Predicting solution aggregation rates for therapeutic proteins: Approaches and challenges

International Journal of Pharmaceutics

Volumn 418, Issue 2, 2011, Pages 318-333

  Roberts, Christopher J ^a   Das, Tapan K ^b   Sahin, Erinc ^a  

^a University of Delaware   (United States)

^b PFIZER INC   (United States)

Author keywords

Biotechnology; Modeling; Non native aggregation; Protein stability

Indexed keywords

ACCURACY; ARTICLE; BIOTECHNOLOGY; CONFORMATION; MOLECULAR MODEL; OSMOSIS; PREDICTION; PRIORITY JOURNAL; PRODUCT DEVELOPMENT; PROTEIN INTERACTION; PROTEIN STABILITY; QUANTITATIVE ANALYSIS; THERMODYNAMICS;

DRUG COMPOUNDING; DRUG DESIGN; DRUG STABILITY; ELECTROMAGNETIC PHENOMENA; HUMANS; MODELS, MOLECULAR; OSMOSIS; PHARMACEUTICAL PREPARATIONS; PROTEIN CONFORMATION; PROTEIN UNFOLDING; PROTEINS; SOLUTIONS; TEMPERATURE;

EID: 80052976278     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.03.064     Document Type: Article

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