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Volumn 378, Issue 9786, 2011, Pages 182-197

Management of type 2 diabetes: New and future developments in treatment

Author keywords

[No Author keywords available]

Indexed keywords

ACARBOSE; ALBIGLUTIDE; ANTIDIABETIC AGENT; CJC 1134 PC; EXENDIN 4; GLIBENCLAMIDE; GLICLAZIDE; GLIMEPIRIDE; GLIPIZIDE; INSULIN ASPART; INSULIN GLULISINE; INSULIN LISPRO; ISOPHANE INSULIN; LIRAGLUTIDE; LIXISENATIDE; METFORMIN; MIGLITOL; NATEGLINIDE; NEUTRAL INSULIN; ORAL ANTIDIABETIC AGENT; PIOGLITAZONE; PRAMLINTIDE; RECOMBINANT HUMAN INSULIN; REPAGLINIDE; ROSIGLITAZONE; SAXAGLIPTIN; SITAGLIPTIN; TASPOGLUTIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VILDAGLIPTIN;

EID: 79960262492     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(11)60207-9     Document Type: Review
Times cited : (471)

References (133)
  • 1
    • 17044386953 scopus 로고    scopus 로고
    • Type 2 diabetes: Principles of pathogenesis and therapy
    • M Stumvoll, BJ Goldstein, TW van Haeften Type 2 diabetes: principles of pathogenesis and therapy Lancet 365 2005 1333 1346
    • (2005) Lancet , vol.365 , pp. 1333-1346
    • Stumvoll, M.1    Goldstein, B.J.2    Van Haeften, T.W.3
  • 2
    • 0024160877 scopus 로고
    • Role of insulin resistance in human disease
    • GM Reaven Role of insulin resistance in human disease Diabetes 37 1988 1595 1607 (Pubitemid 19004941)
    • (1988) Diabetes , vol.37 , Issue.12 , pp. 1595-1607
    • Reaven, G.M.1
  • 3
    • 33845881411 scopus 로고    scopus 로고
    • Mechanisms linking obesity to insulin resistance and type 2 diabetes
    • DOI 10.1038/nature05482, PII NATURE05482
    • SE Kahn, RL Hull, KM Utzschneider Mechanisms linking obesity to insulin resistance and type 2 diabetes Nature 444 2006 840 846 (Pubitemid 46024990)
    • (2006) Nature , vol.444 , Issue.7121 , pp. 840-846
    • Kahn, S.E.1    Hull, R.L.2    Utzschneider, K.M.3
  • 4
    • 47149095990 scopus 로고    scopus 로고
    • Pancreatic alpha-cell dysfunction in diabetes
    • R Burcelin, C Knauf, PD Cani Pancreatic alpha-cell dysfunction in diabetes Diabetes Metab 34 suppl 2 2008 S49 S55
    • (2008) Diabetes Metab , vol.34 , Issue.SUPPL. 2
    • Burcelin, R.1    Knauf, C.2    Cani, P.D.3
  • 5
    • 67349224047 scopus 로고    scopus 로고
    • Melatonin receptors in pancreatic islets: Good morning to a novel type 2 diabetes gene
    • H Mulder, C Nagorny, V Lyssenko, L Groop Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene Diabetologia 52 2009 1240 1249
    • (2009) Diabetologia , vol.52 , pp. 1240-1249
    • Mulder, H.1    Nagorny, C.2    Lyssenko, V.3    Groop, L.4
  • 6
    • 73249141243 scopus 로고    scopus 로고
    • 11β-hydroxysteroid dehydrogenase type 1 and its role in the hypothalamus-pituitary-adrenal axis, metabolic syndrome, and inflammation
    • MS Cooper, PM Stewart 11β-hydroxysteroid dehydrogenase type 1 and its role in the hypothalamus-pituitary-adrenal axis, metabolic syndrome, and inflammation J Clin Endocrinol Metab 94 2009 4645 4654
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 4645-4654
    • Cooper, M.S.1    Stewart, P.M.2
  • 7
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    • DOI 10.1016/S0140-6736(06)69705-5, PII S0140673606697055
    • DJ Drucker, MA Nauck The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes Lancet 368 2006 1696 1705 (Pubitemid 46048557)
    • (2006) Lancet , vol.368 , Issue.9548 , pp. 1696-1705
    • Drucker, D.J.1    Nauck, M.A.2
  • 8
    • 64649104158 scopus 로고    scopus 로고
    • From the triumvirate to the ominous octet: A new paradigm for the treatment of type 2 diabetes mellitus
    • RA DeFronzo From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus Diabetes 58 2009 773 795
    • (2009) Diabetes , vol.58 , pp. 773-795
    • Defronzo, R.A.1
  • 9
    • 0023792352 scopus 로고
    • Insulin resistance and β-cell dysfunction in aging: The importance of dietary carbohydrate
    • M Chen, RN Bergman, D Porte Insulin resistance and β-cell dysfunction in aging: the importance of dietary carbohydrate J Clin Endocrinol Metab 67 1988 951 957
    • (1988) J Clin Endocrinol Metab , vol.67 , pp. 951-957
    • Chen, M.1    Bergman, R.N.2    Porte, D.3
  • 10
    • 0018702014 scopus 로고
    • Glucose intolerance and aging. Evidence for tissue insensitivity to insulin
    • RA DeFronzo Glucose intolerance of aging. Evidence for tissue insensitivity to insulin Diabetes 28 1979 1095 1101 (Pubitemid 10215014)
    • (1979) Diabetes , vol.28 , Issue.12 , pp. 1095-1101
    • Defronzo, R.A.1
  • 11
  • 14
    • 0036830636 scopus 로고    scopus 로고
    • SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2
    • DOI 10.1074/jbc.C200444200
    • L Rui, M Yuan, D Frantz, S Shoelson, MF White SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2 J Biol Chem 277 2002 42394 42398 (Pubitemid 35257562)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.44 , pp. 42394-42398
    • Rui, L.1    Yuan, M.2    Frantz, D.3    Shoelson, S.4    White, M.F.5
  • 15
    • 17844373625 scopus 로고    scopus 로고
    • Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis
    • DOI 10.1016/j.cmet.2005.02.001, PII S1550413105000549
    • SH Bates, RN Kulkarni, M Seifert, MG Myers Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis Cell Metab 1 2005 169 178 (Pubitemid 43960601)
    • (2005) Cell Metabolism , vol.1 , Issue.3 , pp. 169-178
    • Bates, S.H.1    Kulkarni, R.N.2    Seifert, M.3    Myers Jr., M.G.4
  • 16
    • 0037341238 scopus 로고    scopus 로고
    • Glucose toxicity in β-cells: Type 2 diabetes, good radicals gone bad, and the glutathione connection
    • DOI 10.2337/diabetes.52.3.581
    • RP Robertson, J Harmon, PO Tran, Y Tanaka, H Takahashi Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection Diabetes 52 2003 581 587 (Pubitemid 36323562)
    • (2003) Diabetes , vol.52 , Issue.3 , pp. 581-587
    • Robertson, R.P.1    Harmon, J.2    Tran, P.O.3    Tanaka, Y.4    Takahashi, H.5
  • 19
    • 70449394029 scopus 로고    scopus 로고
    • Pancreatic islet inflammation in type 2 diabetes: From alpha and beta cell compensation to dysfunction
    • JA Ehses, H Ellingsgaard, M Boni-Schnetzler, MY Donath Pancreatic islet inflammation in type 2 diabetes: from alpha and beta cell compensation to dysfunction Arch Physiol Biochem 115 2009 240 247
    • (2009) Arch Physiol Biochem , vol.115 , pp. 240-247
    • Ehses, J.A.1    Ellingsgaard, H.2    Boni-Schnetzler, M.3    Donath, M.Y.4
  • 20
    • 79952310049 scopus 로고    scopus 로고
    • Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: What is up, what is down?
