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Volumn 25, Issue 2, 2011, Pages 119-131

Resveratrol shows vasoprotective effect reducing oxidative stress without affecting metabolic disturbances in insulin-dependent diabetes of rabbits

Author keywords

Alloxan; Diabetic rabbits; Endothelial and vascular function; Insulin; Nitric oxide; Resveratrol; Superoxide

Indexed keywords

ACETYLCHOLINE; GLUCOSE; INSULIN; LIPID; LIPID PEROXIDE; NITRATE; NITRITE; PHENYLEPHRINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RESVERATROL; SUPEROXIDE; SUPEROXIDE DISMUTASE;

EID: 79958243683     PISSN: 09203206     EISSN: 15737241     Source Type: Journal    
DOI: 10.1007/s10557-010-6255-7     Document Type: Article
Times cited : (43)

References (40)
  • 2
    • 0035793616 scopus 로고    scopus 로고
    • Mechanisms underlying endothelial dysfunction in diabetes mellitus
    • Hink U, Li H, Mollnau H, et al. Mechanisms underlying endothelial dysfunction in diabetes mellitus. Circ Res. 2001;88:E14-22.
    • (2001) Circ Res , vol.88
    • Hink, U.1    Li, H.2    Mollnau, H.3
  • 3
    • 33847073821 scopus 로고    scopus 로고
    • Attenuation of angiotensin II signaling recouples eNOS and inhibits nonendothelial NOX activity in diabetic mice
    • Oak JH, Cai H. Attenuation of angiotensin II signaling recouples eNOS and inhibits nonendothelial NOX activity in diabetic mice. Diabetes. 2007;56:118-26.
    • (2007) Diabetes , vol.56 , pp. 118-126
    • Oak, J.H.1    Cai, H.2
  • 4
    • 62349116866 scopus 로고    scopus 로고
    • Vascular NAD(P)H oxidase activation in diabetes: A double-edged sword in redox signaling
    • Gao L, Mann GE. Vascular NAD(P)H oxidase activation in diabetes: a double-edged sword in redox signaling. Cardiovasc Res. 2009;82:9-20.
    • (2009) Cardiovasc Res , vol.82 , pp. 9-20
    • Gao, L.1    Mann, G.E.2
  • 5
    • 0036158062 scopus 로고    scopus 로고
    • The possible implication of trans-Resveratrol in the cardioprotective effects of long-term moderate wine consumption
    • DOI 10.1124/mol.61.2.294
    • Orallo F, Alvarez E, Camina M, Leiro JM, Gomez E, Fernandez P. The possible implication of trans-resveratrol in the cardioprotective effects of long-term moderate wine consumption. Mol Pharmacol. 2002;61:294-302. (Pubitemid 34112803)
    • (2002) Molecular Pharmacology , vol.61 , Issue.2 , pp. 294-302
    • Orallo, F.1    Alvarez, E.2    Camina, M.3    Leiro, J.M.4    Gomez, E.5    Fernandez, P.6
  • 6
    • 33745699560 scopus 로고    scopus 로고
    • Effect of resveratrol on nitrate tolerance in isolated human internal mammary Artery
    • DOI 10.1097/01.fjc.0000211798.91023.14, PII 0000534420060300000015
    • Coskun B, Soylemez S, Parlar AI, Ulus AT, Katircioglu SF, Akar F. Effect of resveratrol on nitrate tolerance in isolated human internal mammary artery. J Cardiovas Pharmacol. 2006;47:437-45. (Pubitemid 44309698)
    • (2006) Journal of Cardiovascular Pharmacology , vol.47 , Issue.3 , pp. 437-445
    • Coskun, B.1    Soylemez, S.2    Parlar, A.I.3    Tulga, U.A.4    Fehmi, K.S.5    Akar, F.6
  • 7
    • 34147182364 scopus 로고    scopus 로고
    • Resveratrol attenuates oxLDL-stimulated NADPH oxidase activity and protects endothelial cells from oxidative functional damages
    • DOI 10.1152/japplphysiol.00881.2006
    • Chow S-E, Hshu Y-C, Wang J-S, Chen J-K. Resveratrol attenuates oxLDL-stimulated NADPH oxidase activity and protects endothelial cells from oxidative functional damages. J Appl Physiol. 2007;102:1520-7. (Pubitemid 46571048)
    • (2007) Journal of Applied Physiology , vol.102 , Issue.4 , pp. 1520-1527
    • Chow, S.-E.1    Hshu, Y.-C.2    Wang, J.-S.3    Chen, J.-K.4
  • 8
    • 50949093304 scopus 로고    scopus 로고
    • The effect of long-term resveratrol treatment on relaxation to estrogen in aortae from male and female rats: Role of nitric oxide and superoxide
    • Soylemez S, Gurdal H, Sepici A, Akar F. The effect of long-term resveratrol treatment on relaxation to estrogen in aortae from male and female rats: role of nitric oxide and superoxide. Vasc Pharmacol. 2008;49:97-105.
