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Volumn 24, Issue 5-6, 2009, Pages 429-440

Gymnema montanum H. Protects against alloxan-induced oxidative stress and apoptosis in pancreatic β-cells

Author keywords

Apoptosis; Diabetes; Free radicals; Gymnema montanum; Medicinal plants; Pancreatic cells

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ALLOXAN; ANTIDIABETIC AGENT; CALCIUM; CASPASE 3; GYMNEMA MONTANUM EXTRACT; LIPID PEROXIDE; LIPOCORTIN 5; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE; PLANT EXTRACT; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

EID: 70450267608     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000257480     Document Type: Article
Times cited : (26)

References (62)
  • 1
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • Brownlee M: Biochemistry and molecular cell biology of diabetic complications. Nature 2001;414:813-820.
    • (2001) Nature , vol.414 , pp. 813-820
    • Brownlee, M.1
  • 2
    • 33846449882 scopus 로고    scopus 로고
    • Metabolic disorders in diabetes mellitus: Impact of mitochondrial function and oxidative stress on diabetes and its complications
    • DOI 10.1089/ars.2006.1486
    • Araki E, Miyazaki J: Metabolic disorders in diabetes mellitus: impact of mitochondrial function and oxidative stress on diabetes and its complications. Antioxid Redox Signal 2007;9:289-291. (Pubitemid 46145977)
    • (2007) Antioxidants and Redox Signaling , vol.9 , Issue.3 , pp. 289-291
    • Araki, E.1    Miyazaki, J.-I.2
  • 3
    • 0030837471 scopus 로고    scopus 로고
    • Acute hyperglycaemia and oxidative stress generation
    • Ceriello A. Acute hyperglycaemia and oxidative stress generation. Diabet Med 1997;3:S45-9.
    • (1997) Diabet Med , vol.3
    • Ceriello, A.1
  • 4
    • 0025540553 scopus 로고
    • Free radical generation by early glycation products: A mechanism for accelerated atherogenesis in diabetes
    • Mullarkey CJ, Edelstein D, Brownlee M: Free radical generation by early glycation products: a mechanism for accelerated atherogenesis in diabetes. Biochem Biophys Res Commun 1990;173:932-939.
    • (1990) Biochem Biophys Res Commun , vol.173 , pp. 932-939
    • Mullarkey, C.J.1    Edelstein, D.2    Brownlee, M.3
  • 5
    • 0028068046 scopus 로고
    • Cellular receptors for advanced glycation end products Implications for induction of oxidant stress and cellular dysfunction in the pathogenesis of vascular lesions
    • Schmidt AM, Hori O, Brett J, Yan SD, Wautier JL, Stern D: Cellular receptors for advanced glycation end products. Implications for induction of oxidant stress and cellular dysfunction in the pathogenesis of vascular lesions. Arterioscler Thromb 1994;14:1521-1528.
    • (1994) Arterioscler Thromb , vol.14 , pp. 1521-1528
    • Schmidt, A.M.1    Hori, O.2    Brett, J.3    Yan, S.D.4    Wautier, J.L.5    Stern, D.6
  • 6
    • 0032981514 scopus 로고    scopus 로고
    • Glucose-induced oxidative stress and programmed cell death in diabetic neuropathy
    • Greene DA, Stevens MJ, Obrosova I, Feldman EL: Glucose-induced oxidative stress and programmed cell death in diabetic neuropathy. Eur J Pharmacol 1999;375:217-223.
    • (1999) Eur J Pharmacol , vol.375 , pp. 217-223
    • Greene, D.A.1    Stevens, M.J.2    Obrosova, I.3    Feldman, E.L.4
  • 8
    • 0033596980 scopus 로고    scopus 로고
    • An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9
    • Zou H, Li Y, Liu X, Wang X: An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J Biol Chem 1999;274:11549-11556.
    • (1999) J Biol Chem , vol.274 , pp. 11549-11556
    • Zou, H.1    Li, Y.2    Liu, X.3    Wang, X.4
  • 9
    • 0034613302 scopus 로고    scopus 로고
    • Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1
    • Jiang X, Wang X: Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1. J Biol Chem 2000;275:31199-31203.
