Induction and analysis of aggregates in a liquid IgG1-antibody formulation

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 59, Issue 3, 2005, Pages 407-417

  Mahler, Hanns Christian ^a   Müller, Robert ^a   Frieß, Wolfgang ^b   Delille, Aurelie ^a   Matheus, Susanne ^a  

^a MERCK KGAA   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

Aggregation; Antibody; Association; Dynamic light scattering; Light obscuration; Mechanical stress; Protein stability; Turbidity

Indexed keywords

IMMUNOGLOBULIN G ANTIBODY; POLYSORBATE 80; SURFACTANT;

ARTICLE; DRUG FORMULATION; HIGH THROUGHPUT SCREENING; LIGHT SCATTERING; MOLECULAR MODEL; PARTICLE SIZE; PROTEIN AGGREGATION; TURBIDITY;

EID: 14844334231     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2004.12.004     Document Type: Article

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