    • MA Nauck, I Vardarli, CF Deacon, JJ Holst, JJ Meier Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down? Diabetologia 54 2011 10 18
    • (2011) Diabetologia , vol.54 , pp. 10-18
    • Nauck, M.A.1    Vardarli, I.2    Deacon, C.F.3    Holst, J.J.4    Meier, J.J.5
  • 21
    • 77954848215 scopus 로고    scopus 로고
    • Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes
    • B Marcheva, KM Ramsey, ED Buhr et al. Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes Nature 466 2010 627 631
    • (2010) Nature , vol.466 , pp. 627-631
    • Marcheva, B.1    Ramsey, K.M.2    Buhr, E.D.3
  • 22
    • 77957554805 scopus 로고    scopus 로고
    • Hypothalamic AMP-activated protein kinase regulates glucose production
    • CS Yang, CK Lam, M Chari et al. Hypothalamic AMP-activated protein kinase regulates glucose production Diabetes 59 2010 2435 2443
    • (2010) Diabetes , vol.59 , pp. 2435-2443
    • Yang, C.S.1    Lam, C.K.2    Chari, M.3
  • 23
    • 0037034257 scopus 로고    scopus 로고
    • Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    • Diabetes Prevention Program Research Group
    • Diabetes Prevention Program Research Group Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin N Engl J Med 346 2002 393 403
    • (2002) N Engl J Med , vol.346 , pp. 393-403
  • 24
    • 58449135068 scopus 로고    scopus 로고
    • Treating type 2 diabetes: How safe are current therapeutic agents?
    • J Philippe, D Raccah Treating type 2 diabetes: how safe are current therapeutic agents? Int J Clin Pract 63 2009 321 332
    • (2009) Int J Clin Pract , vol.63 , pp. 321-332
    • Philippe, J.1    Raccah, D.2
  • 25
    • 77349102455 scopus 로고    scopus 로고
    • Glycaemic control in type 2 diabetes: Targets and new therapies
    • AA Tahrani, MK Piya, A Kennedy, AH Barnett Glycaemic control in type 2 diabetes: targets and new therapies Pharmacol Ther 125 2010 328 361
    • (2010) Pharmacol Ther , vol.125 , pp. 328-361
    • Tahrani, A.A.1    Piya, M.K.2    Kennedy, A.3    Barnett, A.H.4
  • 26
    • 13644263258 scopus 로고    scopus 로고
    • Oral antidiabetic agents: Current role in type 2 diabetes mellitus
    • DOI 10.2165/00003495-200565030-00005
    • AJ Krentz, CJ Bailey Oral antidiabetic agents: current role in type 2 diabetes mellitus Drugs 653 2005 385 411 (Pubitemid 40227460)
    • (2005) Drugs , vol.65 , Issue.3 , pp. 385-411
    • Krentz, A.J.1    Bailey, C.J.2
  • 30
    • 19244365650 scopus 로고    scopus 로고
    • Thiazolidinediones
    • H Yki-Jarvinen Thiazolidinediones N Engl J Med 351 2004 1106 1118
    • (2004) N Engl J Med , vol.351 , pp. 1106-1118
    • Yki-Jarvinen, H.1
  • 31
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • SE Nissen, K Wolski Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes N Engl J Med 356 2007 2457 2471 (Pubitemid 46919772)
    • (2007) New England Journal of Medicine , vol.356 , Issue.24 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 32
    • 77649102941 scopus 로고    scopus 로고
    • Effects of incretin hormones on β-cell mass and function, body weight, and hepatic and myocardial function
    • S Mudaliar, RR Henry Effects of incretin hormones on β-cell mass and function, body weight, and hepatic and myocardial function Am J Med 123 suppl 1 2010 S19 S27
    • (2010) Am J Med , vol.123 , Issue.SUPPL. 1
    • Mudaliar, S.1    Henry, R.R.2
  • 33
    • 34248223285 scopus 로고    scopus 로고
    • Biology of Incretins: GLP-1 and GIP
    • DOI 10.1053/j.gastro.2007.03.054, PII S001650850700580X
    • LL Baggio, DJ Drucker Biology of incretins: GLP-1 and GIP Gastroenterology 132 2007 2131 2157 (Pubitemid 46711096)
    • (2007) Gastroenterology , vol.132 , Issue.6 , pp. 2131-2157
    • Baggio, L.L.1    Drucker, D.J.2
  • 34
    • 3242752688 scopus 로고    scopus 로고
    • Pramlintide for the treatment of insulin-requiring diabetes mellitus: Rationale and review of clinical data
    • DOI 10.2165/00003495-200464130-00003
    • DF Kruger, MA Gloster Pramlintide for the treatment of insulin-requiring diabetes mellitus: rationale and review of clinical data Drugs 64 2004 1419 1432 (Pubitemid 38980456)
    • (2004) Drugs , vol.64 , Issue.13 , pp. 1419-1432
    • Kruger, D.F.1    Gloster, M.A.2
  • 35
    • 77958579813 scopus 로고    scopus 로고
    • Bromocriptine: Old drug, new formulation and new indication
    • RI Holt, AH Barnett, CJ Bailey Bromocriptine: old drug, new formulation and new indication Diabetes Obes Metab 12 2010 1048 1057
    • (2010) Diabetes Obes Metab , vol.12 , pp. 1048-1057
    • Holt, R.I.1    Barnett, A.H.2    Bailey, C.J.3
  • 36
    • 60349099802 scopus 로고    scopus 로고
    • New treatments in type 2 diabetes - A focus on the incretin-based therapies
    • AH Barnett New treatments in type 2 diabetes - a focus on the incretin-based therapies Clin Endocrinol (Oxf) 70 2008 343 353
    • (2008) Clin Endocrinol (Oxf) , vol.70 , pp. 343-353
    • Barnett, A.H.1
  • 37
    • 35748957503 scopus 로고    scopus 로고
    • The physiology of glucagon-like peptide 1
    • DOI 10.1152/physrev.00034.2006
    • JJ Holst The physiology of glucagon-like peptide 1 Physiol Rev 87 2007 1409 1439 (Pubitemid 350041474)
    • (2007) Physiological Reviews , vol.87 , Issue.4 , pp. 1409-1439
    • Holst, J.J.1
  • 38
    • 0037341252 scopus 로고    scopus 로고
    • Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat
    • DOI 10.2337/diabetes.52.3.734
    • DA Stoffers, BM Desai, DD DeLeon, RA Simmons Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat Diabetes 52 2003 734 740 (Pubitemid 36323581)
    • (2003) Diabetes , vol.52 , Issue.3 , pp. 734-740
    • Stoffers, D.A.1    Desai, B.M.2    DeLeon, D.D.3    Simmons, R.A.4
  • 39
    • 34249682591 scopus 로고    scopus 로고