    • (2000) J Biol Chem , vol.275 , pp. 31199-31203
    • Jiang, X.1    Wang, X.2
  • 10
    • 0029984682 scopus 로고    scopus 로고
    • Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues
    • Lenzen S, Drinkgern J, Tiedge M: Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radic Biol Med 1996;20:463-466.
    • (1996) Free Radic Biol Med , vol.20 , pp. 463-466
    • Lenzen, S.1    Drinkgern, J.2    Tiedge, M.3
  • 11
    • 0036195710 scopus 로고    scopus 로고
    • Oxidative stress and antioxidant status in type 1 diabetes mellitus
    • Vessby J, Basu S, Mohsen R, Berne C, Vessby B: Oxidative stress and antioxidant status in type 1 diabetes mellitus. J Intern Med 2002;251:69-76.
    • (2002) J Intern Med , vol.251 , pp. 69-76
    • Vessby, J.1    Basu, S.2    Mohsen, R.3    Berne, C.4    Vessby, B.5
  • 12
    • 0036796875 scopus 로고    scopus 로고
    • Oxidative stress and stress-activated signaling pathways: A unifying hypothesis of type 2 diabetes
    • Evans JL, Goldfine ID, Maddux BA, Grodsky GM: Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev 2002;23:599-622.
    • (2002) Endocr Rev , vol.23 , pp. 599-622
    • Evans, J.L.1    Goldfine, I.D.2    Maddux, B.A.3    Grodsky, G.M.4
  • 13
    • 0037984766 scopus 로고    scopus 로고
    • High glucose-induced oxidative stress causes apoptosis in proximal tubular epithelial cells and is mediated by multiple caspases
    • Allen DA, Harwood S, Varagunam M, Raftery MJ, Yaqoob MM: High glucose-induced oxidative stress causes apoptosis in proximal tubular epithelial cells and is mediated by multiple caspases. FASEB J 2003;17:908-910.
    • (2003) FASEB J , vol.17 , pp. 908-910
    • Allen, D.A.1    Harwood, S.2    Varagunam, M.3    Raftery, M.J.4    Yaqoob, M.M.5
  • 14
    • 35448932469 scopus 로고    scopus 로고
    • Curcumin prevents streptozotocin-induced islet damage by scavenging free radicals: A prophylactic and protective role
    • Meghana K, Sanjeev G, Ramesh B: Curcumin prevents streptozotocin-induced islet damage by scavenging free radicals: a prophylactic and protective role. Eur J Pharmacol 2007;577:183-191.
    • (2007) Eur J Pharmacol , vol.577 , pp. 183-191
    • Meghana, K.1    Sanjeev, G.2    Ramesh, B.3
  • 15
    • 40549096413 scopus 로고    scopus 로고
    • Protective effects of an herbal formulation of Radix astragali, Radix codonopsis and Cortex lycii on streptozotocin-induced apoptosis in pancreatic beta-cells: An implication for its treatment of diabetes mellitus
    • Chan JY, Leung PC, Che CT, Fung KP. Protective effects of an herbal formulation of Radix astragali, Radix codonopsis and Cortex lycii on streptozotocin-induced apoptosis in pancreatic beta-cells: an implication for its treatment of diabetes mellitus. Phytother Res 2008;22:190-196.
    • (2008) Phytother Res , vol.22 , pp. 190-196
    • Chan, J.Y.1    Leung, P.C.2    Che, C.T.3    Fung, K.P.4
  • 17
    • 0032168821 scopus 로고    scopus 로고
    • Possible mechanism of antihyperglycemic effect of Gymnema sylvestre leaf extract, part i
    • Chattopadhyay RR: Possible mechanism of antihyperglycemic effect of Gymnema sylvestre leaf extract, part I. Gen Pharmacol 1998;31:495-496.
    • (1998) Gen Pharmacol , vol.31 , pp. 495-496
    • Chattopadhyay, R.R.1
  • 18
    • 0032694421 scopus 로고    scopus 로고
    • Gymnema sylvestre stimulates insulin release in vitro by increased membrane permeability
    • Persaud SJ, Al-Majed H, Raman A, Jones PM: Gymnema sylvestre stimulates insulin release in vitro by increased membrane permeability. J Endocrinol 1999;163:207-212.
