Herbal therapies for type 2 diabetes mellitus: Chemistry, biology, and potential application of selected plants and compounds

Evidence-based Complementary and Alternative Medicine

Volumn 2013, Issue , 2013, Pages

  Chang, Cicero L T ^a   Lin, Yenshou ^b   Bartolome, Arlene P ^c,d   Chen, Yi Ching ^d   Chiu, Shao Chih ^e,f   Yang, Wen Chin ^a,d,g,h  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN NORMAL UNIVERSITY   (Taiwan)

^c University of the Philippines Diliman   (Philippines)

^d AGRICULTURAL BIOTECHNOLOGY RESEARCH CENTER   (Taiwan)

^e CHINA MEDICAL UNIVERSITY   (Taiwan)

^f CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^g NATIONAL YANG MING UNIVERSITY   (Taiwan)

^h NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ALOE VERA EXTRACT; ANTIDIABETIC AGENT; ASTRAGALUS MEMBRANACEUS EXTRACT; BIDENS PILOSA EXTRACT; CARICA PAPAYA EXTRACT; CINNAMOMUM CASSIA EXTRACT; CORDYCEPS SINENSIS EXTRACT; CURCUMA LONGA EXTRACT; EPIGALLOCATECHIN GALLATE; GASTRODIA ELATA EXTRACT; GINSENG EXTRACT; GLUCAGON LIKE PEPTIDE 1; GLYCYRRHIZA URALENSIS EXTRACT; GYMNEMA SYLVESTRE EXTRACT; LONICERA JAPONICA EXTRACT; MOMORDICA CHARANTIA EXTRACT; ORAL ANTIDIABETIC AGENT; PEPPER EXTRACT; PLANT EXTRACT; RESVERATROL; SAFFLOWER EXTRACT; SILYBUM MARIANUM EXTRACT; TRIGONELLA FOENUM GRAECUM EXTRACT;

ALOE VERA; ANTIDIABETIC ACTIVITY; ASTRAGALUS MEMBRANACEUS; BIDENS PILOSA; BUFO; CINNAMOMUM CASSIA; CINNAMOMUM ZEYLANICUM; CLONORCHIS SINENSIS; COFFEE; CURCUMA LONGA; FENUGREEK; GASTRODIA ELATA; GINSENG; GLUCOSE ABSORPTION; GLUCOSE BLOOD LEVEL; GLYCYRRHIZA URALENSIS; GYMNEMA SYLVESTRE; HUMAN; ILEX PARAGUARIENSIS; INSULIN RELEASE; INSULIN RESISTANCE; LONICERA JAPONICA; LYCHEE; MEDICINAL PLANT; MOMORDICA CHARANTIA; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET CELL FUNCTION; PAPAYA; PATHOGENESIS; PEPPER; PHYTOCHEMISTRY; PRIORITY JOURNAL; REVIEW; SAFFLOWER; SILYBUM MARIANUM;

EID: 84877311655     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2013/378657     Document Type: Review

References (225)

1. Shaw J. E., Sicree R. A., Zimmet P. Z., Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Research and Clinical Practice 2010 87 1 4 14 2-s2.0-73749083481 10.1016/j.diabres.2009.10.007
2. Boyle J. P., Engelgau M. M., Thompson T. J., Goldschmid M. G., Beckles G. L., Timberlake D. S., Herman W. H., Ziemer D. C., Gallina D. L., Estimating prevalence of type 1 and type 2 diabetes in a population of African Americans with diabetes mellitus. American Journal of Epidemiology 1999 149 1 55 63 2-s2.0-0032962002 (Pubitemid 29028862)
3. Attele A. S., Zhou Y. P., Xie J. T., Wu J. A., Zhang L., Dey L., Pugh W., Rue P. A., Polonsky K. S., Yuan C. S., Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabetes 2002 51 6 1851 1858 2-s2.0-0036266324 (Pubitemid 34564298)
4. Cashen A., Lopez S., Gao F., Calandra G., MacFarland R., Badel K., DiPersio J., A phase II Study of plerixafor (AMD3100) plus G-CSF for autologous hematopoietic progenitor cell mobilization in patients with hodgkin lymphoma. Biology of Blood and Marrow Transplantation 2008 14 11 1253 1261 2-s2.0-53749085874 10.1016/j.bbmt.2008.08.011
5. Laakso M., Insulin resistance and its impact on the approach to therapy of Type 2 diabetes. International Journal of Clinical Practice, Supplement 2001 121 8 12 2-s2.0-0034804703 (Pubitemid 32916690)
6. Clements R. S., Bell D. S. H., Complications of diabetes: prevalence, detection, current treatment, and prognosis. American Journal of Medicine 1985 79 5 2 7 2-s2.0-0022380838 (Pubitemid 16213221)
7. Leahy J. L., Hirsch I. B., Peterson K. A., Schneider D., Targeting β -cell function early in the course of therapy for type 2 diabetes mellitus. Journal of Clinical Endocrinology and Metabolism 2010 95 9 4206 4216 2-s2.0-77956584167 10.1210/jc.2010-0668
8. Gianani R., Beta cell regeneration in human pancreas. Seminars in Immunopathology 2011 33 1 23 27
9. Defronzo R. A., From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes 2009 58 4 773 795 2-s2.0-64649104158 10.2337/db09-9028
10. Gastaldelli A., Ferrannini E., Miyazaki Y., Matsuda M., Mari A., DeFronzo R. A., Thiazolidinediones improve β -cell function in type 2 diabetic patients. American Journal of Physiology 2007 292 3 E871 E883 2-s2.0-33947144118 10.1152/ajpendo.00551.2006 (Pubitemid 46411067)
11. Tourrel C., Bailbe D., Lacorne M., Meile M. J., Kergoat M., Portha B., Persistent improvement of type 2 diabetes in the Goto-Kakizaki rat model by expansion of the β -cell mass during the prediabetic period with glucagon-like peptide-1 or exendin-4. Diabetes 2002 51 5 1443 1452 2-s2.0-0036312680 (Pubitemid 34826610)
12. Tourrel C., Bailbé D., Meile M. J., Kergoat M., Portha B., Glucagon-Like peptide-1 and exendin-4 stimulate β -cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age. Diabetes 2001 50 7 1562 1570 2-s2.0-0035405821 (Pubitemid 33639596)
13. Szabat M., Lynn F. C., Hoffman B. G., Maintenance of beta-cell maturity and plasticity in the adult pancreas: developmental biology concepts in adult physiology. Diabetes 2012 61 6 1365 1371
14. Ackermann A. M., Gannon M., Molecular regulation of pancreatic β -cell mass development, maintenance, and expansion. Journal of Molecular Endocrinology 2007 38 1-2 193 206 2-s2.0-33847687194 10.1677/JME-06-0053 (Pubitemid 46351603)
15. Tahrani A. A., Bailey C. J., Del Prato S., Barnett A. H., Management of type 2 diabetes: new and future developments in treatment. The Lancet 2011 378 9786 182 197 2-s2.0-79960262492 10.1016/S0140-6736(11)60207-9
16. Tanti J. F., Jager J., Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation. Current Opinion in Pharmacology 2009 9 6 753 762 2-s2.0-70449724835 10.1016/j.coph.2009.07.004
17. Jones D., Diabetes field cautiously upbeat despite possible setback for leading SGLT2 inhibitor. Nature Reviews Drug Discovery 2011 10 9 645 646
18. Encina G., Ezquer F., Conget P., Israel Y., Insulin is secreted upon glucose stimulation by both gastrointestinal enteroendocrine K-cells and L-cells engineered with the preproinsulin gene. Biological Research 2011 44 3 301 305
19. Pratley R. E., Gilbert M., Targeting incretins in type 2 diabetes: role of GLP-1 receptor agonists and DPP-4 inhibitors. Review of Diabetic Studies 2008 5 2 73 94 2-s2.0-60549097258 10.1900/RDS.2008.5.73
20. Hlebowicz J., Hlebowicz A., Lindstedt S., Björgell O., Höglund P., Hoist J. J., Darwiche G., Almér L. O., Effects of 1 and 3 g cinnamon on gastric emptying, satiety, and postprandial blood glucose, insulin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and ghrelin concentrations in healthy subjects. American Journal of Clinical Nutrition 2009 89 3 815 821 2-s2.0-61449114791 10.3945/ajcn.2008.26807
21. Nauck M., Stockmann F., Ebert R., Creutzfeldt W., Reduced incretin effect in Type 2 (non-insulin-dependent) diabetes. Diabetologia 1986 29 1 46 52 2-s2.0-0022617246 (Pubitemid 16162741)
22. Näslund E., Backman L., Holst J. J., Theodorsson E., Hellström P. M., Importance of small bowel peptides for the improved glucose metabolism 20 years after jejunoileal bypass for obesity. Obesity Surgery 1998 8 3 253 260 2-s2.0-0031874016 10.1381/096089298765554449 (Pubitemid 28334120)
23. Muscelli E., Mari A., Casolaro A., Camastra S., Seghieri G., Gastaldelli A., Holst J. J., Ferrannini E., Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patients. Diabetes 2008 57 5 1340 1348 2-s2.0-48449093468 10.2337/db07-1315