    • β-Cell failure in diabetes and preservation by clinical treatment
    • DOI 10.1210/10.1210/er.2006-0038
    • BL Wajchenberg Beta-cell failure in diabetes and preservation by clinical treatment Endocr Rev 28 2007 187 218 (Pubitemid 46984834)
    • (2007) Endocrine Reviews , vol.28 , Issue.2 , pp. 187-218
    • Wajchenberg, B.L.1
  • 41
    • 0028953577 scopus 로고
    • Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo
    • CF Deacon, AH Johnsen, JJ Holst Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo J Clin Endocrinol Metab 80 1995 952 957
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 952-957
    • Deacon, C.F.1    Johnsen, A.H.2    Holst, J.J.3
  • 42
  • 43
    • 77953613604 scopus 로고    scopus 로고
    • Once-weekly GLP-1 agonists: How do they differ from exenatide and liraglutide?
    • M Christensen, F Knop Once-weekly GLP-1 agonists: how do they differ from exenatide and liraglutide? Curr Diab Rep 10 2010 124 132
    • (2010) Curr Diab Rep , vol.10 , pp. 124-132
    • Christensen, M.1    Knop, F.2
  • 45
    • 53249142132 scopus 로고    scopus 로고
    • Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: A randomised, open-label, non-inferiority study
    • DJ Drucker, JB Buse, K Taylor et al. Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study Lancet 372 2008 1240 1250
    • (2008) Lancet , vol.372 , pp. 1240-1250
    • Drucker, D.J.1    Buse, J.B.2    Taylor, K.3
  • 46
    • 34249891874 scopus 로고    scopus 로고
    • Effects of once-weekly dosing of a long-acting release formulation of exenatide on glucose control and body weight in subjects with type 2 diabetes
    • DOI 10.2337/dc06-2375
    • D Kim, L MacConell, D Zhuang et al. Effects of once-weekly dosing of a long-acting release formulation of exenatide on glucose control and body weight in subjects with type 2 diabetes Diabetes Care 30 2007 1487 1493 (Pubitemid 46871159)
    • (2007) Diabetes Care , vol.30 , Issue.6 , pp. 1487-1493
    • Kim, D.1    MacConell, L.2    Zhuang, D.3    Kothare, P.A.4    Trautmann, M.5    Fineman, M.6    Taylor, K.7
  • 47
    • 73549096393 scopus 로고    scopus 로고
    • Safety, tolerability, pharmacokinetics, and pharmacodynamics of exenatide once weekly in Japanese patients with type 2 diabetes
    • K Iwamoto, R Nasu, A Yamamura et al. Safety, tolerability, pharmacokinetics, and pharmacodynamics of exenatide once weekly in Japanese patients with type 2 diabetes Endocr J 56 2009 951 962
    • (2009) Endocr J , vol.56 , pp. 951-962
    • Iwamoto, K.1    Nasu, R.2    Yamamura, A.3
  • 48
    • 77953859640 scopus 로고    scopus 로고
    • Once weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes (DURATION-3): An open-label randomised trial
    • M Diamant, L Van Gaal, S Stranks et al. Once weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes (DURATION-3): an open-label randomised trial Lancet 375 2010 2234 2243
    • (2010) Lancet , vol.375 , pp. 2234-2243
    • Diamant, M.1    Van Gaal, L.2    Stranks, S.3
  • 49
    • 67649523294 scopus 로고    scopus 로고
    • Treatment with the human once-weekly glucagon-like peptide-1 analog taspoglutide in combination with metformin improves glycemic control and lowers body weight in patients with type 2 diabetes inadequately controlled with metformin alone: A double-blind placebo-controlled study
    • MA Nauck, RE Ratner, C Kapitza, R Berria, M Boldrin, R Balena Treatment with the human once-weekly glucagon-like peptide-1 analog taspoglutide in combination with metformin improves glycemic control and lowers body weight in patients with type 2 diabetes inadequately controlled with metformin alone: a double-blind placebo-controlled study Diabetes Care 32 2009 1237 1243
    • (2009) Diabetes Care , vol.32 , pp. 1237-1243
    • Nauck, M.A.1    Ratner, R.E.2    Kapitza, C.3    Berria, R.4    Boldrin, M.5    Balena, R.6
  • 50
    • 77951277026 scopus 로고    scopus 로고
    • Safety and tolerability of high doses of taspoglutide, a once-weekly human GLP-1 analogue, in diabetic patients treated with metformin: A randomized double-blind placebo-controlled study
    • R Ratner, M Nauck, C Kapitza, V Asnaghi, M Boldrin, R Balena Safety and tolerability of high doses of taspoglutide, a once-weekly human GLP-1 analogue, in diabetic patients treated with metformin: a randomized double-blind placebo-controlled study Diabet Med 27 2010 556 562
    • (2010) Diabet Med , vol.27 , pp. 556-562
    • Ratner, R.1    Nauck, M.2    Kapitza, C.3    Asnaghi, V.4    Boldrin, M.5    Balena, R.6
  • 51
    • 70349664297 scopus 로고    scopus 로고
    • Potential of albiglutide, a long-acting GLP-1 receptor agonist, in type 2 diabetes: A randomized controlled trial exploring weekly, biweekly, and monthly dosing
    • J Rosenstock, J Reusch, M Bush, F Yang, M Stewart Potential of albiglutide, a long-acting GLP-1 receptor agonist, in type 2 diabetes: a randomized controlled trial exploring weekly, biweekly, and monthly dosing Diabetes Care 32 2009 1880 1886
    • (2009) Diabetes Care , vol.32 , pp. 1880-1886
    • Rosenstock, J.1    Reusch, J.2    Bush, M.3    Yang, F.4    Stewart, M.5
  • 52
    • 77953828230 scopus 로고    scopus 로고
    • DURATION-1: Exenatide once weekly produces sustained glycemic control and weight loss over 52 weeks
    • JB Buse, DJ Drucker, KL Taylor et al. DURATION-1: exenatide once weekly produces sustained glycemic control and weight loss over 52 weeks Diabetes Care 33 2010 1255 1261
    • (2010) Diabetes Care , vol.33 , pp. 1255-1261
    • Buse, J.B.1    Drucker, D.J.2    Taylor, K.L.3
  • 53
    • 76749157778 scopus 로고    scopus 로고
    • Exenatide once-weekly treatment elicits sustained glycaemic control and weight loss over 2 years
    • (abstr).
