Defects of the insulin receptor substrate (IRS) system in human metabolic disorders

FASEB Journal

Volumn 15, Issue 12, 2001, Pages 2099-2111

  Sesti, Giorgio ^a   Federici, Massimo ^b   Hribal, Marta L ^b   Lauro, Davide ^b   Sbraccia, Paolo ^b   Lauro, Renato ^b  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Insulin signaling; IRS 1; IRS 2; IRS 3; IRS 4; Type 2 diabetes

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER; INSULIN; INSULIN RECEPTOR;

ADIPOSE TISSUE; AMINO ACID ANALYSIS; AMINO ACID SUBSTITUTION; GLUCONEOGENESIS; GLUCOSE TRANSPORT; GLUCOSE UTILIZATION; HORMONE RECEPTOR INTERACTION; HUMAN; KNOCKOUT MOUSE; METABOLIC DISORDER; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN POLYMORPHISM; REVIEW; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; DIABETES MELLITUS, TYPE 2; HUMANS; INSULIN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; METABOLIC DISEASES; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; PHOSPHOPROTEINS; POLYMORPHISM, GENETIC; PROTEIN STRUCTURE, TERTIARY;

EID: 0034810894     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.01-0009rev     Document Type: Review

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49. Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover
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56. Mice lacking insulin receptor substrate 4 exhibit mild defects in growth reproduction, and glucose homeostasis
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60. Impaired glucose transport and insulin receptor tyrosine phosphorylation in skeletal muscle from obese women with gestational diabetes
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62. Multiple signaling pathways of the insulin like growth factor I receptor in protection from apoptosis
63. Low cellular IRS 1 gene and protein expression predict insulin resistance and NIDDM
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76. Prevalence of variants in candidate genes for type 2 diabetes mellitus in the Netherlands: The Rotterdam study and the Hoorn study
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78. Lack of IRS-1 codon 513 and 972 polymorphism in Pima Indians
79. Insulin resistance: Interaction between obesity and a common variant of insulin receptor substrate-1
80. A common mutation of the insulin receptor substrate-1 gene is a risk factor for coronary disease
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82. The Gly972Arg polymorphism in the insulin receptor substrate-1 gene contributes to the variation in insulin secretion in normal glucose-tolerant humans
83. A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling
84. Impact of natural IRS-1 mutations on insulin signals
85. Expression of variant forms of insulin receptor substrate-1 identified in patients with noninsulin-dependent diabetes mellitus
86. Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells
87. 972 polymorphism in insulin receptor substrate-1 causes apoptosis of human pancreatic islets
88. Insulin receptor substrate-2 amino acid polymorphisms are not associated with random type 2 diabetes among Caucasians
89. Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: Evaluation of their relation with alterations in insulin secretion and insulin sensitivity
90. Exclusion of the insulin receptor substrate-2 (IRS-2) as a major locus for early-onset autosomal dominant type 2 diabetes
91. Interaction between the G1057D variant of IRS-2 and overweight in the pathogenesis of type 2 diabetes
92. Common amino acid substitutions in insulin receptor substrate-4 are not associated with type II diabetes mellitus or insulin resistance
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94. Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and β-cell glucokinase genes