Anti-apoptotic function and mechanism of ginseng saponins in rattus pancreatic β-cells

Biological and Pharmaceutical Bulletin

Volumn 35, Issue 9, 2012, Pages 1568-1573

  Chen, Fang ^a,b   Chen, Yuewen ^a,b   Kang, Xincong ^b   Zhou, Zhiguang ^d   Zhang, Zhixu ^b,c   Liu, Dongbo ^a,b,c  

^a HUNAN AGRICULTURAL UNIVERSITY   (China)

^b State Administration of Traditional Chinese Medicine   (China)

^c Key Laboratory for Crop Germplasm Innovation and Utilization of Hunan Province   (China)

^d CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Apoptosis; Cytokine; Diabetes; Ginsenoside; High glucose

Indexed keywords

CASPASE 3; CYTOKINE; FAS ANTIGEN; GINSENG SAPONIN; GINSENOSIDE RB 1; GINSENOSIDE RG 1; GLUCOSE; INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN; NITRIC OXIDE; PROTEIN BAX;

ANIMAL CELL; APOPTOSIS; ARTICLE; BAX GENE; CASPASE 3 GENE; CELL PROTECTION; CONTROLLED STUDY; DOWN REGULATION; FAS GENE; GENE; GENE EXPRESSION; INOS GENE; INSULIN RELEASE; NONHUMAN; PANCREAS ISLET BETA CELL; RAT; SIGNAL TRANSDUCTION; UPREGULATION;

EID: 84866038334     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b12-00461     Document Type: Article

References (54)

