Cell survival and metastasis regulation by Akt signaling in colorectal cancer

Cellular Signalling

Volumn 25, Issue 8, 2013, Pages 1711-1719

  Agarwal, Ekta ^a,b   Brattain, Michael G ^a,b   Chowdhury, Sanjib ^b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Akt isoforms; Cell survival; Colorectal cancer; Metastasis; PI3K; TGF PKA signaling

Indexed keywords

4 [2 (4 AMINO 1,2,5 OXADIAZOL 3 YL) 1 ETHYL 7 (3 PIPERIDINYLMETHOXY) 1H IMIDAZO[4,5 C]PYRIDIN 4 YL] 2 METHYL 3 BUTYN 2 OL; 8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; AKT1 PROTEIN; AKT3 PROTEIN; APC PROTEIN; BETA1 INTEGRIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; ISOPROTEIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PACLITAXEL; PERIFOSINE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN KINASE B BETA; PROTEIN MDM2; PROTEIN TYROSINE KINASE; RAF PROTEIN; RHO KINASE; SURVIVIN; TRANSCRIPTION FACTOR NFAT; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; UNINDEXED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; BINDING KINETICS; BREAST CANCER; BREAST TUMOR; CANCER COMBINATION CHEMOTHERAPY; CANCER GROWTH; CANCER MODEL; CARCINOGENESIS; CELL ADHESION; CELL SURVIVAL; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL TRIAL (TOPIC); COLON CANCER; COLORECTAL CANCER; COMPLEX FORMATION; ENDOMETRIUM CARCINOMA; ENZYME ACTIVATION; EPITHELIAL MESENCHYMAL TRANSITION; GENE SILENCING; GENOMICS; GLIOBLASTOMA; HEMATOLOGIC MALIGNANCY; HUMAN; LEUKEMIA; LUNG CANCER; LUNG NON SMALL CELL CANCER; METASTASIS; METASTASIS INHIBITION; MICROSATELLITE INSTABILITY; MOLECULARLY TARGETED THERAPY; MULTIPLE MYELOMA; NASOPHARYNX CARCINOMA; NONHODGKIN LYMPHOMA; NONHUMAN; OVARY CANCER; OVARY CARCINOMA; PANCREAS CANCER; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN SUBUNIT; REVIEW; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT;

ANTINEOPLASTIC AGENTS; CELL SURVIVAL; COLORECTAL NEOPLASMS; HUMANS; NEOPLASM METASTASIS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN ISOFORMS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 84878904455     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2013.03.025     Document Type: Review

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