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Volumn 64, Issue 6, 2012, Pages 651-658

Antidiabetic, antihyperlipidemic and antioxidant effects of the flavonoid rich fraction of Pilea microphylla (L.) in high fat diet/streptozotocin-induced diabetes in mice

Author keywords

Antidiabetic; Antioxidants; High fat diet; In vitro DPP IV inhibition; Pilea microphylla (L.); Streptozotocin

Indexed keywords

ANTIDIABETIC AGENT; APIGETRIN; CATALASE; CHLOROGENIC ACID; DIPEPTIDYL PEPTIDASE IV; FLAVONOID; GLIBENCLAMIDE; GLUCOSE; GLUTATHIONE; HEMOGLOBIN; ISORHOIFOLIN; LUTEOLIN 7 GLUCOSIDE; MALONALDEHYDE; PILEA MICROPHYLLA EXTRACT; PIOGLITAZONE; PLANT EXTRACT; QUERCETIN; RUTOSIDE; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 84864508209     PISSN: 09402993     EISSN: 16181433     Source Type: Journal    
DOI: 10.1016/j.etp.2010.12.009     Document Type: Article
Times cited : (146)

References (35)
  • 1
    • 77955444921 scopus 로고    scopus 로고
    • Confirmatory studies on the antioxidant and antidiabetic effect of quercetin in rats
    • Abdelmoaty M.A., Ibrahim M.A., Ahmed N.S., Abdelaziz M.A. Confirmatory studies on the antioxidant and antidiabetic effect of quercetin in rats. Indian J Clin Biochem 2010, 25:188-192.
    • (2010) Indian J Clin Biochem , vol.25 , pp. 188-192
    • Abdelmoaty, M.A.1    Ibrahim, M.A.2    Ahmed, N.S.3    Abdelaziz, M.A.4
  • 2
    • 77953884960 scopus 로고    scopus 로고
    • Ursolic acid and luteolin-7-glucoside improve lipid profiles and increase liver glycogen content through glycogen synthase kinase-3
    • Azevedo M.F., Camsari C., Sá C.M., Lima C.F., Fernandes-Ferreira M., Pereira-Wilson C. Ursolic acid and luteolin-7-glucoside improve lipid profiles and increase liver glycogen content through glycogen synthase kinase-3. Phytother Res 2010, 24:S220-S224.
    • (2010) Phytother Res , vol.24
    • Azevedo, M.F.1    Camsari, C.2    Sá, C.M.3    Lima, C.F.4    Fernandes-Ferreira, M.5    Pereira-Wilson, C.6
  • 3
    • 77549083993 scopus 로고    scopus 로고
    • Antidiabetic activity of cycloart-23-ene-3β, 25-diol (B2) isolated from Pongamia pinnata (L. Pierre) in streptozotocin-nicotinamide induced diabetic mice
    • Badole S.L., Bodhankar S.L. Antidiabetic activity of cycloart-23-ene-3β, 25-diol (B2) isolated from Pongamia pinnata (L. Pierre) in streptozotocin-nicotinamide induced diabetic mice. Eur J Pharmacol 2010, 632:103-109.
    • (2010) Eur J Pharmacol , vol.632 , pp. 103-109
    • Badole, S.L.1    Bodhankar, S.L.2
  • 5
    • 84864511665 scopus 로고    scopus 로고
    • Antidiabetic activity of novel DPP-IV inhibitor from active fraction from Pilea microphylla (L.) in Swiss albino mice
    • Bansal P., Paul P., Mudgal J., Ramya E., Priyadarsini K.I., Nampurath G.K., et al. Antidiabetic activity of novel DPP-IV inhibitor from active fraction from Pilea microphylla (L.) in Swiss albino mice. Malays J Pharm 2009, 1:S73.
    • (2009) Malays J Pharm , vol.1
    • Bansal, P.1    Paul, P.2    Mudgal, J.3    Ramya, E.4    Priyadarsini, K.I.5    Nampurath, G.K.6
  • 6
    • 84864507949 scopus 로고    scopus 로고
    • Mechanism of blood glucose lowering effect of active fraction of Pilea microphylla (L.) in mouse
    • Poster session presented at International Conference on Advances in Free Radical Research: Natural Products and Antioxidants 8th Annual meet of the Society For Free Radical Research, Lucknow, India, 2009;
