Astragalus polysaccharide improves insulin sensitivity in KKAy mice: Regulation of PKB/GLUT4 signaling in skeletal muscle

Journal of Ethnopharmacology

Volumn 127, Issue 1, 2010, Pages 32-37

  Liu, Min ^a   Wu, Ke ^a   Mao, Xianqing ^a   Wu, Yong ^a   Ouyang, Jingping ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

Astragalus polysaccharide; Glucose transporter 4; Insulin resistance; Protein kinase B; Skeletal muscle; Type 2 diabetes

Indexed keywords

ASTRAGALUS POLYSACCHARIDE; GLUCOSE TRANSPORTER 4; INSULIN SENSITIZING AGENT; POLYSACCHARIDE; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTRAGALUS MEMBRANACEUS; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; GLUCOSE HOMEOSTASIS; HYPERGLYCEMIA; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; INSULIN SENSITIVITY; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SKELETAL MUSCLE; WEIGHT REDUCTION;

ANIMALS; ASTRAGALUS MEMBRANACEUS; BLOOD GLUCOSE; BODY WEIGHT; CELL MEMBRANE; DIABETES MELLITUS, TYPE 2; DRUGS, CHINESE HERBAL; ENZYME ACTIVATION; FEMALE; GLUCOSE TRANSPORTER TYPE 4; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; MICE; MUSCLE, SKELETAL; PHOSPHORYLATION; PLANT ROOTS; POLYSACCHARIDES; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

ASTRAGALUS (ANGIOSPERM); ASTRAGALUS MEMBRANACEUS; FABACEAE; MUS;

EID: 72149094306     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2009.09.055     Document Type: Article

References (31)