    • (2008) Vasc Pharmacol , vol.49 , pp. 97-105
    • Soylemez, S.1    Gurdal, H.2    Sepici, A.3    Akar, F.4
  • 9
    • 48349144852 scopus 로고    scopus 로고
    • Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending lifespan
    • Pearson KJ, Baur JA, Lewis KN, et al. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending lifespan. Cell Metab. 2008;8:157-68.
    • (2008) Cell Metab , vol.8 , pp. 157-168
    • Pearson, K.J.1    Baur, J.A.2    Lewis, K.N.3
  • 10
    • 49249100288 scopus 로고    scopus 로고
    • Vasoprotective effects of resveratrol and SIRT1: Attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations
    • Csiszar A, Labinskyy N, Podlutsky A, et al. Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations. Am J Physiol Heart Circ Physiol. 2008;294:H2721-35.
    • (2008) Am J Physiol Heart Circ Physiol , vol.294
    • Csiszar, A.1    Labinskyy, N.2    Podlutsky, A.3
  • 11
    • 77649215842 scopus 로고    scopus 로고
    • Resveratrol supplementation gender independently improves endothelial reactivity and suppresses superoxide production in healthy rats
    • Soylemez S, Sepici A, Akar F. Resveratrol supplementation gender independently improves endothelial reactivity and suppresses superoxide production in healthy rats. Cardiovasc Drugs Ther. 2009;23:449-58.
    • (2009) Cardiovasc Drugs Ther , vol.23 , pp. 449-458
    • Soylemez, S.1    Sepici, A.2    Akar, F.3
  • 12
    • 68149150584 scopus 로고    scopus 로고
    • Resveratrol improves endothelial function. Role of TNF and vascular oxidative stress
    • Zhang H, Zhang J, Ungvari Z, Zhang C. Resveratrol improves endothelial function. Role of TNF and vascular oxidative stress. Arterioscler Thromb Vasc Biol. 2009;29:1164-71.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 1164-1171
    • Zhang, H.1    Zhang, J.2    Ungvari, Z.3    Zhang, C.4
  • 13
    • 33751072349 scopus 로고    scopus 로고
    • Resveratrol improves health and survival of mice on a high-calorie diet
    • Baur JA, Pearson KJ, Price NL, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006;444:337-42.
    • (2006) Nature , vol.444 , pp. 337-342
    • Baur, J.A.1    Pearson, K.J.2    Price, N.L.3
  • 15
    • 33744946526 scopus 로고    scopus 로고
    • Resveratrol, a red wine antioxidant, possesses an insulin-like effect in streptozotocin-induced diabetic rats
    • Su H-C, Hung L-M, Chen J-K. Resveratrol, a red wine antioxidant, possesses an insulin-like effect in streptozotocin-induced diabetic rats. Am J Physiol Endocrinol Metab. 2006;290:E1339-46.