    • M Trautmann, K Wilhelm, K Taylor, T Kim, D Zhuang, L Porter Exenatide once-weekly treatment elicits sustained glycaemic control and weight loss over 2 years Diabetologia 52 suppl 1 2009 S286 (abstr).
    • (2009) Diabetologia , vol.52 , Issue.SUPPL. 1 , pp. 286
    • Trautmann, M.1    Wilhelm, K.2    Taylor, K.3    Kim, T.4    Zhuang, D.5    Porter, L.6
  • 54
    • 67649774247 scopus 로고    scopus 로고
    • Improved treatment satisfaction and weight-related quality of life with exenatide once weekly or twice daily
    • JH Best, KS Boye, RR Rubin, D Cao, TH Kim, M Peyrot Improved treatment satisfaction and weight-related quality of life with exenatide once weekly or twice daily Diabet Med 26 2009 722 728
    • (2009) Diabet Med , vol.26 , pp. 722-728
    • Best, J.H.1    Boye, K.S.2    Rubin, R.R.3    Cao, D.4    Kim, T.H.5    Peyrot, M.6
  • 58
    • 67649998759 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics and tolerability of multiple oral doses of linagliptin, a dipeptidyl peptidase-4 inhibitor in male type 2 diabetes patients
    • T Heise, EU Graefe-Mody, S Huttner, A Ring, D Trommeshauser, KA Dugi Pharmacokinetics, pharmacodynamics and tolerability of multiple oral doses of linagliptin, a dipeptidyl peptidase-4 inhibitor in male type 2 diabetes patients Diabetes Obes Metab 11 2009 786 794
    • (2009) Diabetes Obes Metab , vol.11 , pp. 786-794
    • Heise, T.1    Graefe-Mody, E.U.2    Huttner, S.3    Ring, A.4    Trommeshauser, D.5    Dugi, K.A.6
  • 61
    • 78649691630 scopus 로고    scopus 로고
    • Safety and efficacy of linagliptin as add-on therapy to metformin in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled study
    • MR Taskinen, J Rosenstock, I Tamminen et al. Safety and efficacy of linagliptin as add-on therapy to metformin in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled study Diabetes Obes Metab 13 2011 65 74
    • (2011) Diabetes Obes Metab , vol.13 , pp. 65-74
    • Taskinen, M.R.1    Rosenstock, J.2    Tamminen, I.3
  • 63
    • 58149171060 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes mellitus and inadequate glycemic control: A randomized, double-blind, placebo-controlled study
    • RA DeFronzo, PR Fleck, CA Wilson, Q Mekki Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes mellitus and inadequate glycemic control: a randomized, double-blind, placebo-controlled study Diabetes Care 31 2008 2315 2317
    • (2008) Diabetes Care , vol.31 , pp. 2315-2317
    • Defronzo, R.A.1    Fleck, P.R.2    Wilson, C.A.3    Mekki, Q.4
  • 64
    • 57649225147 scopus 로고    scopus 로고
    • Efficacy and safety of adding the dipeptidyl peptidase-4 inhibitor alogliptin to metformin therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: A multicentre, randomised, double-blind, placebo-controlled study
    • MA Nauck, GC Ellis, PR Fleck, CA Wilson, Q Mekki Efficacy and safety of adding the dipeptidyl peptidase-4 inhibitor alogliptin to metformin therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: a multicentre, randomised, double-blind, placebo-controlled study Int J Clin Pract 63 2009 46 55
    • (2009) Int J Clin Pract , vol.63 , pp. 46-55
    • Nauck, M.A.1    Ellis, G.C.2    Fleck, P.R.3    Wilson, C.A.4    Mekki, Q.5
  • 65
    • 58149335320 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes inadequately controlled by glyburide monotherapy
    • RE Pratley, MS Kipnes, PR Fleck, C Wilson, Q Mekki Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes inadequately controlled by glyburide monotherapy Diabetes Obes Metab 11 2009 167 176
    • (2009) Diabetes Obes Metab , vol.11 , pp. 167-176
    • Pratley, R.E.1    Kipnes, M.S.2    Fleck, P.R.3    Wilson, C.4    Mekki, Q.5
  • 66
    • 70450173642 scopus 로고    scopus 로고
    • Alogliptin added to insulin therapy in patients with type 2 diabetes reduces HbA(1C) without causing weight gain or increased hypoglycaemia
    • J Rosenstock, MS Rendell, JL Gross, PR Fleck, CA Wilson, Q Mekki Alogliptin added to insulin therapy in patients with type 2 diabetes reduces HbA(1C) without causing weight gain or increased hypoglycaemia Diabetes Obes Metab 11 2009 1145 1152
    • (2009) Diabetes Obes Metab , vol.11 , pp. 1145-1152
    • Rosenstock, J.1    Rendell, M.S.2    Gross, J.L.3    Fleck, P.R.4    Wilson, C.A.5    Mekki, Q.6
  • 67
    • 70349730026 scopus 로고    scopus 로고
    • New therapies for diabesity
    • CJ Bailey New therapies for diabesity Curr Diab Rep 9 2009 360 367
    • (2009) Curr Diab Rep , vol.9 , pp. 360-367
    • Bailey, C.J.1
  • 68
    • 67651213750 scopus 로고    scopus 로고
    • Recent advances in glucokinase activators for the treatment of type 2 diabetes
    • M Pal Recent advances in glucokinase activators for the treatment of type 2 diabetes Drug Discov Today 14 2009 784 792
    • (2009) Drug Discov Today , vol.14 , pp. 784-792
    • Pal, M.1
  • 69
    • 78049512890 scopus 로고    scopus 로고
    • Piragliatin (RO4389620), a novel glucokinase activator, lowers plasma glucose both in the postabsorptive state and after a glucose challenge in patients with type 2 diabetes mellitus: A mechanistic study
    • RC Bonadonna, T Heise, C Arbet-Engels et al. Piragliatin (RO4389620), a novel glucokinase activator, lowers plasma glucose both in the postabsorptive state and after a glucose challenge in patients with type 2 diabetes mellitus: a mechanistic study J Clin Endocrinol Metab 95 2010 5028 5036
