The complex inter-relationships between protein flexibility and stability

Journal of Pharmaceutical Sciences

Volumn 97, Issue 9, 2008, Pages 3494-3517

  Kamerzell, Tim J ^a,b   Middaugh, C Russell ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b GENENTECH INC   (United States)

Author keywords

Chemical stability; Deamidation; Formulation; Oxidation; Physical stability; Physicochemical; Protein folding refolding

Indexed keywords

ASPARTIC ACID; LIGAND; METAL ION;

AMINO ACID METABOLISM; CALORIMETRY; DEAMINATION; ENERGY; HUMAN; ISOMERIZATION; MOLECULAR DYNAMICS; MONITORING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PH; POINT MUTATION; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN FLEXIBILITY; PROTEIN FOLDING; PROTEIN METABOLISM; PROTEIN PROCESSING; PROTEIN STABILITY; REVIEW; TEMPERATURE SENSITIVITY;

EID: 53549116738     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21269     Document Type: Article

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