24. Hansen L., Deacon C. F., Ørskov C., Holst J. J., Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine. Endocrinology 1999 140 11 5356 5363 2-s2.0-0033303516
25. Holst J. J., Deacon C. F., Glucagon-like peptide-1 mediates the therapeutic actions of DPP-IV inhibitors. Diabetologia 2005 48 4 612 615 2-s2.0-17844399596 10.1007/s00125-005-1705-7 (Pubitemid 40591213)
26. Nori Janosz K. K., Zalesin K. C., Miller W. M., McCullough P. A., Treating type 2 diabetes: incretin mimetics and enhancers. Therapeutic Advances in Cardiovascular Disease 2009 3 5 387 395 2-s2.0-70350026679 10.1177/1753944709341377
27. Marre M., Penfornis A., GLP-1 receptor agonists today. Diabetes Research and Clinical Practice 2011 93 3 317 327
28. Krentz A. J., Bailey C. J., Oral antidiabetic agents: current role in type 2 diabetes mellitus. Drugs 2005 65 3 385 411 2-s2.0-13644263258 10.2165/00003495-200565030-00005 (Pubitemid 40227460)
29. Egan J. M., Bulotta A., Hui H., Perfetti R., GLP-1 receptor agonists are growth and differentiation factors for pancreatic islet beta cells. Diabetes/Metabolism Research and Reviews 2003 19 2 115 123 2-s2.0-0037357951 10.1002/dmrr.357 (Pubitemid 36417195)
30. Parkes D. G., Mace K. F., Trautmann M. E., Discovery and development of exenatide: the first antidiabetic agent to leverage the multiple benefits of the incretin hormone, GLP-1. Expert Opinion on Drug Discovery 2013 8 2 219 244 10.1517/17460441.2013.741580
31. Howlett H. C. S., Bailey C. J., A risk-benefit assessment of metformin in type 2 diabetes mellitus. Drug Safety 1999 20 6 489 503 2-s2.0-0032985166 10.2165/00002018-199920060-00003 (Pubitemid 29296595)
32. Purnell J. Q., Weyer C., Weight effect of current and experimental drugs for diabetes mellitus: from promotion to alleviation of obesity. Treatments in Endocrinology 2003 2 1 33 47 2-s2.0-0042861368 10.2165/00024677-200302010-00004 (Pubitemid 37051601)
33. Zhang B. B., Moller D. E., New approaches in the treatment of type 2 diabetes. Current Opinion in Chemical Biology 2000 4 4 461 467 (Pubitemid 30621049)
34. Basch E., Ulbricht C., Kuo G., Szapary P., Smith M., Therapeutic applications of fenugreek. Alternative Medicine Review 2003 8 1 20 27 2-s2.0-0037296088 (Pubitemid 36330565)
35. Kaur R., Afzal M., Kazmi I., Polypharmacy (herbal and synthetic drug combination): a novel approach in the treatment of type-2 diabetes and its complications in rats. Journal of Natural Medicines 2012 10.1007/s11418-012- 0720-5
36. Marles R. J., Farnsworth N. R., Antidiabetic plants and their active constituents. Phytomedicine 1995 2 2 137 189 2-s2.0-0028835878
37. Habeck M., Diabetes treatments get sweet help from nature. Nature Medicine 2003 9 10 1228 2-s2.0-0142073834 (Pubitemid 37279826)
38. Singh J., Cumming E., Manoharan G., Kalasz H., Adeghate E., Medicinal chemistry of the anti-diabetic effects of momordica charantia: active constituents and modes of actions. Open Medicinal Chemistry Journal 2011 5 supplement 2 70 77
39. Oubré A. Y., Carlson T. J., King S. R., Reaven G. M., From plant to patient: an ethnomedical approach to the identification of new drugs for the treatment of NIDDM. Diabetologia 1997 40 5 614 617 2-s2.0-0030903290 10.1007/s001250050724 (Pubitemid 27186801)
40. Weidner C., de Groot J. C., Prasad A., Amorfrutins are potent antidiabetic dietary natural products. Proceedings of the National Academy of Sciences of the United States of America 2012 109 19 7257 7262
41. Kim S., Jwa H., Yanagawa Y., Park T., Extract from Dioscorea batatas ameliorates insulin resistance in mice fed a high-fat diet. Journal of Medicinal Food 2012 15 6 527 534
42. Lee B. H., Hsu W. H., Pan T. M., Inhibitory effects of dioscorea polysaccharide on TNF- α -induced insulin resistance in mouse FL83B cells. Journal of Agricultural and Food Chemistry 2011 59 10 5279 5285 2-s2.0-79957929690 10.1021/jf200651c
43. Hsu J. H., Wu Y. C., Liu I. M., Cheng J. T., Dioscorea as the principal herb of Die-Huang-Wan, a widely used herbal mixture in China, for improvement of insulin resistance in fructose-rich chow-fed rats. Journal of Ethnopharmacology 2007 112 3 577 584 2-s2.0-34347388209 10.1016/j.jep.2007.05.013 (Pubitemid 47023038)
44. Gao X., Li B., Jiang H., Liu F., Xu D., Liu Z., Dioscorea opposita reverses dexamethasone induced insulin resistance. Fitoterapia 2007 78 1 12 15 2-s2.0-33845398363 10.1016/j.fitote.2006.09.015 (Pubitemid 44909357)
45. Grace M. H., Ribnicky D. M., Kuhn P., Poulev A., Logendra S., Yousef G. G., Raskin I., Lila M. A., Hypoglycemic activity of a novel anthocyanin-rich formulation from lowbush blueberry. Vaccinium Angustifolium Aiton Phytomedicine 2009 16 5 406 415 2-s2.0-64449085329 10.1016/j.phymed.2009.02.018
46. Liu Y., Wang D., Zhang D., Inhibitory effect of blueberry polyphenolic compounds on oleic acid-induced hepatic steatosis in vitro. Journal of Agricultural and Food Chemistry 2011 59 22 12254 12263
47. Stull A. J., Cash K. C., Johnson W. D., Champagne C. M., Cefalu W. T., Bioactives in blueberries improve insulin sensitivity in obese, insulin-resistant men and women. Journal of Nutrition 2010 140 10 1764 1768 2-s2.0-77958141574 10.3945/jn.110.125336
48. Liu M., Wu K., Mao X., Wu Y., Ouyang J., Astragalus polysaccharide improves insulin sensitivity in KKAy mice: regulation of PKB/GLUT4 signaling in skeletal muscle. Journal of Ethnopharmacology 2010 127 1 32 37 2-s2.0-72149094306 10.1016/j.jep.2009.09.055
49. Mao X. Q., Yu F., Wang N., Wu Y., Zou F., Wu K., Liu M., Ouyang J. P., Hypoglycemic effect of polysaccharide enriched extract of Astragalus membranaceus in diet induced insulin resistant C57BL/6J mice and its potential mechanism. Phytomedicine 2009 16 5 416 425 2-s2.0-64449084587 10.1016/j.phymed.2008.12.011
50. Zhao M., Zhang Z. F., Ding Y., Wang J. B., Li Y., Astragalus polysaccharide improves palmitate-induced insulin resistance by inhibiting PTP1B and NF-kappaB in C2C12 myotubes. Molecules 2012 17 6 7083 7092
51. Wu Y., Ou-Yang J. P., Wu K., Wang Y., Zhou Y. F., Wen C. Y., Hypoglycemic effect of Astragalus polysaccharide and its effect on PTP1B. Acta Pharmacologica Sinica 2005 26 3 345 352 2-s2.0-15244348325 10.1111/j.1745-7254. 2005.00062.x (Pubitemid 40388072)
52. Park S., Kim D. S., Kang S., Gastrodia elata Blume water extracts improve insulin resistance by decreasing body fat in diet-induced obese rats: vanillin and 4-hydroxybenzaldehyde are the bioactive candidates. European Journal of Nutrition 2011 50 2 107 118 2-s2.0-79958284479 10.1007/s00394-010-0120-0
53. Li J., Liu T., Wang L., Antihyperglycemic and antihyperlipidemic action of cinnamaldehyde in C57BLKS/J db/db mice. Journal of Traditional Chinese Medicine 2012 32 3 446 452
54. Uemura T., Hirai S., Mizoguchi N., Goto T., Lee J. Y., Taketani K., Nakano Y., Shono J., Hoshino S., Tsuge N., Narukami T., Takahashi N., Kawada T., Diosgenin present in fenugreek improves glucose metabolism by promoting adipocyte differentiation and inhibiting inflammation in adipose tissues. Molecular Nutrition and Food Research 2010 54 11 1596 1608 2-s2.0-78349261237 10.1002/mnfr.200900609
55. Puri D., Prabhu K. M., Murthy P. S., Mechanism of action of a hypoglycemic principle isolated from fenugreek seeds. Indian Journal of Physiology and Pharmacology 2002 46 4 457 462 2-s2.0-0036791812
