Protective effect of ginseng on cytokine-induced apoptosis in pancreatic β-cells

Journal of Agricultural and Food Chemistry

Volumn 55, Issue 8, 2007, Pages 2816-2823

  Hye, Young Kim ^a   Kim, Kyong ^a  

^a Korea Food Research Institute   (South Korea)

Author keywords

Apoptosis; Cytokines; Diabetes; Ginseng; Pancreatic cells

Indexed keywords

CYTOKINE; GINSENOSIDE; PLANT EXTRACT;

ANIMAL; APOPTOSIS; ARTICLE; CELL LINE; CHEMISTRY; DRUG EFFECT; GINSENG; INSULIN DEPENDENT DIABETES MELLITUS; INSULINOMA; MOUSE; NONOBESE DIABETIC MOUSE; PANCREAS ISLET; PANCREAS TUMOR; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; CELL LINE; CELL LINE, TUMOR; CYTOKINES; DIABETES MELLITUS, TYPE 1; GINSENOSIDES; INSULINOMA; ISLETS OF LANGERHANS; MICE; MICE, INBRED NOD; PANAX; PANCREATIC NEOPLASMS; PLANT EXTRACTS;

PANAX GINSENG;

EID: 34247646402     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf062577r     Document Type: Article

References (35)

1. Huang, K. C. The Pharmacology of Chinese Herbs; CRC Press: Boca Raton, FL, 1999.
2. Kimura, M.; Waki, I.; Chujo, T.; Kikuchi, T.; Hiyama, C.; Yamazaki, K.; Tanaka, O. Effects of hypoglycemic compounds in ginseng radix on blood insulin level in alloxan diabetic mice and on insulin release from perfused rat pancreas. J. Pharmacobio-Dyn. 1981, 4, 410-417.
3. Kimura, M.; Waki, I.; Tanaka, O.; Nagi, Y.; Shibata, S. Pharmacological sequential trials for the fractionation of components with hypoglycemic activity in alloxan diabetic mice from ginseng radix. J. Pharmacobio-Dyn. 1981, 4, 402-409.
4. Yokozawa, T.; Kobayashi, T.; Oura, H.; Kawashima, Y. Studies on the mechanism of the hypoglycemic activity of ginsenoside-Rb2 in streptozocin-diabetic rats. Chem. Pharm. Bull. 1985, 33, 869-872.
5. y mice. Phytother. Res. 1999, 13, 484-488.
6. y mice. J. Pharmacobio-Dyn. 1981, 4, 907-915.
7. Chung, S. H.; Choi, C. G.; Park, S. H. Comparisons between white ginseng radix and rootlet for antidiabetic activity and mechanism in KKAy mice. Arch. Pharmacol. Res. 2001, 24, 214-218.
8. Dey, L.; Xie, J. T.; Wang, A.; Wu, J.; Maleckar, S. A.; Yuan, C. S. Anti-hyperglycemic effects of ginseng: Comparison between root and berry. Phytomedicine 2003, 10, 600-605.
9. Sievenpiper, J. L.; Sung, M. K.; Di Buono, M.; Leiter, L. A.; Nam, K. Y.; Vuksan, V. Korean red ginseng rootlets decrease postprandial glycemia in healthy subjects: results of an acute dose esculation study. Diabetes 2003, 52 (Suppl. 1), A387.
10. st international symposium for the study of diabetes and nutrition; June 19-21, Brugge, Belgium, 2003.
11. Vuksan, V.; Sievenpiper, J. L.; Sung, M. K.; Di Buono, M.; Stavro, P. M.; Jenkins, A. L.; et al. Safety and efficacy of Korean red ginseng intervention (SAEKI): results of a double-blind, placebo-controlled crossover trial in type 2 diabetes. Diabetes 2003, 52 (Suppl. 1), A137.
12. Cnop, M.; Welsh, N.; Jonas, J. C.; Jorns, A.; Lenzen, S.; Eizirik, D. L. Mechanisms of pancreatic β-cell death in type 1 and type 2 diabetes. Diabetes 2005, 54, S97-S107.
13. Kim, W. H.; Lee, J. W.; Gao, B.; Jung, M. H. Synergistic activation of JNK/SAPK induced by TNF-α and IFN-γ: Apoptosis of pancreatic β-cells via the p53 and ROS pathway. Cell. Signalling 2005, 17, 1516-1532.
14. Attele, A. S.; Wu, J. A.; Yuan, C. S. Multiple pharmacological effects of ginseng. Biochem. Pharmacol. 1999, 58, 1685-1693.
15. Lau, A. J.; Woo, S. O.; Koh, H. L. Analysis of saponins in raw and steamed Panax notoginseng using high-performance liquid chromatography with diode array detection. J. Chromatogr., A 2003, 1011, 77-87.