    • Bansal P, Paul P, Mudgal J, Ramya E, Priyadarsini KI, Nampurath GK, et al. Mechanism of blood glucose lowering effect of active fraction of Pilea microphylla (L.) in mouse. Poster session presented at International Conference on Advances in Free Radical Research: Natural Products and Antioxidants 8th Annual meet of the Society For Free Radical Research, Lucknow, India, 2009;P-18:84.
    • (2009)
    • Bansal, P.1    Paul, P.2    Mudgal, J.3    Ramya, E.4    Priyadarsini, K.I.5    Nampurath, G.K.6
  • 7
    • 33645982255 scopus 로고    scopus 로고
    • From mice to men: insights into the insulin resistance syndromes
    • Biddinger S.B., Kahn C.R. From mice to men: insights into the insulin resistance syndromes. Annu Rev Physiol 2006, 68:123-158.
    • (2006) Annu Rev Physiol , vol.68 , pp. 123-158
    • Biddinger, S.B.1    Kahn, C.R.2
  • 8
    • 76749122292 scopus 로고    scopus 로고
    • Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice
    • Cho A.S., Jeon S.M., Kim M.J., Yeo J., Seo K.I., Choi M.S., et al. Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice. Food Chem Toxicol 2010, 48:937-943.
    • (2010) Food Chem Toxicol , vol.48 , pp. 937-943
    • Cho, A.S.1    Jeon, S.M.2    Kim, M.J.3    Yeo, J.4    Seo, K.I.5    Choi, M.S.6
  • 10
    • 11144328863 scopus 로고    scopus 로고
    • Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and β-cell damage in rat pancreas
    • Coskun O., Kanter M., Korkmaz A., Oter S. Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and β-cell damage in rat pancreas. Pharmacol Res 2005, 51:117-123.
    • (2005) Pharmacol Res , vol.51 , pp. 117-123
    • Coskun, O.1    Kanter, M.2    Korkmaz, A.3    Oter, S.4
  • 11
    • 0034434893 scopus 로고    scopus 로고
    • Relative importance of transport and alkylation for pancreatic β-cell toxicity of streptozotocin
    • Elsner M., Guldbakke B., Tiedge M., Munday R., Lenzen S. Relative importance of transport and alkylation for pancreatic β-cell toxicity of streptozotocin. Diabetologia 2000, 43:1528-1533.
    • (2000) Diabetologia , vol.43 , pp. 1528-1533
    • Elsner, M.1    Guldbakke, B.2    Tiedge, M.3    Munday, R.4    Lenzen, S.5
  • 12
    • 0031856531 scopus 로고    scopus 로고
    • Biologic markers as predictors of cardiovascular disease
    • Frishman W.H. Biologic markers as predictors of cardiovascular disease. Am J Med 1998, 104:18S-27S.
    • (1998) Am J Med , vol.104
    • Frishman, W.H.1
  • 13
    • 0025100501 scopus 로고
    • Different cellular targets for Cu- and Fe-catalyzed oxidation observed using a Cu-compatible thiobarbituric acid assay
    • Gelvan D., Saltman P. Different cellular targets for Cu- and Fe-catalyzed oxidation observed using a Cu-compatible thiobarbituric acid assay. Biochim Biophys Acta 1990, 1035:353-360.
    • (1990) Biochim Biophys Acta , vol.1035 , pp. 353-360
    • Gelvan, D.1    Saltman, P.2
  • 14
    • 0022795605 scopus 로고
    • Histopathology of streptozotocin-induced diabetic DBA/2N and CD-1 mice
    • Honjo K., Doi K., Doi C., Mitsuoka T. Histopathology of streptozotocin-induced diabetic DBA/2N and CD-1 mice. Lab Anim 1986, 20:298-303.
    • (1986) Lab Anim , vol.20 , pp. 298-303
    • Honjo, K.1    Doi, K.2    Doi, C.3    Mitsuoka, T.4
  • 15
    • 34249811180 scopus 로고    scopus 로고
    • New aspects of natural products in drug discovery
    • Lam K.S. New aspects of natural products in drug discovery. Trends Microbiol 2007, 15:279-289.
    • (2007) Trends Microbiol , vol.15 , pp. 279-289
    • Lam, K.S.1
  • 16
    • 46549083771 scopus 로고    scopus 로고
    • Pharmacokinetic, pharmacodynamic, and efficacy profiles of alogliptin, a novel inhibitor of dipeptidyl peptidase-4, in rats, dogs, and monkeys