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 5028-5036
    • Bonadonna, R.C.1    Heise, T.2    Arbet-Engels, C.3
  • 70
    • 36549069114 scopus 로고    scopus 로고
    • New hepatic targets for glycaemic control in diabetes
    • DOI 10.1016/j.beem.2007.09.001, PII S1521690X0700084X, New Therapies for Diabetes
    • L Agius New hepatic targets for glycaemic control in diabetes Best Pract Res Clin Endocrinol Metab 21 2007 587 605 (Pubitemid 350177566)
    • (2007) Best Practice and Research in Clinical Endocrinology and Metabolism , vol.21 , Issue.4 , pp. 587-605
    • Agius, L.1
  • 72
    • 77953509184 scopus 로고    scopus 로고
    • Glucokinase-activating GCKR polymorphisms increase plasma levels of triglycerides and free fatty acids, but do not elevate cardiovascular risk in the Ludwigshafen Risk and Cardiovascular Health Study
    • DH Kozian, A Barthel, E Cousin et al. Glucokinase-activating GCKR polymorphisms increase plasma levels of triglycerides and free fatty acids, but do not elevate cardiovascular risk in the Ludwigshafen Risk and Cardiovascular Health Study Horm Metab Res 42 2010 502 506
    • (2010) Horm Metab Res , vol.42 , pp. 502-506
    • Kozian, D.H.1    Barthel, A.2    Cousin, E.3
  • 74
    • 49849105507 scopus 로고    scopus 로고
    • The use of exenatide in islet transplant recipients with chronic allograft dysfunction: Safety, efficacy, and metabolic effects
    • T Froud, RN Faradji, A Pileggi et al. The use of exenatide in islet transplant recipients with chronic allograft dysfunction: safety, efficacy, and metabolic effects Transplantation 86 2008 36 45
    • (2008) Transplantation , vol.86 , pp. 36-45
    • Froud, T.1    Faradji, R.N.2    Pileggi, A.3
  • 76
    • 69549098032 scopus 로고    scopus 로고
    • IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat
    • JA Ehses, G Lacraz, MH Giroix et al. IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat Proc Natl Acad Sci USA 106 2009 13998 14003
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 13998-14003
    • Ehses, J.A.1    Lacraz, G.2    Giroix, M.H.3
  • 77
    • 12244284000 scopus 로고    scopus 로고
    • Beta- and alpha-cell dysfunction in type 2 diabetes
    • DOI 10.1055/s-2004-826163
    • S Del Prato, P Marchetti Beta- and alpha-cell dysfunction in type 2 diabetes Horm Metab Res 36 2004 775 781 (Pubitemid 40115899)
    • (2004) Hormone and Metabolic Research , vol.36 , Issue.11-12 , pp. 775-781
    • Del Prato, S.1    Marchetti, P.2
  • 79
    • 65649140171 scopus 로고    scopus 로고
    • Human glucagon receptor antagonists with thiazole cores. A novel series with superior pharmacokinetic properties
    • P Madsen, J Kodra, C Behrens et al. Human glucagon receptor antagonists with thiazole cores. A novel series with superior pharmacokinetic properties J Med Chem 52 2009 2989 3000
    • (2009) J Med Chem , vol.52 , pp. 2989-3000
    • Madsen, P.1    Kodra, J.2    Behrens, C.3
  • 80
    • 51849157833 scopus 로고    scopus 로고
    • Novel glucagon receptor antagonists with improved selectivity over the glucose-dependent insulinotropic polypeptide receptor
    • J Kodra, AS Jørgensen, B Andersen et al. Novel glucagon receptor antagonists with improved selectivity over the glucose-dependent insulinotropic polypeptide receptor J Med Chem 51 2008 5387 5396
    • (2008) J Med Chem , vol.51 , pp. 5387-5396
    • Kodra, J.1    Jørgensen, A.S.2    Andersen, B.3
  • 82
    • 72949102814 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic modeling of a monoclonal antibody antagonist of glucagon receptor in male ob/ob mice
    • Y Lau, P Ma, L Gibiansky et al. Pharmacokinetic and pharmacodynamic modeling of a monoclonal antibody antagonist of glucagon receptor in male ob/ob mice AAPS J 11 2009 700 709
    • (2009) AAPS J , vol.11 , pp. 700-709
    • Lau, Y.1    Ma, P.2    Gibiansky, L.3
  • 84
    • 70349644658 scopus 로고    scopus 로고
    • Glucagon-like peptide 1/glucagon receptor dual agonism reverses obesity in mice
    • A Pocai, PE Carrington, JR Adams et al. Glucagon-like peptide 1/glucagon receptor dual agonism reverses obesity in mice Diabetes 58 2009 2258 2266
    • (2009) Diabetes , vol.58 , pp. 2258-2266
    • Pocai, A.1    Carrington, P.E.2    Adams, J.R.3
  • 85
    • 33749339257 scopus 로고    scopus 로고
    • Oxyntomodulin increases energy expenditure in addition to decreasing energy intake in overweight and obese humans: A randomised controlled trial
    • DOI 10.1038/sj.ijo.0803344, PII 0803344
    • K Wynne, AJ Park, CJ Small et al. Oxyntomodulin increases energy expenditure in addition to decreasing energy intake in overweight and obese humans: a randomised controlled trial Int J Obes 30 2006 1729 1736 (Pubitemid 44863404)
    • (2006) International Journal of Obesity , vol.30 , Issue.12 , pp. 1729-1736
    • Wynne, K.1    Park, A.J.2    Small, C.J.3    Meeran, K.4    Ghatei, M.A.5    Frost, G.S.6    Bloom, S.R.7
  • 86
    • 34247547470 scopus 로고    scopus 로고
    • Treating insulin resistance: Future prospects
    • DOI 10.3132/dvdr.2007.002
    • CJ Bailey Treating insulin resistance: future prospects Diab Vasc Dis Res 4 2007 20 31 (Pubitemid 46649070)
    • (2007) Diabetes and Vascular Disease Research , vol.4 , Issue.1 , pp. 20-31
    • Bailey, C.J.1
  • 88
    • 69449098665 scopus 로고    scopus 로고