    • (1999) J Endocrinol , vol.163 , pp. 207-212
    • Persaud, S.J.1    Al-Majed, H.2    Raman, A.3    Jones, P.M.4
  • 19
    • 0034939108 scopus 로고    scopus 로고
    • Structure-activity relationships of triterpenoid derivatives extracted from Gymnema inodorum leaves on glucose absorption
    • Shimizu K, Ozeki M, Iino A, Nakajyo S, Urakawa N, Atsuchi M: Structure-activity relationships of triterpenoid derivatives extracted from Gymnema inodorum leaves on glucose absorption. Jpn J Pharmacol 2001;86:223-239.
    • (2001) Jpn J Pharmacol , vol.86 , pp. 223-239
    • Shimizu, K.1    Ozeki, M.2    Iino, A.3    Nakajyo, S.4    Urakawa, N.5    Atsuchi, M.6
  • 21
    • 0037951503 scopus 로고    scopus 로고
    • Effect of Gymnema montanum on blood glucose, plasma insulin, and carbohydrate metabolic enzymes in alloxan-induced diabetic rats
    • Ananthan R, Latha M, Pari L, Ramkumar KM, Baskar CG, Bai VN: Effect of Gymnema montanum on blood glucose, plasma insulin, and carbohydrate metabolic enzymes in alloxan-induced diabetic rats. J Med Food 2003;6:43-49.
    • (2003) J Med Food , vol.6 , pp. 43-49
    • Ananthan, R.1    Latha, M.2    Pari, L.3    Ramkumar, K.M.4    Baskar, C.G.5    Bai, V.N.6
  • 22
    • 33847335079 scopus 로고    scopus 로고
    • Ethanol extract of Gymnema montanum leaves reduces glycoprotein components in experimental diabetes
    • Ramkumar KM, Rajaguru P, Latha M, Ananthan R: Ethanol extract of Gymnema montanum leaves reduces glycoprotein components in experimental diabetes. Nut Res 2007;27:97-103.
    • (2007) Nut Res , vol.27 , pp. 97-103
    • Ramkumar, K.M.1    Rajaguru, P.2    Latha, M.3    Ananthan, R.4
  • 23
    • 42549134043 scopus 로고    scopus 로고
    • Effect of Gymnema montanum leaves on red blood cell resistance to oxidative stress in experimental diabetes
    • Ramkumar KM, Rajaguru P, Latha M, Ananthan R: Effect of Gymnema montanum leaves on red blood cell resistance to oxidative stress in experimental diabetes. Cell Biol Toxicol 2008;24:233-241.
    • (2008) Cell Biol Toxicol , vol.24 , pp. 233-241
    • Ramkumar, K.M.1    Rajaguru, P.2    Latha, M.3    Ananthan, R.4
  • 25
    • 24944579576 scopus 로고    scopus 로고
    • Modulation of impaired cholinesterase activity in experimental diabetes: Effect of Gymnema montanum leaf extract
    • Ramkumar KM, Latha M, Ashokkumar N, Pari L, Ananthan R: Modulation of impaired cholinesterase activity in experimental diabetes: effect of Gymnema montanum leaf extract. J Basic Clin Physiol Pharmacol 2005;16:17-35.
    • (2005) J Basic Clin Physiol Pharmacol , vol.16 , pp. 17-35
    • Ramkumar, K.M.1    Latha, M.2    Ashokkumar, N.3    Pari, L.4    Ananthan, R.5
  • 26
    • 0032616031 scopus 로고    scopus 로고
    • 2+ channel inhibition induced by nitric oxide in rat insulinoma RINm5F cells
    • Grassi C, D'Ascenzo M, Valente A, Battista Azzena G. Ca2+ channel inhibition induced by nitric oxide in rat insulinoma RINm5F cells. Eur J Physiol 1999;437:241-247.
