Structure-based Mutagenesis Reveals Distinct Functions for Ras Switch 1 and Switch 2 in Sos-catalyzed Guanine Nucleotide Exchange

Journal of Biological Chemistry

Volumn 276, Issue 29, 2001, Pages 27629-27637

  Hall, Brian E ^a   Yang, Shao Song ^a   Boriack Sjodin, P Ann ^b,c   Kuriyan, John ^b   Bar Sagi, Dafna ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

^c BIOGEN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELLS; CONFORMATIONS; CRYSTAL STRUCTURE; ENZYMES; HYDROPHOBICITY; MOLECULAR STRUCTURE; SUBSTITUTION REACTIONS;

EXTRACELLULAR SIGNALS;

MUTAGENESIS;

GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR SOS; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; UNCLASSIFIED DRUG; GUANOSINE DIPHOSPHATE; MAGNESIUM; PHOSPHATE; PROTEIN P21;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING KINETICS; CATALYSIS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DISSOCIATION CONSTANT; ENZYME ACTIVE SITE; HYDROPHOBICITY; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; METABOLISM; PHYSIOLOGY; PROTEIN CONFORMATION;

AMINO ACID SUBSTITUTION; GUANOSINE DIPHOSPHATE; HUMANS; MAGNESIUM; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; ONCOGENE PROTEIN P21(RAS); PHOSPHATES; PROTEIN CONFORMATION;

EID: 0035920116     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M101727200     Document Type: Article

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