Perturbation of thermal unfolding and aggregation of human IgG1 Fc fragment by hofmeister anions

Molecular Pharmaceutics

Volumn 10, Issue 2, 2013, Pages 619-630

  Zhang Van Enk, Jian ^a   Mason, Bruce D ^a   Yu, Lei ^a   Zhang, Le ^a   Hamouda, Wael ^a   Huang, Gang ^a   Liu, Dingjiang ^a,b   Remmele, Richard L ^a,c   Zhang, Jifeng ^a,d  

^a AMGEN INC   (United States)

^b REGENERON PHARMACEUTICALS INC   (United States)

^c MEDIMMUNE   (United States)

^d ELI LILLY AND COMPANY   (United States)

Author keywords

aggregation; CD; DSC; Fc; Hofmeister salt series; protein protein interactions; thermal unfolding

Indexed keywords

ANION; HYBRID PROTEIN; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G1 ANTIBODY; MONOCLONAL ANTIBODY; POTASSIUM CHLORIDE; POTASSIUM FLUORIDE; SODIUM CHLORIDE; SODIUM SULFATE; THIOCYANATE POTASSIUM;

ARTICLE; CHEMICAL REACTION KINETICS; CIRCULAR DICHROISM; COMPUTER SIMULATION; CONCENTRATION (PARAMETERS); DIFFERENTIAL SCANNING CALORIMETRY; EXPERIMENTAL STUDY; GEL PERMEATION CHROMATOGRAPHY; GLYCOSYLATION; LIGHT SCATTERING; MELTING POINT; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN PROTEIN INTERACTION; PROTEIN UNFOLDING; STATIC ELECTRICITY; THERMAL ANALYSIS; THERMODYNAMICS; THERMOGRAPHY; THERMOSTABILITY; ULTRAVIOLET RADIATION; ZETA POTENTIAL;

EID: 84873378461     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300378y     Document Type: Article

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