Insulin receptor isoform A, a newly recognized, high-affinity insulin- like growth factor II receptor in fetal and cancer cells

Molecular and Cellular Biology

Volumn 19, Issue 5, 1999, Pages 3278-3288

  Frasca, F ^a   Pandini, G ^a   Scalia, P ^a   Sciacca, L ^a   Mineo, R ^a   Costantino, A ^a   Goldfine, I D ^b   Belfiore, A ^c   Vigneri, R ^a,d  

^a UNIVERSITY OF CATANIA   (Italy)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^d GARIBALDI HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; INSULIN RECEPTOR; SOMATOMEDIN B; THYMIDINE;

ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; BINDING AFFINITY; CANCER CELL; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; FETUS CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING;

ANIMALIA; MUS MUSCULUS;

EID: 0032932822     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.5.3278     Document Type: Article

References (62)

1. Alexandrides, T., A. C. Moses, and R. J. Smith. 1989. Developmental expression of receptors for insulin, insulin-like growth factor I (IGF-I), and IGF-II in rat skeletal muscle. Endocrinology 124:1064-1076.
2. Avruch, J. 1998. Insulin signal transduction through protein kinase cascades. Mol. Cell. Biochem. 182:31-48.
3. Belfiore, A., A. Costantino, F. Frasca, G. Pandini, R. Mineo, P. Vigneri, I. D. Goldfine, B. A. Maddux, and R. Vigneri. 1996. Overexpression of membrane glycoprotein PC-1 in MDA-MB 231 breast cancer cells is associated with inhibition of insulin receptor tyrosine kinase activity. Mol. Endocrinol. 10: 1318-1326.
4. Boge, A., and R. A. Roth. 1995. A non radioactive assay for the insulin receptor tyrosine kinase: use in monitoring receptor tyrosine kinase activity after activation of overexpressed protein kinase C alpha and high glucose treatment. Anal. Biochem. 231:323-332.
5. Borsi, L., E. Balza, B. Gaggero, G. Alemanni, and L. Zardi. 1995. The alternative splicing pattern of the tenascin-C pre-mRNA is controlled by the extracellular pH. J. Biol. Chem. 270:6243-6245.
6. Boulle, N., A. Logie, C. Gicquel, L. Perin, and Y. Le Bouc. 1998. Increased levels of insulin-like growth factor II (IGF-II) and IGF-binding protein-2 are associated with malignancy in sporadic adrenocortical tumors. J. Clin. Endocrinol. Metab. 83:1713-1720.
7. Carrascosa, J. M., B. Vogt, A. Ullrich, and H. U. Haring. 1991. Activation of phosphatidylinositol-3-kinase by insulin is mediated by both A and B human insulin receptor types. Biochem. Biophys. Res. Commun. 174:123-127.
8. Cullen, K. C., M. E. Lippman, D. Chow, S. Hill, N. Rosen, and J. A. Zwiebel. 1992. Insulin-like growth factor-II overexpression in MCF-7 cells induces phenotypic changes associated with malignant progression. Mol. Endocrinol. 6:91-100.
9. DeChiara, T. M., A. Efstratiadis, and E. J. Robertson. 1990. A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature 345:78-80.
10. De Meyts, P. 1994. The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling. Diabetologia 37:S135-S148.
11. Efstratiadis, A. 1996. Genetics of growth: developmental roles of IGF and insulin receptors. Exp. Clin. Endocrinol. Diabetes 104(Suppl. 2):4-6.
12. Forsayeth, J. R., A. Montemurro, B. A. Maddux, R. DePirro, and I. D. Goldfine. 1987. Effect of Monoclonal antibodies on human insulin receptor autophosphorylation, negative cooperativity, and down-regulation. J. Biol. Chem. 262:4134-4140.
13. Frittitta, L., L. Sciacca, R. Catalfamo, A. Ippolito, P. Gangemi, V. Pezzino, S. Filetti, and R. Vigneri. 1999. Functional insulin receptors are overexpressed in thyroid tumors. Is this an early event in thyroid tumorigenesis? Cancer 85:492-498.