1. Chen W., Li Y.M., and Yu M.H. Astragalus polysaccharides: an effective treatment for diabetes prevention in NOD mice. Experimental and Clinical Endocrinology & Diabetes 116 (2008) 468-474
2. Chen, W., Li, Y.M., Yu, M.H., in pressa. Astragalus polysaccharides inhibited diabetic cardiomyopathy in hamsters depending on suppression of heart chymase activation. Journal of Diabetes and its Complications DOI:10.1016/j.jdiacomp.2008.12.003.
3. Chen, W., Yu, M.H., Li, Y.M., Chen, W.J., Xia, Y.P., in pressb. Beneficial effects of astragalus polysaccharides treatment on cardiac chymase activities and cardiomyopathy in diabetic hamsters. Acta Diabetologica DOI:10.1007/s00592-009-0116-5.
4. Cho H., Mu J., Kim J.K., Thorvaldsen J.L., Chu Q., Crenshaw III E.B., Kaestner K.H., Bartolomei M.S., Shulman G.I., and Birnbaum M.J. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science 292 (2001) 1728-1731
5. Clark M.G. Impaired microvascular perfusion: a consequence of vascular dysfunction and a potential cause of insulin resistance in muscle. American Journal of Physiology-Endocrinology and Metabolism 295 (2008) E732-E750
6. Galuska D., Ryder J., Kawano Y., Charron M.J., and Zierath J.R. Insulin signaling and glucose transport in insulin resistant skeletal muscle. Special reference to GLUT4 transgenic and GLUT4 knockout mice. Advances in Experimental Medicine and Biology 441 (1998) 73-85
7. Garvey W.T., Maianu L., Zhu J.H., Brechtel-Hook G., Wallace P., and Baron A.D. Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance. The Journal of Clinical Investigation 101 (1998) 2377-2386
8. Halaby M.J., Hibma J.C., He J., and Yang D.Q. ATM protein kinase mediates full activation of Akt and regulates glucose transporter 4 translocation by insulin in muscle cells. Cellular Signalling 20 (2008) 1555-1563
9. Han D.H., Chen M.M., and Holloszy J.O. Glucosamine and glucose induce insulin resistance by different mechanisms in rat skeletal muscle. American Journal of Physiology-Endocrinology and Metabolism 285 (2003) E1267-E1272
10. Hayase M., Ogawa Y., Katsuura G., Shintaku H., Hosoda K., and Nakao K. Regulation of obese gene expression in KK mice and congenic lethal yellow obese KKAy mice. The American Journal of Physiology 271 (1996) E333-E339
11. He A., Liu X., Liu L., Chang Y., and Fang F. How many signals impinge on GLUT4 activation by insulin?. Cellular Signalling 19 (2007) 1-7
12. Huang C.L., and Lu Y.P. Effect of Astragalus injection on insulin resistance in auxiliary treating patients with diabetes mellitus type 2. Zhongguo Zhong Xi Yi Jie He Za Zhi 23 (2003) 779-780
13. Karlsson H.K., Zierath J.R., Kane S., Krook A., Lienhard G.E., and Wallberg-Henriksson H. Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects. Diabetes 54 (2005) 1692-1697
14. Kim Y.B., Nikoulina S.E., Ciaraldi T.P., Henry R.R., and Kahn B.B. Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes. The Journal of Clinical Investigation 104 (1999) 733-741
15. Krook A., Roth R.A., Jiang X.J., Zierath J.R., and Wallberg-Henriksson H. Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects. Diabetes 47 (1998) 1281-1286
16. Kurowski T.G., Lin Y., Luo Z., Tsichlis P.N., Buse M.G., Heydrick S.J., and Ruderman N.B. Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not phosphatidylinositol 3-kinase in rat skeletal muscle. Diabetes 48 (1999) 658-663
17. Mao X.Q., Wu Y., Wu K., Liu M., Zhang J.F., Zou F., and Ou-Yang J.P. Astragalus polysaccharide reduces hepatic endoplasmic reticulum stress and restores glucose homeostasis in a diabetic KKAy mouse model. Acta Pharmacologica Sinica 28 (2007) 1947-1956
18. Ni Y., Su Q., Liu X., and Li X.R. Experimental study of optimized techniques of water decoction extraction of Astragalus polysaccharide. Zhongguo Zhong Yao Za Zhi 23 (1998) 284-286
19. Oku A., Nawano M., Ueta K., Fujita T., Umebayashi I., Arakawa K., Kano-Ishihara T., Saito A., Anai M., Funaki M., Kikuchi M., Oka Y., and Asano T. Inhibitory effect of hyperglycemia on insulin-induced Akt/protein kinase B activation in skeletal muscle. American Journal of Physiology-Endocrinology and Metabolism 280 (2001) E816-E824
20. Ruderman N.B., Kapeller R., White M.F., and Cantley L.C. Activation of phosphatidylinositol 3-kinase by insulin. Proceedings of the National Academy of Sciences of the United States of America 87 (1990) 1411-1415
21. Shao J., Yamashita H., Qiao L., and Friedman J.E. Decreased Akt kinase activity and insulin resistance in C57BL/KsJ-Leprdb/db mice. The Journal of Endocrinology 167 (2000) 107-115
22. Standaert M.L., Ortmeyer H.K., Sajan M.P., Kanoh Y., Bandyopadhyay G., Hansen B.C., and Farese R.V. Skeletal muscle insulin resistance in obesity-associated type 2 diabetes in monkeys is linked to a defect in insulin activation of protein kinase C-zeta/lambda/iota. Diabetes 51 (2002) 2936-2943
23. Stenbit A.E., Tsao T.S., Li J., Burcelin R., Geenen D.L., Factor S.M., Houseknecht K., Katz E.B., and Charron M.J. GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes. Nature Medicine 3 (1997) 1096-1101
24. Tong Y., and Hou H. Effects of Huangqi Guizhi Wuwu Tang on diabetic peripheral neuropathy. Journal of Alternative and Complementary Medicine 12 (2006) 506-509
25. Tremblay F., Lavigne C., Jacques H., and Marette A. Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both Akt/protein kinase B and atypical protein kinase C (zeta/lambda) activities. Diabetes 50 (2001) 1901-1910
26. Tremblay F., Lavigne C., Jacques H., and Marette A. Dietary cod protein restores insulin-induced activation of phosphatidylinositol 3-kinase/Akt and GLUT4 translocation to the T-tubules in skeletal muscle of high-fat-fed obese rats. Diabetes 52 (2003) 29-37
27. Turcotte L.P., and Fisher J.S. Skeletal muscle insulin resistance: roles of fatty acid metabolism and exercise. Physical Therapy 88 (2008) 1279-1296
28. van Dam E.M., Govers R., and James D.E. Akt activation is required at a late stage of insulin-induced GLUT4 translocation to the plasma membrane. Molecular Endocrinology 19 (2005) 1067-1077
29. Wang Q., Somwar R., Bilan P.J., Liu Z., Jin J., Woodgett J.R., and Klip A. Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts. Molecular and Cellular Biology 19 (1999) 4008-4018
30. Wu Y., Ou-Yang J.P., Wu K., Wang Y., Zhou Y.F., and Wen C.Y. Hypoglycemic effect of Astragalus polysaccharide and its effect on PTP1B. Acta Pharmacologica Sinica 26 (2005) 345-352
31. Zhou G.X., Meier K.E., and Buse M.G. Sequential activation of two mitogen activated protein (MAP) kinase isoforms in rat skeletal muscle following insulin injection. Biochemical and Biophysical Research Communications 197 (1993) 578-584