16. Yagi, N.; Yokono, K.; Amano, K.; Nagata, M.; Tsukamoto, K.; Hasegawa, Y.; Yoneda, R.; Okamoto, N.; Moriyama, H.; Miki, M.; Tominaga, Y.; Miyazaki, J. I.; Yagita, H.; Okumura, K.; Mizoguchi, A.; Miki, A.; Ide, C.; Maeda, S.; Kasuga, M. Expression of intercellular adhesion molecule 1 on pancreatic β-cell destruction by cytotoxic T-cells in murine autoimmune diabetes. Diabetes 1995, 44, 744-752.
17. Di Matteo, M. A.; Loweth, A. C.; Thomas, S.; Mabley, J. G.; Morgan, N. G.; Thorpe, J. R.; Green, I. C. Superoxide, nitric oxide, peroxynitrite and cytokine combinations all cause functional impairment and morphological changes in rat islets of langerhans and insulin-secreting cell lines but dictate cell death by different mechanism. Apoptosis 1997, 2, 164-177.
18. Kumar, R.; Mandal, M.; Lipton, A.; et al. Overexpression of HER2 modulate BCL-2, BCL-XL and tamoxifen-induced apoptosis in human MCF-7 breast cancer cells. Clin. Cancer Res. 1996, 2, 1215-1219.
19. Green, L. C.; Wagner, D. A.; Glogowski, J.; Skipper, P. L.; Wishnok, J. S.; Tannerbaum, S. R. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal. Biochem. 1982, 126, 131-138.
20. Takeshi, N.; Diane, E.; Xue, L. D.; Sho, I. Y.; Takeshi, M.; Yasufumi, K.; Mark, A. Y.; David, B.; Peter, J. O.; Hans, P. H.; Ida, G.; Michael, B. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycemic damage. Nature 2000, 404, 787-790.
21. Allen, R. T.; Hunter, W. J., III; Agrawal, D. W. Morphological and biochemical characterization and analysis of apoptosis. J. Pharmacol. Toxicol. 1997, 37, 215-228.
22. Moncada, S.; Palmer, R. M.; Higgs, E. A. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 1991, 43, 109-142.
23. Chang, I.; Cho, N.; Kim, S.; Kim, J. Y.; Kim, E.; Woo, J.; Nam, J. H.; Kim, S. J.; Lee, M. S. Role of calcium in pancreatic islet cell death by IFN-γ/TNF-α. J. Immunol. 2004, 7008-7014.
24. Levine, A. J. p53, the cellular gatekeeper for growth and division. Cell 1997, 88, 32f3-331.
25. Tewari, M.; Quan, L. T.; O'Rourke, K.; Desnoyers, S.; Zeng, Z.; Beidler, D. R.; Poirier, G. G.; Salvessen, G. S.; Dixit, V. M. Yama/CPP32β, a mammalian homology of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell 1995, 81, 801-809.
26. Ankarcrona, M.; Dypbukt, J. M.; Brune, B.; Nicotera, P. Interleukin-1 beta-induced nitric oxide production activates apoptosis in pancreatic RINm5F cells. Exp. Cell Exp. 1994, 213, 172-177.
27. Mandrup-Poulsen, T. The role of interleukin-1 in the pathogenensis of IDDM. Diabetologia 1996, 39, 1005-1029.
28. Messmer, U. K.; Ankarcrona, M.; Nicotera, P.; Brune, B. p53 expression in nitric oxide-induced apoptosis. FEBS Lett. 1994, 355, 23-26.
29. Rabinovitch, A.; Suarez-Pinzon, W. L.; Strynadka, K.; Lakey, J. R.; Rajott, R. V. Human pancreatic islet β-cell destruction by cytokines involves oxygen free radical and aldehyde production. J. Clin. Endocrinol. Metab. 1996, 81, 3197-3202.
30. Green, D. R.; Reed, J. C. Mitochondria and apoptosis. Science 1998, 281, 1309-1312.
31. Sansome, C.; Zaika, A.; Marchenko, N. D.; Moll, U. T. Hypoxia death stimulus induces translocation of p53 protein to mitochondria. FEBS Lett. 2001, 488, 110-115.
32. Li, P.-F.; Dietz, R.; Harsdorf, R. p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2. EMBO J. 1999, 18, 6027-6036.
33. Cheng, E. H.; Wei, M. C.; Weiler, S. W.; Flavell, R. A.; Mak, T. W.; Lindsten, T.; Korsmeyer, S. J. Bcl-2, Bcl-XL sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondria apoptosis. Mol. Cell 2001, 8, 705-711.
34. Mathis, D.; Vence, L.; Benoist, C. β-cell death during progression to diabetes. Nature 2001, 414, 792-798.
35. Donath, M. Y.; Gross, D. J.; Cerasi, E.; Kaiser, N. Hyperglycemia-induced β-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes. Diabetes 1999, 48, 738-744.