1. DeFronzo RA. Lilly lecture 1987. The triumvirate: β-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes, 37, 667-687 (1988).
2. Wilkin TJ. The accelerator hypothesis: weight gain as the missing link between type I and type II diabetes. Diabetologia, 44, 914-922 (2001).
3. Burn P. Type 1 diabetes. Nat. Rev. Drug Discov., 9, 187-188 (2010).
4. Cnop M, Welsh N, Jonas JC, Jörns A, Lenzen S, Eizirik DL. Mechanisms of pancreatic β-cell death in type 1 and type 2 diabetes. Diabetes, 54, S97-S107 (2005).
5. Wajchenberg BL. β-cell failure in diabetes and preservation by clinical treatment. Endocr. Rev., 28, 187-218 (2007).
6. Hui HX, Dotta F, Di Mario U, Perfetti R. Role of caspases in the regulation of apoptotic pancreatic islet beta-cells death. J. Cell. Physiol., 200, 177-200 (2004).
7. Donath MY, Ehses JA, Maedler K, Schumann DM, Ellingsgaard H, Eppler E, Reinecke M. Mechanisms of β-cell death in type 2 diabetes. Diabetes, 54, S108-S113 (2005).
8. Saldeen J. Cytokines induce both necrosis and apoptosis via a common Bcl-2-inhibitable pathway in rat insulin-producing cells. Endocrinology, 141, 2003-2010 (2000).
9. Mellado-Gil JM, Aguilar-Diosdado M. High glucose potentiates cytokine-and streptozotocin-induced apoptosis of rat islet cells: effect on apoptosis-related genes. J. Endocrinol., 183, 155-162 (2004).
10. Maedler K, Sergeev P, Ris F, Oberholzer J, Joller-Jemelka HI, Spinas GA, Kaiser N, Halban PA, Donath MY. Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets. J. Clin. Invest., 110, 851-860 (2002).
11. Eizirik DL, Mandrup-Poulsen T. A choice of death - the signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia, 44, 2115-2133 (2001).
12. Rabinovitch A. An update on cytokines in the pathogenesis of insulin-dependent diabetes mellitus. Diabetes Metab. Rev., 14, 129-151 (1998).
13. Eizirik DL, Darville MI. β-Cell apoptosis and defense mechanisms: lessons from type 1 diabetes. Diabetes, 50 (Suppl. 1), S64-S69 (2001).
14. Strasser A, O'Connor L, Dixit VM. Apoptosis signaling. Annu. Rev. Biochem., 69, 217-245 (2000).
15. Brunelle JK, Letai A. Control of mitochondrial apoptosis by the Bcl-2 family. J. Cell Sci., 122, 437-441 (2009).
16. Newmeyer DD, Ferguson-Miller S. Mitochondria: releasing power for life and unleashing the machineries of death. Cell, 112, 481-490 (2003).
17. Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β. Nature, 403, 98-103 (2000).
18. Barone MV, Crozat A, Tabaee A, Philipson L, Ron D. CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest. Genes Dev., 8, 453-464 (1994).
19. Matsumoto M, Minami M, Takeda K, Sakao Y, Akira S. Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells. FEBS Lett., 395, 143-147 (1996).
20. Oyadomari S, Araki E, Mori M. Endoplasmic reticulum stress-mediated apoptosis in pancreatic β-cells. Apoptosis, 7, 335-345 (2002).
21. Yamada K, Ichikawa F, Ishiyama-Shigemoto S, Yuan X, Nonaka K. Essential role of caspase-3 in apoptosis of mouse beta-cells transfected with human Fas. Diabetes, 48, 478-483 (1999).
22. Salvesen GS, Dixit VM. Caspases: intracellular signaling by proteolysis. Cell, 91, 443-446 (1997).
23. Ghavami S, Hashemi M, Ande SR, Yeganeh B, Xiao W, Eshraghi M, Bus CJ, Kadkhoda K, Wiechec E, Halayko AJ, Los M. Apoptosis and cancer: mutations within caspase genes. J. Med. Genet., 46, 497-510 (2009).
24. Friedlander RM. Apoptosis and caspases in neurodegenerative diseases. N. Engl. J. Med., 348, 1365-1375 (2003).
25. Hengartner MO, Horvitz HR. C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Cell, 76, 665-676 (1994).
26. Stassi G, Todaro M, Richiusa P, Giordano M, Mattina A, Sbriglia MS, Lo Monte A, Buscemi G, Galluzzo A, Giordano C. Expression of apoptosis-inducing CD95 (Fas/Apo-1) on human beta-cells sorted by flow-cytometry and cultured in vitro. Transplant. Proc., 27, 3271-3275 (1995).
27. Yamada K, Takane-Gyotoku N, Yuan X, Ichikawa F, Inada C, Nonaka K. Mouse islet cell lysis mediated by interleukin-1-induced Fas. Diabetologia, 39, 1306-1312 (1996).
28. Loweth AC, Williams GT, James RFL, Scarpello JH, Morgan NG. Human islets of langerhans express Fas ligand and undergo apoptosis in response to interleukin-1beta and Fas ligation. Diabetes, 47, 727-732 (1998).
29. Wachlin G, Augstein P, Schroder D, Kuttler B, Kloting I, Heinke P, Schmidt S. IL-1β, IFN-γ and TNF-α increase vulnerability of pancreatic beta cells to autoimmune destruction. J. Autoimmunity, 20, 303-312 (2003).
30. Liu DB, Darville M, Eizirik DL. Double-stranded ribonucleic acid (RNA) induces β-cell Fas messenger RNA expression and increases cytokine-induced β-cell apoptosis. Endocrinology, 142, 2593-2599 (2001).