    • A novel hydroxyfuroic acid compound as an insulin receptor activator. Structure and activity relationship of a prenylindole moiety to insulin receptor activation
    • HJ Tsai, SY Chou A novel hydroxyfuroic acid compound as an insulin receptor activator. Structure and activity relationship of a prenylindole moiety to insulin receptor activation J Biomed Sci 16 2009 68
    • (2009) J Biomed Sci , vol.16 , pp. 68
    • Tsai, H.J.1    Chou, S.Y.2
  • 90
    • 36549059075 scopus 로고    scopus 로고
    • Inhibition of the protein tyrosine phosphatase PTP1B: Potential therapy for obesity, insulin resistance and type-2 diabetes mellitus
    • DOI 10.1016/j.beem.2007.08.004, PII S1521690X07000814, New Therapies for Diabetes
    • S Koren, IG Fantus Inhibition of the protein tyrosine phosphatase PTP1B: potential therapy for obesity, insulin resistance and type-2 diabetes mellitus Best Pract Res Clin Endocrinol Metab 21 2007 621 640 (Pubitemid 350185860)
    • (2007) Best Practice and Research in Clinical Endocrinology and Metabolism , vol.21 , Issue.4 , pp. 621-640
    • Koren, S.1    Fantus, I.G.2
  • 91
    • 33847018785 scopus 로고    scopus 로고
    • Oral insulin-mimetic compounds that act independently of insulin
    • S Garcia-Vicente, F Yraola, L Marti et al. Oral insulin-mimetic compounds that act independently of insulin Diabetes 56 2007 486 493
    • (2007) Diabetes , vol.56 , pp. 486-493
    • Garcia-Vicente, S.1    Yraola, F.2    Marti, L.3
  • 92
    • 76249133903 scopus 로고    scopus 로고
    • Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: Therapeutic implications
    • JE Gerich Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: therapeutic implications Diabet Med 27 2010 136 142
    • (2010) Diabet Med , vol.27 , pp. 136-142
    • Gerich, J.E.1
  • 93
    • 33846023326 scopus 로고    scopus 로고
    • Active sugar transport in health and disease
    • DOI 10.1111/j.1365-2796.2006.01746.x
    • EM Wright, BA Hirayama, DF Loo Active sugar transport in health and disease J Intern Med 261 2007 32 43 (Pubitemid 46046470)
    • (2007) Journal of Internal Medicine , vol.261 , Issue.1 , pp. 32-43
    • Wright, E.M.1    Hirayama, B.A.2    Loo, D.F.3
  • 94
    • 77957128949 scopus 로고    scopus 로고
    • SGLT2 inhibitors: Glucuretic treatment for type 2 diabetes
    • CJ Bailey, C Day SGLT2 inhibitors: glucuretic treatment for type 2 diabetes Br J Diab Vasc Dis 10 2010 193 199
    • (2010) Br J Diab Vasc Dis , vol.10 , pp. 193-199
    • Bailey, C.J.1    Day, C.2
  • 95
    • 75749094398 scopus 로고    scopus 로고
    • Familial renal glucosuria and SGLT2: From a mendelian trait to a therapeutic target
    • R Santer, J Calado Familial renal glucosuria and SGLT2: from a mendelian trait to a therapeutic target Clin J Am Soc Nephrol 5 2010 133 141
    • (2010) Clin J Am Soc Nephrol , vol.5 , pp. 133-141
    • Santer, R.1    Calado, J.2
  • 96
    • 77954242599 scopus 로고    scopus 로고
    • SGLT2 inhibition - A novel strategy for diabetes treatment
    • EC Chao, RR Henry SGLT2 inhibition-a novel strategy for diabetes treatment Nat Rev Drug Discov 9 2010 551 559
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 551-559
    • Chao, E.C.1    Henry, R.R.2
  • 97
    • 77953857048 scopus 로고    scopus 로고
    • Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: A randomised, double-blind, placebo-controlled trial
    • CJ Bailey, JL Gross, A Pieters, A Bastien, JF List Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trial Lancet 375 2010 2223 2233
    • (2010) Lancet , vol.375 , pp. 2223-2233
    • Bailey, C.J.1    Gross, J.L.2    Pieters, A.3    Bastien, A.4    List, J.F.5
  • 98
    • 77953181310 scopus 로고    scopus 로고
    • Dapagliflozin treatment in patients with different stages of type 2 diabetes mellitus: Effects on glycaemic control and body weight
    • L Zhang, Y Feng, J List, S Kasichayanula, M Pfister Dapagliflozin treatment in patients with different stages of type 2 diabetes mellitus: effects on glycaemic control and body weight Diabetes Obes Metab 12 2010 510 516
    • (2010) Diabetes Obes Metab , vol.12 , pp. 510-516
    • Zhang, L.1    Feng, Y.2    List, J.3    Kasichayanula, S.4    Pfister, M.5
  • 99
    • 65349196064 scopus 로고    scopus 로고
    • Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes
    • JF List, V Woo, E Morales, W Tang, FT Fiedorek Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes Diabetes Care 32 2009 650 657
    • (2009) Diabetes Care , vol.32 , pp. 650-657
    • List, J.F.1    Woo, V.2    Morales, E.3    Tang, W.4    Fiedorek, F.T.5
  • 100
    • 69549095914 scopus 로고    scopus 로고
    • A study of dapagliflozin in patients with type 2 diabetes receiving high doses of insulin plus insulin sensitizers: Applicability of a novel insulin-independent treatment
    • JPH Wilding, P Norwood, C T'joen, A Bastien, JF List, FT Fiedorek A study of dapagliflozin in patients with type 2 diabetes receiving high doses of insulin plus insulin sensitizers: applicability of a novel insulin-independent treatment Diabetes Care 32 2009 1656 1662
    • (2009) Diabetes Care , vol.32 , pp. 1656-1662
    • Wilding, J.P.H.1    Norwood, P.2    T'Joen, C.3    Bastien, A.4    List, J.F.5    Fiedorek, F.T.6
  • 101
    • 77956921439 scopus 로고    scopus 로고
    • Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: A randomized, double-blind, placebo-controlled, phase 3 trial