    • (1999) Eur J Physiol , vol.437 , pp. 241-247
    • Grassi, C.1    D'ascenzo, M.2    Valente, A.3    Battista Azzena, G.4
  • 27
    • 24044441667 scopus 로고    scopus 로고
    • Biotechnology to harness the benefits of dietry phenolics: Focus on Lamiaceae
    • Shetty K. Biotechnology to harness the benefits of dietry phenolics: focus on Lamiaceae. Asia Pac J Clin Nut 1997;6:162-171.
    • (1997) Asia Pac J Clin Nut , vol.6 , pp. 162-171
    • Shetty, K.1
  • 28
    • 0025294320 scopus 로고
    • A feasibility study of the MTT assay for chemosensitivity testing in ovarian malignancy
    • Wilson JK, Sargent JM, Elgie AW, Hill JG, Taylor CG: A feasibility study of the MTT assay for chemosensitivity testing in ovarian malignancy. Br J Cancer 1990;62:189-194.
    • (1990) Br J Cancer , vol.62 , pp. 189-194
    • Wilson, J.K.1    Sargent, J.M.2    Elgie, A.W.3    Hill, J.G.4    Taylor, C.G.5
  • 29
    • 0023505509 scopus 로고
    • Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide
    • Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G: Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci U S A 1987;84:9265-9269.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 9265-9269
    • Ignarro, L.J.1    Buga, G.M.2    Wood, K.S.3    Byrns, R.E.4    Chaudhuri, G.5
  • 30
    • 0025697262 scopus 로고
    • Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury
    • Janero DR: Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Radic Biol Med 1990;9:515-540.
    • (1990) Free Radic Biol Med , vol.9 , pp. 515-540
    • Janero, D.R.1
  • 31
    • 0021681627 scopus 로고
    • A modified spectrophotometric assay of superoxide dismutase
    • Kakkar P, Das B, Viswanathan PN: A modified spectrophotometric assay of superoxide dismutase. Indian J Biochem Biophys 1984;21:130-132.
    • (1984) Indian J Biochem Biophys , vol.21 , pp. 130-132
    • Kakkar, P.1    Das, B.2    Viswanathan, P.N.3
  • 32
    • 0015353270 scopus 로고
    • Colorimetric assay of catalase
    • Sinha AK: Colorimetric assay of catalase. Anal Biochem 1972;47:389-394.
    • (1972) Anal Biochem , vol.47 , pp. 389-394
    • Sinha, A.K.1
  • 35
    • 0032571294 scopus 로고    scopus 로고
    • The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition
    • Pastorino JG, Chen ST, Tafani M, Snyder JW, Farber JL: The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition. J Biol Chem 1998;273:7770-7775.
    • (1998) J Biol Chem , vol.273 , pp. 7770-7775
    • Pastorino, J.G.1    Chen, S.T.2    Tafani, M.3    Snyder, J.W.4    Farber, J.L.5
  • 36
    • 33749338642 scopus 로고    scopus 로고
    • 2 -induced oxidative injury via opening mitochondrial ATP-sensitive potassium channel
    • Chai Y, Niu L, Sun XL, Ding JH, Hu G: Iptakalim protects PC12 cell against H2O2-induced oxidative injury via opening mitochondrial ATP-sensitive potassium channel. Biochem Biophys Res Commun 2006;350:307-314.
    • (2006) Biochem Biophys Res Commun , vol.350 , pp. 307-314
    • Chai, Y.1    Niu, L.2    Sun, X.L.3    Ding, J.H.4    Hu, G.5
  • 38
    • 0025211779 scopus 로고
    • Quantitation of protein
    • Stoscheck CM: Quantitation of protein. Methods Enzymol 1990;182:50-68.
    • (1990) Methods Enzymol , vol.182 , pp. 50-68
    • Stoscheck, C.M.1
  • 40
    • 0035124874 scopus 로고    scopus 로고
    • Beta-cell apoptosis and defense mechanisms: Lessons from type 1 diabetes
    • Eizirik DL, Darville MI: beta-cell apoptosis and defense mechanisms: lessons from type 1 diabetes. Diabetes 2001;50 Suppl 1:S64-69.
    • (2001) Diabetes , vol.50 , Issue.SUPPL. 1
    • Eizirik, D.L.1    Darville, M.I.2
  • 41
    • 0035691617 scopus 로고    scopus 로고
    • The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas
    • Szkudelski T: The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol Res 2001;50:537-546.