31. Eizirik DL, Pavlovic D. Is there a role for nitric oxide in β-cell dysfunction and damage in IDDM? Diabetes Metab. Rev., 13, 293-307 (1997).
32. Attele AS, Zhou YP, Xie JT, Wu JA, Zhang L, Dey L, Pugh W, Rue PA, Polonsky KS, Yuan CS. Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabetes, 51, 1851-1858 (2002).
33. Ohnishi Y, Takagi S, Miura T, Usami M, Kako M, Ishihara E, Yano H, Tanigawa K, Seino Y. Effect of ginseng radix on GLUT2 protein content in mouse liver in normal and epinephrine-induced hyperglycemic mice. Biol. Pharm. Bull., 19, 1238-1240 (1996).
34. Chung SH, Choi CG, Park SH. Comparisons between white ginseng radix and rootlet for antidiabetic activity and mechanism in KKAy mice. Arch. Pharm. Res., 24, 214-218 (2001).
35. Kimura M, Waki I, Chujo T, Kikuchi T, Hiyama C, Yamazaki K, Tanaka O. Effects of hypoglycemic components in ginseng radix on blood insulin level in alloxan diabetic mice and on insulin release from perfused rat pancreas. J. Pharmacobiodyn., 4, 410-417 (1981).
36. Waki I, Kyo H, Yasuda M, Kimura M. Effects of a hypoglycemic component of ginseng radix on insulin biosynthesis in normal and diabetic animals. J. Pharmacobiodyn., 5, 547-554 (1982).
37. Rotshteyn Y, Zito SW. Application of modified in vitro screening procedure for identifying herbals possessing sulfonylurea-like activity. J. Ethnopharmacol., 93, 337-344 (2004).
38. Lee FC. Facts about ginseng: The elixir of life. Hollym International Corp. (Elizabeth), 104 (1992).
39. Attele AS, Wu JA, Yuan CS. Ginseng pharmacology: multiple constituents and multiple actions. Biochem. Pharmacol., 58, 1685-1693 (1999).
40. Tsang D, Yeung HW, Tso WW, Peck H. Ginseng saponins: influence on neurotransmitter uptake in rat brain synaptosomes. Planta Med., 3, 221-224 (1985).
41. Benishin CG. Actions of ginsenoside Rb1 on choline uptake in central cholinergic nerve endings. Neurochem. Int., 21, 1-5 (1992).
42. Wang D, Huang Y, Li Q, Xu S, Liu X. Anti-apoptotic effect of ginsenoside Rg1 on neuron after neonatal hypoxia ischemia brain damage. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi, 24, 1107-1112 (2010).
43. Cai BX, Jin SL, Luo D, Lin XF, Gao J. Ginsenoside Rb1 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair. Biol. Pharm. Bull., 32, 837-841 (2009).
44. Hwang YP, Jeong HG. Ginsenoside Rb1 protects against 6-hydroxy-dopamine- induced oxidative stress by increasing heme oxygenase-1 expression through an estrogen receptor-related PI3K/Akt/Nrf2-dependent pathway in human dopaminergic cells. Toxicol. Appl. Pharmacol., 242, 18-28 (2010).
45. Radad K, Gille G, Moldzio R, Saito H, Rausch WD, Rausch WD. Ginsenosides Rb1 and Rg1 effects on mesencephalic dopaminergic cells stressed with glutamate. Brain Res., 1021, 41-53 (2004).
46. 2+ channel-mediated cell death in rat cortical neurons. Biochem. Biophys. Res. Commun., 365, 399-405 (2008).
47. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev., 43, 109-142 (1991).
48. Laybutt R, Hasenkamp W, Groff A, Grey S, Jonas JC, Kaneto H, Sharma A, Bonner-Weir S, Weir G. Beta-cell adaptation to hyperglycemia. Diabetes, 50 (Suppl. 1), S180-S181 (2001).
49. Sandler S, Bendtzen K, Eizirik DL, Strandell E, Welsh M, Welsh N. Metabolism and beta-cell function of rat pancreatic islets exposed to human interleukin-1 beta in the presence of a high glucose concentration. Immunol. Lett., 26, 245-251 (1990).
50. Maedler K, Spinas GA, Lehmann R, Sergeev P, Weber M, Fontana A, Kaiser N, Donath MY. Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets. Diabetes, 50, 1683-1690 (2001).
51. Aguilar-Diosdado M, Parkinson D, Corbett JA, Kwon G, Marshall CA, Gingerich RL, Santoago JV, McDaniel ML. Potential autoantigens in JDDM: Expression of carboxypeptidase-H and insulin but not glutamate decarboxylase on the β-cell surface. Diabetes, 43, 418-425 (1994).
52. Rabinovitch A, Suarez-Pinzon WL. Cytokines and their roles in pancreatic islet β-cell destruction and insulin-dependent diabetes mellitus. Biochem. Pharmacol., 55, 1139-1149 (1998).
53. Liu DB, Cardozo AK, Darville MI, Eizirik DL. Double-stranded RNA cooperates with interferon-γ and IL-1 β to induce both chemokine expression and nuclear factor-κ B-dependent apoptosis in pancreatic β-cells: potential mechanisms for viral-induced insulitis and β-cell death in type 1 diabetes mellitus. Endocrinology, 143, 1225-1234 (2002).
54. Chandra J, Zhivotovsky B, Zaitsev S, Juntti-Berggren L, Berggren PO, Orrenius S. Role of apoptosis in pancreatic beta-cell death in diabetes. Diabetes, 50, S44-S47 (2001).