14. Gerweck, L. E., and K. Seetharaman. 1996. Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer. Cancer Res. 56:1194-1198.
15. Giddings, S. J., and L. R. Carnaghi. 1992. Insulin receptor gene expression during development: developmental regulation of insulin receptor mRNA abundance in embryonic rat liver and yolk sac, developmental regulation of insulin receptor gene splicing, and comparison to abundance of insulin-like growth factor 1 receptor mRNA. Mol. Endocrinol. 6:1665-1672.
16. Gliozzo, B., C. K. Sung, P. L. Scalia, V. Papa, F. Frasca, L. Sciacca, F. Giorgino, G. Milazzo, I. D. Goldfine, R. Vigneri, and V. Pezzino. 1998. Insulin-stimulated cell growth in IRS-1 deficient ZR-75-1 cells is mediated by a phosphatidylinositol-3 kinase independent pathway. J. Cell. Biochem. 70:268-280.
17. Hansen, B. F., G. M. Danielsen, K. Drejer, A. R. Sorensen, F. C. Wiberg, H. H. Klein, and A. G. Lundemose. 1996. Sustained signalling from the insulin receptor after stimulation with insulin analogues exhibiting increased mitogenic potency. Biochem. J. 315:271-279.
18. Hintz, R. L., A. V. Thorsson, G. Enberg, and K. Hall. 1984. IGF-II binding on human lymphoid cells: demonstration of a common high affinity receptor for insulin like peptides. Biochem. Biophys. Res. Commun. 118:774-782.
19. Jonas, H. A., J. D. Newman, and L. C. Harrison. 1986. An atypical insulin receptor with high affinity for insulin-like growth factors copurified with placental insulin receptors. Proc. Natl. Acad. Sci. USA 83:4124-4128.
20. Kao, A. W., S. B. Waters, S. Okada, and J. E. Pessin. 1997. Insulin stimulates the phosphorylation of the 66- and 52-kilodalton She isoforms by distinct pathways. Endocrinology 138:2474-2480.
21. Kore, M., C. A. Haussler, and N. S. Trookman. 1987. Divergent effects of epidermal growth factor and transforming growth factors on a human endometrial carcinoma cell line. Cancer Res. 47:4909-4914.
22. Kosaki, A., and N. J. Webster. 1993. Effect of dexamethasone on the alternative splicing of the insulin receptor mRNA and insulin action in HepG2 hepatoma cells. J. Biol. Chem. 268:21990-21996.
23. Kosaki, A., J. Nelson, and N. J. G. Webster. 1998. Identification of intron and exon sequences involved in alternative splicing of insulin receptor pre-mRNA. J. Biol. Chem. 273:10331-10337.
24. Kristiensen, C., F. C. Wiberg, L. Schaffer, and A. S. Andersen. 1998. Expression and characterization of a 70 kDa fragment of the insulin receptor that binds insulin. J. Biol. Chem. 273:17780-17786.
25. Lamothe, B., A. Bandry, C. T. Christoffersen, P. De Meyts, J. Jami, D. Bucchini, and R. L. Joshi. 1998. Insulin receptor-deficient cells as a new tool for dissecting complex interplay in insulin and insulin-like growth factors. FEBS Lett. 426:381-385.
26. Lipeski, L. E., J. M. Boylan, and P. A. Gruppuso. 1996. A comparison of epidermal growth factor receptor-mediated mitogenic signaling in response to transforming growth factor alpha and epidermal growth factor in cultured fetal rat hepatocytes. Biochem. Mol. Biol. Int. 39:975-983.
27. Liu, J-P., J. Baker, A. S. Perkins, E. J. Robertson, and A. Efstratiadis. 1993. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 75:59-72.
28. Louvi, A., D. Accili, and A. Efstratiadis. 1997. Growth promoting interaction of IGF-II with the insulin receptor during mouse embryonic development. Dev. Biol. 189:33-48.
29. Mayeda, A., D. M. Helfman, and A. R. Krainer. 1993. Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein Al and pre-mRNA splicing factor SF2/ASF. Mol. Cell. Biol. 13:2993-3001.
