The phosphatase PHLPP1 regulates Akt2, promotes pancreatic cancer cell death, and inhibits tumor formation

Gastroenterology

Volumn 142, Issue 2, 2012, Pages

  Nitsche, Claudia ^a   Edderkaoui, Mouad ^a   Moore, Ryan M ^a   Eibl, Guido ^a   Kasahara, Noriyuki ^a   Treger, Janet ^a   Grippo, Paul J ^c   Mayerle, Julia ^b   Lerch, Markus M ^b   Gukovskaya, Anna S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF GREIFSWALD   (Germany)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Apoptosis; NADPH Oxidase; ROS; Tumor Progression

Indexed keywords

GROWTH FACTOR; PHLPP1 PROTEIN; PHLPP2 PROTEIN; PHOSPHATASE; PROTEIN KINASE B; PROTEIN KINASE B BETA; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CARCINOGENESIS; CELL DEATH; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; GENE OVEREXPRESSION; GENE SILENCING; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MORTALITY; MOUSE; NONHUMAN; PANCREAS ADENOCARCINOMA; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SURVIVAL TIME; TUMOR XENOGRAFT; UPREGULATION;

EID: 84856170913     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2011.10.026     Document Type: Article

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