56. Guo J., Li L., Pan J., Qiu G., Li A., Huang G., Xu L., Pharmacological mechanism of Semen Litchi on antagonizing insulin resistance in rats with type 2 diabetes. Zhong Yao Cai 2004 27 6 435 438 2-s2.0-16644403667
57. Noh J. S., Park C. H., Yokozawa T., Treatment with oligonol, a low-molecular polyphenol derived from lychee fruit, attenuates diabetes-induced hepatic damage through regulation of oxidative stress and lipid metabolism. British Journal of Nutrition 2011 106 7 1013 1022 2-s2.0-79953749744 10.1017/S0007114511001322
58. Noh J. S., Kim H. Y., Park C. H., Fujii H., Yokozawa T., Hypolipidaemic and antioxidative effects of oligonol, a low-molecular-weight polyphenol derived from lychee fruit, on renal damage in type 2 diabetic mice. British Journal of Nutrition 2010 104 8 1120 1128 2-s2.0-78049521011 10.1017/S0007114510001819
59. Sasidharan S., Sumathi V., Jegathambigai N. R., Latha L. Y., Antihyperglycaemic effects of ethanol extracts of Carica papaya and Pandanus amaryfollius leaf in streptozotocin-induced diabetic mice. Natural Product Research 2011 25 20 1982 1987
60. Kawakami M., Hirayama A., Tsuchiya K., Ohgawara H., Nakamura M., Umezawa K., Promotion of β -cell differentiation by the alkaloid conophylline in porcine pancreatic endocrine cells. Biomedicine and Pharmacotherapy 2010 64 3 226 231 2-s2.0-77649238968 10.1016/j.biopha.2009.09.025
61. Kodera T., Yamada S., Yamamoto Y., Hara A., Tanaka Y., Seno M., Umezawa K., Takei I., Kojima I., Administration of conophylline and betacellulin- δ 4 increases the β -cell mass in neonatal streptozotocin-treated rats. Endocrine Journal 2009 56 6 799 806 2-s2.0-70349967847 10.1507/endocrj.K09E-158
62. Ogata T., Li L., Yamada S., Yamamoto Y., Tanaka Y., Takei I., Umezawa K., Kojima I., Promotion of β -cell differentiation by conophylline in fetal and neonatal rat pancreas. Diabetes 2004 53 10 2596 2602 2-s2.0-4644352368 10.2337/diabetes.53.10.2596 (Pubitemid 39299267)
63. Saito R., Yamada S., Yamamoto Y., Conophylline suppresses pancreatic stellate cells and improves islet fibrosis in Goto-Kakizaki rats. Endocrinology 2012 153 2 621 630
64. Zhang Y., Cai J., Ruan H., Pi H., Wu J., Antihyperglycemic activity of kinsenoside, a high yielding constituent from Anoectochilus roxburghii in streptozotocin diabetic rats. Journal of Ethnopharmacology 2007 114 2 141 145 2-s2.0-35148841561 10.1016/j.jep.2007.05.022 (Pubitemid 47539815)
65. Subash-Babu P., Ignacimuthu S., Agastian P., Varghese B., Partial regeneration of β -cells in the islets of Langerhans by Nymphayol a sterol isolated from Nymphaea stellata (Willd.) flowers. Bioorganic and Medicinal Chemistry 2009 17 7 2864 2870 2-s2.0-62949091444 10.1016/j.bmc.2009.02.021
66. Huseini H. F., Larijani B., Heshmat R., Fakhrzadeh H., Radjabipour B., Toliat T., Raza M., The efficacy of Silybum marianum (L.) Gaertn. (silymarin) in the treatment of type II diabetes: a randomized, double-blind, placebo-controlled, clinical trial. Phytotherapy Research 2006 20 12 1036 1039 2-s2.0-33845618025 10.1002/ptr.1988 (Pubitemid 44951705)
67. Hussain S. A. R., Silymarin as an adjunct to glibenclamide therapy improves long-term and postprandial glycemic control and body mass index in type 2 diabetes. Journal of Medicinal Food 2007 10 3 543 547 2-s2.0-34848881620 10.1089/jmf.2006.089
68. Soto C., Mena R., Luna J., Cerbón M., Larrieta E., Vital P., Uría E., Sánchez M., Recoba R., Barrón H., Favari L., Lara A., Silymarin induces recovery of pancreatic function after alloxan damage in rats. Life Sciences 2004 75 18 2167 2180 2-s2.0-4344675511 10.1016/j.lfs.2004. 04.019 (Pubitemid 39120024)
69. Soto C., Pérez J., García V., Uría E., Vadillo M., Raya L., Effect of silymarin on kidneys of rats suffering from alloxan-induced diabetes mellitus. Phytomedicine 2010 17 14 1090 1094 2-s2.0-78149406055 10.1016/j.phymed.2010.04.011
70. Srivastava R. K., Sharma S., Verma S., Arora B., Lal H., Influence of diabetes on liver injury induced by antitubercular drugs and on silymarin hepatoprotection in rats. Methods and Findings in Experimental and Clinical Pharmacology 2008 30 10 731 737 2-s2.0-63649109725 10.1358/mf.2008.30.10.1316824
71. Vengerovskii A. I., Khazanov V. A., Eskina K. A., Vasilyev K. Y., Effects of silymarin (hepatoprotector) and succinic acid (bioenergy regulator) on metabolic disorders in experimental diabetes mellitus. Bulletin of Experimental Biology and Medicine 2007 144 1 53 56 2-s2.0-36348975777 10.1007/s10517-007- 0252-2 (Pubitemid 350142485)
72. Jose M. A., Abraham A., Narmadha M. P., Effect of silymarin in diabetes mellitus patients with liver diseases. Journal of Pharmacology and Pharmacotherapeutics 2011 2 4 287 289
73. Soto C., Recoba R., Barrón H., Alvarez C., Favari L., Silymarin increases antioxidant enzymes in alloxan-induced diabetes in rat pancreas. Comparative Biochemistry and Physiology C 2003 136 3 205 212 2-s2.0-0345059197 10.1016/S1532-0456(03)00214-X (Pubitemid 37500850)
74. Soto C. P., Perez B. L., Favari L. P., Reyes J. L., Prevention of alloxan-induced diabetes mellitus in the rat by silymarin. Comparative Biochemistry and Physiology C 1998 119 2 125 129 2-s2.0-0032006345 10.1016/S0742-8413(97)00198-9 (Pubitemid 28221648)
75. Ubillas R. P., Mendez C. D., Jolad S. D., Luo J., King S. R., Carlson T. J., Fort D. M., Antihyperglycemic acetylenic glucosides from Bidens pilosa. Planta Medica 2000 66 1 82 83 2-s2.0-0033974926 (Pubitemid 30097291)
76. Chien S. C., Young P. H., Hsu Y. J., Chen C. H., Tien Y. J., Shiu S. Y., Li T. H., Yang C. W., Marimuthu P., Tsai L. F. L., Yang W. C., Anti-diabetic properties of three common Bidens pilosa variants in Taiwan. Phytochemistry 2009 70 10 1246 1254 2-s2.0-69249156977 10.1016/j.phytochem.2009.07.011
77. Ramkumar K. M., Lee A. S., Krishnamurthi K., Devi S. S., Chakrabarti T., Kang K. P., Lee S., Kim W., Park S. K., Lee N. H., Rajaguru P., Gymnema montanum H. Protects against alloxan-induced oxidative stress and apoptosis in pancreatic β -cells. Cellular Physiology and Biochemistry 2009 24 5-6 429 440 2-s2.0-70450267608 10.1159/000257480
78. Al-Romaiyan A., King A. J., Persaud S. J., Jones P. M., A novel extract of Gymnema sylvestre improves glucose tolerance in vivo and stimulates insulin secretion and synthesis in vitro. Phytotherapy Research 24 9 1370 1376
79. Al-Romaiyan A., Liu B., Asare-Anane H., Maity C. R., Chatterjee S. K., Koley N., Biswas T., Chatterji A. K., Huang G. C., Amiel S. A., Persaud S. J., Jones P. M., A novel Gymnema sylvestre extract stimulates insulin secretion from human islets in vivo and in vitro. Phytotherapy Research 2010 24 9 1370 1376 2-s2.0-77957258230 10.1002/ptr.3125
80. Cani P. D., Daubioul C. A., Reusens B., Remacle C., Catillon G., Delzenne N. M., Involvement of endogenous glucagon-like peptide-1 (7-36) amide on glycaemia-lowering effect of oligofructose in streptozotocin-treated rats. Journal of Endocrinology 2005 185 3 457 465 2-s2.0-21244450727 10.1677/joe.1.06100 (Pubitemid 40883391)
81. Kok N. N., Morgan L. M., Williams C. M., Roberfroid M. B., Thissen J. P., Delzenne N. M., Insulin, glucagon-like peptide 1, glucose-dependent insulinotropic polypeptide and insulin-like growth factor I as putative mediators of the hypolipidemic effect of oligofructose in rats. Journal of Nutrition 1998 128 7 1099 1103 2-s2.0-0031847435 (Pubitemid 28317672)
