Histone deacetylase inhibitor belinostat represses survivin expression through reactivation of transforming growth factor β (TGFβ) receptor II leading to cancer cell death

Journal of Biological Chemistry

Volumn 286, Issue 35, 2011, Pages 30937-30948

  Chowdhury, Sanjib ^a   Howell, Gillian M ^a   Teggart, Carol A ^a   Chowdhury, Aparajita ^a   Person, Jonathan J ^a   Bowers, Dawn M ^b   Brattain, Michael G ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEINS; ANGIOGENESIS; ANTICANCER EFFECTS; CANCER CELLS; CELL DIVISIONS; CELL SURVIVAL; DOWN-REGULATION; HISTONE DEACETYLASE INHIBITOR; KINASE A; MOLECULAR MECHANISM; PATIENT POPULATION; PROTEASOMAL DEGRADATION; SIGNALING PATHWAYS; SIGNIFICANT MECHANISM; SURVIVIN; TIME POINTS; TRANSFORMING GROWTH FACTORS; TUMOR SUPPRESSOR GENES;

CELL DEATH; CELL PROLIFERATION; DISEASES; ENZYMES; PEPTIDES; SIGNALING; TUMORS;

GENE EXPRESSION;

BELINOSTAT; CYCLIC AMP DEPENDENT PROTEIN KINASE; HISTONE DEACETYLASE INHIBITOR; MESSENGER RNA; PROTEASOME; SURVIVIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DOWN REGULATION; DOWNSTREAM PROCESSING; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN INDUCTION; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION;

CATALYSIS; CELL DEATH; CELL LINE, TUMOR; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; EPIGENESIS, GENETIC; HISTONE DEACETYLASE INHIBITORS; HUMANS; HYDROXAMIC ACIDS; INHIBITOR OF APOPTOSIS PROTEINS; NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 80052255348     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.212035     Document Type: Article

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