30. 3H1 myocites. Diabetes 41:274-284.
31. Milazzo, G., F. Giorgino, G. Damante, C. K. Sung, M. R. Stampfer, R. Vigneri, I. D. Goldfine, and A. Belfiore. 1992. Insulin receptor expression and function in human breast cancer cell lines. Cancer Res. 52:3924-3930.
32. Miura, M., E. Surmacz, J.-L. Burgaud, and R. Baserga. 1995. Different effects on mitogenesis and transformation of a mutation at tyrosine 1251 of the insulin-like growth factor I receptor. J. Biol. Chem. 270:22639-22644.
33. Moller, D. E., A. Yokota, J. F. Caro, and J. S. Flier. 1989. Tissue-specific expression of two alternatively spliced insulin receptor mRNAs in man. Mol. Endocrinol. 3:1263-1269.
34. Morrione, A., B. Valentinis, S. Xu, G. Yumet, A. Louvi, A. Efstratiadis, and R. Baserga. 1997. Insulin-like growth factor II stimulates cell proliferation through the insulin receptor. Proc. Natl. Acad. Sci. USA 94:3777-3782.
35. Mosthaf, L., K. Grako, T. J. Dull, L. Coussens, A. Ullrich, and D. A. McClain. 1990. Functionally distinct insulin receptors generated by tissue-specific alternative splicing. EMBO J. 8:2409-2413.
36. Myers, M. G., Jr., and M. F. White. 1996. Insulin signal transduction and the IRS proteins. Annu. Rev. Pharmacol. Toxicol. 36:615-658.
37. Nonomura, N., K. Nishimura, T. Miki, N. Kanno, Y. Kojima, M. Yokoyama, and A. Okuyama. 1997. Loss of imprinting of the insulin-like growth factor II gene in renal cell carcinoma. Cancer Res. 57:2575-2577.
38. Nordqvist, A. C., M. Peyrard, H. Pettersson, T. Mathiesen, V. P. Collins, J. P. Dumanski, and M. Schalling. 1997. A high ratio of insulin-like growth factor II/insulin-like growth factor binding protein 2 messenger RNA as a marker for anaplasia in meningiomas. Cancer Res. 57:2611-2614.
39. Nguyen, T. T., J-C. Scimeca, C. C. Filioux, P. Peraldi, J-L. Carpentier, and E. Van Obberghen. 1993. Co-regulation of the mitogen-activated protein kinase, extracellular signal-regulated kinase 1, and the 90-kDa ribosomal S6 kinase in PC12 cells. J. Biol. Chem. 268:9803-9810.
40. Okada, S., A. W. Kao, B. P. Ceresa, P. Blaikie, B. Margolis, and J. Pessin. 1997. The 66-kDa She isoform is a negative regulator of the epidermal-growth factor-stimulated mitogen-activated protein kinase pathway. J. Biol. Chem. 272:28042-28049.
41. Okamoto, K., I. M. Morison, T. Taniguchi, and A. E. Reeve. 1997. Epigenetic changes at the insulin-like growth factor II/H19 locus in developing kidney is an early event in Wilms tumorigenesis. Proc. Natl. Acad. Sci. USA 94:5367-5371.
42. Pandini, G., R. Vigneri, A. Costantino, F. Frasca, A. Ippolito, Y. Fujita-Yamaguchi, K. Siddle, I. D. Goldfine, and A. Belfiore. Insulin/IGF-I hybrid receptors play a major role in IGF-I signaling in breast cancer. Submitted for publication.
43. Papa, V., V. Pezzino, A. Costantino, A. Belfiore, D. Giufrida, L. Frittitta, G. B. Vannelli, R. Brand, I. D. Goldfine, and R. Vigneri. 1990. Elevated insulin receptor content in human breast cancer. J. Clin. Investig. 86:1503-1510.
44. Parruti, G., F. Peracchia, M. Sallese, G. Ambrosini, M. Masini, D. Rotilio, and A. De Blasi. 1993. Molecular analysis of human β-arrestin-1: cloning, tissue distribution, and regulation of expression. J. Biol. Chem. 268:9753-9761.
45. Roth, R. A., G. Steele-Perkins, J. Hari, C. Stover, S. Pierce, J. Turner, J. C. Edman, and W. J. Rutter. 1988. Insulin and insulin-like growth factor receptors and responses. Cold Spring Harbor Symp. Quant. Biol. 53:537-543.