82. Urías-Silvas J. E., Cani P. D., Delmée E., Neyrinck A., López M. G., Delzenne N. M., Physiological effects of dietary fructans extracted from Agave tequilana Gto. and Dasylirion spp. British Journal of Nutrition 2008 99 2 254 261 2-s2.0-38049112349 10.1017/S0007114507795338
83. Rocca A. S., Lagreca J., Kalitsky J., Brubaker P. L., Monounsaturated fatty acid diets improve glycemic tolerance through increased secretion of glucagon-like peptide-1. Endocrinology 2001 142 3 1148 1155 2-s2.0-0035095031 10.1210/en.142.3.1148 (Pubitemid 32202825)
84. Prieto P. G., Cancelas J., Villanueva-Peñacarrillo M. L., Valverde I., Malaisse W. J., Effects of an olive oil-enriched diet on plasma GLP-1 concentration and intestinal content, plasma insulin concentration, and glucose tolerance in normal rats. Endocrine 2005 26 2 107 115 2-s2.0-23844471668 10.1385/ENDO:26:2:107 (Pubitemid 41271102)
85. Thomsen C., Storm H., Holst J. J., Hermansen K., Differential effects of saturated and monounsaturated fats on postprandial lipemia and glucagon-like peptide 1 responses in patients with type 2 diabetes. American Journal of Clinical Nutrition 2003 77 3 605 611 2-s2.0-0037371203 (Pubitemid 36258569)
86. Gentilcore D., Chaikomin R., Jones K. L., Russo A., Feinle-Bisset C., Wishart J. M., Rayner C. K., Horowitz M., Effects of fat on gastric emptying of and the glycemic, insulin, and incretin responses to a carbohydrate meal in type 2 diabetes. Journal of Clinical Endocrinology and Metabolism 2006 91 6 2062 2067 2-s2.0-33744954242 10.1210/jc.2005-2644 (Pubitemid 43854982)
87. Takahashi T., Miyazawa M., Potent alpha-glucosidase inhibitors from safflower (Carthamus tinctorius L.) seed. Phytotherapy Research 2012 26 5 722 726
88. Akar F., Pektas M. B., Tufan C., Soylemez S., Sepici A., Ulus A. T., Gokalp B., Ozturk K., Surucu H. S., Resveratrol shows vasoprotective effect reducing oxidative stress without affecting metabolic disturbances in insulin-dependent diabetes of rabbits. Cardiovascular Drugs and Therapy 2011 25 2 119 131 2-s2.0-79958243683 10.1007/s10557-010-6255-7
89. Chen C., Zhang Y., Huang C., Berberine inhibits PTP1B activity and mimics insulin action. Biochemical and Biophysical Research Communications 2010 397 3 543 547 2-s2.0-77954214500 10.1016/j.bbrc.2010.05.153
90. Jeong H. W., Hsu K. C., Lee J. W., Ham M., Huh J. Y., Shin H. J., Kim W. S., Kim J. B., Berberine suppresses proinflammatory responses through AMPK activation in macrophages. American Journal of Physiology 2009 296 4 E955 E964 2-s2.0-65649108647 10.1152/ajpendo.90599.2008
91. Kim W. S., Lee Y. S., Cha S. H., Jeong H. W., Choe S. S., Lee M. R., Oh G. T., Park H. S., Lee K. U., Lane M. D., Kim J. B., Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity. American Journal of Physiology 2009 296 4 E812 E819 2-s2.0-65649089100 10.1152/ajpendo.90710.2008
92. Lee Y. S., Kim W. S., Kim K. H., Yoon M. J., Cho H. J., Shen Y., Ye J. M., Lee C. H., Oh W. K., Kim C. T., Hohnen-Behrens C., Gosby A., Kraegen E. W., James D. E., Kim J. B., Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes 2006 55 8 2256 2264 2-s2.0-33749336146 10.2337/db06-0006 (Pubitemid 44743622)
93. Han J., Lin H., Huang W., Modulating gut microbiota as an anti-diabetic mechanism of berberine. Medical Science Monitor 2011 17 7 RA164 RA167 2-s2.0-79959964544
94. Dong H., Wang N., Zhao L., Lu F., Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis. Evidence-Based Complementary and Alternative Medicine 2012 2012 12 591654 10.1155/2012/591654
95. Hwang J. T., Park I. J., Shin J. I., Lee Y. K., Lee S. K., Baik H. W., Ha J., Park O. J., Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinase. Biochemical and Biophysical Research Communications 2005 338 2 694 699 2-s2.0-27744455616 10.1016/j.bbrc.2005.09.195 (Pubitemid 41597699)
96. Gram D. X., Ahrén B., Nagy I., Olsen U. B., Brand C. L., Sundler F., Tabanera R., Svendsen O., Carr R. D., Santha P., Wierup N., Hansen A. J., Capsaicin-sensitive sensory fibers in the islets of Langerhans contribute to defective insulin secretion in Zucker diabetic rat, an animal model for some aspects of human type 2 diabetes. European Journal of Neuroscience 2007 25 1 213 223 2-s2.0-33846194056 10.1111/j.1460-9568.2006.05261.x (Pubitemid 46096235)
97. Lee W. K., Kao S. T., Liu L. M., Cheng J. T., Ginsenoside Rh2 is one of the active principles of Panax ginseng root to improve insulin sensitivity in fructose-rich chow-fed rats. Hormone and Metabolic Research 2007 39 5 347 354 2-s2.0-34249947136 10.1055/s-2007-976537 (Pubitemid 46877850)
98. Cho W. C. S., Chung W. S., Lee S. K. W., Leung A. W. N., Cheng C. H. K., Yue K. K. M., Ginsenoside Re of Panax ginseng possesses significant antioxidant and antihyperlipidemic efficacies in streptozotocin-induced diabetic rats. European Journal of Pharmacology 2006 550 1-3 173 179 2-s2.0-33749990092 10.1016/j.ejphar.2006.08.056 (Pubitemid 44572271)
99. Wickenberg J., Ingemansson S. L., Hlebowicz J., Effects of Curcuma longa (turmeric) on postprandial plasma glucose and insulin in healthy subjects. Nutrition Journal 2010 9 1, article 43 2-s2.0-77957740137 10.1186/1475-2891-9-43
100. Lekshmi P. C., Arimboor R., Indulekha P. S., Menon A. N., Turmeric (Curcuma longa L.) volatile oil inhibits key enzymes linked to type 2 diabetes. International Journal of Food Sciences and Nutrition 2012 63 7 832 834
101. Hussein G. M., Matsuda H., Nakamura S., Protective and ameliorative effects of mate (Ilex paraguariensis) on metabolic syndrome in TSOD mice. Phytomedicine 2011 19 1 88 97
102. Chakraborty D., Mukherjee A., Sikdar S., [6]-Gingerol isolated from ginger attenuates sodium arsenite induced oxidative stress and plays a corrective role in improving insulin signaling in mice. Toxicology Letters 2012 210 1 34 43
103. Li Y., Tran V. H., Duke C. C., Roufogalis B. D., Preventive and protective properties of Zingiber officinale (ginger) in diabetes mellitus, diabetic complications, and associated lipid and other metabolic disorders: a brief review. Evidence-Based Complementary and Alternative Medicine 2012 2012 10 516870 10.1155/2012/516870
104. Ortsater H., Grankvist N., Wolfram S., Kuehn N., Sjoholm A., Diet supplementation with green tea extract epigallocatechin gallate prevents progression to glucose intolerance in db/db mice. Nutrition & Metabolism 2012 9 article 11
105. Wolfram S., Raederstorff D., Preller M., Wang Y., Teixeira S. R., Riegger C., Weber P., Epigallocatechin gallate supplementation alleviates diabetes in rodents. Journal of Nutrition 2006 136 10 2512 2518 2-s2.0-33749456308 (Pubitemid 44521606)
106. Waltner-Law M. E., Wang X. L., Law B. K., Hall R. K., Nawano M., Granner D. K., Epigallocatechin gallate, a constituent of green tea, represses hepatic glucose production. Journal of Biological Chemistry 2002 277 38 34933 34940 2-s2.0-0037144406 10.1074/jbc.M204672200
107. Heo S. J., Hwang J. Y., Choi J. I., Han J. S., Kim H. J., Jeon Y. J., Diphlorethohydroxycarmalol isolated from Ishige okamurae, a brown algae, a potent α -glucosidase and α -amylase inhibitor, alleviates postprandial hyperglycemia in diabetic mice. European Journal of Pharmacology 2009 615 1-3 252 256 2-s2.0-67449116102 10.1016/j.ejphar.2009.05.017
108. Fu Z., Gilbert E. R., Pfeiffer L., Genistein ameliorates hyperglycemia in a mouse model of nongenetic type 2 diabetes. Applied Physiology, Nutrition, and Metabolism 2012 37 3 480 488