    • Lee B., Shi L., Kassel D.B., Asakawa T., Takeuchi K., Christopher R.J. Pharmacokinetic, pharmacodynamic, and efficacy profiles of alogliptin, a novel inhibitor of dipeptidyl peptidase-4, in rats, dogs, and monkeys. Eur J Pharmacol 2008, 589:306-314.
    • (2008) Eur J Pharmacol , vol.589 , pp. 306-314
    • Lee, B.1    Shi, L.2    Kassel, D.B.3    Asakawa, T.4    Takeuchi, K.5    Christopher, R.J.6
  • 17
    • 0031749544 scopus 로고    scopus 로고
    • Nongenetic mouse models of non-insulin-dependent diabetes mellitus
    • Luo J., Quan J., Tsai J., Hobensack C.K., Sullivan C., Hector R., et al. Nongenetic mouse models of non-insulin-dependent diabetes mellitus. Metabolism 1998, 47:663-668.
    • (1998) Metabolism , vol.47 , pp. 663-668
    • Luo, J.1    Quan, J.2    Tsai, J.3    Hobensack, C.K.4    Sullivan, C.5    Hector, R.6
  • 18
    • 0028835878 scopus 로고
    • Antidiabetic plants and their active constituents
    • Marles R.J., Farnsworth N.R. Antidiabetic plants and their active constituents. Phytomedicine 1995, 2:137-189.
    • (1995) Phytomedicine , vol.2 , pp. 137-189
    • Marles, R.J.1    Farnsworth, N.R.2
  • 19
    • 33646175809 scopus 로고    scopus 로고
    • Hypolipidemic and antioxidant activities from Tamarindus indica L. pulp fruit extract in hypercholesterolemic hamsters
    • Martinello F., Soares S.M., Franco J.J., Santos A.C., Sugohara A., Garcia S.B., et al. Hypolipidemic and antioxidant activities from Tamarindus indica L. pulp fruit extract in hypercholesterolemic hamsters. Food Chem Toxicol 2006, 44:810-818.
    • (2006) Food Chem Toxicol , vol.44 , pp. 810-818
    • Martinello, F.1    Soares, S.M.2    Franco, J.J.3    Santos, A.C.4    Sugohara, A.5    Garcia, S.B.6
  • 21
    • 0015523099 scopus 로고
    • The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase
    • Misra H.P., Fridovich I. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 1972, 247:3170-3175.
    • (1972) J Biol Chem , vol.247 , pp. 3170-3175
    • Misra, H.P.1    Fridovich, I.2
  • 22
    • 0018327389 scopus 로고
    • Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver
    • Moron M.S., Depierre J.W., Mannervik B. Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochim Biophys Acta 1979, 582:67-68.
    • (1979) Biochim Biophys Acta , vol.582 , pp. 67-68
    • Moron, M.S.1    Depierre, J.W.2    Mannervik, B.3
  • 23
    • 33748331194 scopus 로고    scopus 로고
    • Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes
    • Mu J., Woods J., Zhou Y.P., Roy R.S., Li Z., Zycband E., et al. Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes. Diabetes 2006, 55:1695-1704.
    • (2006) Diabetes , vol.55 , pp. 1695-1704
    • Mu, J.1    Woods, J.2    Zhou, Y.P.3    Roy, R.S.4    Li, Z.5    Zycband, E.6
  • 24
    • 83655206052 scopus 로고    scopus 로고
    • Perspectives in efficacy, safety and clinical evaluation of bioactive natural products
    • M/S. Studium Press LLC, USA
    • Nayak Y., Veerapur V.P., Nagappa A.N., Unnikrishnan M.K. Perspectives in efficacy, safety and clinical evaluation of bioactive natural products. Compendium of Bioactive Natural Products 2009, vol. 2:1-30. M/S. Studium Press LLC, USA.
    • (2009) Compendium of Bioactive Natural Products , Issue.2 , pp. 1-30
    • Nayak, Y.1    Veerapur, V.P.2    Nagappa, A.N.3    Unnikrishnan, M.K.4
  • 26
    • 24944491279 scopus 로고    scopus 로고
    • Attenuation of hyperglycemia and hyperlipidemia in streptozotocin-induced diabetic rats by aqueous extract of seed of Tamarindus indica
