Antibody solubility behavior in monovalent salt solutions reveals specific anion effects at low ionic strength

Journal of Pharmaceutical Sciences

Volumn 101, Issue 3, 2012, Pages 965-977

  Zhang, Le ^a   Tan, Helming ^a   Fesinmeyer, R Matthew ^b   Li, Cynthia ^a   Catrone, David ^a   Le, David ^a   Remmele, Richard L ^a   Zhang, Jifeng ^a  

^a AMGEN INC   (United States)

^b AMGEN INC   (United States)

Author keywords

Excipients; HPLC (high performance pressure liquid chromatography); Protein formulation; Solubility; Solvation

Indexed keywords

ANION; POTASSIUM CHLORIDE; POTASSIUM FLUORIDE; RECOMBINANT ANTIBODY; SODIUM CHLORIDE; THIOCYANATE POTASSIUM;

ANTIBODY BLOOD LEVEL; ARTICLE; CHEMICAL BINDING; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG SOLUBILITY; ELECTROPHORETIC MOBILITY; EQUILIBRIUM CONSTANT; IONIC STRENGTH; ISOELECTRIC POINT; MEASUREMENT; PH; SOLUBILIZATION; SURFACE CHARGE; ZETA POTENTIAL;

EID: 84855901823     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22826     Document Type: Article

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