109. Fu Z., Zhang W., Zhen W., Lum H., Nadler J., Bassaganya-Riera J., Jia Z., Wang Y., Misra H., Liu D., Genistein induces pancreatic β -cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice. Endocrinology 2010 151 7 3026 3037 2-s2.0-77954580620 10.1210/en.2009-1294
110. Leiherer A., Mundlein A., Drexel H., Phytochemicals and their impact on adipose tissue inflammation and diabetes. Vascular Pharmacology 2013 58 1-2 3 20
111. Bhathena S. J., Velasquez M. T., Beneficial role of dietary phytoestrogens in obesity and diabetes. American Journal of Clinical Nutrition 2002 76 6 1191 1201 2-s2.0-0036895683 (Pubitemid 35416551)
112. Park S., Ahn I. S., Kim J. H., Glyceollins, one of the phytoalexins derived from soybeans under fungal stress, enhance insulin sensitivity and exert insulinotropic actions. Journal of Agricultural and Food Chemistry 2010 58 3 1551 1557
113. Kawano A., Nakamura H., Hata S. I., Minakawa M., Miura Y., Yagasaki K., Hypoglycemic effect of aspalathin, a rooibos tea component from Aspalathus linearis, in type 2 diabetic model db/db mice. Phytomedicine 2009 16 5 437 443 2-s2.0-64449086955 10.1016/j.phymed.2008.11.009
114. Muller C. J., Joubert E., de Beer D., Acute assessment of an aspalathin-enriched green rooibos (Aspalathus linearis) extract with hypoglycemic potential. Phytomedicine 2012 20 1 32 39
115. Jo S., Ka E., Lee H., Comparison of antioxidant potential and rat intestinal α -glucosidases inihibitory activities of quercetin, rutin, and isoquercetin. International Journal of Applied Research in Natural Products 2009 2 52 60
116. Mainzen P. S., Kamalakkannan N., Rutin improves glucose homeostasis in streptozotocin diabetic tissues by altering glycolytic and gluconeogenic enzymes. Journal of Biochemical and Molecular Toxicology 2006 20 2 96 102 2-s2.0-33645817531 10.1002/jbt.20117
117. Lee C. C., Hsu W. H., Shen S. R., Cheng Y. H., Wu S. C., Fagopyrum tataricum (buckwheat) improved high-glucose-induced insulin resistance in mouse hepatocytes and diabetes in fructose-rich diet-induced mice. Experimental Diabetes Research 2012 2012 10 375673 10.1155/2012/375673
118. Jong-Anurakkun N., Bhandari M. R., Hong G., Kawabata J., α -Glucosidase inhibitor from Chinese aloes. Fitoterapia 2008 79 6 456 457 2-s2.0-49849091696 10.1016/j.fitote.2008.02.010
119. Nuraliev Yu N., Avezov G. A., The efficacy of quercetin in alloxan diabetes. Experimental and Clinical Pharmacology 1992 55 1 42 44 2-s2.0-0027074281 (Pubitemid 23031657)
120. Di Maggio G., Ciaceri G., Effect of quercetin on blood sugar levels in alloxan diabetes. La Rassegna di Clinica, Terapia e Scienze Affini 1958 57 1 14 16
121. Do G. M., Jung U. J., Park H. J., Resveratrol ameliorates diabetes-related metabolic changes via activation of AMP-activated protein kinase and its downstream targets in db/db mice. Molecular Nutrition & Food Research 2012 56 8 1282 1291
122. Ding D. F., You N., Wu X. M., Xu J. R., Hu A. P., Ye X. L., Zhu Q., Jiang X. Q., Miao H., Liu C., Lu Y. B., Resveratrol attenuates renal hypertrophy in early-stage diabetes by activating AMPK. American Journal of Nephrology 2010 31 4 363 374 2-s2.0-77949552845 10.1159/000300388
123. Mishra R., Sellin D., Radovan D., Gohlke A., Winter R., Inhibiting islet amyloid polypeptide fibril formation by the red wine compound resveratrol. ChemBioChem 2009 10 3 445 449 2-s2.0-60349096360 10.1002/cbic.200800762
124. Vetterli L., Brun T., Giovannoni L., Bosco D., Maechler P., Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E β -cells and human islets through a SIRT1-dependent mechanism. Journal of Biological Chemistry 2011 286 8 6049 6060 2-s2.0-79953206276 10.1074/jbc.M110.176842
125. Bhatt J. K., Thomas S., Nanjan M. J., Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus. Nutrition Research 2012 32 7 537 541
126. Shearer J., Farah A., De Paulis T., Bracy D. P., Pencek R. R., Graham T. E., Wasserman D. H., Quinides of roasted coffee enhance insulin action in conscious rats. Journal of Nutrition 2003 133 11 3529 3532 2-s2.0-0242661243 (Pubitemid 37409483)
127. Tunnicliffe J. M., Shearer J., Coffee, glucose homeostasis, and insulin
128. Mae T., Kishida H., Nishiyama T., Tsukagawa M., Konishi E., Kuroda M., Mimaki Y., Sashida Y., Takahashi K., Kawada T., Nakagawa K., Kitahara M., A licorice ethanolic extract with peroxisome proliferator-activated receptor- γ ligand-binding activity affects diabetes in KK-Ay mice, abdominal obesity in diet-induced obese C57BL mice and hypertension in spontaneously hypertensive rats. Journal of Nutrition 2003 133 11 3369 3377 2-s2.0-0242493512 (Pubitemid 37409461)
129. Basu A., Lyons T. J., Strawberries, blueberries, and cranberries in the metabolic syndrome: clinical perspectives. Journal of Agricultural and Food Chemistry 2011 60 23 5687 5692
130. DeFuria J., Bennett G., Strissel K. J., Perfield J. W., Milbury P. E., Greenberg A. S., Obin M. S., Dietary blueberry attenuates whole-body insulin resistance in high fat-fed mice by reducing adipocyte death and its inflammatory sequelae. Journal of Nutrition 2009 139 8 1510 1516 2-s2.0-67749132533 10.3945/jn.109.105155
131. Seymour E. M., Tanone I. I., Urcuyo-Llanes D. E., Blueberry intake alters skeletal muscle and adipose tissue peroxisome proliferator-activated receptor activity and reduces insulin resistance in obese rats. Journal of Medicinal Food 2011 14 12 1511 1518
132. Vuong T., Benhaddou-Andaloussi A., Brault A., Harbilas D., Martineau L. C., Vallerand D., Ramassamy C., Matar C., Haddad P. S., Antiobesity and antidiabetic effects of biotransformed blueberry juice in KKA y mice. International Journal of Obesity 2009 33 10 1166 1173 2-s2.0-70349976016 10.1038/ijo.2009.149
133. Wu F., Chen X., A review of pharmacological study on Astragalus membranaceus (Fisch.) Bge. Zhong Yao Cai 2004 27 3 232 234 2-s2.0-4644266305
134. Li C., Cao L., Zeng Q., Astragalus prevents diabetic rats from developing cardiomyopathy by downregulating angiotensin II type2 receptors' expression. Journal of Huazhong University of Science and Technology 2004 24 4 379 384 2-s2.0-27644549858 (Pubitemid 41559602)
135. Qin B., Panickar K. S., Anderson R. A., Cinnamon: potential role in the prevention of insulin resistance, metabolic syndrome, and type 2 diabetes. Journal of Diabetes Science and Technology 2010 4 3 685 693 2-s2.0-77956179596
136. Rafehi H., Ververis K., Karagiannis T. C., Controversies surrounding the clinical potential of cinnamon for the management of diabetes. Diabetes, Obesity and Metabolism 2012 14 6 493 499
137. Couturier K., Qin B., Batandier C., Cinnamon increases liver glycogen in an animal model of insulin resistance. Metabolism 2011 60 11 1590 1597
138. Qin B., Dawson H. D., Schoene N. W., Polansky M. M., Anderson R. A., Cinnamon polyphenols regulate multiple metabolic pathways involved in insulin signaling and intestinal lipoprotein metabolism of small intestinal enterocytes. Nutrition 2012 28 11-12 1172 1179
139. Subash Babu P., Prabuseenivasan S., Ignacimuthu S., Cinnamaldehyde-A potential antidiabetic agent. Phytomedicine 2007 14 1 15 22 2-s2.0-33845624872 10.1016/j.phymed.2006.11.005 (Pubitemid 44960809)
140. Pavithran K., Fenugreek in diabetes mellitus. The Journal of the Association of Physicians of India 1994 42 7 584 2-s2.0-0028475566