    • E Ferrannini, SJ Ramos, A Salsali, W Tang, JF List Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: a randomized, double-blind, placebo-controlled, phase 3 trial Diabetes Care 33 2010 2217 2224
    • (2010) Diabetes Care , vol.33 , pp. 2217-2224
    • Ferrannini, E.1    Ramos, S.J.2    Salsali, A.3    Tang, W.4    List, J.F.5
  • 104
    • 0242384237 scopus 로고    scopus 로고
    • Glucokinase (GCK) Mutations in Hyper- and Hypoglycemia: Maturity-Onset Diabetes of the Young, Permanent Neonatal Diabetes, and Hyperinsulinemia of Infancy
    • DOI 10.1002/humu.10277
    • AL Gloyn Glucokinase (GCK) mutations in hyper- and hypoglycemia: maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemia of infancy Hum Mutat 22 2003 353 362 (Pubitemid 37346107)
    • (2003) Human Mutation , vol.22 , Issue.5 , pp. 353-362
    • Gloyn, A.L.1
  • 105
    • 70350361190 scopus 로고    scopus 로고
    • Regulation of Glucose-6-phosphatase gene expression by insulin and metformin
    • C Mues, J Zhou, KN Manolopoulos et al. Regulation of Glucose-6- phosphatase gene expression by insulin and metformin Horm Metab Res 41 2009 730 735
    • (2009) Horm Metab Res , vol.41 , pp. 730-735
    • Mues, C.1    Zhou, J.2    Manolopoulos, K.N.3
  • 106
    • 77952524998 scopus 로고    scopus 로고
    • Prolonged inhibition of glycogen phosphorylase in livers of Zucker Diabetic Fatty rats models human glycogen storage diseases
    • E Floettmann, L Gregory, J Teague et al. Prolonged inhibition of glycogen phosphorylase in livers of Zucker Diabetic Fatty rats models human glycogen storage diseases Toxicol Pathol 38 2010 393 401
    • (2010) Toxicol Pathol , vol.38 , pp. 393-401
    • Floettmann, E.1    Gregory, L.2    Teague, J.3
  • 107
    • 65549144889 scopus 로고    scopus 로고
    • Recent advances in antidiabetic drug therapies targeting the enteroinsular axis
    • PR Flatt, CJ Bailey, BD Green Recent advances in antidiabetic drug therapies targeting the enteroinsular axis Curr Drug Metab 10 2009 125 137
    • (2009) Curr Drug Metab , vol.10 , pp. 125-137
    • Flatt, P.R.1    Bailey, C.J.2    Green, B.D.3
  • 109
    • 70350540686 scopus 로고    scopus 로고
    • 11β-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle
    • SA Morgan, M Sherlock, LL Gathercole et al. 11β-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle Diabetes 58 2009 2506 2515
    • (2009) Diabetes , vol.58 , pp. 2506-2515
    • Morgan, S.A.1    Sherlock, M.2    Gathercole, L.L.3
  • 110
    • 77955630861 scopus 로고    scopus 로고
    • The 11-β-hydroxysteroid dehydrogenase type 1 inhibitor incb13739 improves hyperglycemia in patients with type 2 diabetes inadequately controlled by metformin monotherapy
    • J Rosenstock, S Banarer, VA Fonseca et al. The 11-β-hydroxysteroid dehydrogenase type 1 inhibitor incb13739 improves hyperglycemia in patients with type 2 diabetes inadequately controlled by metformin monotherapy Diabetes Care 33 2010 1516 1522
    • (2010) Diabetes Care , vol.33 , pp. 1516-1522
    • Rosenstock, J.1    Banarer, S.2    Fonseca, V.A.3
  • 111
    • 67449103220 scopus 로고    scopus 로고
    • Redefining the role of thiazolidinediones in the management of type 2 diabetes
    • AH Barnett Redefining the role of thiazolidinediones in the management of type 2 diabetes Vasc Health Risk Manag 5 2009 141 151
    • (2009) Vasc Health Risk Manag , vol.5 , pp. 141-151
    • Barnett, A.H.1
  • 112
    • 77954887093 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics, and tolerability of aleglitazar in patients with type 2 diabetes: Results from a randomized, placebo-controlled clinical study
    • P Sanwald-Ducray, X Liogier D'ardhuy, C Jamois, L Banken Pharmacokinetics, pharmacodynamics, and tolerability of aleglitazar in patients with type 2 diabetes: results from a randomized, placebo-controlled clinical study Clin Pharmacol Ther 88 2010 197 203
    • (2010) Clin Pharmacol Ther , vol.88 , pp. 197-203
    • Sanwald-Ducray, P.1    D'Ardhuy, X.L.2    Jamois, C.3    Banken, L.4
  • 113
    • 67649839953 scopus 로고    scopus 로고
    • Effect of the dual peroxisome proliferator-activated receptor-α/ γ agonist aleglitazar on risk of cardiovascular disease in patients with type 2 diabetes (SYNCHRONY): A phase II, randomised, dose-ranging study
    • RR Henry, AM Lincoff, S Mudaliar, M Rabbia, C Chognot, M Herz Effect of the dual peroxisome proliferator-activated receptor-α/γ agonist aleglitazar on risk of cardiovascular disease in patients with type 2 diabetes (SYNCHRONY): a phase II, randomised, dose-ranging study Lancet 374 2009 126 135
    • (2009) Lancet , vol.374 , pp. 126-135
    • Henry, R.R.1    Lincoff, A.M.2    Mudaliar, S.3    Rabbia, M.4    Chognot, C.5    Herz, M.6
  • 114
    • 77956335013 scopus 로고    scopus 로고
    • Potential remains for PPAR-targeted drugs
    • D Jones Potential remains for PPAR-targeted drugs Nat Rev Drug Discov 9 2010 668 669
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 668-669
    • Jones, D.1
  • 115
    • 0032844650 scopus 로고    scopus 로고
    • Bromocriptine improves glycaemic control and serum lipid profile in obese Type 2 diabetic subjects: A new approach in the treatment of diabetes
    • DOI 10.1517/13543784.8.10.1683
    • AH Cincotta, AH Meier, JM Cincotta Bromocriptine improves glycaemic control and serum lipid profile in obese type 2 diabetic subjects: a new approach in the treatment of diabetes Expert Opin Investig Drugs 8 1999 1683 1707 (Pubitemid 29460532)
