Development of a potent Bcl-xL antagonist based on α-helix mimicry

Journal of the American Chemical Society

Volumn 124, Issue 40, 2002, Pages 11838-11839

  Kutzki, Olaf ^a   Park, Hyung Soon ^a   Ernst, Justin T ^a   Orner, Brendan P ^a   Yin, Hang ^a   Hamilton, Andrew D ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BORONIC ACID DERIVATIVE; PROTEIN BAD; PROTEIN BAK; PROTEIN BCL XL; PROTEIN BCL XL ANTAGONIST; PROTEIN INHIBITOR; TRIFLUOROMETHANESULFONIC ACID; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; BINDING AFFINITY; DIMERIZATION; DRUG BINDING SITE; DRUG CONFORMATION; DRUG STRUCTURE; DRUG SYNTHESIS; FLUORESCENCE POLARIZATION; HYDROPHOBICITY; MOLECULAR MIMICRY; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN PROTEIN INTERACTION;

BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-X PROTEIN; BINDING SITES; FLUORESCENCE POLARIZATION; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR MIMICRY; PROTEIN STRUCTURE, SECONDARY; PROTO-ONCOGENE PROTEINS C-BCL-2; TERPHENYL COMPOUNDS;

EID: 0037048711     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja026861k     Document Type: Article

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