Molecular level insight into intra-solvent interaction effects on protein stability and aggregation

Advanced Drug Delivery Reviews

Volumn 63, Issue 13, 2011, Pages 1074-1085

  Shukla, Diwakar ^a   Schneider, Curtiss P ^a   Trout, Bernhardt L ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

Additives; Aggregation suppression; Cosolutes; Cosolvents; Excipients; Preferential interactions; Protein aggregation

Indexed keywords

AGGREGATION SUPPRESSION; CO-SOLUTES; COSOLVENTS; EXCIPIENTS; PREFERENTIAL INTERACTION; PROTEIN AGGREGATION;

DRUG INTERACTIONS; PROTEINS;

ADDITIVES;

ARGININE; CARBOHYDRATE; DRUG ADDITIVE; GLYCEROL; GUANIDINE; PROLINE; SOLVENT; TRIMETHYLAMINE OXIDE; UREA;

COLLOID; CONCENTRATION (PARAMETERS); GAP EFFECT; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR DYNAMICS; PHYSICAL PHENOMENA; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN INTERACTION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STABILITY; PROTEIN UNFOLDING; REVIEW; SOLUBILITY; SURFACE PROPERTY; THERMODYNAMICS;

DRUG STABILITY; EXCIPIENTS; HUMANS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEINS; SOLUTIONS; SOLVENTS; THERMODYNAMICS;

EID: 80054771438     PISSN: 0169409X     EISSN: 18728294     Source Type: Journal    
DOI: 10.1016/j.addr.2011.06.014     Document Type: Review

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