley, S. E. Shoelson, and H. Band. 1995. The SH3 domain binding T cell tyrosyl phosphoprotein p120. Demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and phosphatidylinositol 3-kinase. J. Biol. Chem. 270:19141-19150.
15. Galisteo, M. L., I. Dikic, A. G. Batzer, W. Y. Langdon, and J. Schlessinger. 1995. Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation. J. Biol. Chem. 270:20242-20245.
16. Holgado-Madruga, M., D. R. Emlet, D. K. Moscatello, A. K. Godwin, and A. J. Wong. 1996. A Grb2-associated docking protein in EGF- and insulin-receptor signaling. Nature (London) 379:560-564.
17. Kandror, K. V., J. M. Stephens, and P. F. Pilch. 1995. Expression and compartmentalization of caveolin in adipocytes cells: coordinate regulation with and structural segregation from GLUT4. J. Cell Biol. 129:999-1006.
18. cbl in antigen receptor-ligated B cells. J. Biol. Chem. 270:27504-27509.
19. Lazar, F. D., R. J. Wiese, M. J. Brady, C. M. Mastik, S. B. Waters, K. Yamauchi, J. E. Pessin, P. Cuatrecasas, and A. R. Saltiel. 1995. Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin. J. Biol. Chem. 270:20801-20807.
20. Levkowitz, G., L. N. Klapper, E. Tzahar, A. Freywald, M. Sela, and Y. Yarden. 1996. Coupling of the c-Cbl protooncogene product to ErbB-1/EGF-receptor but not to other ErbB proteins. Oncogene 12:1117-1125.
21. Odai, H., K. Sasaki, A. Iwamatsu, Y. Hanazono, T. Tanaka, K. Mitani, Y. Vazaki, and H. Hirai. 1995. The proto-oncogene product c-Cbl becomes tyrosine phosphorylated by stimulation with GM-CSF or Epo and constitutively hinds to the SH3 domain of Grb2/Ash in human hematopoietic cells. J. Biol. Chem. 270:10800-10805.
22. cbl links c-Src and phosphatidylinositol 3′-kinase to the integrin signaling pathway. J. Biol. Chem. 272:3780-3787.
23. Okada, S., and J. E. Pessin. 1996. Interactions between Src homology (SH)2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factor. J. Biol. Chem. 271:25533-25538.
24. Okada, S., K. Yamauchi, and J. E. Pessin. 1995. She isoform-specific tyrosine phosphorylation by the insulin and epidermal growth factor receptors. J. Biol. Chem. 270:20737-20741.
25. Pawson, T. 1995. Protein modules and signaling networks. Nature (London) 373:573-580.
26. Printen, J. A., and J. F. Sprague. 1994. Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade. Genetics 138:609-619.
27. ras. Mol. Cell. Biol. 14:1575-1581.
28. Ribon, V., S. Hubbell, R. Herrera, and A. R. Saltiel. 1996. The product of the cbl oncogene forms stable complexes in vivo with endogenous Crk in a tyrosine phosphorylation-dependent manner. Mol. Cell. Biol. 16:45-52.
29. Cas in PC-12 cells. J. Biol. Chem. 270:10800-10805.
30. Ribon, V., and A. R. Saltiel. 1997. Insulin stimulates tyrosine phosphorylation of the proto-oncogene product of c-Cbl in 3T3-L1 adipocytes. Biochem. J. 324:839-846.
31. Rivero-Lezcano, O., J. Sameshima, A. Marcilla, and K. Robbins. 1994. Physical association between src homology 3 elements and the protein product of the c-cbl proto-oncogene. J. Biol. Chem. 269:17363-17366.
32. Rose, D. W., A. R. Saltiel, M. Majumdar, S. J. Decker, and J. M. Olefsky. Insulin receptor substrate 1 is required for insulin-mediated mitogenic signal transduction. Proc. Natl. Acad. Sci. USA 91:797-801.
33. Rubin, C. S., E. Lai, and O. M. Rosen. 1977. Acquisition of increased hormone sensitivity during in vitro adipocyte development. J. Biol. Chem. 252:3554-3557.
34. Saltiel, A. R. 1996. Diverse signaling pathways in the cellular actions of insulin. Am. J. Physiol. 270:E375-E385.
35. ras-GTP formation. J. Biol. Chem. 269:10734-10738.
36. Skolnik, E. Y., C. H. Lee, A. Batzer, L. M. Vicentini, M. Zhou, R. Daly, M. J. Myers, J. M. Baker, A. Ullrich, M. F. White, and J. Schlessinger. 1993. The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and SHC: implications for insulin control of ras signaling. EMBO J. 12:1929-1936.
37. cbl is a cytosolic adapter protein that associates with phosphoinositide 3-kinase in response to epidermal growth factor in PC12 and other cells. J. Biol. Chem. 271:563-567.
38. Sparks, A. B., N. G. Hoffman, S. J. McConnell, D. M. Fowlkes, and B. K. Kay. 1996. Cloning of ligand targets: systematic isolation of SH3 domain containing proteins. Nat. Biotechnol. 14:741-745.
39. Sun, X.-J., P. Rothenberg, C. R. Kahn, J. M. Backer, E. Araki, P. A. Wilden, D. A. Cahill, B. J. Goldstein, and M. F. White. 1991. Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature (London) 352:73-77.
40. Sun, X.-J., L. M. Wang, Y. Zhang, L. Yenush, M. G. Myers, E. Glasheen, W. S. Lane, J. H. Pierce, and M. F. White. 1995. Role of IRS-2 in insulin and cytokine signaling. Nature (London) 377:173-177.
41. Tanaka, S., L. Neff, R. Baron, and J. B. Levy. 1995. Tyrosine phosphorylation and translocation of the c-Cbl protein after activation of tyrosine kinase signaling pathways. J. Biol. Chem. 270:14347-14351.
42. Vagne-descroix, M., D. Panasu, H. Jornvall, M. Carlquist, H. Guignard, G. Jourdan, G. Desvigne, M. Collinet, C. Caillet, and V. Mutt. 1991. Isolation and characterization of porcine sorbin. Eur. J. Biochem. 201:53-59.
43. van den Berghe, N., D. M. Ouwens, J. A. Maassen, M. G. H. van Mackelenbergh, H. C. M. Sips, and H. M. J. Krans. 1994. Activation of the Ras/mitogen-activated protein kinase signaling pathway alone is not sufficient to induce glucose uptake in 3T3-L1 adipocytes. Mol. Cell Biol. 14:2372-2377.
44. Waters, S. B., K. Yamauchi, and J. E. Pessin. 1995. Insulin-stimulated dissociation of the SOS-Grb2 complex. Mol. Cell. Biol. 15:2791-2799.
45. White, M. F., and C. R. Kahn. 1994. The insulin signaling system. J. Biol. Chem. 269:1-4.
46. Wiese, R. J., C. M. Mastik, F. D. Lazar, and A. R. Saltiel. 1995. Activation of mitogen-activated protein kinase and phosphatidylinositol 3′-kinase is not sufficient for the hormonal stimulation of glucose uptake, lipogenesis, or glycogen synthesis in 3T3-L1 adipocytes. J. Biol. Chem. 270:3442-3446.