Design, synthesis, and evaluation of an a-helix mimetic library targeting protein-protein interactions

Journal of the American Chemical Society

Volumn 131, Issue 15, 2009, Pages 5564-5572

  Shaginian, Alex ^a   Whitby, Landon R ^a   Hong, Sukwon ^a   Hwang, Inkyu ^a   Farooqi, Bilal ^b   Searcey, Mark ^c   Chen, Jiandong ^b   Vogt, Peter K ^a   Boger, Dale L ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRAL COMPONENTS; ITERATIVE DESIGN; LIQUID-LIQUID EXTRACTION; NATURALLY OCCURRING; PROTEIN-PROTEIN INTERACTIONS; SIDE CHAINS; SMALL-MOLECULE LIBRARY; SOLUTION PHASE SYNTHESIS; SYNTHETIC PROTOCOLS;

AMINES; AMINO ACIDS; COMPLEXATION; DESIGN; LIQUIDS; ORGANIC ACIDS; SOLVENT EXTRACTION; SYNTHESIS (CHEMICAL);

AVAILABILITY;

ACID; AMINO ACID; BASE; PROTEIN MDM2; PROTEIN P53; PROTEIN;

ALPHA HELIX; ARTICLE; EVALUATION; INHIBITION KINETICS; LIQUID LIQUID EXTRACTION; MUTATION; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PURIFICATION; SCREENING; SOLUTION AND SOLUBILITY; SYNTHESIS; ANIMAL; DRUG DESIGN; DRUG EFFECT; DRUG SCREENING; HUMAN; METABOLISM; METHODOLOGY; MOLECULAR LIBRARY; MOLECULAR MIMICRY; PROTEIN SECONDARY STRUCTURE;

ANIMALS; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HUMANS; MOLECULAR MIMICRY; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; SMALL MOLECULE LIBRARIES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 67849119649     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja810025g     Document Type: Article

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84. A figure displaying a complete table of all coupling yields and product amounts (400 compounds) is provided in the Supporting Information.
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86. 2O absorption). At our present usage rate of the α-helix mimetic library, we anticipate only accessing the master plate approximately every 2 years.