46. Sasaoka, T., M. Ishiki, T. Sawa, H. Ishihara, Y. Takata, T. Imamura, I. Usui, J. M. Olefsky, and M. Kobayashi. 1996. Comparison of the insulin and insulin-like growth factor 1 mitogenic intracellular signalling pathways. Endocrinology 137:4427-4434.
47. Sbraccia, P., M. D'Adamo, F. Leonetti, S. Caiola, P. Iozzo, A. Giaccari, A. Buongiorno, and G. Tamburrano. 1996. Chronic primary hyperinsulinemia is associated with altered insulin receptor mRNA splicing in muscle of patients with insulinoma. Diabetologia 39:220-225.
48. Sciacca, L., A. Costantino, G. Pandini, R. Mineo, F. Frasca, P. Scalia, P. Sbraccia, I. D. Goldfine, R. Vigneri, and A. Belfiore. Insulin receptor activation by IGF-II in breast cancers: evidence for a new autocrine/paracrine mechanism. Oncogene, in press.
49. Sell, C., M. Rubini, R. Rubin, J-P. Liu, A. Efstratiadis, and R. Baserga. 1993. Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor. Proc. Natl. Acad. Sci. USA 90:11217-11221.
50. Shymko, M. R., P. De Meyts, and R. Thomas. 1997. Logical analysis of timing signalling specificity: application to the insulin receptor metabolic and mitogenic signalling pathways. Biochem. J. 326:463-469.
51. Singer, C. F., A. Rasmussen, M. E. Lippman, and K. J. Cullen. 1997. Coexpression of stromelysin-3 and insulin-like growth factor II in tumors of ectodermal, mesodermal, and endodermal origin: indicator of a fetal cell phenotype. J. Clin. Endocrinol. Metab. 82:1917-1922.
52. Soos, M. A., C. E. Field, R. Lammers, A. Ullrich, B. Zhang, R. A. Roth, A. S. Andersen, T. Kjeldsen, and K. Siddle. 1992. A panel of monoclonal antibodies for the type I insulin-like growth factor receptor. J. Biol. Chem. 267:12955-12963.
53. Steele-Perkins, G., J. Turner, J. C. Edman, J. Hari, S. B. Pierce, C. Stover, W. J. Rutter, and R. A. Roth. 1988. Expression and characterization of a functional human insulin-like growth factor 1 receptor. J. Biol. Chem. 263: 11486-11492.
54. Traverse, S., N. Gomez, H. Paterson, C. Marshall, and P. Cohen. 1992. Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor. Biochem. J. 288:351-355.
55. Ullrich, A., A. Gray, A. W. Tam, T. Yang-Feng, M. Tsubokawa, C. Collins, W. Henzel, T. Le Bon, S. Kathuria, E. Chen, S. Jacobs, U. Francke, J. Ramachandran, and Y. Fujita-Yamaguchi. 1986. Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. EMBO J. 5:2503-2512.
56. Wang, W., P. Kumar, W. Wang, J. Epstein, L. Helman, J. V. Moore, and S. Kumar. 1998. Insulin-like growth factor II and PAX-FKHHR cooperate in the oncogenesis of rhabdomyosarcoma. Cancer Res. 58:4426-4433.
57. Waters, S. B., K. H. Holt, S. E. Ross, L.-J. Syu, K.-L. Guan, A. R. Saltiel, G. A. Koretky, and J. E. Pessin. 1995. Desensitization of Ras activation by a feedback dissociation of the SOS-Grb2 complex. J. Biol. Chem. 270:20833-20886.
58. Werner, H., and D. LeRoith. 1996. The role of the insulin-like growth factor system in human cancer. Adv. Cancer Res. 68:183-223.
59. White, M. F. 1997. The insulin signalling system and the IRS proteins. Diabetologia 40(Suppl.):S2-S17.
60. Yamaguchi, Y., J. S. Flier, H. Benecke, B. J. Ransil, and D. E. Moller. 1993. Ligand-binding properties of the two isoforms of the human insulin receptor. Endocrinology 132:1132-1138.
61. Zhang, L., S. Zhan, F. Navid, Q. Li, Y. H. Choi, M. Kim, P. Seth, and J. L. Helman. 1998. AP 2 may contribute to IGF-II overexpression in rhabdomyosarcoma. Oncogene 17:1261-1270.
62. Zhang, L., Q. Zhan, S. Zhan, F. Kashanchi, A. J. Jr Fornace, P. Seth, and L. J. Helman. 1998. p53 regulates human insulin-like growth factor II gene expression through active P4 promoter in rhabdomyosarcoma cells. DNA Cell Biol. 17:125-131.