    • Rajkumar M., Uttam K.D., Debidas G. Attenuation of hyperglycemia and hyperlipidemia in streptozotocin-induced diabetic rats by aqueous extract of seed of Tamarindus indica. Biol Pharm Bull 2005, 28:1172-1176.
    • (2005) Biol Pharm Bull , vol.28 , pp. 1172-1176
    • Rajkumar, M.1    Uttam, K.D.2    Debidas, G.3
  • 27
    • 77953902140 scopus 로고    scopus 로고
    • Antihyperglycemic and protective effects of flavonoids on streptozotocin-induced diabetic rats
    • Rauter A.P., Martins A., Borges C., Filipe H.M., Pinto R., Sepodes B., et al. Antihyperglycemic and protective effects of flavonoids on streptozotocin-induced diabetic rats. Phytother Res 2010, 24:S133-S138.
    • (2010) Phytother Res , vol.24
    • Rauter, A.P.1    Martins, A.2    Borges, C.3    Filipe, H.M.4    Pinto, R.5    Sepodes, B.6
  • 28
    • 0014886814 scopus 로고
    • Dugs producing diabetes through damage of the insulin secreting cells
    • Rerup C.C. Dugs producing diabetes through damage of the insulin secreting cells. Pharmacol Rev 1970, 22:485-518.
    • (1970) Pharmacol Rev , vol.22 , pp. 485-518
    • Rerup, C.C.1
  • 29
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signalling and the regulation of glucose and lipid metabolism
    • Saltiel A.R., Kahn C.R. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 2001, 414:799-806.
    • (2001) Nature , vol.414 , pp. 799-806
    • Saltiel, A.R.1    Kahn, C.R.2
  • 31
    • 0023806101 scopus 로고
    • Functional characteristics of cultured mouse pancreatic islets following exposure to different streptozotocin concentrations
    • Strandell E., Eizirik D.L., Korsgren O., Sandler S. Functional characteristics of cultured mouse pancreatic islets following exposure to different streptozotocin concentrations. Mol Cell Endocrinol 1988, 59:83-91.
    • (1988) Mol Cell Endocrinol , vol.59 , pp. 83-91
    • Strandell, E.1    Eizirik, D.L.2    Korsgren, O.3    Sandler, S.4
  • 32
    • 0037822245 scopus 로고    scopus 로고
    • Diabetes mellitus and multiple therapeutic approaches of phytochemicals: present status and future prospects
    • Tiwari A.K., Rao M.J. Diabetes mellitus and multiple therapeutic approaches of phytochemicals: present status and future prospects. Curr Sci 2002, 83:30-38.
    • (2002) Curr Sci , vol.83 , pp. 30-38
    • Tiwari, A.K.1    Rao, M.J.2
  • 34
    • 77954969847 scopus 로고    scopus 로고
    • Antidiabetic effect of Dodonaea viscosa (L). Lacq. aerial parts in high fructose-fed insulin resistant rats: a mechanism based study
    • Veerapur V.P., Prabhakar K.R., Thippeswamy B.S., Bansal P., Srinivasan K.K., Unnikrishnan M.K. Antidiabetic effect of Dodonaea viscosa (L). Lacq. aerial parts in high fructose-fed insulin resistant rats: a mechanism based study. Indian J Exp Biol 2010, 48:800-810.
    • (2010) Indian J Exp Biol , vol.48 , pp. 800-810
    • Veerapur, V.P.1    Prabhakar, K.R.2    Thippeswamy, B.S.3    Bansal, P.4    Srinivasan, K.K.5    Unnikrishnan, M.K.6
  • 35
    • 0020566115 scopus 로고
    • The role of circulating glucose and triglyceride concentration and their interactions with other risk factors as determinants of arterial disease in nine diabetic population samples from the WHO multinational study
    • West K.M., Ahuja M.M.S., Bennet P.H. The role of circulating glucose and triglyceride concentration and their interactions with other risk factors as determinants of arterial disease in nine diabetic population samples from the WHO multinational study. Diabetes Care 1983, 6:361-369.
    • (1983) Diabetes Care , vol.6 , pp. 361-369
    • West, K.M.1    Ahuja, M.M.S.2    Bennet, P.H.3


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