    • (1999) Expert Opinion on Investigational Drugs , vol.8 , Issue.10 , pp. 1683-1707
    • Cincotta, A.H.1    Meier, A.H.2    Cincotta Jr., M.3
  • 118
    • 77958179761 scopus 로고    scopus 로고
    • Randomized clinical trial of quick-release bromocriptine among patients with type 2 diabetes on overall safety and cardiovascular outcomes
    • JM Gaziano, AH Cincotta, CM O'Connor et al. Randomized clinical trial of quick-release bromocriptine among patients with type 2 diabetes on overall safety and cardiovascular outcomes Diabetes Care 33 2010 1503 1508
    • (2010) Diabetes Care , vol.33 , pp. 1503-1508
    • Gaziano, J.M.1    Cincotta, A.H.2    O'Connor, C.M.3
  • 119
    • 77952048634 scopus 로고    scopus 로고
    • Colesevelam lowers glucose and lipid levels in type 2 diabetes: The clinical evidence
    • VA Fonseca, Y Handelsman, B Staels Colesevelam lowers glucose and lipid levels in type 2 diabetes: the clinical evidence Diabetes Obes Metab 12 2010 384 392
    • (2010) Diabetes Obes Metab , vol.12 , pp. 384-392
    • Fonseca, V.A.1    Handelsman, Y.2    Staels, B.3
  • 120
    • 0029130754 scopus 로고
    • Who would have thought it? An operation proves to be the most effective therapy for adult-onset diabetes mellitus
    • WJ Pories, MS Swanson, KG MacDonald et al. Who would have thought it? An operation proves to be the most effective therapy for adult-onset diabetes mellitus Ann Surg 222 1995 339 352
    • (1995) Ann Surg , vol.222 , pp. 339-352
    • Pories, W.J.1    Swanson, M.S.2    MacDonald, K.G.3
  • 122
    • 34249657825 scopus 로고    scopus 로고
    • Bariatric surgery for morbid obesity
    • EJ DeMaria Bariatric surgery for morbid obesity N Engl J Med 356 2007 2176 2183
    • (2007) N Engl J Med , vol.356 , pp. 2176-2183
    • Demaria, E.J.1
  • 123
    • 61549094077 scopus 로고    scopus 로고
    • Weight and type 2 diabetes after bariatric surgery: Systematic review and meta-analysis
    • H Buchwald, R Estok, K Fahrbach et al. Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis Am J Med 122 2009 248 256
    • (2009) Am J Med , vol.122 , pp. 248-256
    • Buchwald, H.1    Estok, R.2    Fahrbach, K.3
  • 125
    • 70349314432 scopus 로고    scopus 로고
    • Obesity, gut hormones, and bariatric surgery
    • D Pournaras, C le Roux Obesity, gut hormones, and bariatric surgery World J Surg 33 2009 1983 1988
    • (2009) World J Surg , vol.33 , pp. 1983-1988
    • Pournaras, D.1    Le Roux, C.2
  • 126
    • 64149110845 scopus 로고    scopus 로고
    • Circadian rhythms of GIP and GLP1 in glucose-tolerant and in type 2 diabetic patients after biliopancreatic diversion
    • G Mingrone, G Nolfe, G Castagneto Gissey et al. Circadian rhythms of GIP and GLP1 in glucose-tolerant and in type 2 diabetic patients after biliopancreatic diversion Diabetologia 52 2009 873 881
    • (2009) Diabetologia , vol.52 , pp. 873-881
    • Mingrone, G.1    Nolfe, G.2    Gissey, G.C.3
  • 127
    • 77951667606 scopus 로고    scopus 로고
    • Gastric bypass increases energy expenditure in rats
    • M Bueter, C Löwenstein, T Olbers et al. Gastric bypass increases energy expenditure in rats Gastroenterology 138 2010 1845 1853
    • (2010) Gastroenterology , vol.138 , pp. 1845-1853
    • Bueter, M.1    Löwenstein, C.2    Olbers, T.3
  • 128
    • 77149155340 scopus 로고    scopus 로고
    • Bariatric surgery and taste: Novel mechanisms of weight loss
    • AD Miras, CW Le Roux Bariatric surgery and taste: novel mechanisms of weight loss Curr Opin Gastroenterol 26 2010 140 145
    • (2010) Curr Opin Gastroenterol , vol.26 , pp. 140-145
    • Miras, A.D.1    Le Roux, C.W.2
  • 129
    • 34250155983 scopus 로고    scopus 로고
    • Increases in morbid obesity in the USA: 2000-2005
    • DOI 10.1016/j.puhe.2007.01.006, PII S0033350607000121
    • R Sturm Increases in morbid obesity in the USA: 2000-2005 Public Health 121 2007 492 496 (Pubitemid 46895458)
    • (2007) Public Health , vol.121 , Issue.7 , pp. 492-496
    • Sturm, R.1
  • 131
    • 79955718548 scopus 로고    scopus 로고
    • Surgical treatment of morbid obesity: Mid-term outcomes of the laparoscopic ileal interposition associated to a sleeve gastrectomy in 120 patients
    • A DePaula, A Stival, A Halpern, S Vencio Surgical treatment of morbid obesity: mid-term outcomes of the laparoscopic ileal interposition associated to a sleeve gastrectomy in 120 patients Obes Surg 21 2011 668 675
    • (2011) Obes Surg , vol.21 , pp. 668-675
    • Depaula, A.1    Stival, A.2    Halpern, A.3    Vencio, S.4
  • 132
    • 77449137384 scopus 로고    scopus 로고
    • A multicenter, randomized efficacy study of the EndoBarrier Gastrointestinal Liner for presurgical weight loss prior to bariatric surgery
    • R Schouten, CS Rijs, ND Bouvy et al. A multicenter, randomized efficacy study of the EndoBarrier Gastrointestinal Liner for presurgical weight loss prior to bariatric surgery Ann Surg 251 2010 236 243
    • (2010) Ann Surg , vol.251 , pp. 236-243
    • Schouten, R.1    Rijs, C.S.2    Bouvy, N.D.3
  • 133
    • 70449338919 scopus 로고    scopus 로고
    • How do we define cure of diabetes?
    • JB Buse, S Caprio, WT Cefalu et al. How do we define cure of diabetes? Diabetes Care 32 2009 2133 2135
    • (2009) Diabetes Care , vol.32 , pp. 2133-2135
    • Buse, J.B.1    Caprio, S.2    Cefalu, W.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.