141. Valette G., Sauvaire Y., Baccou J. C., Ribes G., Hypocholesterolaemic effect of fenugreek seeds in dogs. Atherosclerosis 1984 50 1 105 111 2-s2.0-0021365835 (Pubitemid 14224348)
142. Mohan V., Balasubramanyam M., Fenugreek and insulin resistance. The Journal of the Association of Physicians of India 2001 49 1055 1056 2-s2.0-0035523844
143. Gupta A., Gupta R., Lal B., Effect of Trigonella foenum-graecum (Fenugreek) seeds on glycaemic control and insulin resistance in type 2 diabetes mellitus: a Double Blind Placebo Controlled Study. Journal of Association of Physicians of India 2001 49 1057 1061 2-s2.0-0035523777 (Pubitemid 33645101)
144. Zhang H., Teng Y., Effect of li ren (semen litchi) anti-diabetes pills in 45 cases of diabetes mellitus. Journal of Traditional Chinese Medicine 1986 6 4 277 278 2-s2.0-0022836109
145. Fujii M., Takei I., Umezawa K., Antidiabetic effect of orally administered conophylline-containing plant extract on streptozotocin-treated and Goto-Kakizaki rats. Biomedicine and Pharmacotherapy 2009 63 10 710 716 2-s2.0-71749096644 10.1016/j.biopha.2009.01.006
146. Rui Y. C., Advances in pharmacological studies of silymarin. Memorias do Instituto Oswaldo Cruz 1991 86 supplement 2 79 85 2-s2.0-0026366146
147. Chandalia M., Garg A., Lutjohann D., Von Bergmann K., Grundy S. M., Brinkley L. J., Beneficial effects of high dietary fiber intake in patients with type 2 diabetes mellitus. The New England Journal of Medicine 2000 342 19 1392 1398 2-s2.0-0034636549 10.1056/NEJM200005113421903 (Pubitemid 30262396)
148. Zimmet P., Alberti K. G. M. M., Shaw J., Global and societal implications of the diabetes epidemic. Nature 2001 414 6865 782 787 2-s2.0-0035856920 10.1038/414782a (Pubitemid 34000780)
149. Thanopoulou A. C., Karamanos B. G., Angelico F. V., Assaad-Khalil S. H., Barbato A. F., Del Ben M. P., Djordjevic P. B., Dimitrijevic-Sreckovic V. S., Gallotti C. A., Katsilambros N. L., Migdalis I. N., Mrabet M. M., Petkova M. K., Roussi D. P., Tenconi M. T. P., Dietary fat intake as risk factor for the development of diabetes: multinational, multicenter study of the Mediterranean Group for the Study of Diabetes (MGSD). Diabetes Care 2003 26 2 302 307 2-s2.0-0041963077 10.2337/diacare.26.2.302 (Pubitemid 36934463)
150. Feinle C., O'Donovan D., Doran S., Andrews J. M., Wishart J., Chapman I., Horowitz M., Effects of fat digestion on appetite, APD motility, and gut hormones in response to duodenal fat infusion in humans. American Journal of Physiology 2003 284 5 G798 G807 2-s2.0-0037403765 (Pubitemid 36437980)
151. Asgary S., Rahimi P., Mahzouni P., Madani H., Antidiabetic effect of hydroalcoholic extract of Carthamus tinctorius L. in alloxan-induced diabetic rats. Journal of Research in Medical Sciences 2012 17 4 386 392
152. Vuddanda P. R., Chakraborty S., Singh S., Berberine: a potential phytochemical with multispectrum therapeutic activities. Expert Opinion on Investigational Drugs 2010 19 10 1297 1307 2-s2.0-77956589652 10.1517/13543784.2010.517745
153. Kulkarni S. K., Dhir A., Berberine: a plant alkaloid with therapeutic potential for central nervous system disorders. Phytotherapy Research 2010 24 3 317 324 2-s2.0-77349115762 10.1002/ptr.2968
154. Imanshahidi M., Hosseinzadeh H., Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine. Phytotherapy Research 2008 22 8 999 1012 2-s2.0-50149108987 10.1002/ptr.2399
155. Lau C. W., Yao X. Q., Chen Z. Y., Ko W. H., Huang Y., Cardiovascular actions of berberine. Cardiovascular Drug Reviews 2001 19 3 234 244 2-s2.0-0035672517 (Pubitemid 34019907)
156. Saxena A., Vikram N. K., Role of selected indian plants in management of type 2 diabetes: a review. Journal of Alternative and Complementary Medicine 2004 10 2 369 378 2-s2.0-1942436069 (Pubitemid 38528738)
157. Islam M. S., Choi H., Dietary red chilli (Capsicum frutescens L.) is insulinotropic rather than hypoglycemic in type 2 diabetes model of rats. Phytotherapy Research 2008 22 8 1025 1029 2-s2.0-50149096826 10.1002/ptr.2417
158. Yun S. N., Moon S. J., Ko S. K., Im B. O., Chung S. H., Wild ginseng prevents the onset of high-fat diet induced hyperglycemia and obesity in ICR mice. Archives of Pharmacal Research 2004 27 7 790 796 2-s2.0-16644380244 (Pubitemid 43086225)
159. Yoo K. M., Lee C., Lo Y. M., Moon B., The hypoglycemic effects of American red ginseng (Panax quinquefolius L.) on a diabetic mouse model. Journal of Food Science 2012 77 7 H147 H152
160. Dey L., Xie J. T., Wang A., Wu J., Maleckar S. A., Yuan C. S., Anti-hyperglycemic effects of ginseng: comparison between root and berry. Phytomedicine 2003 10 6-7 600 605 2-s2.0-0041336976 10.1078/094471103322331908 (Pubitemid 37092688)
161. Xie J. T., Aung H. H., Wu J. A., Attele A. S., Yuan C. S., Effects of American ginseng berry extract on blood glucose levels in ob/ob mice. American Journal of Chinese Medicine 2002 30 2-3 187 194 2-s2.0-0012397405 10.1142/S0192415X02000442 (Pubitemid 41758892)
162. Xie J. T., Wang C. Z., Ni M., Wu J. A., Mehendale S. R., Aung H. H., Foo A., Yuan C. S., American ginseng berry juice intake reduces blood glucose and body weight in ob/ob mice: S: sensory and nutritive qualities of food. Journal of Food Science 2007 72 8 S590 S594 2-s2.0-35348876798 10.1111/j.1750-3841.2007. 00481.x (Pubitemid 47583545)
163. Xie J. T., Wu J. A., Mehendale S., Aung H. H., Yuan C. S., Anti-hyperglycemic effect of the polysaccharides fraction from American ginseng berry extract in ob/ob mice. Phytomedicine 2004 11 2-3 182 187 2-s2.0-1542288352 10.1078/0944-7113-00325 (Pubitemid 38314060)
164. Xie J. T., Zhou Y. P., Dey L., Attele A. S., Wu J. A., Gu M., Polonsky K. S., Yuan C. S., Ginseng berry reduces blood glucose and body weight in db/db mice. Phytomedicine 2002 9 3 254 258 2-s2.0-0036250280 (Pubitemid 34475559)
165. Vuksan V., Sievenpiper J. L., Koo V. Y. Y., Francis T., Beljan-Zdravkovic U., Xu Z., Vidgen E., American ginseng (Panax quinquefolius L.) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus. Archives of Internal Medicine 2000 160 7 1009 1013 2-s2.0-0034630423 (Pubitemid 30191931)
166. Vuksan V., Sung M. K., Sievenpiper J. L., Stavro P. M., Jenkins A. L., Di Buono M., Lee K. S., Leiter L. A., Nam K. Y., Arnason J. T., Choi M., Naeem A., Korean red ginseng (Panax ginseng) improves glucose and insulin regulation in well-controlled, type 2 diabetes: results of a randomized, double-blind, placebo-controlled study of efficacy and safety. Nutrition, Metabolism and Cardiovascular Diseases 2008 18 1 46 56 2-s2.0-37349037807 10.1016/j.numecd. 2006.04.003 (Pubitemid 350297892)
167. Kim S., Shin B. C., Lee M. S., Lee H., Ernst E., Red ginseng for type 2 diabetes mellitus: a systematic review of randomized controlled trials. Chinese Journal of Integrative Medicine 2011 17 12 937 944
168. Sievenpiper J. L., Arnason J. T., Vidgen E., Leiter L. A., Vuksan V., A systematic quantitative analysis of the literature of the high variability in ginseng (Panax spp.). Diabetes Care 2004 27 3 839 840 2-s2.0-1442275290 10.2337/diacare.27.3.839
169. Lee H. J., Lee Y. H., Park S. K., Kang E. S., Kim H. J., Lee Y. C., Choi C. S., Park S. E., Ahn C. W., Cha B. S., Lee K. W., Kim K. S., Lim S. K., Lee H. C., Korean red ginseng (Panax ginseng) improves insulin sensitivity and attenuates the development of diabetes in Otsuka Long-Evans Tokushima fatty rats. Metabolism 2009 58 8 1170 1177 2-s2.0-67651089992 10.1016/j.metabol.2009. 03.015