    • (2001) Physiol Res , vol.50 , pp. 537-546
    • Szkudelski, T.1
  • 42
    • 0025894930 scopus 로고
    • Alloxan-induced DNA strand breaks in pancreatic islets. Evidence for H2O2 as an intermediate
    • Takasu N, Asawa T, Komiya I, Nagasawa Y, Yamada T: Alloxan-induced DNA strand breaks in pancreatic islets. Evidence for H2O2 as an intermediate. J Biol Chem 1991;266:2112-2114.
    • (1991) J Biol Chem , vol.266 , pp. 2112-2114
    • Takasu, N.1    Asawa, T.2    Komiya, I.3    Nagasawa, Y.4    Yamada, T.5
  • 43
    • 0034871056 scopus 로고    scopus 로고
    • Apoptosis and mitochondrial damage in INS-1 cells treated with alloxan
    • Sakurai K, Katoh M, Someno K, Fujimoto Y: Apoptosis and mitochondrial damage in INS-1 cells treated with alloxan. Biol Pharm Bull 2001;24:876-882.
    • (2001) Biol Pharm Bull , vol.24 , pp. 876-882
    • Sakurai, K.1    Katoh, M.2    Someno, K.3    Fujimoto, Y.4
  • 44
    • 0027303008 scopus 로고
    • Lipid peroxide and glutathione levels in the liver and its subcellular fractions of alloxan diabetic rats
    • Seckin S, Alptekin N, Kocak-Toker N, Uysal M: Lipid peroxide and glutathione levels in the liver and its subcellular fractions of alloxan diabetic rats. Horm Metab Res 1993;25:444-445.
    • (1993) Horm Metab Res , vol.25 , pp. 444-445
    • Seckin, S.1    Alptekin, N.2    Kocak-Toker, N.3    Uysal, M.4
  • 46
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • Green DR, Reed JC: Mitochondria and apoptosis. Science 1998;281:1309-1312.
    • (1998) Science , vol.281 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 47
    • 33846448497 scopus 로고    scopus 로고
    • Glycemic control of apoptosis in the pancreatic beta cell: Danger of extremes?
    • Martens GA, Van de Casteele M: Glycemic control of apoptosis in the pancreatic beta cell: danger of extremes? Antioxid Redox Signal. 2007;9:309-317.
    • (2007) Antioxid Redox Signal , vol.9 , pp. 309-317
    • Martens, G.A.1    Van De Casteele, M.2
  • 50
    • 0028287096 scopus 로고
    • Nitric oxide reacts with intracellular glutathione and activates the hexose monophosphate shunt in human neutrophils: Evidence for S-nitrosoglutathione as a bioactive intermediary
    • Clancy RM, Levartovsky D, Leszczynska-Piziak J, Yegudin J, Abramson SB: Nitric oxide reacts with intracellular glutathione and activates the hexose monophosphate shunt in human neutrophils: evidence for S-nitrosoglutathione as a bioactive intermediary. Proc Natl Acad Sci U S A. 1994;91:3680-3684.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 3680-3684
    • Clancy, R.M.1    Levartovsky, D.2    Leszczynska-Piziak, J.3    Yegudin, J.4    Abramson, S.B.5
  • 51
    • 0037125997 scopus 로고    scopus 로고
    • A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity
    • Tanaka Y, Tran PO, Harmon J, Robertson RP. A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity. Proc Natl Acad Sci U S A. 2002;99:12363-12368.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 12363-12368
    • Tanaka, Y.1    Tran, P.O.2    Harmon, J.3    Robertson, R.P.4
  • 52
    • 0029984682 scopus 로고    scopus 로고
    • Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues
    • Lenzen S, Drinkgern J, Tiedge M. Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radic Biol Med. 1996;20:463-466.