    • (2006) Am J Physiol Endocrinol Metab , vol.290
    • Su, H.-C.1    Hung, L.-M.2    Chen, J.-K.3
  • 16
    • 33947321153 scopus 로고    scopus 로고
    • Phosphatidylinositol-3-kinase is involved in the antihyperglycemic effect induced by resveratrol in streptozotocin-induced diabetic rats
    • Chi TC, Chen WP, Chi TL, Kuo TF, Lee SS, Cheng JT, et al. Phosphatidylinositol-3-kinase is involved in the antihyperglycemic effect induced by resveratrol in streptozotocin-induced diabetic rats. Life Sci. 2007;80:1713-20.
    • (2007) Life Sci , vol.80 , pp. 1713-1720
    • Chi, T.C.1    Chen, W.P.2    Chi, T.L.3    Kuo, T.F.4    Lee, S.S.5    Cheng, J.T.6
  • 17
    • 60149083560 scopus 로고    scopus 로고
    • Effects of resveratrol on nucleotide degrading enzymes in streptozotocin-induced diabetic rats
    • Schmatz R, Schetinger MR, Spanevello RM, et al. Effects of resveratrol on nucleotide degrading enzymes in streptozotocin-induced diabetic rats. Life Sci. 2009;84:345-50.
    • (2009) Life Sci , vol.84 , pp. 345-350
    • Schmatz, R.1    Schetinger, M.R.2    Spanevello, R.M.3
  • 18
  • 20
    • 33745962138 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol: The in vivo evidence
    • DOI 10.1038/nrd2060, PII NRD2060
    • Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov. 2006;5:493-506. (Pubitemid 44136961)
    • (2006) Nature Reviews Drug Discovery , vol.5 , Issue.6 , pp. 493-506
    • Baur, J.A.1    Sinclair, D.A.2
  • 21
    • 0025215946 scopus 로고
    • Elevated glucose promotes generation of endothelium-derived vasoconstrictor prostanoids in rabbit aorta
    • Tesfamariam B, Brown ML, Deykin D, Cohen RA. Elevated glucose promotes generation of endothelium-derived vasoconstrictor prostanoids in rabbit aorta. J Clin Invest. 1990;85:929-32. (Pubitemid 20087498)
    • (1990) Journal of Clinical Investigation , vol.85 , Issue.3 , pp. 929-932
    • Tesfamariam, B.1    Brown, M.L.2    Deykin, D.3    Cohen, R.A.4
  • 22
    • 0025832494 scopus 로고
    • Elevated glucose impairs endothelium-dependent relaxations by activating protein kinase C
    • Tesfamariam B, Brown ML, Deykin D, Cohen RA. Elevated glucose impairs endothelium-dependent relaxations by activating protein kinase C. J Clin Invest. 1991;87:1643-8.
    • (1991) J Clin Invest , vol.87 , pp. 1643-1648
    • Tesfamariam, B.1    Brown, M.L.2    Deykin, D.3    Cohen, R.A.4
  • 23
    • 0034987628 scopus 로고    scopus 로고
    • Gene transfer of superoxide dismutase isoforms reverses endothelial dysfunction in diabetic rabbit aorta
    • Zanetti M, Sato J, Katusic ZS, O'Brien T. Gene transfer of superoxide dismutase isoforms reverses endothelial dysfunction in diabetic rabbit aorta. Am J Physiol Heart Circ Physiol. 2001;280:H2516-23.
