Plucking the high hanging fruit: A systematic approach for targeting protein-protein interactions

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 14, 2013, Pages 4051-4057

  Raj, Monika ^a   Bullock, Brooke N ^a   Arora, Paramjit S ^a  

^a NEW YORK UNIVERSITY   (United States)

Author keywords

Computational design; Hot spot residues; Protein protein interactions; Rational design; Secondary structure mimics

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE; CALMODULIN; CYCLIN DEPENDENT KINASE 2; GLYCOPROTEIN GP 41; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; NUCLEOTIDE BINDING PROTEIN; PHOSPHOTRANSFERASE; PROTEIN BAK; PROTEIN BCL XL; PROTEIN KB752; PROTEIN MDM2; PROTEIN P27; PROTEIN P53; RAS PROTEIN; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; HIGH THROUGHPUT SCREENING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; STRUCTURE ANALYSIS;

COMPUTER SIMULATION; DRUG DELIVERY SYSTEMS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEINS; SMALL MOLECULE LIBRARIES;

EID: 84879020527     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.11.023     Document Type: Article

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