    • (1996) Free Radic Biol Med , vol.20 , pp. 463-466
    • Lenzen, S.1    Drinkgern, J.2    Tiedge, M.3
  • 53
    • 33746766202 scopus 로고    scopus 로고
    • Relative importance of cellular uptake and reactive oxygen species for the toxicity of alloxan and dialuric acid to insulin-producing cells
    • Elsner M, Gurgul-Convey E, Lenzen S. Relative importance of cellular uptake and reactive oxygen species for the toxicity of alloxan and dialuric acid to insulin-producing cells. Free Radic Biol Med. 2006;41:825-834.
    • (2006) Free Radic Biol Med , vol.41 , pp. 825-834
    • Elsner, M.1    Gurgul-Convey, E.2    Lenzen, S.3
  • 55
    • 0034737784 scopus 로고    scopus 로고
    • Protective mechanism of glucose against alloxan-induced beta-cell damage: Pivotal role of ATP
    • Rho HW, Lee JN, Kim HR, Park BH, Park JW: Protective mechanism of glucose against alloxan-induced beta-cell damage: pivotal role of ATP. Exp Mol Med 2000;32:12-17.
    • (2000) Exp Mol Med , vol.32 , pp. 12-17
    • Rho, H.W.1    Lee, J.N.2    Kim, H.R.3    Park, B.H.4    Park, J.W.5
  • 57
    • 0033565557 scopus 로고    scopus 로고
    • The mitochondrial permeability transition pore and its role in cell death
    • Crompton M: The mitochondrial permeability transition pore and its role in cell death. Biochem J 1999;341:233-249.
    • (1999) Biochem J , vol.341 , pp. 233-249
    • Crompton, M.1
  • 58
    • 0032608336 scopus 로고    scopus 로고
    • Necrapoptosis and the mitochondrial permeability transition: Shared pathways to necrosis and apoptosis
    • Lemasters JJ: V. Necrapoptosis and the mitochondrial permeability transition: shared pathways to necrosis and apoptosis. Am J Physiol 1999;276:G1-6.
    • (1999) Am J Physiol , vol.276
    • Lemasters, J.J.1
  • 59
    • 0033569747 scopus 로고    scopus 로고
    • Bcl-2 and mitochondrial oxygen radicals. New approaches with reactive oxygen species-sensitive probes
    • Esposti MD, Hatzinisiriou I, McLennan H, Ralph S: Bcl-2 and mitochondrial oxygen radicals. New approaches with reactive oxygen species-sensitive probes. J Biol Chem 1999;274:29831-29837.
    • (1999) J Biol Chem , vol.274 , pp. 29831-29837
    • Esposti, M.D.1    Hatzinisiriou, I.2    McLennan, H.3    Ralph, S.4
  • 60
    • 0036478928 scopus 로고    scopus 로고
    • The Apaf-1 apoptosome: A large caspase-activating complex
    • Cain K, Bratton SB, Cohen GM: The Apaf-1 apoptosome: a large caspase-activating complex. Biochimie 2002;84:203-214.
    • (2002) Biochimie , vol.84 , pp. 203-214
    • Cain, K.1    Bratton, S.B.2    Cohen, G.M.3
  • 61
    • 0000324698 scopus 로고
    • Phenolic compounds in food: An overview
    • Huang MT, Ho CT, Lee CY, editors American Chemical Society, Washington, DC
    • Ho CT: Phenolic compounds in food: an overview. In: Huang MT, Ho CT, Lee CY, editors. Phenolic Compounds in Food and their Effects on Health. II. American Chemical Society, Washington, DC; 1992. p. 2-7.
    • (1992) Phenolic Compounds in Food and Their Effects on Health. II , pp. 2-7
    • Ho, C.T.1
  • 62
    • 34248140585 scopus 로고    scopus 로고
    • Cytoprotective effects of KIOM-79 on streptozotocin induced cell damage by inhibiting ERK and AP-1
    • Kang KA, Lee KH, Kim SY, Kim HS, Kim JS, Hyun JW. Cytoprotective effects of KIOM-79 on streptozotocin induced cell damage by inhibiting ERK and AP-1. Biol Pharm Bull 2007;30:852-858
    • (2007) Biol Pharm Bull , vol.30 , pp. 852-858
    • Kang, K.A.1    Lee, K.H.2    Kim, S.Y.3    Kim, H.S.4    Kim, J.S.5    Hyun, J.W.6


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