    • (2001) Am J Physiol Heart Circ Physiol , vol.280
    • Zanetti, M.1    Sato, J.2    Katusic, Z.S.3    O'Brien, T.4
  • 24
    • 33846519417 scopus 로고    scopus 로고
    • Possible role of Akt to improve vascular endothelial dysfunction in diabetic and hyperhomocysteinemic rats
    • DOI 10.1007/s11010-006-9273-9
    • Shah DI, Singh M. Possible role of Akt to improve vascular endothelial dysfunction in diabetic and hyperhomocysteinemic rats. Mol Cell Biochem. 2007;295:65-74. (Pubitemid 46157988)
    • (2007) Molecular and Cellular Biochemistry , vol.295 , Issue.1-2 , pp. 65-74
    • Shah, D.I.1    Singh, M.2
  • 25
    • 54049155669 scopus 로고    scopus 로고
    • Resveratrol, a natural phytoalexin, normalizes hyperglycemia in streptozotocin-nicotinamide induced experimental diabetic rats
    • Palsamy P, Subramanian S. Resveratrol, a natural phytoalexin, normalizes hyperglycemia in streptozotocin-nicotinamide induced experimental diabetic rats. Biomed Pharmacother. 2008;62:598-605.
    • (2008) Biomed Pharmacother , vol.62 , pp. 598-605
    • Palsamy, P.1    Subramanian, S.2
  • 26
    • 34250854589 scopus 로고    scopus 로고
    • V channels of beta cells
    • DOI 10.1016/j.ejphar.2007.04.062, PII S0014299907005146
    • Chen W-P, Chi T-C, Chuang L-M, Su M-J. Resveratrol enhances insulin secretion by blocking KATP and KV channels of beta cells. Eur J Pharmacol. 2007;568:269-77. (Pubitemid 46976913)
    • (2007) European Journal of Pharmacology , vol.568 , Issue.1-3 , pp. 269-277
    • Chen, W.-P.1    Chi, T.-C.2    Chuang, L.-M.3    Su, M.-J.4
  • 27
    • 44349141200 scopus 로고    scopus 로고
    • The effects of chronic resveratrol treatment on vascular responsiveness of streptozotocin-induced diabetic rats
    • DOI 10.1248/bpb.31.897
    • Silan C. The effects of chronic resveratrol treatment on vascular responsiveness of streptozotocin-induced diabetic rats. Biol Pharm Bull. 2008;31:897-902. (Pubitemid 351731986)
    • (2008) Biological and Pharmaceutical Bulletin , vol.31 , Issue.5 , pp. 897-902
    • Silan, C.1
  • 28
    • 20344374750 scopus 로고    scopus 로고
    • Trans- and cis-resveratrol increase cytoplasmic calcium levels in A7r5 vascular smooth muscle cells
    • DOI 10.1002/mnfr.200400108
    • Campos-Toimil M, Elíes J, Orallo F. Trans- and cis-resveratrol increase cytoplasmic calcium levels in A7r5 vascular smooth muscle cells. Mol Nutr Food Res. 2005;49:396-404. (Pubitemid 40780388)
    • (2005) Molecular Nutrition and Food Research , vol.49 , Issue.5 , pp. 396-404
    • Campos-Toimil, M.1    Elies, J.2    Orallo, F.3
  • 30
    • 0033090615 scopus 로고    scopus 로고
    • Relaxant effect of transresveratrol on isolated porcine coronary arteries
    • Jager U, Nguyen-Doung H. Relaxant effect of trans-resveratrol on isolated porcine coronary arteries. Arzneim Forsch Drug Res. 1999;49:207-11. (Pubitemid 29142817)
    • (1999) Arzneimittel-Forschung/Drug Research , vol.49 , Issue.3 , pp. 207-211
    • Jager, U.1    Nguyen-Duong, H.2
  • 31
    • 0033593662 scopus 로고    scopus 로고
    • Diabetes abolishes the vascular protective effects of estrogen in female rats
    • DOI 10.1016/S0024-3205(98)00615-8, PII S0024320598006158
    • Bolego C, Cignarella A, Zancan V, Pinna C, Zanardo R, Puglisi L. Diabetes abolishes the vascular protective effects of estrogen in female rats. Life Sci. 1999;64:741-9. (Pubitemid 29098968)
    • (1999) Life Sciences , vol.64 , Issue.9 , pp. 741-749