170. Chen F., Chen Y., Kang X., Anti-apoptotic function and mechanism of ginseng saponins in rattus pancreatic beta-cells. Biological & Pharmaceutical Bulletin 2012 35 9 1568 1573
171. Hye Y. K., Kim K., Protective effect of ginseng on cytokine-induced apoptosis in pancreatic β -cells. Journal of Agricultural and Food Chemistry 2007 55 8 2816 2823 2-s2.0-34247646402 10.1021/jf062577r (Pubitemid 46668283)
172. Kim H. Y., Kim K., Regulation of signaling molecules associated with insulin action, insulin secretion and pancreatic beta-cell mass in the hypoglycemic effects of Korean red ginseng in Goto-Kakizaki rats. Journal of Ethnopharmacology 2012 142 1 53 58
173. Wu Z., Luo J. Z., Luo L., American ginseng modulates pancreatic beta cell activities. Chinese Medicine 2007 2 article 11 2-s2.0-36549049452 10.1186/1749-8546-2-11
174. Luo J. Z., Luo L., Ginseng on hyperglycemia: effects and mechanisms. Evidence-Based Complementary and Alternative Medicine 2009 6 4 423 427
175. Madkor H. R., Mansour S. W., Ramadan G., Modulatory effects of garlic, ginger, turmeric and their mixture on hyperglycaemia, dyslipidaemia and oxidative stress in streptozotocin-nicotinamide diabetic rats. British Journal of Nutrition 2011 105 8 1210 1217
176. Meng B., Li J., Cao H., Antioxidant and antiinflammatory activities of curcumin on diabetes mellitus and its complications. Current Pharmaceutical Design 2013 19 11 2101 2113
177. Chuengsamarn S., Rattanamongkolgul S., Luechapudiporn R., Phisalaphong C., Jirawatnotai S., Curcumin extract for prevention of type 2 diabetes. Diabetes Care 2012 35 11 2121 2127
178. Weisberg S. P., Leibel R., Tortoriello D. V., Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity. Endocrinology 2008 149 7 3549 3558 2-s2.0-46349088791 10.1210/en.2008-0262 (Pubitemid 351919581)
179. Chang S., Vogelbaum M., Lang F. F., Haines S., Kunwar S., Chiocca A. A., Olivi A., Quinones-Hinojosa A., Parsa A., Warnick R., GNOSIS: guidelines for neuro-oncology: standards for investigational studies-reporting of surgically based therapeutic clinical trials. Journal of Neuro-Oncology 2007 82 2 211 220 2-s2.0-33947220937 10.1007/s11060-006-9271-5 (Pubitemid 46431868)
180. 2 Journal of Agricultural and Food Chemistry 1999 47 9 3804 3808 2-s2.0-0032840619 10.1021/jf981369z (Pubitemid 29449509)
181. Bracesco N., Sanchez A. G., Contreras V., Menini T., Gugliucci A., Recent advances on Ilex paraguariensis research: minireview. Journal of Ethnopharmacology 2011 136 3 378 384 2-s2.0-79960301180 10.1016/j.jep.2010.06. 032
182. Pittler M. H., Schmidt K., Ernst E., Adverse events of herbal food supplements for body weight reduction: systematic review. Obesity Reviews 2005 6 2 93 111 2-s2.0-18044398564 10.1111/j.1467-789X.2005.00169.x (Pubitemid 40604417)
183. Priya Rani M., Padmakumari K. P., Sankarikutty B., Lijo Cherian O., Nisha V. M., Raghu K. G., Inhibitory potential of ginger extracts against enzymes linked to type 2 diabetes, inflammation and induced oxidative stress. International Journal of Food Sciences and Nutrition 2011 62 2 106 110 2-s2.0-79551503947 10.3109/09637486.2010.515565
184. Fritsche A., Larbig M., Owens D., Häring H. U., Comparison between a basal-bolus and a premixed insulin regimen in individuals with type 2 diabetes-results of the GINGER study. Diabetes, Obesity and Metabolism 2010 12 2 115 123 2-s2.0-73349140858 10.1111/j.1463-1326.2009.01165.x
185. Islam M. S., Choi H., Comparative effects of dietary ginger (Zingiber officinale) and garlic (Allium sativum) investigated in a type 2 diabetes model of rats. Journal of Medicinal Food 2008 11 1 152 159 2-s2.0-41349117455 10.1089/jmf.2007.634 (Pubitemid 351450508)
186. Andallu B., Radhika B., Suryakantham V., Effect of aswagandha, ginger and mulberry on hyperglycemia and hyperlipidemia. Plant Foods for Human Nutrition 2003 58 3 1 7 2-s2.0-18644374720 (Pubitemid 40660236)
187. Bordia A., Verma S. K., Srivastava K. C., Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostaglandins Leukotrienes and Essential Fatty Acids 1997 56 5 379 384 2-s2.0-0030978825 (Pubitemid 27208438)
188. Iso H., Date C., Wakai K., Fukui M., Tamakoshi A., Mori M., Motohashi Y., Tsuji I., Nakamura Y., Mikami H., Hashimoto S., Inaba Y., Hoshiyama Y., Suzuki H., Shimizu H., Toyoshima H., Tokudome S., Ito Y., Kikuchi S., Koizumi A., Kawamura T., Watanabe Y., Miki T., Sakata K., Nose T., Hayakawa N., Yoshimura T., Fukuda K., Okamoto N., Shio H., Ohno Y., Kitagawa T., Kuroki T., Tajima K., The relationship between green tea and total caffeine intake and risk for self-reported type 2 diabetes among Japanese adults. Annals of Internal Medicine 2006 144 8 554 562 2-s2.0-33645977193 (Pubitemid 46768144)
189. Hosoda K., Wang M. F., Liao M. L., Chuang C. K., Iha M., Clevidence B., Yamamoto S., Antihyperglycemic effect of oolong tea in type 2 diabetes. Diabetes Care 2003 26 6 1714 1718 2-s2.0-0042169001 10.2337/diacare.26.6.1714 (Pubitemid 36929109)
190. Hayashino Y., Fukuhara S., Okamura T., Tanaka T., Ueshima H., High oolong tea consumption predicts future risk of diabetes among Japanese male workers: a prospective cohort study. Diabetic Medicine 2011 28 7 805 810 2-s2.0-79955032367 10.1111/j.1464-5491.2011.03239.x
191. Sabu M. C., Smitha K., Kuttan R., Anti-diabetic activity of green tea polyphenols and their role in reducing oxidative stress in experimental diabetes. Journal of Ethnopharmacology 2002 83 1-2 109 116 2-s2.0-0036876637 10.1016/S0378-8741(02)00217-9 (Pubitemid 36164734)
192. Hale P. J., Horrocks P. M., Wright A. D., Fitzgerald M. G., Nattrass M., Bailey C. J., Xiaoke tea, a Chinese herbal treatment for diabetes mellitus. Diabetic Medicine 1989 6 8 675 676 2-s2.0-0024426911 (Pubitemid 19265963)
193. Meng F., Abedini A., Plesner A., Verchere C. B., Raleigh D. P., The Flavanol (-)-epigallocatechin 3-gallate inhibits amyloid formation by islet amyloid polypeptide, disaggregates amyloid fibrils, and protects cultured cells against IAPP-induced toxicity. Biochemistry 2010 49 37 8127 8133 2-s2.0-77956595088 10.1021/bi100939a
194. Kaprel'iants L. V., Kiselev S. V., Iorgacheva E. G., Soybean isoflavones and prospects of their therapeutic application. Voprosy Pitaniia 2003 72 4 36 41 2-s2.0-0642312268
195. Kwon D. Y., Hong S. M., Lee J. E., Sung S. R., Park S., Long-term consumption of fermented soybean-derived Chungkookjang attenuates hepatic insulin resistance in 90% pancreatectomized diabetic rats. Hormone and Metabolic Research 2007 39 10 752 757 2-s2.0-36049017770 10.1055/s-2007-990287 (Pubitemid 350099825)
196. Kwon D. Y., Jang J. S., Hong S. M., Lee J. E., Sung S. R., Park H. R., Park S., Long-term consumption of fermented soybean-derived Chungkookjang enhances insulinotropic action unlike soybeans in 90% pancreatectomized diabetic rats. European Journal of Nutrition 2007 46 1 44 52 2-s2.0-33846794850 10.1007/s00394-006-0630-y (Pubitemid 46208260)
197. Behloul N., Wu G., Genistein: a promising therapeutic agent for obesity and diabetes treatment. European Journal of Pharmacology 2013 698 1-3 31 38
198. Tie L., An Y., Han J., Genistein accelerates refractory wound healing by suppressing superoxide and FoxO1/iNOS pathway in type 1 diabetes. The Journal of Nutritional Biochemistry 2013 24 1 88 96
199. Benter I. F., Yousif M. H. M., Griffiths S. M., Benboubetra M., Akhtar S., Epidermal growth factor receptor tyrosine kinase-mediated signalling contributes to diabetes-induced vascular dysfunction in the mesenteric bed. British Journal of Pharmacology 2005 145 6 829 836 2-s2.0-23044488194 10.1038/sj.bjp.0706238 (Pubitemid 41076290)
200. Nanri A., Mizoue T., Takahashi Y., Kirii K., Inoue M., Noda M., Tsugane S., Soy product and isoflavone intakes are associated with a lower risk of type 2 diabetes in overweight Japanese women. Journal of Nutrition 2010 140 3 580 586 2-s2.0-77249125353 10.3945/jn.109.116020
201. Haberer D., Tasker M., Foltz M., Intragastric infusion of pea-protein hydrolysate reduces test-meal size in rats more than pea protein. Physiology & Behavior 2011 104 5 1041 1047
202. Ghannam N., Kingston M., Al-Meshaal I. A., The antidiabetic activity of aloes: preliminary clinical and experimental observations. Hormone Research 1986 24 4 288 294 2-s2.0-0022469014 (Pubitemid 16004133)
203. Yongchaiyudha S., Rungpitarangsi V., Bunyapraphatsara N., Chokechaijaroenporn O., Antidiabetic activity of Aloe vera L. juice. I. Clinical trial in new cases of diabetes mellitus. Phytomedicine 1996 3 3 241 243 2-s2.0-0002249094 (Pubitemid 126504564)
204. Beppu H., Shimpo K., Chihara T., Kaneko T., Tamai I., Yamaji S., Ozaki S., Kuzuya H., Sonoda S., Antidiabetic effects of dietary administration of Aloe arborescens Miller components on multiple low-dose streptozotocin-induced diabetes in mice: investigation on hypoglycemic action and systemic absorption dynamics of aloe components. Journal of Ethnopharmacology 2006 103 3 468 477 2-s2.0-31344476763 10.1016/j.jep.2005.10.034 (Pubitemid 43143385)
205. Rajasekaran S., Sivagnanam K., Ravi K., Subramanian S., Hypoglycemic effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats. Journal of Medicinal Food 2004 7 1 61 66 2-s2.0-1842423773 10.1089/ 109662004322984725 (Pubitemid 38445924)
206. Bouras N., Kim Y. M., Strelkov S. E., Influence of water activity and temperature on growth and mycotoxin production by isolates of Pyrenophora tritici-repentis from wheat. International Journal of Food Microbiology 2009 131 2-3 251 255 2-s2.0-64349091521 10.1016/j.ijfoodmicro.2009.02.001
207. Pérez Y. Y., Jiménez-Ferrer E., Zamilpa A., Hernández-Valencia M., Alarcón-Aguilar F. J., Tortoriello J., Román-Ramos R., Effect of a polyphenol-rich extract from Aloe vera gel on experimentally induced insulin resistance in mice. American Journal of Chinese Medicine 2007 35 6 1037 1046 2-s2.0-37849051676 10.1142/S0192415X07005491
208. Bansal P., Paul P., Mudgal J., Nayak P. G., Thomas Pannakal S., Priyadarsini K. I., Unnikrishnan M. K., Antidiabetic, antihyperlipidemic and antioxidant effects of the flavonoid rich fraction of Pilea microphylla (L.) in high fat diet/streptozotocin-induced diabetes in mice. Experimental and Toxicologic Pathology 2012 64 6 651 658 2-s2.0-78650647730 10.1016/j.etp.2010. 12.009
209. Coskun O., Kanter M., Korkmaz A., Oter S., Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and β -cell damage in rat pancreas. Pharmacological Research 2005 51 2 117 123 2-s2.0-11144328863 10.1016/j.phrs.2004.06.002 (Pubitemid 40040541)
210. Kim J. H., Kang M. J., Choi H. N., Jeong S. M., Lee Y. M., Kim J. I., Quercetin attenuates fasting and postprandial hyperglycemia in animal models of diabetes mellitus. Nutrition Research and Practice 2011 5 2 107 111 2-s2.0-79956273349 10.4162/nrp.2011.5.2.107
211. Li Y. Q., Zhou F. C., Gao F., Bian J. S., Shan F., Comparative evaluation of quercetin, isoquercetin and rutin as inhibitors of α -glucosidase. Journal of Agricultural and Food Chemistry 2009 57 24 11463 11468 2-s2.0-73349100639 10.1021/jf903083h
212. Szkudelska K., Szkudelski T., Resveratrol, obesity and diabetes. European Journal of Pharmacology 2010 635 1-3 1 8 2-s2.0-77952321187 10.1016/j.ejphar.2010.02.054
213. Ramadori G., Gautron L., Fujikawa T., Vianna C. R., Elmquist J. K., Coppari R., Central administration of resveratrol improves diet-induced diabetes. Endocrinology 2009 150 12 5326 5333 2-s2.0-71949100263 10.1210/en.2009-0528
214. Aribal-Kocatürk P., Özelçi Kavas G., Iren Büyükkanici D., Pretreatment effect of resveratrol on streptozotocin-induced diabetes in rats. Biological Trace Element Research 2007 118 3 244 249 2-s2.0-35048825260 10.1007/s12011-007-0031-y (Pubitemid 47556622)
215. Hong Y. J., Kim N., Lee K., Korean red ginseng (Panax ginseng) ameliorates type 1 diabetes and restores immune cell compartments. Journal of Ethnopharmacology 2012 144 2 225 233
216. Venturini C. D., Merlo S., Souto A. A., Fernandes M. C., Gomez R., Rhoden C. R., Resveratrol and red wine function as antioxidants in the nervous system without cellular proliferative effects during experimental diabetes. Oxidative Medicine and Cellular Longevity 2010 3 6 434 441 2-s2.0-79960940619 10.4161/oxim.3.6.14741
217. Ungvari Z., Csiszar A., Resveratrol confers endothelial protection in insulin-dependent diabetes mellitus: editorial to: "Resveratrol shows vasoprotective effect reducing oxidative stress without affecting metabolic disturbances in insulin-dependent diabetes of rabbits" by F. Akar et al. Cardiovascular Drugs and Therapy 2011 25 2 111 113 2-s2.0-79958288912 10.1007/s10557-010-6267-3
218. Huang J. P., Huang S. S., Deng J. Y., Chang C. C., Day Y. J., Hung L. M., Insulin and resveratrol act synergistically, preventing cardiac dysfunction in diabetes, but the advantage of resveratrol in diabetics with acute heart attack is antagonized by insulin. Free Radical Biology and Medicine 2010 49 11 1710 1721 2-s2.0-78049356035 10.1016/j.freeradbiomed.2010.08.032
219. Zhang H., Morgan B., Potter B. J., Ma L., Dellsperger K. C., Ungvari Z., Zhang C., Resveratrol improves left ventricular diastolic relaxation in type 2 diabetes by inhibiting oxidative/nitrative stress: in vivo demonstration with magnetic resonance imaging. American Journal of Physiology 2010 299 4 H985 H994 2-s2.0-77958026411 10.1152/ajpheart.00489.2010
220. Resmi H., The combination of bortezomib and resveratrol may prevent muscle wasting in diabetes. Medical Hypotheses 2011 76 2 291 292 2-s2.0-78651065947 10.1016/j.mehy.2010.10.026
221. Ku C. R., Lee H. J., Kim S. K., Resveratrol prevents streptozotocin- induced diabetes by inhibiting the apoptosis of pancreatic beta-cell and the cleavage of poly (ADP-ribose) polymerase. Endocrine Journal 2012 59 2 103 109
222. Pacholec M., Bleasdale J. E., Chrunyk B., Cunningham D., Flynn D., Garofalo R. S., Griffith D., Griffor M., Loulakis P., Pabst B., Qiu X., Stockman B., Thanabal V., Varghese A., Ward J., Withka J., Ahn K., SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. Journal of Biological Chemistry 2010 285 11 8340 8351 2-s2.0-77950246109 10.1074/jbc.M109.088682
223. Haigis M. C., Sinclair D. A., Mammalian sirtuins: biological insights and disease relevance. Annual Review of Pathology 2010 5 253 295 2-s2.0-77949887506 10.1146/annurev.pathol.4.110807.092250
224. Van Dam R. M., Hu F. B., Coffee consumption and risk of type 2 diabetes: a systematic review. Journal of the American Medical Association 2005 294 1 97 104 2-s2.0-21444448910 10.1001/jama.294.1.97 (Pubitemid 41002844)
225. Wedick N. M., Brennan A. M., Sun Q., Effects of caffeinated and decaffeinated coffee on biological risk factors for type 2 diabetes: a randomized controlled trial. Nutrition Journal 2011 10 article 93