    • Bolego, C.1    Cignarella, A.2    Zancan, V.3    Pinna, C.4    Zanardo, R.5    Puglisi, L.6
  • 32
    • 34249720541 scopus 로고    scopus 로고
    • Chronic resveratrol enhances endothelium-dependent relaxation but does not alter eNOS levels in aorta of spontaneously hypertensive rats
    • Rush JWE, Quadrilatero J, Levy AS, Ford RJ. Chronic resveratrol enhances endothelium-dependent relaxation but does not alter eNOS levels in aorta of spontaneously hypertensive rats. Exp Biol Med. 2007;232:814-22. (Pubitemid 46827824)
    • (2007) Experimental Biology and Medicine , vol.232 , Issue.6 , pp. 814-822
    • Rush, J.W.E.1    Quadrilatero, J.2    Levy, A.S.3    Ford, R.J.4
  • 33
    • 19744369830 scopus 로고    scopus 로고
    • Chronic administration of resveratrol prevents biochemical cardiovascular changes in fructose-fed rats
    • DOI 10.1016/j.amjhyper.2004.12.012, PII S0895706105000130
    • Miatello R, Vázquez M, Renna N, Cruzado M, Zumino AP, Risler N. Chronic administration of resveratrol prevents biochemical cardiovascular changes in fructose-fed rats. Am J Hypertens. 2005;18:864-70. (Pubitemid 40745275)
    • (2005) American Journal of Hypertension , vol.18 , Issue.6 , pp. 864-870
    • Miatello, R.1    Vazquez, M.2    Renna, N.3    Cruzado, M.4    Zumino, A.P.5    Risler, N.6
  • 34
    • 0032881636 scopus 로고    scopus 로고
    • Endothelial cell regrowth and morphology after balloon catheter injury of alloxan-induced diabetic rabbits
    • Schiller NK, Timothy AM, Chen IL, et al. Endothelial cell regrowth and morphology after balloon catheter injury of alloxan-induced diabetic rabbits. Am J Physiol Heart Circ Physiol. 1999;277:H740-8.
    • (1999) Am J Physiol Heart Circ Physiol , vol.277
    • Schiller, N.K.1    Timothy, A.M.2    Chen, I.L.3
  • 36
    • 70350464512 scopus 로고    scopus 로고
    • Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells
    • Ungvari Z, Labinskyy N, Mukhopadhyay P, et al. Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells. Am J Physiol Heart Circ Physiol. 2009;297: H1876-81.
    • (2009) Am J Physiol Heart Circ Physiol , vol.297
    • Ungvari, Z.1    Labinskyy, N.2    Mukhopadhyay, P.3
  • 37
    • 77953741269 scopus 로고    scopus 로고
    • Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2
    • Ungvari Z, Bagi Z, Feher A, et al. Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2. Am J Physiol Heart Circ Physiol. 2010;299:H18-24.
    • (2010) Am J Physiol Heart Circ Physiol , vol.299
    • Ungvari, Z.1    Bagi, Z.2    Feher, A.3
  • 39
    • 67650659852 scopus 로고    scopus 로고
    • Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: Role of circulating factors and SIRT1
    • Csiszar A, Labinskyy N, Jimenez R, et al. Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1. Mech Ageing Dev. 2009;130:518-27.
    • (2009) Mech Ageing Dev , vol.130 , pp. 518-527
    • Csiszar, A.1    Labinskyy, N.2    Jimenez, R.3
  • 40
    • 33745623098 scopus 로고    scopus 로고
    • The red wine polyphenol resveratrol displays bilevel inhibition on aromatase in breast cancer cells
    • DOI 10.1093/toxsci/kfj190
    • Wang Y, Lee KW, Chan FL, Shiuan CS, Leung LK. The red wine polyphenol resveratrol displays bilevel inhibition on aromatase in breast cancer cells. Toxicol Sci. 2006;92:71-7. (Pubitemid 43985791)
    • (2006) Toxicological Sciences , vol.92 , Issue.1 , pp. 71-77
    • Wang, Y.1    Lee, K.W.2    Chan, F.L.3    Chen, S.4    Leung, L.K.5


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